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Infammatory bowel disease (IBD) and Homoeopathy
Dr. Rajneesh Kumar Sharma MD (Homo Dr. Dr. Swati Sw ati Vishn Vis hn Dr. Preetika Lakhe Dr. Mohammad ayya! Da Dr. Mohammad ayya! "m
Infammatory bowel disease (IBD) and Homoeopathy Homoeopathy
Infammatory bowel disease (IBD) and Homoeopathy #
Dr. Dr. Rajneesh Kumar Sharma MD (Homoeopathy) Dr. Swati Vishnoi BHMS Dr. Preetika Lakhera BHMS Lakhera BHMS Dr. Dr. Mohammad Mo hammad ayya! Daud Da ud BHMS Dr. Dr. Mohammad Mo hammad ayya! "mi r BHMS Homoeo Cure Research Institute H !"# Moradabad Road $ashipur (%&&'R'CH') # IDI' h# *+,+!-1,.+" /0 mail# drraneeshhom2hotmail0com www0 treatmenthomeopathy0com3 treatmenthomeopathy0com3 www0homeopathyworldcommunity0com
Infammatory bowel disease (IBD) and Homoeopathy Homoeopathy
De4nition &he relapsin6 and remittin6 (sora) infammatory conditions o; the 9I tract3 includ includin6 in6 Crohn Crohn dis diseas ease e and ulcerat ulcerati8e i8e coliti colitis s (%C)3 (%C)3 are are collec collecti8 ti8ely ely called called as Infammatory bowel disease (IBD)3 characteri>ed by chronic infammation (sora? Sycosis? Syphilis) at 8arious sites in the colon and small intestine3 resultin6 in diarrhea and abdominal pain0
athophysiolo6y &he e:act etiolo6y is un;amiliar0 un;amiliar0 But it is seen that a cell#mediated immune response in the 9I mucosa leads to infammation by release o; infammatory mediato mediators3 rs3 includ includin6 in6 cyto@i cyto@ines nes33 interle interleu@i u@ins3 ns3 and tissue tissue necro necrotic tic ;actor ;actor (&A) (&A) (sor (sora)0 a)0 &he normal normal intest intestinal inal fora fora tri66e tri66ers rs an abnorm abnormal al immune immune reacti reaction on in indi8i indi8idua duals ls with with a multi;a multi;acto ctoria riall 6eneti 6enetic c tendenc tendency y (Syphi (Syphilis lis)0 )0 &hese &hese ;actors ;actors possib possibly ly in8ol8 in8ol8e e abnorm abnormal al epithel epithelial ial barrier barriers s and mucosa mucosall immune immune de;ens de;ense e mechanisms (sora)0 Crohn disease and ulcerati8e colitis3 are both caused by a wea@enin6 in 6ut barrier (sora? Syphilis) and only dier in that %C is mainly due to incr increas eased ed in4l in4ltr trat atio ion n o; 6ut 6ut bact bacteri eria a and and the the resu result ltan antt recr recrui uitm tmen entt o; neutrophils and ;ormation o; crypt abscess (sora? Syphilis)3 while CD is mainly due to increased in4ltration o; anti6ens and particles ;rom 6ut lumen and the result resultant ant recrui recruitme tment nt o; macro macropha pha6es 6es and ;ormat ;ormation ion o; 6ranul 6ranulomas omas (sor (sora? a? Sycosis)0
o speci4c en8ironmental3 dietary3 or in;ectious causes are still @nown which tri66er this reaction0 Howe8er3 the ;ollowin6 ;actors ; actors modi;y IBD# • •
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• • •
'ppendectomy appears to lower the ris@ o; ulcerati8e colitis Ci6arette smo@in6 helps in de8elopment or e:acerbation o; Crohn disease but decreases ris@ o; ulcerati8e colitis It is seen that people with hi6her socioeconomic status are li@ely to ha8e Crohn disease S'IDs may e:acerbate IBD ral contracepti8es may increase the ris@ o; Crohn disease erina erinata tall illn illnes ess s and and the the us use e o; anti antibi biot otic ics s in child childho hood od may may caus cause e increased ris@ o; IBD = Dr0 Raneesh $umar Sharma MD (Homoeopathy) 5
Infammatory bowel disease (IBD) and Homoeopathy Homoeopathy
