SINTESIS METIL SALISILAT
LABORATORIUM KIMIA FARMASI FAKULTAS FARMASI UNIVERSITAS MUSLIM INDONESIA
LAPORAN KIMIA ORGANIK SINTESIS SINTESIS METIL SALISILAT SALISILAT
NAMA
:
DHIYA DHIYA LUTHFIYYAH LUTHFIYYAH LUKMAN LUKMAN
STAMBUK
:
15020140126
KELAS
:
C6
KELOMPOK
:
3
ASISTEN
:
ANDI VIDYA SARI
FAKULTAS FARMASI UNIVERSITAS MUSLIM INDONESIA MAKASSAR 2016
DHIYA LUTHFIYYAH L 15020150126
ANDI VIDYA SARI
SINTESIS METIL SALISILAT
BAB I PENDAHULUAN 1.1
Latar Belakang See!"# $%&' (#)e"%*+# ,%*-% Me"#. /%.#/#.%" e!+%)%& /e&$%-%
%.%# $%&' "e!)%&(+&' (%.% #&$%) '%&(%+!% (%& (%%" (#"e+)%& %(% (%+& /e!"% '%'%&' "%&%%& '%&(%+!% G%+."*e!#% / Me"#. /%.#/#.%" ,%&$%) (#'+&%)%& (%.% #&(+/"!##&(+/"!# ,%" ,%"%& ,%*%& e-%&'# #&(+/"!# %)%&%& (%& #&+%& Me"#. /%.#/#.%" (%%" (#,+%" e.%.+# /#&"e/#/#/ (e&'%& !e%)/# e,e&"+)%& e/"e! e/"e!e7#)%/# Re%)/# e/"e!#7#)%/# %(%.%* /+%"+ !e%)/# %&"%!% %/% )%!,)/#.%" (%& %.)*. e,e&"+) e/"e! T+!+&%& %/% )%!,)/#.%" e,e&"+) e/"e! %/% )%!,)/#.%" E/"e! %/% )%!,)/#.%" #%.%* /+%"+ /e&$%-% $%&' e&'%&(+&' '+'+/ 8CO2R (e&'%& R (%%" ,e!+% %.)#. %++& %!#. E/"e!#7#)%/# (#)%"%.#/#/ %/% (%& ,e!/#7%" (%%" ,%.#) Re%)/# e,e&"+)%& /e&$%-% e/"e! (%!# %/% )%!,)/#.%" (%& %.)*. (e&'%& )%"%.#/ %/% (#/e,+" (e&'%& !e%)/# e/"e!#7#)%/# Se&$%-% e/"e! $%&' (#*%/#.)%& %)%& e#.#)# %!% "e!"e&"+ (%& ,e!/#7%" )*%/ D%.% #.+ )##% (%& ,#(%&' 7%!%/# !e%)/# e/"e!#7#)%/# # 9+)+ e&"#&' e&'#&'%" !e%)/# "e!/e,+" e!+%)%& (%/%! /#&"e/#/ ,%&$%) /e&$%-% )##% $%&' (%%" ,e!)*%/#%" /e,%'%# ,%" S%.%* %"+ e&''+&%%&&$% %(%.%* /#&"e/#/ e"#. /%.#/#.%" (%!# %/% /%.#/#.%" (e&'%& e"%&. %,/.+" Se&$%-%/e&$%-% e/"e! (%%" e&'%.%# *#(!.#/#/ (%.% /+%/%&% %/% %++& ,%/% +&"+) e&'*%/#.)%& %/% )%!,)/#.%" (%& %.)*. H#(!.#/#/ e/"e! (%.% /+%/%&% %/% (%%" "e!%(# e.%.+# ,e,e!%% %9% e)%/e !e%)/# "e!'%&"+&' (%!# /"!+)"+! e/"e!&$% "e"%# e)%/e !e%)/# $%&' ++ e!+%)%& )e,%.#)%& (%!# !e%)/# e/"e!#7#)%/# F#/9*e! P%(% !%)"#)+ )%.# # %)%& (#.%)+)%& /#&"e/#/ e"#. /%.#/#.%" ,e!(%/%!)%& !e%)/# e/"e!e7#)%/# $%#"+ e!e%)/#)%& %/% /%.#/#.%" (e&'%& e"*%&. (%& e&''+&%)%& %/% /+.7%" e)%" /e,%'%# )%"%.#/ Se,%'%#%&% %/% /%.#/#.%" e#.#)# '+'+/ 7+&'/# %!%"#) (%& %/% )%!,)/#. DHIYA LUTHFIYYAH L 15020150126
ANDI VIDYA SARI
SINTESIS METIL SALISILAT
1.2 Maksud Praktikum U&"+) e&'e"%*+#
(%&
e%*%#
/#&"e/%
e"#.
