laporan rifampisin

LAPORAN KIMIA FARMASI FARMASI ANALISIS II GOLONGAN ANTIBIOTIK  “RIFAMPISIN”

Disusun oleh: Risa Rahayuni

: 3111!"

Resi #uliasa$i

: 3111!

S$i% $i%an&i A&isah

: 3111!'

STIK(S BAKTI T)NAS *)SADA    

TASIKMALA#A "13+"1!

RIFAMPISIN A. Tujuan Menen&u,an ,a-a$ $i.a/0isin -ala/ en&u, &ale& -en2an /en22una,an /e&o-e

&i&$asi io-o/e&$i B. Mekanisme Reaksi Io- eas se0e$&i halo2en lain -a0a& /enan2,a0 ele4&$on -a$i 5a& 0e$e-u,si6

sehin22a io- sea2ai o,si-a&o$ Ion I+ sia0 /e/e$i,an ele4&$on -en2an a-anya 5a&  0enan2,a0 ele4&$on6 sehin22a I+ e$&in-a, sea2ai 5a& 0e$e-u,si Me&o-a io-o/e&$i -ala/ analisis 7olu/e&$i -i-asa$,an 0a-a 0$oses o,si-asi $e-u,si yan2 /elia&,an: I"80a-a&9  "e ; "I+ Pa-a ee$a0a li&e$a&u$e6 se$in2 $ea,si ini -i&ulis,an sea2ai: I3+  "e ; 3I+ C. Dasar Teori Ke/a/0uan sua&u &e$a0i an&i/i,$oial san2a& e$2an&un2 ,e0a-a oa&6 0e?@ -i I&ali -a$iSterptomycess mediterranei. Ri.a/0isin /e$u0a,an ,o/0onen /ayo$ -a$i OAT a,&i7i&as an&i/i,$oa i,a&an an&a$a DNA  -e0en-en& RNA 0oly/e$ase -a$i /i,oa&e$iu/6 ,e/u-ian /en2ha/a& sin&esis a%al RNA

Ri.a/0isin /e$u0a,an se$u, ,$is&al /e$ah+4o,la& -an san2a& se-i,i& la$u& -ala/ ai$  -an se-i,i& la$u& -ala/ al,ohol Oa& ini /e/0unyai 0Ka @6> La$u& -ala/ ,lo$o.o$/6 DMSO6 e&il ase&a&6 /e&anol6 &e&$ahi-$o.u$an Dala/ 0e$-a2an2an6 $i.a/0isin &e$se-ia -ala/  en&u, se$u, s&e$il un&u, in
D. Alat dan Bahan a. Alat - Lau sen&$i.u2e - S&a&i.  - Kle/ - Bu$e& 4o,la& - Pi0e& 7olu/e 1 /l - ($len/eye$ "? /l 3 uah - Gelas ,i/ia "? /l 1 uah - Gelas ,i/ia 1 /l 1 uah + Ba&an2 0en2a-u,  - S&a&i.  - Pi0e& &e&es b. Bahan - Ri.a/0isin 8No sa/0el R"9 - KI - *l 1 N -  Na&$iu/ &iosul.a& - A/ilu/ - Me&hanol - ACua-es&ila&a . Prosedur Sa/0el

Sa/ el A

Sa/ el B

Masin2+/asin2 89 ,an /e&anol 1 /l

Sa/ el 

Dila$u&,an -en2an /e&hanol 1 /l

Sen&$i.u2e

Te$en&u, " .asa : - Fasa /e&anol

-

A/il .ase /e&anol

Ti&$asi io-o/e&$i

F. Data !asil Ti-a, -i0e$oleh -a&a 0a-a 0$a,&i,u/ ini

". Pembahasan P$a,&i,u/ ini e$&u
/e/0unyai $u/us s&$u,&u$ yai&u sea2ai e$i,u&:

Diliha& -a$i s&$u,&u$nya 0enen&uan ,a-a$ $i.a/0isin -a0a& -i&en&u,an -en2an /en22una,an ins&$u/en& s0e,&$o.o&o/e&$i ,a$ena $i.a/0isin /e/0unyai i,a&an $an2,a0 &e$,on
-isen&$i.u2e -ia/il .ase /e&anolnya ,e/u-ian la,u,an 0enen&uan ,a-a$ $i.s/0isin Me&o-e yan2 -i2una,an 0a-a 0enen&uan ,a-a$ ini yai&u /e&o-e &i&$asi Re-o,s 8io-o/e&$i9 Ti$asi $e-o,s ini -i-asa$,an 0a-a 0e$0in-ahan ele,&$on an&a$a anali& Penen&uan &i&i, a,hi$nya -a0a& /en22una,an in-i,a&o$ yan2 -a0a& e$uah %a$nanya -en2an a-anya ,eleihan &i&$an Pa-a &i&$asi $e-o,s ini a-a ee$a0aa
a%al &i&$asi6 ,e&i,a /asih anya, &e$-a0a& io- -ala/ la$u&an6 /a,a se
yan2 ,e4il -ala/ ai$6 sehin22a u/u/nya

-i&a/ah,an 0a-a &i&i, a,hi$ &i&$asi Ei,a la$u&an io-iu/ -ala/ KI 0a-a suasana ne&$al -i&i&$asi -en2an na&$iu/ &hiosul.a&6 /a,a : I3+  "S"O3"+ ; 3I+  S!O"+ S"O3"+  I3+ ; S"O3I+  "I+ "S"O3I+  I+ ; S!O"+  I3+ S"O3I+  S"O3"+ ; S!O"+  I+ Te&a0i se&elah -ila,u,an 0$a,&i,u/ &i&$asi ini 2a2al ,e/un2,inan -isea,an oleh  ee$a0a .a,&o$ -ian&a$anya I" &i-a, &e$en&u,6 ,a$ena I" /u-ah /en2ua0 ,e/un2,inan I" hais /en2ua0 seelu/ &i&i, a,hi$ &i&$asi &e$
Ka-a$ $i.a/0isin -en2an no sa/0el R" &i-a, -a0a& -i&en&u,an ,e/un2,inan -isea,an oleh ee$a0a .a,&o$ -ian&a$anya I" &i-a, &e$en&u,6 ,a$ena I" /u-ah /en2ua0 ,e/un2,inan I" hais /en2ua0 seelu/ &i&i, a,hi$ &i&$asi &e$
I. Da%tar Pustaka i-o-o6 Di-i, Se&iyo6 -an Lusiana6 Re&no A$ia-i6 8"19 Kimia Analisis Kuantitatif. G$aha Il/u: #o2ya,a$&a Anonim (2007). British Pharmacopoeia, one & t wo Edition. Hal 5206

Anoni/ Analytical Profiles of Drug Substances, Vol 05 *al !@ Anoni/ An&iio&i,a h&&0:==i-%i,i0e-iao$2=%i,i=An&iio&i,a 8a,ses &an22al " /a$e& "13