Staphylococcus

STAPHYLOCOCCUS SP.

A S I S T E N S I M I K R O B I O LO LO G I BLOK KULIT 2015

GANI DWI CAHYA G0012082

MORFOLOGI Coccus Grape-like cluster  Nonmotil  Tidak  T idak membentuk !o"a

KARAKTERISTIK  G"am #$% men&'ailkan !i&men be"(a"iai ) Staphylococcus epidermidis *uti' Staphylococcus citreus Kunin& te"an& Staphylococcus aureus kunin& ema Staphylococcus saprophyticus +i,au 'idu! !ada kondii ae"ob mau!un anae"ob Katalae #$% membedakan den&an Streptococcus sp. Koa&ulae #$% !ada Staphylococcus sp. (i"uleni tin&&i Sta!'-lo.o..u koa&ulae ne&ati(e me"u!akan kom!onen mik"o/o"a utama !ada kulit no"mal dan mukoa 

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RESISTENSI da!at be"ta'an !ada u'u 50  elama 03 !ada u'u "enda' da!at be"ta'an be"bulan4 bulan !ada ke"ta kain benan& -an& ke"in& da!at be"ta'an ) 6 7 18 m&& °

ENZIM DAN TOKSIN 1. Katalase Men&u"ai +2O2 men,adi +2 dan O2 #tam!ak &elembun& uda"a !ada u,i katalae% 2. Koagulase & clumping facto Be"ama den&an ta!'-lot"ombin  9b"in .lot te"'inda" da"i :a&oitoi !. H"aluoni#ase $spea#ing facto% Meme.a' aam '-alu"onat . 'ain(lain Sta!'-lokinae *"oteinae Li!ae ;4laktamae 

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CONT’D .. (TOKSIN) 1. )*soto*sin -

<4to=in ) 'emoliin

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;4to=in ) mende&"adai !'-&om-elin !ada e"it"oit

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>4to=in ) men&an&&u biolo&ikal memb"an

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?4to=in ) meliikan leukoit den&an membentuk !o"i !ada memb"an -an& da!at menin&katkan !e"meabilita leukoit

2. 'eu*osi#in

me"uak dindin& el da"a' !uti' #mekanime e"u!a ?4to=in% !. +o*sin e*sfoliatif 

men-ebabkan !iode"ma dan ,u&a Sta!'-lo.o..al Skin S.alded S-nd"ome meliikan mat"ik e!ide"mi #e!ide"molii%

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.+,,+(1 $to-ic soc* s"n#ome to-in(1%

menimbulkan mani:etai demam -ok "uam dan dekuamai kulit !ada tokik -ok -nd"om #TSS%

/I ID)N+IIKA,I Hemolisis

3em4ent u*an pigmen

anitol

Katalase

Koagulas i

S. aureus

S. epidermidis

S. epidermidis

S. aureus

 ASPEK KLINIS Bebe"a!a an&&ota Staphylococcus sp. me"u!akan)  4 /o"a no"mal !ada kulit dan memb"an mukoa naal 4 !e"n-ebab te"bentukn-a nana' abe dan be"ba&ai in:eki !io&enik kulit  4 !en-ebab kondii :atal e!e"ti e!tikemia SSSS TSS db  &olon&an te"e"in&) S. aureus  (i"uleni tin&&i   (i"uleni "enda'@ S. Epidermidis S. Sapr!p"#$i%us in:eki o!o"tunitik INOS  alu" t"anmii ) te"utama kontak den&an luka  !ende"ita C :ood !oionin& 

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 ASPEK KLINIS (CONT’D)

,+A3HY'5C5CCA' ,CA'D)D ,KIN ,YND65) $,,,,% a !e.t"um o: u!e"9.ial blite"in& kin .aued b- t'e e=:oliati(e to=in o: ome t"ain o: S. aureus #!'a&e &"ou! II in.ludin& t-!e 55 D1 A B %  T'e to=in likel- a.t a !"oteae t'at ta"&et t'e demo&lein41 #G41% !"otein *o!olation at "ik )   T'e .'ild'ood i mot o:ten  unde"l-in& dieae "elated to immunou!!"eion abno"mal immunit- and "enal inuF.ien.= ) 4 Nikolk-3 i&n #$% 4 ultu"e !e.imen #taken :"om t'e e-e noe t'"oat bullae and an- ob(ioul- in:e.ted a"ea% ) S. aureus •