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,e!(%/%!)%& !e%)/# e/"e!#7#)%/# 1.3 Tujuan Praktikum U&"+) e&/#&"e/#/ e"#. /%.#/#.%" ,e!(%/%!)%& !e%)/# e/"e!e7#)%/# %&"%!% %/% /%.#/#.%" (%& e"*%&. %,/.+" /e!"% e&%,%*%& %/% /+.7%" e)%" /e,%'%# )%"%.#/%"!
DHIYA LUTHFIYYAH L 15020150126
ANDI VIDYA SARI
SINTESIS METIL SALISILAT
BAB 2 TINAUAN PU!TA"A 2.1
Te#ri Umum Re%)/# e/"e!#7#)%/# %(%.%* /+%"+ !e%)/# %&"%!% %/% )%!,)/#.%" (%&
%.9*. e,e&"+) e/"e!T+!+&%& %/% )%!%,)/#.%" e,e&"+) e/"e! %/% )%!,)/#.%" Fe/e&(e&1;<1 S+%"+ e/"e! %/% )%!,)/#.%" #%.%* /+%"+ /e&$%-% $%&' e&'%&(+&' '+'+/ 8CO2R (e&'%& R (%%" ,e!,e&"+) %.)#. %++& %!#. S+%"+ e/"e! (%%" (#,e&"+) (e&'%& !e%)/# .%&'/+&' %&"%!% /+%"+ %/% )%!,)/#.%" (%& /+%"+ %.9*. /+%"+ !e%)/# $%&' (#/e,+" e/"e!#7#)%/# E/"e!#7#)%/# ,e!)%"%.#/)%& %/% (%& e!+%)%& !e%)/# $%&' !e=e!/#,.e Fe//e&(e& 1;<2 L%+ e/"e!#7#)%/# %/% )%!,)/#.%" "e!'%&"+&' %(% *%.%&'%& /"e!#. (%.% %.)*. (%& %/% )%!,)/#.%" Ke)+%"%& %/% (%!# %/% )%!,)/#.%" *%&$% e+&$%# e&'%!+* )e9#. (%.% e,e&"+)%& e/"e! A& 200; Re%)/# e/"e!#7#)%/# ,e!/#7%" !e=e!/#,e. +&"+) ee!.e* !e&(%e& "#&''# (%!# e/"e! #"+ )e/e"#,%&'%& *%!+/ *%!+/ (#'e/e! )e %!%* /#/# e/"e! S%"+ "e)) +&"+) e&9%%# # %(%.%* e&''+&%)%& /%.%* /%"+ >%" e!e%)/# $%&' +!%* /e9%!% ,e!.e,#*%& Te)) .%#& #%.%* e,+%&' /%.%* /%"+ !(+) (%!# (%.% 9%+!%& !e%)/# #/%.&$% (e&'%& (e/"#.%/# %#! /e9%!% %>e"!#) De&'%& ,e!"%,%*&$% *%.%&'%& /"e!#) (%.% >%" %&"%!% .%+ e,e&"+)%& e/"e! %)%& e&+!+& Re&(%e& e/"e!&$% +& ,e!)+!%&' E/"e! %(%.%* "+!+&%& %/% /%.#/#.%"? )%!,)/#.%" $%&' '+'+/ 8OH (%!# )%!,)/#.&$% (#'%&"# (e&'%& '+'+/ 8OR (%!# %.9*. E/"e! e&'%&(+&' '+'+/ )%!,. (%& /%"+ #)%"%& e/"e! (e&'%& )%!,& )%!,. E/"e! (#,+%" (%!# %/% (%& %.)*. (%!# %&*#(!%" %/% (%& %.)*. D#!e& POM 1;@; Me"#. /%.#/#.%" e!+%)%& "+!+&%& (%!# %/% /%.#/%" $%&' %.#&' e&"#&' /e9%!% )e!/#%. (#/%#&' %/% %/e"#. /%.#/#.%" %/#!#& Me"#. /%.#/#.%" e!+%)%& /e&$%-% e/"e! $%&' %(% /+*+ !+%&'%& ,e!7%/e 9%#! "#(%) ,e!-%!&% e+&$%# %!% $%&' )*%/ .%!+" /e+!&% (%.% %.)*. &%+& /+)%! .%!+" (%.% %#! Me"#. /%.#/#.%" /e!#&' (#)e&%. (e&'%& DHIYA LUTHFIYYAH L 15020150126
