Neonatal Sepsis Pathophysiology

Pathophysiology of the Disease Process Precipitating Factor Factor Early-Onset Maternal Pyrexia n!ection Abuse #acteria- ". Aureus$ E. %oli$

-

- Recurrent Abortion - Maternal "ubstance - &ow birt' (eig't

%'la)ydia$ Enterobacter irus- Entero,irus$ adeno,irus$ iral dses. !etus Prolonged ROM PROM en,iron)ent Maternal 01 %'orioa)nionitis Poor 2renatal care Poor )aternal nutrition &ow socio-econo)ic status

- *i+cult *eli,ery - Meconiu) "taining - "tress and illness o! t'e at deli,ery - a/ardous uterine

&ate-Onset Prolonged os2itali/ation Prese Presence nce o! o! !orei !orei n bod bod -

nitial nsult #acteria$ ,iral$ trau)atic$

Antibioti

n!ection

Predisposing Factor Gender Race Age- <35 wks. AOG

Monocytes kills

"yste)ic Reaction

Pro-n6a))atory Res2onse % tokines

#alance Production o! 1'ro)bi %oagulation Pro)otes %lot 9or)ation o)eostasis

Anti-n6a))atory Res2onse &-78

)balance