Fisiologia Cardiovascular Propiedades del miocito cardiaco

@d|dofojèa Laun Laundopa|lrfau dopa|lrfau

Afbw Tpam B|loebno Gdmo|~uo{a

Suosdbnanb| bfbl~uohblámdla| Sofaudnan nb fa hbheuama Bwld~aedfdnan Ub`ual~audbnan Ar~oha~d|ho Lomnrlldüm Dmo~uosd|ho

D-

Sofaudnan nb fa hbheuama

Paudaldüm nb al~dpdnan bfbl~udla ‥

Suosdbnanb| ;  “

\bfbl~dpdnan

 “

Nd`bubmlda nb lomlbm~ualdomb| nb domb|

 “

@rbu{a bfbl~uo|~a~dla

D-

Sofaudnan nb fa hbheuama

Fa läfrfa läfrfa bm ubso|o ubso|o '(43hp$ ~dbmb rma sofaudnan; Sou nbm~uo ; LAUJA MBJA^DPA Sou `rbua ; LAUJA SO\D^DPA ‥ ‥

Hbndldüm nbf so~bmldaf nb hbheuama lom rm jafpamühb~uo

DPafoub| mouhafb|

Sofaudnan nb fa hbheuama Bw~ualbfrfau

Dm~ualbfrfau

1<2(1>2 hBq/f

13 hBq/f

SO^A\DO ')$

<-2(>-2 hBq/f

1>3(123 hBq/f

LFOUO

133(137 hBq/f

> hbq/f

2 hBq/f

>3 hBq/f

\ONDO

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Suo~bdma '($

Fa sofaudnan nb fa hbheuama b|~a nano sou fo| domb| t |r lomlbm~ualdüm

Sau dm~ualbfrfau; Suo~bdma(I Sau bw~ualbfrfau; bw~ualbfrfau; Ma(LF

Fa hbheuama b| |bfbl~dpa& sbuhd~b sa|dpahbm~b fa |afdna nb so~a|do- B|~o gauá qrb sou

D-

Sofaudnan nb fa hbheuama Bf so~a|do nbebuèa |bjrdu |afdbmno saua djrafau |r lomlbm~ualdüm dm~ua t bw~ualbfrfau- SBUO MO OLRUUB

Suo~bèma \ondo

Saua Saua ham~bmbu fa sofaudnan bm bf 'la|o qrb bf so~a|do |dja |afdbmno$ ~ahedäm nbebuèa |afdu bf amdüm suo~bdlo& suo~bdlo& af lraf b|~a rmdno bf so~a|do

DD- Bwld~ Bwld~aedfdnan aedfdnan nb fa `deua laundala Fo| hdolaundold~o| jbmbuam jbmbuam rm so~bmldaf a sau~du sau~ du nb rm b|~dhrfoBm fa jbmbualdüm nbf so~bmldaf b|~ám dmpofrluano| lamafb| t hopdhdbm~o nb domb|

B\^DHRFO

UB\SRB\^A

SO^BMLDAF NB

(43

^dso| So~bmldafb| nb alldüm

So~bmldafb| nb ub|srb|~a fbm~a

Fo| nbhá| |om So~bmldafb| nb ub|srb|~a uásdna

So~bmldaf nb alldüm nb us~a uásdna

‥

So|bb 2 `a|b|;  “

@a|b 3

 “

@a|b 1

 “

@a|b 5

 “

@a|b <

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@a|b >

So~bmldaf nb alldüm nb us~a fbm~a

‥

So|bb < `a|b|;  “

@a|b 3

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@a|b <

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@a|b >

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3 >

@a|b 1& 5 t < sual~dlahbm~b |om fa hd|ha lrupaMO BWD\^B HB\B^A

So~bmldaf nb alldüm nb us~a uásdna @a|b nb nb|sofaud{aldom uasdna

@A\B 3

1- Fa läfr läfrfa fa bm ubso ubso|o |o aeub aeub fo| fo| lamafb| UASDNO\ NB \ONDO-

Ma)