ANDI VIDYA SARI
SINTESIS METIL SALISILAT
&%% .%#& #. 7 -#&"e!'!ee& %"%+ #&$%) ,e"+.+ Ke'+&%%&&$% $%&' .+%/ (%.% ,e!,%'%# #&(+/"!# e,+%" e!#&"%%& %)%& )(#"%/ "e!/e,+" e&')%" "#% "%*+&&$% P%(% #&(+/"!# 7%!%/# e"#. /%.#/#.%" (#'+&%)%& /e,%'%# ,%*%& %)"#7 (%.% ,e!,%'%# 7!+.%/# !(+) +&"+) e&(%%")%& e7e) %&%.'e/#)&$% A!% (%& !%/%&$% $%&' )*%/ +'% e,+%"&$% ,%&$%) (#'+&%)%& (# #&(+/"!# %)%&%& %"%+ #&+%& (%& #&(+/"!# )/e"#) Me"#. /%.#/#.%" (%%" (#e)/"!%)/# (%!# %.% (%.% ,e&"+) #&$%) %"/#!# (%!# "%&%%& G%&(%+!% &%+& /e)%!%&' .e,#* ,%&$%) (#+%# %,!#) $%&' e&/#&"e/#/ e"#. /%.#/#.%" (%!# %/% /%.#/#.%" (%& e"%&. Se9%!% ++ !e%)/# e/"e!#7#)%/# %(%.%*
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e&'*%/#.)%& /e&$%-% e/"e! Re%)/# e/"e!#7#)%/# e&''+&%)%& )%"%.#/ %/% (#/e,+" F#/9*e! E/"e!#7#9%"#& P!/e/ !e%)/# %)%& ,e!.%&'/+&' .%,%" "%&% %(%&$% )%"%.#/ ,e!+% %/% )+%" "e"%# !e%)/# %)%& e&9%%# )e/e"#,%&'%& (%.% -%)"+ $%&' /#&')%" )e"#)% %/% )%!,)/#.%" (%& %.)*. (#!e7.+)/ (e&'%& %/% /+.7%" e)%" %"%+ %/% ).!#(% (%.% +.%* /e(#)#" Re%)/# %&"%!% %/% /%.#/#.%" (%& e"*%&. e&''+&%)%& )%"%.#/ ,e!+% %/% /+.7%" %)%& e&'*%/#.)%& e"#. /%.#/#.%" T%&"#% (%& T!#/)% 2013 G.&'%& )##% +"%% /e&$%-% /%.#/#.%" $%&' (#%)%# (%.% e&',%"%& %(%.%* %/% /%.#/#.%" ,e&"+) e/"e! '%!% (%& %#(% $%&' (#e!.e* (e&'%& /+,/"#"+/# %(% '+'+/ )%!,. (%& e/"e! /%.#/#.%" (%!# %/% %/% !'% $%&' (#e!.e* (e&'%& /+,/"#"+/# %(% '+'+/ OH 7e&.%" (%& e+&$%# '+'/ )%!,)/#.%" +"+* D%e. 2011 Me"#. /%.#/#.%" %(%.%* 9%#!%& (e&'%& ,%+ )*%/ $%&' (#e!.e* (%!# (%+& (%& %)%! "+,+*%& %)%! -%&'# G%+"*e!#% !9+,e&/ %" # +'% (#,+%" /#&"e/#/ K*%/#%" %&%.'e"#/&$% %(% e&''+&%%& .)%. /%% (e&'%& /%.#/#.%"/%.#/#.%" .%#&&$% Me"#. /%.#/#.%" (#!e%,/!/# ,%#) .e* )+.#" (%& ,%&$%) (#'+&%)%& (%.% ,%" '/) (%& )!e 310 +&"+) & $e!# "" (%& .%#&.%#& T%&HT 2002