/tiolo6y Cause o; IBD is still un@nown0 Saccharin may be a @ey causati8e ;actor ;or IBD3 throu6h its inhibition on 6ut bacteria and the resultant impaired inacti8ation o; di6est di6esti8e i8e prote protease ases s and o8er o8er di6est di6estion ion o; the mucus mucus layer layer and 6ut barrier barrier00 (Causa occasionalis)
&ypes & ypes %nclassi4ed Some cases are not primarily distinct and are termed unclassi4ed0 I; a sur6ical patholo6ic specimen cannot be classi4ed3 it is called indeterminate colitis0
Classi4ed Crohn Disease • • • •
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Small bowel in8ol8ement in most o; cases Recto#si6moid o;ten spared Colonic in8ol8ement usually ri6ht#sided 9ross rectal bleedin6 rare3 but o;ten seen in Crohn colitis (sora? Sycosis? Syphilis) Aistula3 mass3 and abscess de8elopment common erianal lesions si6ni4cant in some o; cases (sora? Syphilis) n :#ray3 bowel wall aected asymmetrically and se6mentally3 with s@ip areas between diseased se6ments /ndoscopic /ndoscopic appearance patchy3 with discrete discrete ulcerations ulcerations separated by se6ments o; normal#appearin6 mucosa (Syphilis) Microscopic infammation and 4ssurin6 e:tend transmurally and lesions o;ten hi6hly ;ocal in distribution (sora? Syphilis) /pithelioid3 sarcoid#li@e 6ranulomas detected in bowel wall or lymph nodes in most o; cases (sora? Sycosis)
Colitis &he infammatory diseases o; the colon are called colitis0 Colitis may be o; ;ollowin6 types# •
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9ranulomatous colitis 'lso 'ls o called called Crohn Crohns s coliti colitis3 s3 occurs occurs only in the colon with a typica typicall o histolo6ical pattern o; 6ranulomatous infammation (sora? Sycosis) In;ectious colitis Aood poisonin6 ;rom /0 coli3 Salmonella (sora? Syphilis) o Ischemic colitis %sually due to narrowed or bloc@ed blood 8essels (sora? Sycosis) o Radiation#induced colitis o %sually a;ter e:posure to radiation radiation therapy therapy (Causa occasionalis) %lcerati8e colitis (sora? Syphilis)
Spastic or mucous colitis is a misnomer and applied to irritable bowel syndrome3 a ;uncti ;unctiona onall dis disor order der (sor (sora)0 a)0 %lcerat %lcerati8e i8e coliti colitis s is the most most common common ha>ar ha>ard d amon6 these all and must be studied separately0 separately0
%lcerati8e colitis •
Con4ned to the colon = Dr0 Raneesh $umar Sharma MD (Homoeopathy) 7
Infammatory bowel disease (IBD) and Homoeopathy Homoeopathy
• • • • • •
• • •
Recto#si6moid in8ariably in8ol8ed Colonic in8ol8ement usually le;t#sided 9ross rectal bleedin6 always present (sora? Syphilis) o 4stulas o si6ni4cant perianal lesions Bowe Bowell wall wall aec aecte ted d symm symmet etric rical ally ly and and unin uninte terr rrup upte tedl dly y ;rom ;rom rect rectum um pro:imally pro:imally (sora) Infammation uni;orm and diuse (sora) Infammation con4ned to mucosa e:cept in se8ere cases (sora) o typical epithelioid 6ranulomas
Si6ns and symptoms Infammatory bowel disease has ;ollowin6 si6ns and symptoms in 6eneral#
9astrointestinal Symptoms Chronic abdominal pain with or without chronic bloody or non#bloody diarrhea ;or more than ;our wee@s associated with# • •
• • • •
'nemia (sora) /8ide /8idenc nce e o; infa infamm mmat atio ion n E ele8a ele8ate ted d CR3 CR3 ele8 ele8at ated ed plat platele elets ts (so (sora ra?? Sycosis) Aamily history o; IBD octurnal diarrhea (Syphilis) utritional de4ciencies E iron3 B153 ;olate3 low albumin (sora) Fei6ht loss (sora? Syphilis)
= Dr0 Raneesh $umar Sharma MD (Homoeopathy) "
Infammatory bowel disease (IBD) and Homoeopathy Homoeopathy