5- B|~a B|~a bm~ua bm~uana na prbfp prbfpb b so|d~d so|d~dpo po bf dm~budou lbfrfau <- Af olru olruud uduu b|~ b|~o o fa läfr läfrfa fa sdbunb a`dmdnan sou bf

Fa läfrfa sa|a nb (43hp a

So~bmldaf nb alldüm nb us~a uásdna @a|b nb ubsofaud{aldom uasdna I)

@A\B 1

1- Fa läfr läfrfa fa nb|s nb|sof ofau aud{ d{an ana a nbka |afdu so~a|do 5- B|~a B|~a `a|b a|b |b dmdl dmdlda da lra lramno mno |b ldbuuam fo| lamafb| uasdno| nb |ondo <- B| rma rma ub| ub|sr srb| b|~a ~a a fa fa

Fa läfrfa sa|a nb )53 a la|d 3

So~bmldaf nb alldüm nb us~a uásdna @a|b nb Hb|b~a I)

@A\B 5 La))

1- Fa läfr läfrfa fa nb|s nb|sof ofau aud{ d{an ana a nbka |afdu so~a|do 5- B|~a B|~a pb{ pb{ bf so~a| so~a|do do |af |afb b sou sou lamafb| fbm~o| '^dso F$ <- Bf ham~b ham~bmdh mdhdbm dbm~o ~o nb nb pof~ pof~akb akb |b na sou qrb dmjub|am

Ham~bmdhdbm~o

So~bmldaf nb alldüm nb us~a uásdna @a|b nb ubsofaud{aldom fbm~a

@A\B <

I)

1- \b dmdl dmdlda da af lbuu lbuuau au|b |b fo| fo| lamafb| nb lafldo5- Bf so~ so~a| a|do do |djr |djrb b |afd |afdbm bmno no sou sou fo| lamafb| fbm~o|<- Bf so~ so~a| a|do do |afb |afb sou sou < ~ds ~dso| o| nb nb lamafb|& ha| dhsou~am~b8 dhsou~am~b8

Fa läfrfa pa ublrsbuamno

So~bmldaf nb alldüm nb us~a uásdna @a|b nb ubsofaud{aldom uasdna

@A\B >

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1- Fa lbfr lbfrfa fa ubl ublrs rsbu buo o |r sofaudnan 5- \dm bheauj bheaujo o af `af~ `af~au au so~a|d so~a|do o nbm~uo nb fa lbfrfa& |b al~dpa fa eohea |ondo(so~a|do-

5 I)

Fa läfrfa |b ham~dbmb bm

So~bmldaf nb alldüm nb ub|srb|~a FBM^A @a|b 3 \b aeubm fo| lamafb| fbm~o| nb lafldo- T bf pof~akb |reb a 3(2 hp3 @a|b <

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\afb so~a|do lom~dmrahbm~b a ~uapb| nb lamafb| fbm~o|-

@a|b > Bm~ua |ondo sou hbndo nb fo| lamafb| FBM^O\ nb |ondo^ahedäm bm~ua lafldo sou lamafb| fbm~o|

Läfrfa bm ubso|o  “ 03 hp

DDD- Ub`u Ub`ual~audbnan al~audbnan nbf Hdold~o ae|ofr~o

Dm~bupafo nb ~dbhso& nruam~b bm lraf rm dhsrf|o laundalo laundalo mouhaf mo srbnb ub bwld~au rma {oma ta bwld~ana nb hû|lrfo laundalo Fo| hdold~o| laundalo mo srbnbm |bu b|~dhrfano| bm ~ono hohbm~o |dmo |b ~bmnuda bw~ua|d|~ofb|

Sbudono ub`ual~audo ae|ofr~o

Sbudono ub`ual~audo Ubfa~dpo

Sbudono ub`ual~audo Ae|ofr~o Bm b|~b sbudono fa läfrfa hr|lrfau laundala mo ub|somnb a b|~èhrfo|& mo dhsou~amno |r dm~bm|dnan 1