DHIYA LUTHFIYYAH L 15020150126
ANDI VIDYA SARI
SINTESIS METIL SALISILAT
Me"#. /%.#/#.%" %(%.%* /e,+%* /e&$%-% !'%) (%& e!+%)%& /e,+%* e/"e! E/"e! %(%.%* /e,+%* ),#&%/# (%!# /e,+%* %/% !'%) (%& /e,+%* %.)*. Me"#. /%.#/#.%" +'% (#)e&%. /e,%'%# #&$%) '%&(%+!% (%& (#"e+)%& /e9%!% %.%# (#(%.% "%&%%& Me"#. /%.#/#.%" (#'%,%!)%& /e,%'%# /e,+%* /e&$%-% $%&' /%&'%" %!%"#) 9%#!%&&$% )+&' %'%) "e!%&' Me"#. /%.#/#.%" (#e!)#!%)%& e&%(# e.#&(+&' +&"+) "%&%%& $%&' e&'*%/#.)%& #&$%) D%*+.+ Me"#. S%.#/#.%" (#*%/#.)%& (%!# (e/"#.%/# !%&"#&' ,#!9* %/ (%& "%&%%& '%&(%+!% Se)%!%&' e"#. /%.#/#.%" (#/#&"e/#/ (%& (#(%%")%& (%!# e/"e!#7#)%/# %/% /%.#/#.%" (e&'%& e"%&. Me"#. /%.#/#.%" (%%" ,e!+% 9%#!%& #&$%) )+&' %"%+ e!%* D%%" ,e!-%!&% ,e&' +'% D%.% %#! e"#. /%.#/#.%" "e!.%!+" A/% /%.#/#.%" "e!(#!# (%!# %!+ /ee!"# K!#/"%. $%&' !%/%&$% %/ D%%" .%!+" (#,%&$%) >%" "e!%/+) %.)*. ,e&>e&% (%& %#! e&(#(#* Me"%&. %(%.%* ,%'#%& (%!# e"#. /%.#/#.%" (%& '+'+/ *#(!)/#.&$% ,e!e%)/# (e&'%& %/% %/e"%" H%/#.&$% %(%.%* %/% %/e"#./%.#/#.%" $%&' (#)e&%. /e,%'%# %/#!#& I!-%&(# 2014 Me"#. /%.#/#.%" e!+%)%& "+!+&%& (%!# %/% /%.#/%" $%&' %.#&' e&"#&' /e9%!% )e!/#%. (#/%#&' %/% %/e"#. /%.#/#.%" %/#!#& Me"#. /%.#/#.%" e!+%)%& /e&$%-% e/"e! $%&' %(% /+*+ !+%&'%& ,e!7%/e 9%#! "#(%) ,e!-%!&% e+&$%# %!% $%&' )*%/ .%!+" /e+!&% (%.% %.)*. &%+& /+)%! .%!+" (%.% %#! Me"#. /%.#/#.%" /e!#&' (#)e&%. (e&'%& &%% .%#& #. 7 -#&"e!'!ee& %"%+ #&$%) ,e"+.+ Ke'+&%%&&$% $%&' .+%/ (%.% ,e!,%'%# #&(+/"!# e,+%" e!#&"%%& %)%& )(#"%/ "e!/e,+" e&')%" "#% "%*+&&$% P%(% #&(+/"!# 7%!%/# e"#. /%.#/#.%" (#'+&%)%& /e,%'%# ,%*%& %)"#7 (%.% ,e!,%'%# 7!+.%/# !(+) +&"+) e&(%%")%& e7e) %&%.'e/#)&$% A!% (%& !%/%&$% $%&' )*%/ +'% e,+%"&$% ,%&$%) (#'+&%)%& (# #&(+/"!# %)%&%& %"%+ #&+%& (%& #&(+/"!# )/e"#) F%"!#&% 2013 P!(+)/# )!&e!/#%. e"#.
