Farmakoterapi Gangguan Hormon Tiroid_opt

FARMAKOTERAPI GANGGUAN HORMON TIROID : HIPERTIROIDISME & HIPOTIROIDISME

MATERI KULIAH FARMAKOTERAPI 2 PROGRAM STUDI S1 FAKULTAS FARMASI UNIVERSITAS HASANUDDIN OLEH : USMAR, S.Si., M.Si., Apt.

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Koordinasi Hormon

GRH = Growth Releasing Hormone TRH = Thyroid Releasing Hormone CRH = Corticothropine RH GnRH = Gonadothropine RH LHRH = Luiteinezing Hormone RH PIH = Prolactin Inhibitor Hormone PRH = Prolactin RH Hipofisis Anterior 

 ACTH = Adrenocorticothropic Hormone TSH = Thyrothropin Stimulating Hormone FSH = Follicle Stimulating Hormone LH = Luiteineizing Hormone

Prolaktin

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Hormon Tiroid •

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Hormon tiroid mempengaruhi fungsi dari setiap sistem organ Pada anak-anak, sangat penting dalam pertumbuhan dan perkembangan normal Pada org dewasa, peran utama untuk mempertahankan stabilitas metabolik

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Fisiologi hormon tiroid •

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Tiroksin (T4) dan triiodotironin (T 3) terbentuk pada tiroglobulin Tiroglobulin = glikoprotein besar yang disintesis di dalam sel tiroid Karena struktur tersiernya, residu tirosin teriodinasi yang terdapat di dalam

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Struktur hormon-hormon tiroid

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Sintesis hormon tiroid •

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Iodida ditranspor secara aktif lewat membran basolateral melalui simporter Na+/I- dari ruang ekstraseluler ke dalam sel folikular tiroid, melawan gradien elektrokimia, yang dikendalikan oleh transpor natrium  Anion yang terkait secara struktural seperti SCN (tiosianat), ClO4 (perklorat), TcO4 (perteknetat) merupakan inhibitor kompetitif atas trasnspor iodium  –

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Sintesis hormon tiroid dan penghambat sekresi Mekanisme Aksi

Substansi

Memblo Memblok k transp transpor or iodida iodida Brom, Brom, Fluor Fluor Litium Litium

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Sintesis hormon tiroid •

Iodida anorganik Inorganic yang masuk ke dalam sel folikular tiroid dihantar melalui

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BIOSINTESIS HORMON TIROID dan PENGHAMB PENGHAMBA ATNYA MIT = Monoiodotirosin DIT = Diiodotirosin

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KELENJAR TIROID

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HIPERTIROIDISME

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Penyakit Grave

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