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+57IC ,H5CK ,YND65)  TSS likel- "elate to t'e abilit- o: e=oto=in #TSST41% o: S. aureus  to a.t a u!e" anti&en Su!e"anti&en do not "eui"e !"o.ein& b- anti&en4!"eentin& .ell but intead inte"a.t di"e.tl- Hit' t'e .la II M+ mole.ule T'e u!e"anti&en4M+ .om!le= t'en inte"a.t Hit' t'e T4.ell "e.e!to" and timulate la"&e numbe" o: T .ell to .aue an e=a&&e"ated d-"e&ulated .-tokine "e!one lini.al :eatu"e )  :eb"ile ilne  e"-t'"ode"ma   mai(e (aodilatation C in."eae (a.ula" !e"meabilit 'o.k  "enal :ailu"e  multi-tem di-:un.tion

)+HICI''IN(6),I,+AN+ STAP&'LOCOCCS  ARES $6,A% S. aureus me"u!akan itila' untuk stain 4a*tei "ang su#a esisten tea#ap anti4ioti* golongan 4eta la*tam "ang 4iasan"a di&unakan untuk te"a!i S.  Aureus  Ti!e ) 'ealt' .a"e4ao.iated MRSA #+A4MRSA% .ommunit-4ao.iated MRSA #A4MRSA% In:eki ole' MRSA diaoiaikan den&an !enin&katan mo"bidita kebutu'an te"a!i antibiotik -an& lebi' lama "aHat ina! -an& lebi' lama bia-a "uma' akit -an& lebi' ma'al dan !enin&katan "iiko kematian  St"ain MRSA uda' "eiten te"'ada! bebe"a!a antibiotik &olon&an !eni.illin .e!'alo!o"in .a"ba!enem

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H)A'+H CA6)(A,,5CIA+)D 6,A $HA(6,A% *ada "uma' akit C :ailita !ela-anan kee'atan *o!ulai be"iiko ) *aien -an& te"lalu lama di"aHat di RS *aien den&an te"a!i 'emodialia *aien kanke" den&an obat4obat imunou!"ean *aien den&an "iHa-at o!e"ai  S-m!tom) tidak !ei9k  .ende"un& lebi' be"at 'et !ain ou&' o" 'o"tne o: b"eat' Jati&ue Je(e" and .'ill Gene"al ill :eelin& +eada.'e Ra'

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C5/NI+Y(A,,5CIA+)D 6,A $CA(6,A% Studie 'oH t'at about 1 in  !eo!le .a""- staph in t'ei" noe THo in 100 !eo!le .a""- MRSA *o!ulation at "ik ) !eo!le H'o li(e in ."oHded .ondition .'ild"en in da-4.a"e membe" o: t'e milita"at'lete S-m!tom  un!ei9. kin in:e.tion Red SHollen *ain:ul a"m to t'e tou.' Jull o: !u o" ot'e" d"aina&e A..om!anied b- a :e(e" 

6,A $C5N+D...% *eme"ikaan Lab) G"am tainin& Kultu" #da"i luka da"a' u"in !utum db% e:o=itin dik ."een tet *en&obatan) 4 Antibiotika -an& ami' eniti: ) T"imet'o!"im4 ul:amet'o=aole lindam-.in o=-.-.line Mino.-.line Ri:am!in an.om-.in 4 O !ada kau be"at ) an.om-.in *en.e&a'an) Melakukan tindakan '-&ene +inda"i kontak kulit den&an o"an& -an& te"in:eki atau benda -an& me"eka entu' Men&&unakan a"un& tan&an di!oable &oHn dan make" aat meme"ika !aien MRSA 

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DA+A6 3/,+AKA  aHet Melni.k C Adelbe"&3 Medi.al Mi."obiolo&-) 28t' Edition 200D M.G"aH4+ill  Ka-e" J+ Bien KA E.ke"t  inke"na&el RM 2005 Medical Microiolo!y. T'ieme MRSA 'tt!)HHHnlmni'&o(medline!luen.-a"ti.le00D261'tm Met'i.illin4"eitant ta!'-lo.o..u au"eu #MRSA% in:e.tion labinde='tml Reitant Su!e"bu& "eate Need 'tt!)HHHmed.a!e.om(ieHa"ti.le558P5Q

:o"

'tt!)HHH.d.&o(m"a

No(el

Sta!'-lo.o..u S.alded Skin 'tt!)emedi.inemed.a!e.oma"ti.leD1PP4o(e"(ieH

Antibioti.

S-nd"ome

 To=i. S'o.k S-nd"ome 'tt!)emedi.inemed.a!e.oma"ti.le16P1DD4o(e"(ieH K"aue R +abe"l R ol/e" A a=bo.k J Aune" + K"e, G eni.'  et al #200% Mole.ula" t-!in& o: .oa&ulae4ne&ati(e ta!'-lo.o..al blood and kin .ultu"e iolate to die"entiate betHeen ba.te"emia and .ontamination "ur # Cli$ Microiol %$&ect 'is  22)

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