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e/"e!#7#)%/# %/% /%.#./#.%" (%& e"%&% P%(% /#&"e/#/ e"#. /%.#/#.%" (%!# %/% DHIYA LUTHFIYYAH L 15020150126
ANDI VIDYA SARI
SINTESIS METIL SALISILAT
/%.#/#.%" (%& e"%&. (e&'%& e&''+&%)%& )%"%.#/ %/% /+.7%" e)%" # (#,+"+*)%& .%% 9%&%/%& /e)+!%&')+!%&'&$% .#% % %(% /+*+ /e)#"%! .000C ; "e"%# %(% !/e(+! .%#& $%&' e&$%"%)%& ,%*-% +&"+) /#&"e/#/ e"#. /%.#/#.%" # *%&$% (#e!.+)%& e%&%/%& /e.%% !#'% % /%% 4 L%% e!&%&%/%& # %)%& ee&'%!+*# *%/#. /#&!e/#/ e"#. /%.#/#.%" (%& (#(+'% (e&'%& 9%&%/%& $%&' .e,#* .%% %)%& e,e!#)%& 9!/e&"%/e *%/#. $%&' Ie,#* "#&'' /%%# )e!&+(#%& %(% .%% 9%&%/%& "e!"e&"+ /+(%* "#(%) e&')%")%& e!/e&"%/e *%/#. /#&"e/#/ e"#. /%.#/#.%" C*%/%&%* 2010 2.2
Pr#sedur "erja $An#nim% 2&1'(
D#.%)+)%& !e7.+)/ e&''+&%)%& .%,+ %.%/ ,+.%" 100 . %/+))%& 6; ' 005 . %/% /%.#/#.%" (%& 24 ' 30 . 0@5 . e"*%&. (%.% .%,+ T%,%*)%& /e9%!% *%"# 8 *%"# < . %/% /+.7%" e)%" )e (%.% 9%+!%& A(+) .%,+ /e9%!% e!.%*%& %'%! !e%)"%& "e!9%+! /e+%&$% "%,%*)%& ,%"+ (#(#* )e (%.% .%,+ (%& %/%&' e!%.%"%& P%&%/)%& 9%+!%& /%%# e&(#(#* e&''+&%)%& e%&%/%& %&"e. %"%+ "%&'%/ #&$%) B#%!)%& 9%+!%& e&'%.%# !e7.+)/ /e.%% 2 25 % D#&'#&)%& .%!+"%& (%.% .%,+ !e%)/# (e&'%& e&9e.+)%& .%,+ (%.% "%&'%/ e/ )e+(#%& "%,%*)%& 50 . %#!
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!e%)/# )e (%.% 9!&' #/%* (%& #/%*)%& .%#/%& H%"# 8 *%"# e#/%*)%& .%#/%& 9%#!%& $%&' e&'%&(+&' e/"e! C+9# e/"e! )%/%! (e&'%& 50 . N%HCO3 5 (e&'%& e#&(%*)%& e/"e! (%& .%!+"%& N%HCO3 )e 9!&' #/%* (%& )9) 9%+!%& ,e,e!%% /%%" P#/%*)%& (%& ,+%&' .%#/%& %#!&$% C+9# e/"e! %(% /%%" )e"#'% (e&'%& 30 . %#! P#/%*)%& .%#/%& (%& #&(%*)%&
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DHIYA LUTHFIYYAH L 15020150126
ANDI VIDYA SARI
SINTESIS METIL SALISILAT
BAB 3 MET)DE "E*A 3.1 Alat Praktikum A(%+& %.%" $%&' (#'+&%)%& %(% /%%" !%)"#)+ $%#"+
,%/) ,".
/e!" ,%"+ (#(#* 9%-%& !/e.#& 9!&' #/%* e!.e&e$e! 'e.%/ #%.% 'e.%/ +)+! .%,+ %.%/ (%"%! "#,%&'%& %&%.#"#) #e" "e"e/ #e" =.+e e&%&'%/ %#! /e&() "%&(+)/ee!%&')%" %.%" !e7.+)/ 3.2 Ba+an Praktikum A(%+& ,%*%& $%&' (#'+&%)%& %(% /%%" !%)"#)+ $%#"+ A.+#+ 7#. %+%(e/" A/% /+.7%" e)%" A/% /%.#/#.%" e/ ,%"+ K%./#+ ).!#(% (#*#(!%" %'&e/#+ /+.7%" e"%&. %,/.+"e &%"!#+ *#(!)%!,&%" "#//+e (%& = %/e.#& 3.3 ,ara "erja
