Keuntungan dan kerugian pasta
1. Due Due to the the high high soli solids ds cont conten ent, t, phar pharma mace ceut utica icall paste pastess are often often poro porous us,, allow allowin ing g moisture loss from the applied site.Furthermore, pastes may act to absorb moisture and chemicals within the exudates. 2. The opaque opaque nature nature of pastes pastes (due to the the high solids solids content content enables enables this formulati formulation on to be used as a sunbloc!. ". The The chem chemica icall stab stabili ility ty of thera therape peut utic ic agen agents ts that that are are pron pronee tohy tohydr droly olysis sis will will be dramatically enhanced by formulation within pharmaceutical ointments and pastes. 4. #harmaceutical gels may be formulated to pro$ide excellent spreading properties and will pro$ide a cooling effect due to sol$ent e$aporation. %imilarly sol$ent e$aporation from liniments will pro$ide a cooling effect . &. #harmaceutica #harmaceuticall pastes are are generally generally applied applied as a thic! thic! layer at the the required required site and and are therefore considered to be cosmetically unacceptable. '. %tai %taini ning ng of clot clothe hess is ofte often n asso associa ciate ted d with with the the use use of phar pharma mace ceuti utical cal pastes pastes and and ointments. . The The $isc $iscos osit ity y of phar pharma mace ceut utic ical al oint ointme ment nts, s, and and in part partic icul ular ar past pastes es,, may may be problematic in ensuring spreading of the dosage form o$er the affected site. )on$er )on$ersely sely,, the low $iscos $iscosity ity of linime liniments nts and lotion lotionss may result result in applica application tion difficulties. *. #har #harma mace ceut utic ical al past pastes es are are gene genera rall lly y not not appl applie ied d to the the hair hair due due to diff diffic icul ulti ties es associated with remo$al. #engertian #harm #harmace aceuti utica call paste pastess are are gene general rally ly comp compos osed ed of oint ointme ment nt base basess that that cont contain ain a high high concentration (frequentl &+ w-w of dispersed drug. The $iscosity of pharmaceutical pastes is greater than that of pharmaceutical ointments. ntroduction The formulation of ointments and pastes in$ol$es the dispersal or dissolution of the selected therapeutic agent into an ointment base ointment base and, therefore, in addition addition to the physical properties of the dispersed-dissol$ed drug, the physicochemical properties of the ointment base are fundamental to the clinical and non/clinical performance of this type of dosage form. The choice of ointment 0intments, pastes, lotions, gels base is dependent on se$eral factors, including (1 the site of application (2 the required rate of drug release (" the chemical stability of the drug and (3 the effect of the therapeutic agent on formulation $iscosity. Keuntungan Dan Kerugian pasta 1. 4arena !andungan padatan tinggi, pasta farmasi sering berpori, sehingga hilangnya !elemb !elembaba aban n dari ditera diterap!a p!an n site.Fu site.Furth rtherm ermore ore,, pasta pasta dapat dapat bertin bertinda! da! untu! untu! menyer menyerap ap !elembaban dan bahan !imia dalam e!sudat. 2. %ifat buram pasta (!arena !andungan padatan tinggi memung!in!an formulasi ini a!an diguna!an sebagai sunbloc!.
3. %tabilitas !imia agen terapi yang tohydrolysis rawan a!an secara dramatis diting!at!an dengan formulasi dalam salep farmasi dan pasta. 4. 5el farmasi dapat diformulasi!an untu! memberi!an sifat penyebaran yang sangat bai! dan a!an memberi!an efe! pendinginan !arena penguapan pelarut. Demi!ian pula penguapan pelarut dari liniments a!an memberi!an efe! pendinginan. 5. #asta farmasi umumnya diguna!an sebagai lapisan tebal di situs diperlu!an dan !arena itu dianggap !osmeti! tida! dapat diterima. 6.
#ewarnaan pa!aian sering di!ait!an dengan penggunaan pasta farmasi dan salep.
7. 6is!ositas salep farmasi, dan pasta tertentu, mung!in bermasalah dalam memasti!an penyebaran bentu! sediaan atas situs yang ter!ena. %ebali!nya, $is!ositas rendah liniments dan lotion dapat menyebab!an !esulitan apli!asi. 8. #asta farmasi umumnya tida! diterap!an pada rambut !arena !esulitan yang berhubungan dengan penghapusan.
#engertian #asta farmasi umumnya terdiri dari basis salep yang mengandung !onsentrasi tinggi (frequentl &+ b - b obat tersebar. 6is!ositas pasta farmasi lebih besar daripada salep farmasi. #engantar #erumusan salep dan pasta melibat!an penyebaran atau pembubaran agen terapi yang dipilih men7adi basis salep dan, oleh !arena itu, di samping sifat fisi! tersebar - obat terlarut, sifat fisi!o!imia basis salep merupa!an dasar bagi !linis dan !iner7a non/!linis dari 7enis bentu! sediaan. #ilihan salep %alep, pasta, lotion, gel basis tergantung pada beberapa fa!tor, termasu! (1 lo!asi apli!asi (2 ting!at yang diperlu!an pelepasan obat (" stabilitas !imia obat dan (3 pengaruh agen terapeuti! pada formulasi $is!ositas.
