Laporan Kelarutan Tika

KELARUTAN 2014

LABORATORIUM LABORATORIUM FARMASEUTIKA ARMASEUTI KA FAKULT FAKULTAS FARMASI UNIVERSITAS MUSLIM INDONESIA

LAPORAN PRAKTIKUM KELARUTAN

OLEH : NAMA

:

NUR ATIKA AHMAD

STAMBUK

:

15020130271

KELOMPOK

:

II (DUA)

ASISTEN

:

UNIVERSITAS MUSLIM INDONESIA FAKUL AKU LTAS FARMASI ARMA SI M A K A S S A R 2014

NUR ATIKA ATIKA AHMAD 15020130271

KELARUTAN 2014

BAB I PENDAHULUAN A. Latar Latar Belakang Belakang

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NUR ATIKA ATIKA AHMAD 15020130271

KELARUTAN 2014

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1

M$"$"!&a" &$/ar!a" 'a! -a! '$ara &a"!.!a!.

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NUR ATIKA AHMAD 15020130271

KELARUTAN 2014

BAB II TINJAUAN PUSTAKA A. Teori Umum

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KELARUTAN 2014

M$!*,$ ,a/a# #$"a!a&a" &$/ar!a" a.! &$!.&a a"a/.'a ,a!a ,.,a%a!&a" &$/ar!a" ,a%a! ,."a!a&a" ,$"+a" $$ra%a ara *"!* : &$/ar!a" a'a# &/*r.,a ,a/a# a.r 250 #/ ,a%a! ,.!/.' '$%$r!. (R$#."+!*" 2005) : 1 1 + a'a# &/*r.,a /ar! ,a/a# 27>? #L a.r 2 35> + a'a# &/*r.,a /ar! ,a/a# 100 #L a.r 3 100 #L /ar!a" 6$" a'a# &/*r.,a ,a/a# a.r /ar! '$a"a& 3171 + 4 100 + /ar!a" 6$" a'a# &/*r.,a ,a/a# a.r /ar! '$a"a& 2?47 + 5 1 L /ar!a" 6$" a'a# &/*r.,a ,a/a# a.r #$"+a","+ 5425 #*/ -a! !$r/ar! P$r"a!aa" a+.a" ,a/a# &$/ar!a" $rar!. aa 1 + -a! %a,a! a!a 1#/ -a! a.r ,a/a# '$6#/a #/ %$/ar! @.&a &$/ar!a" 'a! -aa! !.,a& ,.&$!a. ,$"+a" %a'!. &$/ar!a""a ,a%a! ,.!"6&&a" ,$"+a" .'!./a (D.!6$" POM 17):

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30 'a#%a. 100

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100 'a#%a. 1000

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1000 'a#%a.10000

Pra&!.' !.,a& /ar!

L$. ,ar. 10000


KELARUTAN 2014

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KELARUTAN 2014

K$!.&a 'a! '*/9$" #$/ar!&a" 'a! '*/! %ar!.&$/ '*/9$" ar' #$#$a %ar!.&$/ '*/! ,a" #$"$#%a!. ra"+ a"+ !$ra/a"+. %$/ar! a"+ %*/ar ,a%a! ,$"+a" $$&!. #$#$a '$"aa a"+ %*/ar I". !$r6a,. 'aa! 6"+ %*'.!. ,ar. 'a! #*/$&/ '*/9$" #$",$&a!. 6"+ "$+a!. ,ar. #*/$&/ '*/! S.a! /ar!a" $r$,a ,$"+a" '.a! %$/ar! #r"."a T$r,a%a! $#%a! '.a! .'.&a a"+ %$"!."+ a"+ $'ar"a $r+a"!"+ %a,a a"a&"a %ar!.&$/ -a! !$r/a r! !$!a%. !.,a& $r+a"!"+ %a,a 6$".' -a! !$r/ar!"a K$$#%a! '.a! .". ,.&$"a/ ,$"+a" '.a! &*/.+a!. /ar!a" S.a! .". $'ar"a $ra",."+ /r' ,$"+a" 6#/a %ar!.&$/ -a! !$r/ar! S.a! &*/.+a!. !$r'$! a,a/a !$&a"a" a% !.!.& ,.,. !.!.& $& ,a" !$&a"a" *'#*'.' M$"r! &# '.a! &*/.+a!. '$/.'. !$&a"a" a% !.!.& $& ,a" !.!.& ,.,. 'a! /ar!a" ,$"+a" !$&a"a" a% !.!.& $& ,a" !.!.& ,.,. %$/ar! #r"."a $ra",."+ /a"+'"+ ,$"+a" &*"'$"!ra'. #*/a/ -a! !$r/ar! Lar!a" a"+ .'a #$#$". &# '.a! &*/.+a!. .". ,.'$! /ar!a" .,$a/ K$a"a&a" /ar!a" #$",$&a!. .,$a/ a"a 6.&a 'a"+a! $"$r (A!&."' 200?) A T$&a"a" Ua% Lar!a" (A!&."' 200?) T$&a"a" a% /ar!a" /$. r$",a ,ar. !$&a"a" a% %$/ar! #r"."a Pa,a /ar!a" .,$a/ #$"r! &# Ra*/! !.a% &*#%*"$" ,a/a# 'a! /ar!a" #$/a&&a" !$&a"a" a"+ 'a#a ,$"+a" ra&'. #*/ &a/. !$&a"a" a% ,ar. %$/ar! #r". Da/a# /ar!a" a"+ #$"+a","+ -a! !$r/ar! a"+ !.,a& #,a #$"+a% (!a&a!'.r. a!a "*"9*/a!./$) !$&a"a" a% a"a ,.'$a&a" */$ %$/ar! '$."++a PA ,a%a! ,.a"++a% '$a+a. !$&a"a" a% %$/ar! #a%" !$&a"a" a% /ar!a" B T.!.& D.,. Lar!a" (A!&."' 200?)