D#/#%)%& %.%" (%& ,%*%& .%.+ (#"#,%&' 35 '!% %/% /%.#/#.%" (%& (#%/+))%& )e(%.% .%,+ %.%/ (%"%! )e+(#%& (#"%,%* e"%&. ;4 L Se.%&+"&$% (#"%,%*)%& A/% /+.7%" P /e,%&$%) 21 L Se"e.%* #"+ (#%(+) 9%+!%& *#&''% *'e& .%.+ (#%/%&' %.%" !e7.+)/ )e+(#%& (#%&%/)%& /e.%% 2 % D#(#&'#&)%& .%!+"%& 9%+!%& )e (%.% %#! e/ Se"e.%* #"+ (##&(%*)%& .%!+"%& 9%+!%& )e (%.% 9!&' #/%* (%& (#,#%!)%& /e.%% ,e,e!%% e" )e+(#%& (#"%,%*)%& 50 . %+%(e/" )e(%.% .%!+"%& 9% +!%& )e+(#%& (#)9) .%.+ (#,#%!)%& *#&''% "e!,e&"+) (+% .%#/%& Se.%&+"&$% (##/%*)%& .%#/%& (%& .%#/%& ,%-%* $%&' (#%,#. .%.+ (#9+9# (e&'%& 50 L N%HCO3 5 (e&'%& e#&(%*)%& .%!+"%& 9%+!%& )e (%.% 9!&' #/%* "e!.e,#* (%*+.+ (%& (#)9) 9%+!%& ,e,e!%% )%.# Ke+(#%& (##/%*)%& .%!+"%& (e&'%& e,+%&' .%#/%& %#!&$% .%.+ (#9+9# .%'# (e&'%& %#! /e,%&$%) 30 L .%.+ (# )9) (%& (##/%*)%& .%!+"%& (e&'%& e%/+))%& e/"e! )e(%.% e!.e&%$e! Ke+(#%& (#%/+))%& .%!+"%& )e (%.% 'e.%/ +)+! (%& (# +)+! =.+e .%!+"%& $%&' (#e!.e* (%& (#*#"+&' e!/e& !e&(%e&
DHIYA LUTHFIYYAH L 15020150126
ANDI VIDYA SARI
SINTESIS METIL SALISILAT
BAB - HA!IL DAN PEMBAHA!AN -.1 Hasil a. Hasil Pengamatan N#
Penama+an /at
A/% /%.#/#.%"
1
Perua+an
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gramasamsalisilat gram metil salisilat = BM asam salisilat BM metil salisilat
2,3 gram 138,12
=
gram metil salisilat 152
G!% e"#. /%.#/#.%" 00166 152 25311 '!% 2 Be!%" P!%)"e) V.+e e"#. /%.#/#.%" 2 L G!% e"#. /%.#/#.%" V.+e e"%. /%.#/#.%" BJ 13 1<5 2405 '!% DHIYA LUTHFIYYAH L 15020150126
ANDI VIDYA SARI
SINTESIS METIL SALISILAT
3 Re&(%e&
¿
Berat praktek Berat Teori 100 ¿
2,405 gram 2,5311 gram
100
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A/% S%.#/#.%"
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Me"#. /%.#/#.%" e!+%)%& "+!+&%& (%!# %/% /%.#/%" $%&' %.#&' e&"#&' /e9%!% )e!/#%. (#/%#&' %/% %/e"#. /%.#/#.%" %/#!#& Me"#. /%.#/#.%" e!+%)%& /e&$%-% e/"e! $%&' %(% /+*+ !+%&'%& ,e!7%/e 9%#! "#(%) ,e!-%!&% e+&$%# %!% $%&' )*%/ .%!+" /e+!&% (%.% %.)*. &%+& /+)%! .%!+" (%.% %#! Me"#. /%.#/#.%" /e!#&' (#)e&%. (e&'%& &%% .%#& #. 7 -#&"e!'!ee& %"%+ #&$%) ,e"+.+ T++%& (%!# !%)"#)+ # %(%.%* U&"+) e&/#&"e/#/ e"#. /%.#/#.%" (e&'%& e!e%)/#)%& %&"%!% %/% /%.#/#.%" (%& e"*%&. %,/.+"
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e&''+&%)%& %/% /+.7%" e)%" /e,%'%# )%"%.#/%"! .%.+ e&''+&%)%& e"(e !e7.+)/ )e+(#% (#*#"+&' !e&(%e&&$% P%(% !%)"#)+ )%.# # (#.%)+)%& e!9,%%& +&"+) e,+%" e"#. /%.#/#.%" (e&'%& ,%*%& (%/%! %/% /%.#/#.%" P!/e/ e,+%"%& e"#. /%.#/#.%" (%.% !%)"#)+ # e&''+&%)%& !#&/# e/"e!#7#)%/# e&''+&%)%& %/% /%.#/#.%" (e&'%& e"*%&. Se9%!% ++ !e%)/# e/"e!#7#)%/# %(%.%* !e%)/# %&"%!% %/% )%!,)/#.%" (e&'%& %.)*. $%&' e&'*%/#.)%& /e&$%-% e/"e! Se&$%-% e/"e! $%&' (# %)/+( (%.% e!9,%%& # %(%.%* e"#. /%.#/#.%" D#.%)+)%& e&%,%*%& .%!+"%& %/% /+.7%" e)%" +&"+) ee!9e%" !e%)/# %"%+ /e,%'%# )%"%.#/ Pe!"%% 8 "%% (#"#,%&' 35 '!% %/% /%.#/#.%" (%&
