laporan indapamide fix.docx

LAPORAN PRAKTIKUM KIMIA FARMASI FARMASI II HUBUNGAN STRUKTUR AKTIVITA AKTIV ITAS S (SAR) ( SAR) DARI DERIVA D ERIVAT T OBAT INDAPAMIDE

 Nama kelompok : 1. Le!a"# Le!a"# H$!ao H$!ao#! #! %. +#ka,a!# Ra-maa/#

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PROGRAM STUDI D III FARMASI FARMASI JURUSAN FARMASI FARMASI POLITEKKES KEMENKES TASIKMALAY TASIKMALAYA A 2016

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I.

Tujuan 1. U/!$k me/2e!a-$# -$4$/2a/ k$a/!#!a!#5 !"$k!$" a/ ak!#6#!a 4#olo2# o4a! (HKSA) %. U/!$k me/2e!a-$# e"#6a!7e"#6a! a"# I/apam#e . U/!$k me/2e!a-a$# pa"ama!e"7pa"ame!e" #5a! 5##ka a/ k#m#a alam HKSA

II.

Dasar Ter!

"u#un$an S%ru&%ur A&%!'!%as ("SA) *an "u#un$an Kuan%!%a%!+ S%ru&%ur A&%!'!%as ("KSA)

I/!# a"# $a!$ pe/el#!#a/ e/,a8a o4a! me/$"$! S9-$/a9k e! al.3 (1&) aala pe/2em4a/2a/ ;a! ak!#5 4a"$ $/!$k me/,em4$-ka/ pe/,ak#! ,a/2 e/2a/ !e"ap# o4a! ampa# aa! #/# !#ak a!a$ 4el$m 4e"
H$4$/2a/ k$a/!#!a!#5 a/!a"a ak!#6#!a 4#olo2# a/ pa"ame!e" ,a/2 me/22am4a"ka/  pe"$4a-a/ #5a! k#m#a 5##ka3 ,a#!$ -arae%er /!*r+#!& 3 ee&%rn!&   a/ s%er!& 3 paa $a!$ e"# molek$l3 m$la# #kem4a/2ka/ e9a"a le4#- #/!e/#5. H$4$/2a/ a!a$ ko"ela# ,a/2 4a#k  #2$/aka/ $/!$k me/$/
Me%*e Yan$ D!$una&an Daa Kaj!an "KSA Me%*e "ans/ Me!oe HKSA pe"!ama a/ ,a/2 pal#/2 !e"ke/al aala- moel ,a/2 #$$lka/ oleHa/9- ,a/2 me/,a!aka/ -$4$/2a/ l#po5#l#!a "ela!#5 e/2a/ po!e/# 4#olo2# ,a/2 #2a4$/2ka/ e/2a/ -$4$/2a/ e/e"2# 4e4a l#/#e" (L>ER) $/!$k moel pe"amaa/ $m$m HKSA alam ko/!ek 4#olo2# (Topl#3 1?). Le4#-
Me%*e Free,3!sn >"ee a/ +#lo/ me/2$$lka/ $a!$ moel ma!ema!#ka $/!$k me/ak#" e5ek  $4!#!$e/ !am4a-a/ a/ $/!$k mempe"k#"aka/ 4ea" e5ek !e"e4$! e9a"a k$a/!#!a!#5. Moel ma!ema!#ka !e"e4$! #!$l#ka/ paa pe"amaa/ (%).

BA# C J a< #<  

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e/2a/ BA me"$paka/ ak!#6#!a 4#olo2#3 < me"$paka/ $4!#!$e/ ke7< e/2a/ /#la# 1 4#la aa a/ & 4#la !#ak aa3 me"$paka/ ko/!"#4$# a"# $4!#!$e/ ke7< kepaa BA3 a/  aalaak!#6#!a a"# e/,a8a #/$k.