/:tra#intestinal Mani;estations Crohn disease and ulcerati8e colitis both aect the person as a whole0 Most e:tra#intes e:tra#intestinal tinal mani;estations mani;estations are more common in ulcerati8e ulcerati8e colitis than in Crohn disease3 as it is limited to the small bowel0 /:tra#intestinal mani;estations o; infammatory bowel disease may be 6rouped into three#
arallel disorders &hese include# • • • •
•
'phthous stomatitis (sora? Syphilis) /piscleritis (sora? Sycosis) /rythema nodosum (sora? Sycosis) eriph eriphera erall arth arthrit ritis is## lar6e lar6e oin oints ts and and mi6r mi6rat ator ory y and and tran transi sien entt (so (sora ra?? Sycosis) yoderma 6an6renosum (sora? Sycosis? Syphilis)
%lcerati8e colitis &here are three three common mani;estations o; ulcerati8e colitis# • • •
'bdominal cramps (sora) Diarrhea with ;resh bri6ht red bleedin6 (sora? Syphilis) %r6ency and tenesmus (sora)
Some associated symptoms are mild ;e8er3 tachycardia3 dehydration3 abdominal tenderness and blood on rectal e:amination0 (sora? Syphilis)
= Dr0 Raneesh $umar Sharma MD (Homoeopathy) -
Infammatory bowel disease (IBD) and Homoeopathy Homoeopathy
Dia6nosis 'lon6 with complete case history3 laboratory in8esti6ations are also needed to con4rm the dia6nosis and pro6nosis o; the case0 &reatment will depend on both o; these0
Routine aboratory &ests • • • • •
• • • • • • • •
CR C#reacti8e protein# non#speci4c infammation /SR /rythrocyte Sedimentation Rate# non#speci4c infammation CBC Complete Blood Count# 'nemia3 in;ection3 infammation /lectrolytes Sodium3 otassium3 Chloride3 C5# Dehydration i8er i8er Aunctio unction n &est# est# i8er i8er /n>yme /n>ymes s and medicat medication ion sid side e eects eects33 SC (primary sclerosin6 cholan6itis) Gitamin B15# 'nemia3 nutritional status Gitamin D# Bone mineral status Calprotectin Stool protein# 'cti8e intestinal infammation acto;errin Stool protein# 'cti8e intestinal infammation p'C' perinuclear anti#neutrophil antibody# Distin6uishes %C ;rom CD 'SC' anti#Saccharomyces cer8isiae antibody# Distin6uishes CD ;rom %C CBir1 anti#fa6ellin antibody# Indicati8e o; Crohns disease mpC anti#mpC antibody# Indicati8e o; Crohns C rohns disease
&ests & ests ;or suspected IBD location or complication •
&reatme & reatment nt Arom o8erall study o; IBD3 it becomes clear that it is not simply a disorder o; local ;actors3 but whole 6enetics and constitutional disharmony is there0 &he person as a whole is aected by the ;actors causin6 IBSJ and later on3 by the eects o; established disease in that indi8idual3 physically as well as mentally0 &hus3 whole person needs treatment rather than a local 6astrointestinal system0 Fell ell sele select cted ed cons consti titu tuti tion onal al remed emedy y almo almost st alwa always ys cur cures permanently i; applied as per laws o; similia0
Biblio6raphy Chap Chapte terr 17 17"0 "0 Syst System emic ic 'u 'uto toin infa famma mmato tory ry Dise Diseas ases es N /arl /arly y#nse #nsett Infammatory Bowel Disease (IBD) Ait>patric@s Dermatolo6y in 9eneral Medicine3 ,e 000 000 /arly /arly#ns #nset et Infamma Infammator tory y Bowel Bowel Diseas Disease e (IBD) (IBD) at a 9lance 9lance Gery rare rare autosomal recessi8e disorder3 early onset IBD (MIM O-171",)0 Mutations in I1*R' 3 on chromosome 11<57 or on I1*RB3 on chromosome 51<553 encodin6 the I#1* receptor Cutaneous ;eatures can include early onset000
Chapt Chapter er -. -.00 Infa Infamma mmato tory ry Bowe Bowell Dise Diseas ase e &he &he Colo Colorr 'tla 'tlas s o; Aamily amily Medicine3 5e