5 <

< 3 >

>

3

So~bmldaf nb ub|srb|~a uásdna

So~bmldaf nb ub|srb|~a fbm~a

Sbudono ub`ual~audo Ubfa~dpo Bm b|~b sbudono fa läfrfa hr|lrfau laundala srbnb ub|somnbu a b|~èhrfo| nb hatou dm~bm|dnan a fo mouhaf 1 1

1

5 < <

5 <<

> 3

So~bmldaf nb ub|srb|~a uásdna

3

>>

>

So~bmldaf nb ub|srb|~a fbm~a

‥

So~bmldaf nb ub|srb|~a uásdna

‥ ‥ ‥

‥ ‥

Hdold~o arudlrfau Hdold~o pbm~udlrfau @deua| nb sruidmkb Ga{ nb gd|

Monrfo \A Monrfo AP

So~bmldaf nb ub|srb|~a fbm~a

DP-- Ar~oh DP Ar~oha~d|h a~d|ho o laundalo Bf loua{üm mo ubqrdbub nbf |d|~bha mbupdo|o saua fa~du fa~d u-

‥

‥

Suonrlb |r suosdo dhsrf|o & b|~o nano sou bf |d|~bha monaf;  “

Mono| o münrfo|

 “

@deua| nb lomnrlldüm

\d|~bha monaf

Ga{ nb Ibm~ ‥

‥

Bf ga{ nb Ibm~ b| rma pèa nb lomnrlldüm amouhaf allb|ouda bm~ub fa| aruèlrfa| t fo| pbm~uèlrfo| nbf loua{ümFo| suoefbha| |rujbm lramno b|~a pèa luba rm ldulrd~o bfäl~udlo bfäl~udlo qrb bpd~a bf münrfo m ünrfo APAP- Bf B f münrfo mün rfo AP ~dbmb fa suosdbnan nb nd|hdmrdu fa pbfoldnan nb fo| dhsrf|o| bfäl~udlo|& hdbm~ua| hdbm~ua| qrb fa pèa qrb |b b|~aefblb ~uapä| nbf ga{ nb Ibm~ mo-

Lramno |b ubafd{a rma lombwdüm bfäl~udla amouhaf a

Münrfo |dmr|af / \A / Ibd~g(`fali Ibd~g(`fali

Bmnolaundo

^bkdno nbf mono \A

Münrfo |dmr|af / \A / Ibd~g(`fali Ibd~g(`fali @ouhano sou hdold~o| b|sbldafd{ano|;Läfrfa| b|sbldafd{ano|;Läfrfa| haulasa|o|/läfrfa| S

Ham~dbmb rma `ublrbmlda laundala nb 03(133 fa~dno| sou hdmr~o

Hdnb asuowdhanahbm~b 53 w > hhhhPaudaefb

^ual~o| dm~bumonafb| Lombl~a bf mono \A lom bf mono mon o AP AP ^ua|hd~bm bf so~bmldaf so~bmlda f nb alldom a rma pbfoldnan nb 1 h/|

Pdakam sou bf bmnolaundo

Am~budou ; Ealgham Hbndo; Zbmlibealg So|~budou; ^goubf

Münrfo AP / Münrfo A|lgo``(^azaua @ouhano ~ahedäm sou hdold~o| b|sbldafd{ano|; Läfrfa| haulasa|o| Sbuhd~b Sbuhd~b bf sa|akb nbf dhsrf|o a fo| pbm~udlrfo| pbm~udlrfo| Ham~dbmb rma `ublrbmlda laundala nb >3(03 fa~dno| sou hdmr~o ' lramno b| haulasa|o$ Hdnb asuowdhanahbm~b
Ga{ nb gd| t `deua| nb Sruidmkb Bf Ga{ nb Gd| lombl~a bf Mono AP lom fa| `deua| nb Sruidmkb Bf Ga{ nb Gd| na 5 uaha|; d{qrdbuna t nbublga nb `deua nb sruidmkb Bf Ga{ nb Gd| hdnb nb 5(< lh Fa| `deua| nb Sruidmkb lomnrlbm a <(2 h/|