DHIYA LUTHFIYYAH L 15020150126
ANDI VIDYA SARI
SINTESIS METIL SALISILAT
(#%/+))%& )e(%.% .%,+ %.%/ (%"%! )e+(#%& (#"%,%* e"%&. %,/.+"e ;4 L P!/e/ !e%)/# %)%& ,e!.%&'/+&' .%,%" "%&% %(%&$% )%"%.#/ ,e!+% %/% )+%" "e"%# !e%)/# %)%& e&9%%# )e/e"#,%&'%& (%.% -%)"+ $%&' /#&')%" )e"#)% %/% )%!,)/#.%" (%& %.)*. (#!e7.+)/ (e&'%& %/% /+.7%" e)%" (%.% +.%* /e(#)#" %)% (%.% !%)"#)+ # (#'+&%)%& %/% /+.7%" e)%" /e,%&$%) 21 L Re7.+)/ (#.%)+)%& *#&''% .%!+"%& e&(#(#* /e.%% 2 % )e+(#%& (#(#&'#&)%& Se*%!+/&$% (%.% !/e/ # "e!,e&"+) 2 .%#/%& (%.% .%!+"%& &%+& *%. # "#(%) "e!%(# %(% e!9,%%& $%&' (#.%)+%)%& !%)"#)%& Se"e.%* (# (#&'#&)%& .%!+"%& %)%& e&'*%/#.)%& ,%+ )*%/ /ee!"# ,%+ ,%./% #&" B%+ ,%./% #&" $%&' +&9+. e&%&(%)%& "e.%* "e!,e&"+) e"#. /%.#/#.%" Se.%&+"&$% .%!+"%& (# "%,%*)%& 50 L %+%(e/ (%& 9%+!%& (#)9) e&''+&%)%& 9!&' #/%* H%. # (#.%)+)%& +&"+) e#/%*)%& #&$%) (%!# .%!+"%& )%!e&% /%.%* /%"+ 9#!# e"#. /%.#/#.%" %(%.%* .%!+" /e+!&% (%.% %.)*. (%& /+)%! .%!+" (%.% %#! %)%& (#e!.e* /e&$%-% e"%. /%.#/#.%" +! (%& ,e,%/ (%!# >%" .%#& Se.%&+"&$% (##/%*)%& .%#/%& (%& .%#/%& ,%-%* $%&' (#%,#. .%.+ (#9+9# (e&'%& 50 . N%HCO3 5 (e&'%& e#&(%*)%& .%!+"%& 9%+!%& )e (%.% 9!&' #/%* "e!.e,#* (%*+.+ (%& (#)9) 9%+!%& ,e,e!%% )%.# A.%/%& e&%,%*%& N%HCO3 5 %(%.%* +&"+) e#/%*)%& %/% /%.#/#.%" (%!# e"#. /%.#/#.%" (#%&% N%HCO3 5
%)%& ,e!e%)/# (e&'%& %/% /%.#/#.%" e,e&"+) N%"!#+
/%.#/#.%" $%&' .%!+" (%.% %#! L%&')%* /e.%&+"&$% %(%.%* (e&'%& e#/%*)%& .%!+"%& (e&'%& e,+%&' .%#/%& %#!&$% )e+(#%& (#9+9# .%'# (e&'%& e&''+&%)%& %#! /e,%&$%) 30 L )e+(#%& (# )9) (%& (##/%*)%& .%!+"%& (e&'%& e%/+))%& e/"e! )e(%.% e!.e&%$e! A.%/%& (#.%)+)%& e&9+9#%& )e(+% (e&'%& %+%(e/" %(%.%* +&"+) e&9+9# )e.e,#*%& (%!# N%"!#+ B#)%!,&%"
DHIYA LUTHFIYYAH L 15020150126
ANDI VIDYA SARI
SINTESIS METIL SALISILAT
Se"e.%* e&9+9#%& (e&'%& %+%(e/ (#%/+))% )e (%.% 'e.%/ +)+! (#,#%!)%& (%.% 'e.%/ +)+! /e.%&+"&$% (# +)+! =.+e .%!+"%& $%&' (#e!.e* (%& (#e!.e* e!/e& !e&(%e& (%!# e"%. /%.#/#.%" %(%.%* ;5 A(%+& 7%)"! )e/%.%*%& (%.% !%)"#)+ # )e"#(%) "e.#"#%& !%)"#)%& "e!*%(% e&%,%*%& A/% /+.7%" e)%" $%&' /e*%!+/&$% (#"%,%*)%& /e(#)#" (e# /e(#)#" /e*#&''% !e%)/# $%&' (##&'##&)%& "#(%) /e+!&% (%& e,e&"+)%& e"#. /%.#/#.%" ,#/% (#%&''% '%'%.