KELARUTAN 2014

T.!.& ,.,. /ar!a" $r+a"!"+ %a,a &$#,aa" -a! !$r/ar!"a #$"+a% @.&a -a! !$r/ar!"a /$. #,a #$"+a% ,ar.%a,a %$/ar!"a (!.!.& ,.,. -a! !$r/ar! /$. r$",a) #a&a !.!.& ,.,. /ar!a" #$"6a,. /$. r$",a ,ar. !.!.& ,.,. %$/ar!"a a!a ,.&a!a&a" !.!.& ,.,. /ar!a" !r" 8 T.!.& B$& Lar!a" (A!&."' 200?) P$"r"a" !$&a"a" a% /ar!a" #$"$a&a" !.!.& $& /ar!a" #$"6a,. /$. r$",a ,ar. !.!.& $& %$/ar! #r"."a H&# '.a! &*/.+a!. "!& %$"r"a" !.!.& $& /ar!a" $r/a& %a,a /ar!a" ,$"+a" -a! !$r/ar! a!'.r. (9*/a!./$)

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!.,a& #$#%"a. ra'a P$".#%a"a"

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K$+"aa"

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KELARUTAN 2014

R#' M*/$&/

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KELARUTAN 2014

P$#$r.a"

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KELARUTAN 2014

K$/ar!a"

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BAB III &ET'DE KE(JA A. Alat

A,a%" a/a! a"+ ,.+"a&a" ,a/a# %ra&!.&# .". a,a/a a!a"+ %$"+a,& *!*/ '$#%r*! aa" %*r'$/." *r*"+ +$/a' $r/$"#$$r 25 #/ +$/a' &.#.a 100 #/ +$/a' &r 100 #/ &$r!a' 'ar."+ #a+"$!. '!r.r$r .!a/. %.%$! !$!$' '$",*& !a",& !.#a"+a" a"a/.!.& ,a" *9$" B. Ba!an

Baa"aa" a"+ ,.+"a&a" ,a/a# %$r*aa" .". a,a/a A'a# 'a/.'./a! a/&**/ Aa,$'! %r*%./$"+/.&*/ !$$" >0 ). )ara Kerja


KELARUTAN 2014

1

M$"$"!&a" &$/ar!a" 'a! -a! '$ara &a"!.!a!. a D.#a'&&a" 1 +ra# a'a# 'a/.'./a! ,a/a# 100 #/ a.r ,a" &**& '$/a#a 50 6a# ,$"+a" '!.r$r 6.&a a,a $",a%a" a"+ /ar! '$/a#a %$"+**&a" !a#a&a" /a+. '$6#/a !$r!$"! a'a# 'a/.'./a! '#%a. ,.%$r*/$ /ar!a" a"+ 6$"  D.'ar."+ ,a" !$"!&a" &a,ar a'a# 'a/.'./a! a"+ !$r/ar! ,a/a# #a'."+ #a'."+ /ar!a"

2

P$"+ar %$/ar! a#%r !$ra,a% &$/ar!a" -a! a. Buatlah 100 ml campuran bahan pelarut yang tertera pada tabel dibawah ini.