Me!oe >"ee7+#lo/ #2$/aka/ <#ka 9a"a ke""ee7+#lo/ aala- em$a o4a! ,a/2 #$<# -a"$ memp$/,a# !"$k!$" #/$k ama a/ $4!#!$e/ -a"$ mem4e"#ka/ ak!#6#!a 4#olo2# e9a"a a#!#5 alam ke$$ka/ ,a/2 ama e/2a/ <$mla- !e!apa/ ,a/2 4e4a a"# aa a!a$ !#ak/,a $4!#!$e/. Ke$/!$/2a/ pe/22$/aa/ moel >"ee7+#lo/ #4a/#/2 moel Ha/9- alam !$# HKSA a/!a"a la#/ aala- pe/2e"
Me%*e "KSA,4D A/al## HKSA !#2a #me/# (D) #kem4a/2ka/ e4a2a# a/!##pa# pe"maala-a/ ,a/2 !e"apa! paa a/al## Ha/9-3 ,a#!$ e/,a8a7e/,a8a e/a/!#ome" ,a/2 mem#l#k# k$a/!#!a k#m#a 5##ka ama !e!ap# ak!#6#!a 4#olo2# 4e"4ea. Te"/,a!a #ke!a-$# 4a-8a e5ek  !e"eok#m#a meme2a/2 pe"a/a/ pe/!#/2 paa -a"2a ak!#6#!a 4#olo2#. Me!oe HKSA D me/22$/aka/ a/al## pe"4a/#/2a/ mea/ molek$la" a!a$ @ompa"a!#6e Mole9$la" >#el A/al,# (@oM>A). @oM>A #kem4a/2ka/ e4a2a# pe/eka!a/ la#/ ,a/2 mema$kka/ 4e/!$k ek"#p!o" alam HKSA. Me!oe #/# 4e"$a-a me/,$$/ $a!$ -$4$/2a/ a/!a"a ak!#6#!a 4#olo2# a/ #5a! !e"#k a/ a!a$ elek!"o!a!#k a"# $a!$ e"# e/,a8a. Me!oe @oM>A 4e"aa"ka/ paa 9o/2e/e"#9 $a!$ e"# molek$l. Molek$l7molek$l !e"e4$! !e"-ampa" e-#/22a !"$k!$"/,a !$mpa/2 !#/#- a/ 4e"aa paa ko/5o"ma# e/2a/ ak!#6#!a op!#m$m. Mea/ molek$la" ma#/27ma#/2 molek$l kem$#a/ #-#!$/2 e/2a/ me/empa!ka/ molek$l ,a/2 !$mpa/2 !#/#- alam 4e/!$k !#2a #me/#. 2.1.2 Parae%er S!+a% K!!a *an F!s!&a Daa "KSA a. Parae%er /!*r+#!&  Koe5##e/ pa"!## ok!a/ola#" ,a/2 #/,a!aka/ alam lo2 P me"$paka/ !a/a"  k$a/!#!a $/!$k me/e/!$ka/ #5a! -#"o5o4#k-#"o5#l#k $a!$ molek$l. Pa"ame!e"  -#"o5o4#k-#"o5#l#k aala- #5a! ,a/2 a/2a! pe/!#/2 alam apl#ka# 4#ome#. Se4a2a# 9o/!o- apl#ka#/,a aala- $/!$k mempe"k#"aka/ #!"#4$# o4a! alam !$4$-. O4a!7o4a! ,a/2  4e"#5a! -#"o5o4#k e/2a/ koe5##e/ pa"!## !#/22# aka/ !e"#!"#4$# paa kompa"!eme/ ,a/2  4e"#5a! -#"o5o4#k p$la3 m#al/,a lap#a/ lemak3 ea/2ka/ o4a!7o4a! ,a/2 4e"#5a! -#"o5#l#k  e/2a/ koe5##e/ pa"!## "e/a- aka/ !e"#!"#4$# paa kompa"!eme/ -#"o5#l#k3 m#al/,a