Bf so~bmldaf pdaka a ~uapb| nbf \REBMNOLAUNDO Bf so~bmldaf pa nb bmnolaundo a

@deua nb sruidmkb

1

5

03(133 fa~dno|/h

\A

\A

AP

>3(03 fa~dno|/h

\D b|~b `affa

<

\A

AP

\D fo| 5 mono| `affam

<3(>3 fa~dno|/h

Uof nb Haulasa|o

Honrfaldüm nbf |d|~bha nb lomnrlldüm

\dhsá~dlo

\d|~bha nb lomnrlldüm nbf loua{üm

Saua|dhsa~dlo

Münrfo \A Münrfo AP Ga{ nb gd| @deua| nb Sruidmkb @deua| dm~bumonafb|

\d|~bha \d|~ bha mbupdo|o mbu pdo|o \d|~bha mbupdo|o lbm~uaf

\d|~bha mbupdo|o sbud`äudlo \d|~bha mbupdo|o ar~ümoho

\d|~bha mbupdo|o |ohá~dlo

\dhsa~dlo Saua|dhsa~dlo

Sfbwo| laundalo|

Jamjfdo| laundalo| Mbupdo pajo

HONRFA

\d|~bha \d|~ bha mbupdo|o mbu pdo|o \d|~bha mbupdo|o sbud`äudlo

\d|~bha mbupdo|o lbm~uaf

\d|~bha mbupdo|o ar~ümoho

\dhsa~dlo Saua|dhsa~dlo

MOUANUBMAFDMA

ALB^DFLOFDMA

Ublbs~ou Eb~a 1

Ublbs~ou

P- Lom Lomnrl nrlldüm ldüm nb hdold hdold~o ~o a hdold hdold~o ~o Münrfo \A

Hdold~o

Louudbm~b

Hdold~o

Münrfo AP

Hdold~o

Lomnrlldüm bm fa hd|ha `deua

Lomnrlldüm nb hdold~o a hdold~o Fa nb|sofaud{aldüm b| suojub|dpa b rmdndubldomaf bm fa| `deua| laundala|\b b|~aefblb rm `frko domdlo dm~ua t bw~ualbfrfau Bf bw~budou nb rma {oma al~dpana b| mbja~dpo ta qrb bf |ondo bm~uo-

¿Lüho |b lomnrlb b|~a nb|sofaud{aldüm/al~dpaldom? JUALDA\ A FA\ RMDOMB\ JAS

PD- Dmo~uosd|ho ‥

Lasaldnan nbf ~bkdno hr|lrfau launèalo bm jbmbuau ~bm|düm nb alou~ahdbm~o'lom~ualldüm$ lramno b| al~dpano sou rm so~bmldaf nb alldüm

Bwld~aldüm

Nb|sofaud{aldüm Nb|sofaud{ald üm

Lom~ualldüm

Ubfakaldüm

Dmo~uosd|ho Saua qrb olruua fa lom~ualldüm nbeb arhbm~au bf lafldo dm~ualbfrfau sou; ( Lafldo bw bw~ualbfrfau ( Lafldo fdebuano nbf ub~èlrfo |aulosfa|ha~dlo

Dmo~uosd|ho 1- So~bmldaf nb alldüm ffbja af ~ûerfo ^ 5- Lafldo bm~ua sou bf ~rerfo ^ <- Lafldo ffbja af ublbs~ou nb udamondma nbf ub~dlrfo |aulosfa|ha~dlo >- Ub~dlrfo |aulosf|ha~dlo fdebua lafldo dm~ualbfrfau

1 Bf lafldo |b rmb a fa fa ~uosomdma L5 B|~a B|~a rmdüm suonrlb qrb fa ~uosohdo|dma |b |b hond`dqrb t nbkb fdeub fo| b|saldom nb rmdüm<- Fa hdo|dma |b rmb a fa al~dma 8LOM^UALLDOM 8LOM^UALLDOM

\dhsá~dlo

Dmo~uosd|ho so|d~dpo

Saua|dhsá~dlo

Dmo~uosd|ho Mbja~dpo