 P$/ar!

 A.r (99)



, A/&**/ (99)



$ Pr*%./$" +/.&*/  (99)



A

+ ?0

 0

.

40

6

B

& ?0

/

5

# 35

" 8

* ?0

% 10

 30

r

D

' ?0

!

15

 25

9 E

 ?0

G 20

 20

- F

aa ?0

 30

 10

,, 

$$ ?0

 35

++ 5

 H

.. ?0

66 40

&& 0

 D.a#./ 50 #/ a#%ra" %$/ar! /ar!&a" a'a# 'a/.'./a! '$a"a& 1 +ra# &$ ,a/a# #a'."+#a'."+ a#%ra" %$/ar! a D.&**& /ar!a" ,$"+a" '!.rr$r '$/a#a 30 #$".! @.&a a,a $",a%a" a"+ /ar! '$/a#a %$"+**&&a" !a#a&a" /a+. '$6#/a !$r!$"! a'a# 'a/.'./a! 'a#%a. ,.%$r*/$ /ar!a" a"+ 6$" &$#a/.  D.'ar."+ /ar!a" ,a" !$"!&a" &a,ar a'a# 'a/.'./a! a"+ /ar!


KELARUTAN 2014

 D.a! &r9a a"!ara &$/ar!a" a'a# 'a/.'./a! ,$"+a" ar+a &*"'!a"!a ,.$/$&!r.& aa" %$/ar! a#%r a"+ ,.!a#a&a" 3

P$"+ar %$"a#aa" 'ra&!a" !$ra,a% &$/ar!a" 'a! -a!

a

D.a! 50 #/ /ar!a" !$$" >0 ,$"+a" &*"'$"!ra'. 0 01 05 10  50  100 

500 ,a" 100 #+100#/  D.!a#a&a" 1 +ra# a'a# 'a/.'./a! &$ ,a/a# #a'."+#a'."+ /ar!a" 

D.&**& /ar!a" ,$"+a" '!.r$r '$/a#a 30 #$".! @.&a a,a $",a%a" a"+ /ar!

'$/a#a %$"+**&a" !a#a&a" /a+. '$6#/a !$r!$"! a'a# 'a/.'./a! 'a#%a. ,.%$r*/$ /ar!a" a"+ 6$" &$#a/. , D.'ar."+ /ar!a" ,a" !$"!&a" &a,ar a'a# 'a/.'./a! a"+ /ar! $

D.a! &r9a a"!ara &$/ar!a" a'a# 'a/.'./a! ,$"+a" &*"'$"!ra'. !$$" >0

a"+ ,.+"a&a" 

D.!$"!&a" &*"'$"!ra'. #.'$/ &r.!.& (KMK) !$$" >0

4

P$"+ar %H !$ra,a% &$/ar!a" 'a! -a!

a

D.a! 100 #/ /ar!a" ,a%ar *'a! ,$"+a" %H 45?7 ,a" >

 D.a#./ 25 #/ #a'."+#a'."+ /ar!a" /a/ !a#a&a" 1 +ra# a'a# 'a/.'./a! &$ ,a/a#"a 

D.&**& /ar!a" ,$"+a" '!.r$r '$/a# 30 #$#.! @.&a a,a $",a%a" a"+ /ar!

'$/a#a %$"+**&a" !a#a&a" /a+. '$6#/a !$r!$"! a'a# 'a/.'./a! 'a#%a. ,.%$r*/$ /ar!a" a+ 6$" &$#a/.

BAB I* HASIL DAN PE&BAHASAN A. Hail


KELARUTAN 2014

a.

Menentukan kelarutan suatu zat secara kuantitatif

A' Sa/.'./a! (+)

B$ra! K$r!a' @#/a V*/#$ A.r B$ra! K$r!a' B$ra! R$'., Sar."+  R$'., !$r/ar! (+) (#/) Sar."+ (+) (+) (+)

100

50

10172

1>0>4

0712

020>>

Per!itungan +

B$ra! r$'.,

J (B$ra! K$r!a' Sar."+  R$'.,)  (B$ra! K$r!a' 'ar."+) J 1>0>4 +ra#  10172 +ra# J 0712 +r

@#/a !$r/ar!

J (A' Sa/.'./a! (+))  (B$ra! R$'.,) J 100 +ra#  0712 +ra# J 020>> +ra#

b.

Pengaruh pelarut campur terhadap kelarutan zat

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KELARUTAN 2014

BAB *I PENUTUP A. Keim"ulan

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