Common Common ar6e ar6e Intestin Intestinal al Disorders Disorders N Colon Cancer Cancer in IBD Ha>>ar Ha>>ards ds 9eriatric Medicine and 9erontolo6y3 !e 000 &he ris@ o; colon cancer in patients with lon6#standin6 IBD is a si6ni4cant complication o; the disease0 Colon cancer rates 6enerally are hi6her in patients with %C than those with Crohn diseaseJ it appears to be the de6ree and e:tent o; on6oin6 infammation in the colon that con;ers000
Dru6s %sed in 9astrointestinal Disorders N 90 Dru6s %sed in Infammatory Bowel Disease Disease (IBD) $at>un6 P &re8ors re8ors harmacolo harmacolo6y 6yQQ /:amination /:amination P Board Re8iew3 11e
/ncyclopedia Homoeopathica
9astrointestinal P Biliary Complications o; re6nancy N '0 Course o; IBD Durin6 re6nancy and in the ostpartum eriod C%RR/& Dia6nosis P &reatmentQ 9astroenterolo6y3 Hepatolo6y3 P /ndoscopy3 7e 000 ' recent meta#analysis o; 1" studies reports the eects o; disease acti8ity at conception on the course o; IBD in 17** pre6nant %C patients and .+* pre6nant CD patients0 &he ris@ o; acti8e disease durin6 pre6nancy was much hi6her i; disease was acti8e at conception compared to those in remission000
Infa Infamma mmato tory ry Bowe Bowell Disea Disease se N CMM CMM/ /S' S' MICR MICRB BI I& &' 'D 'D IBD IBD Harr Harriso ison ns s rin rinci ciple ples s o; Inte Intern rnal al Medi Medici cine ne 000 000 &he &he endo endo6e 6eno nous us comm commen ensa sall microbiota within the intestines plays a central role in the patho6enesis o; IBD0
= Dr0 Raneesh $umar Sharma MD (Homoeopathy) 1.
Infammatory bowel disease (IBD) and Homoeopathy Homoeopathy
Humans are born sterile and ac
Infa Infamm mmat ator ory y Bowe Bowell Dise Diseas ase e N Dia6 Dia6no nost stic ic Crit Criter eria ia ;or ;or IBD IBD Clin Clinic ical al 9enomi 9enomicsQ csQ ractic ractical al 'pplic 'pplicati ations ons in 'd 'dult ult atie atient nt Care Care 000#' 000#'C' C' ) ha8e ha8e hi6h hi6h sens sensit iti8 i8it ity y ;or ;or IBD IBD in comb combin inat atio ion n comp compar ared ed to othe otherr caus causes es o; inte intest stina inall infammation3 infammation3 but sensiti8it sensiti8ity y 8aries ;or dierent dierent ethnic 6roups 6roups (much lower3 e63 in re6ions endemic ;or tuberculos tuberculosis)0 is)0 'SC' shows hi6h speci4city speci4city ;or CD3 and p# 'C' ;or %C3 althou6h patients with CD limited000
Infammatory Bowel Disease rinciples and ractice o; Hospital Medicine3 5e
Infammatory Bowel DiseaseQ Immunolo6ic Considerations P &herapeutic Implications C%RR/& Dia6nosis P &reatmentQ 9astroenterolo6y3 Hepatolo6y3 P /ndoscopy3 7e
Infammatory Bowel DiseaseQ Medical Considerations C onsiderations C%RR/& Dia6nosis P &reatmentQ &reatmentQ 9astroenterolo6y3 9astroenterolo6y3 Hepatolo6y3 P /ndoscopy3 /ndoscopy3 7e
Infammatory Bowel DiseaseQ Sur6ical Considerations C%RR/& Dia6nosis P &reatmentQ &reatmentQ 9astroenterolo6y3 Hepatolo6y3 P /ndoscopy3 7e
harmacotherapy o; Infammatory Bowel Disease 9oodman P 9ilmansQ &he harmacolo6ical Basis o; &herapeutics3 15e
Radar 1*
Fei6ht ei6ht oss3 oss3 %ninte %nintenti ntiona onall N 'lt 'ltern ernati ati8e 8e Dia6no Dia6nosis sisQQ IBD Sympto Symptom m to Dia6nosisQ 'n /8idence#Based 9uide3 7e 000 IBD (Crohn disease and ulcerati8e colitis) are comple: diseases0 9enetic ;actors and commensal bacterial ;actors play a role0 &hey are ;ound most commonly in patients o; ewish descent and amon6 amon6 patient patients s with with a ;amily ;amily history history o; IBD0 IBD0 Crohn Crohn dis diseas ease e is a transm transmura urall process that may aect000