HERPES HERP ES GEN GENIT ITALI ALIS S ELEONORA RUMANDE BANDU ELEONORA 11.2013.046 FK. UKRIDA
Pendah!an He"#e$ %en&'a! (e"#a)an #en*a)&' &n+e)$& a)' #ada %en&'a! den%an %a(,a"an )ha$ ,e"#a -e$&)e! ,e")e!(#) #ada da$a" e"&'e(a'$a/ dan ende"n% ,e"$&+a' "e)"en.
E#&de(&!%& an&'a #"&a
S"-e& )e$eha'an 'e",a" na$&na! *an% d&!a))an d& A(e"&)a Se"&)a' (en%n%)a#)an #"e-a!en$& an'&,d& HS2 da!a( 45 da"& "a$ )!&' h&'a(/ 22 da"& "a$ Me)$&) A(e"&)a/ dan 17 da"& "a$ )!&' #'&h
E'&!%& -&"$ DNA. Fa(&!* Herpesviridae Me!a))an "e#!&)a$& $ea"a &n'"an)!ea" dan (en%ha$&!)an &n)!$& &n'"an)!ea" )ha$ *an% 'e"de'e)$& da!a( #"e#a"a' #e8a"naan. HS1 dan HS2 ada!ah -&"$ lipidenveloped double-stranded DNA
HS1 (en*e,a,)an !)a a'a -e$&)e! (e"adan% d& $e)&'a" (!' da#a' (en*e,a" )e a"ea %en&'a! $e!a(a $e)$ "a!.
HS2 he"#e$ %en&'a!&$. &"$ (en*e,a" (e!a!& )n'a) $e)$a! dan )!&')e)!&'
Pa'%ene$&$
Ge9a!a K!&n&$ N*e"& dan d&$"&a U"e'"a! dan -a%&na! d&$ha"%e Ge9a!a $&$'e(&) :(a!a&$e/ de(a(/ (&a!%&a/ $a)&' )e#a!a; L&(+aden#a'& *an% n*e"& #ada dae"ah &n%&na! N*e"& #ada "e)'(/ 'ene$($
E"&'e(a
e$&)e! dan #$'!
E"$& < !$e"a$&
Le$& den%an K"$'a
Re%ene"a$&
Pe(e"&)$aan Penn9an% T=an) 'e$' #e8a"naan G&e($a da'&a ,e"&n'& ,an*a) M&)"$)# e!e)'"n
Pe(e"&)$aan an'&,d& #!&)!na! den%an a"a &(n>"e$en$&/ &(n#e")$&da$e/ dan ELISA K!'" -&"$ Te$ DNA HS :P?R;
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D&a%n$&$ D&a%n$&$ he"#e$ %en&'a!&$ da#a' d&'e%a))an ,e"da$a")an "&'e"&a d&a%n$&$ $ea"a )!&n&$/ #e(e"&)$aan !a,"a'"&(/ #e(e"&)$aan (&)"$)#&$ !an%$n%/ #e(e"&)$aan )!'" 9a"&n%an/ dan #e(e"&)$aan $e"!%&.
D&a%n$&$ Band&n% U!)$ d"(
U!)$ (!e
L&(+%"an!(a -ene"e(
Pena'a!a)$anaan Id)$"&d&n. Ana!% '&(&d&n/ d&(a$))an )e da!a( DNA -&"$ (en%%an'&)an '&(&d&n (en%a)&,a')an aa' $&n'e$&$ DNA @ a)h&"n*a #en%ha(,a'an "e#!&)a$& -&"$. %a (en%ha(,a' '&(&d&!a' +$+"&!a$e.
A$&)!-&" Pen%,a'an &n+e)$& #"&(e" 200 (% #e" "a! $e'&a# 4 9a( :5 )a!& < ha"&; $e!a(a 7 10 ha"&/ a'a 400 (% #e" "a! 3 )a!& < ha"& $e!a(a 510 ha"&. Te"a#& &n'e"(&'en n') "e)"en$& 200 (% #e" "a! $e'&a# 4 9a( :5 )a!& < ha"&; $e!a(a 5 ha"&/ d&(!a& d& a8a! 'anda a'a %e9a!a "e)"en$&. S#"e$& n') "e)"en$& :,&!a "e)"en C )a!& < 'ahn; 400 (% #e" "a! 2 )a!& < ha"& $a(#a& 12 ,!an/ "e%&(en a!'e"na'&+
Fa($&)!-&" Pen%,a'an e#&$de "e)"en 1000 (% #e" "a! 2 )a!& < ha"& $e!a(a 1 ha"&/ d&(!a& da!a( 8a)' 6 9a( da"& n$e' %e9a!a a'a !e$&. Te"a#& $#"e$&+ 250 (% #e" "a! 2 )a!& < ha"& $a(#a& 1 'ahn. Pen%,a'an e#&$de #"&(e" :!a,e!; 250 (% #e" "a! 3 )a!& < ha"& $e!a(a 510 ha"&
a!a$&)!" E#&$de #"&(e" 1 % #e" "a! $e'&a# 12 9a( $e!a(a 10 ha"&/ ?"?! 102 (L < (en&' 1 % #e" "a! #e" ha"&/ ?"?! 10 (L < (en&' 500 (% #e" "a! #e" ha"&. E#&$de "e)"en 500 (% $e'&a# 12 9a( $e!a(a 3 ha"& :'&da) ada da'a 'en'an% )e(an9"an 9&)a (!a&C 24 9a(;/ ?"?! 30 (L < (en&' 500 (% #e" "a! #e" ha"&. S#"e$&/ &(n)(#e'en 1 % #e" "a! #e" ha"&/ ?"?! 30 (L < (en&' 500 (% #e" "a! #e" ha"& S#"e$&/ &(n)(#e'en dan a'a )"an% "e)"en$& #e" 'ahn 500 (% #e"
K(#!&)a$& In+e)$& (en!a" $e)$a! !a&nn*a In+e)$& TOR?H dan &n+e)$& ,a*& ,a" !ah&" Ma$a!ah )andn% )e(&h Men&n%&'&$ In>$a(a$& "e)'a! : #")'&'&$ ;
P"%n$&$ Pen%,a'an $ea"a d&n& dan 'e#a' a)an (e(,e"& #"%n$&$ *an% !e,&h ,a&)/ *a)n& (a$a #en*a)&' ,e"!an%$n% !e,&h $&n%)a' dan "e)"en$& !e,&h 9a"an%
Ke$&(#!an He"#e$ %en&'a! (e"#a)an #en*a)&' &n+e)$& a)' #ada %en&'a! den%an %a(,a"an )ha$ ,e"#a -e$&)e! ,e")e!(#) #ada da$a" e"&'e(a'$a/ dan ende"n% ,e"$&+a' "e)"en.
U((n*a d&$e,a,)an !eh he"#e$ $&(#!e)$ -&"$ '&#e 2 :HS2;
Te"&(a Ka$&h
