Sintesa Aspirin dengan Reaksi Esterifikasi FenolFull description
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SINTESIS OBA OBAT KELOMPOK 2 GOLONGAN ALKIL AMIN EFEDRIN
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Henny Jayanti
Ika aulia
Imelda yulianti
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Golongan Obat
Nama Kimia
: (1R, 2S)-2-(metthylamino)-1-phenylpropan-1-ol 2S)-2-(metthylamino)-1-phenylpropan 2S)-2-(metthylamino)-1-phenylpropan--1-ol 1-ol hydrochloride Berat Molekul : 201, 0 !emerian : "er#uk atau ha#lur halu", putih, tidak #er#au Kelarutan: mudah larut dalam air, larut dalam etanol, tidak larut dalam eter ($epke" R%, 1&&')
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Pemerian Ephedrine terjadi ebagai hal!" p!tih" tida# berba! #rital ata! b!b!# dan gelap aat ter#ena $aha%a& 'al ini m!dah lar!t dalam air dan edi#it lar!t dalam al#ohol&
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'itor% Di dalam obat(obatan obat(ob atan traditionil )ionghoa" tanaman obat m* h!*ng + 麻黄 " Ephedra ini$a, mengand!ng bahan !tama e-edrina dan pe!doe-edrina& 'al er!pa j!ga terdapat di em!a prod!$t obat(obatan tanaman %ang mengand!ng ari +e.tra$t, dari pe$ie E-edra& E-edrina diiolai pertama #alin%a oleh Naga%ohi Nagai dari tanaman Ephedra dita$h%a +%n& Ephedra /!lgari, pada tah!n
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6t!r!#t!r 3ang!n
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6intei 1. Sintesis efedrin oleh Neuberg dan Hirsch (tahun 1921) a& Mengg!na#an te#ni# intei tereoele#ti-
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b& Kem!dian #atalii hidrogenai dengan bant!an metilamin" platin!m
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b& Propiophenonedi!baholehioamilnitrit +ionitroo#eton," #em!diandihidrolii& C CH2 O
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2. Sintesis efedrin efe drin oleh Manske, Johnson dan Skita Skita (tahun 1929) 6intei ini mengg!na#an deri/at aam propionat pada al#ilai Friedel(8ra-t
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Na*ai dan Kanao melaporkan "inte"i" eedrin
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Identi9#ai
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ene apan #adar
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Proed!r Kerja
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