DHIYA LUTHFIYYAH L 15020150126
ANDI VIDYA SARI
SINTESIS METIL SALISILAT
BAB PENUTUP .1 "esimulan
Be!(%/%!)%& *%/#. !%)"#)+ $%&' "e.%* (#.%)+)%& (%%" (#/#+.)%& ,%*-%
S#&"e/#/ e"#. /%.#/#.%" $%&' (#,+%" (e&'%& 9%!% e!e%)/#)%& %&"%!%
%/% /%.#/#.%" (e&'%& e"*%&. %,/.+" e&''+&%)%& e"(e !e7.+)/ (#(%%")%& *%/#. e!/e& !e&(%e& $%&' $%#"+ ;5 .2 !aran
Se,%#)&$% %/#/"e& "#(%) ,/%& (%.% e,#,#&' (%& e&+&"+& !%)"#)%& /e!"%
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)e!%%%*%&&
%$)e"#)%
,e!#&"e!%)/# (e&'%&
!%)"#)%&
DHIYA LUTHFIYYAH L 15020150126
ANDI VIDYA SARI
SINTESIS METIL SALISILAT
DATA* PU!TA"A
A& 200; Penuntun Praktikum Kimia Organik 2 UGM : Y'$%)%!"% A& 2016 Penuntun Praktikum Kimia Sintetik UMI : M%)%//%! C*%/%&%* U 2010 Pengaruh Lama Pemanasan terhadap Hasil Reaksi Sintesis Metil Salisilat dari Asam Salisilat dan Metanol dengan Katalis Asam Sulfat Pekat. D%e. 2011 Sintesis 2-Hidroksi-N-enil-!en"amida Melalui #sterifikasi Asam Salisilat $ila%utkan Proses Amidasi $engan enilamida. D#!e& POM 1;@; armakope &ndonesia #disi &&& De)e/ RI : J%)%!"% F%"!#&% T (%& #&%!) TU 2013 S&ntesis Metil Salislat UGM : Y'$%)%!"% Fe//e&(e& (%& Fe//e&(e& 1;<1 Kimia Organik #disi Ketiga 'ilid 2 E!.%&''% : J%)%!"% I!-%&(# De(# 2014 #(periment)s of Organi* +hemistr, J%)%!"%: UIN S$%!#7 H#(%$%"+..%* PIPAFITK P!e// : J%)%!"% T%&"#% (%& T!#/)% 2013 Praran*angan Parik Metil Salisilat dari Asam Salisilat dan Metanol denganKapasitas /.///0on10ahun. T%$ TH 2002 Oat Oat Penting PT G!%e(#% : J%)%!"%
DHIYA LUTHFIYYAH L 15020150126
ANDI VIDYA SARI
SINTESIS METIL SALISILAT
LAMPI*AN !"EMA "E*A
A/% /%.#/#.%" 35 '!% Me"%&. %,/.+" ;1 L
H2SO4 P 25 L
Re7.+)/ 2 8 25 %
D#(#&'#&)%& %(% e/ ,%"+
50 L H2O
(#%/+))%& (%.% C!&' #/%*
(##/%*)%& e/"e! (%& %#!&
%$ 50 L N%HCO3 5
(#%/+))%& (%.% C!&' #/%*
DHIYA LUTHFIYYAH L 15020150126
ANDI VIDYA SARI
SINTESIS METIL SALISILAT
30 L H2O
C!&' #/%*
D##/%*)%& e"#. /%.#/#.%" (%& %#!&
%$U)+! V.+e
H#"+&' !e&(%e&
DHIYA LUTHFIYYAH L 15020150126
ANDI VIDYA SARI
SINTESIS METIL SALISILAT
4AMBA*
Alat *e5luks
Didinginkan dalam es
DHIYA LUTHFIYYAH L 15020150126
setela+ emanasan 2 jam
ANDI VIDYA SARI