e"$m a"a-. N#la# lo2 P alam ok!a/ola#" me"$paka/ "a#o lo2a"#!ma ko/e/!"a# ;a! !e"la"$! alam ok!a/ol e/2a/ ko/e/!"a# ;a! !e"la"$! alam a#". #. Parae%er ee&%rn!&  Pe/22$/aa/ !"$k!$" elek!"o/#k e4a2a# p"e#k!o" alam !$# HKSA 9e/e"$/2 #$ka# ka"e/a apa! #!e/!$ka/ e9a"a !eo"#!#k a/ -a#l ,a/2 #pe"ole- 9$k$p mem$aka/. Dalam -al #/#3 me!oe k#m#a k$a!$m apa! #2$/aka/ $/!$k mem#/#malka/ e/e"2# po!e/#al alam !"$k!$" molek$l e"!a mempe"k#"aka/ m$a!a/ a!om3 e/e"2# molek$la" o"4#!al3 a/ ek"#p!o" elek!"o/#k la#//,a ,a/2 apa! me/$/
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e/2a/ ∧ H aala- ope"a!o" Ham#l!o/#a/ ,a/2 me/,a!aka/ e/e"2# k#/e!#k a/ e/e"2# po!e/#al a"# $a!$ #!em ,a/2 me/2a/$/2 elek!"o/ a/ #/!# a!om3  aala- 5$/2# 2elom4a/2 ,a/2 me"$paka/ 5$/2# koo"#/a! #/!# a/ elek!"o/ ,a/2 4e"##ka/ em$a #/5o"ma# me/2e/a# koo"#/a! #!em3 a/ E aala- e/e"2# !o!al a"# #!em. S#5a! molek$l ,a/2 apa! #-#!$/2 melal$# pe/,elea#a/ pe"amaa/ # a!a aala- 2eome!"# molek$l3 !a4#l#!a "ela!#53 #pol3 a/ m$a!a/ a!om#k. Me!oe ,a/2 4e"aa"ka/ mea/ 2a,a molek$la" kla#k a/ me!oe k#m#a k$a/!$m3 ma#/27ma#/2 apa! #2$/aka/ $/!$k mem#/#malka/ e/e"2# po!e/#al !"$k!$" molek$l. Ke$a pe/eka!a/ !e"e4$! apa! #2$/aka/ $/!$k pe"-#!$/2a/ e9a"a !e"mo#/am#k a/ mome/ 8# k$!$4 !e!ap# -a/,a me!oe k#m#a k$a/!$m ,a/2 apa! mempe"k#"aka/ m$a!a/7 m$a!a/ a!om3 e/e"2# o"4#!al molek$l3 a/ 4e4e"apa ek"#p!o" elek!"o/#k la#//,a alam !$# HKSA. Me!oe k#m#a k$a/!$m apa! #apl#ka#ka/ alam HKSA e/2a/ me/$"$/ka/ ek"#p!o" elek!"o/#k e9a"a la/2$/2 a"# 5$/2# 2elom4a/2 molek$la". . Parae%er s%er!&  Pa"ame!e" !e"#k ,a/2 e"#/2 #2$/aka/ alam pe/el#!#a/ aala- 4e"$pa #/ek !opolo2#. Paa -amp#" e!#ap ka$3 pa"a k#m#a8a/ le4#- mem#l#- $/!$k me/22$/aka/ #/ek !opolo2# e4a2a# pa"ame!e" !e"#k $/!$k melak$ka/ e6al$a# !e"-aap !ok##!a a/ $/!$k  memp"e#k# ak!#6#!a 4#olo2#. Hal #/# ka"e/a #/ek !opolo2# me/a8a"ka/ 9a"a ,a/2 m$aalam pe/2$k$"a/ 9a4a/2 molek$l3 4e/!$k3 $k$"a/3 #kl##!a3 #me!"#3 e/!"##!a3 a/ komplek#!a. Topolo2# molek$l apa! #2$/aka/ e4a2a# pe/2$<#a/ molek$l /$me"#k alam HKSA a!a$ HKSS. I/ek !opolo2# me/
S$a!$ 2"a5#k G = G(V,E), ole- I6a/9#$9 a/ Bala4a/ (1?) #
II.1.4 D!ure%!&  D#$"e!#k 4e"aal a"# ka!a diourei%os ,a/2 4e"a"!# me"a/2a/2 4e"kem#- a!a$

me"a/2a/2 pe/2el$a"a/ $"#/. De/2a/ ka!a la#/ #$"e!#k #ala- o4a! ,a/2 apa! me/am4ake9epa!a/ pem4e/!$ka/ $"#/. I!#la- #$"e# mem#l#k# $a pe/2e"!#a/3 #ala- me/$/<$kka/ aa/,a pe/am4a-a/ 6ol$me $"#/ ,a/2 #p"o$k# a/ me/$/<$kka/ <$mla- pe/2el$a"a/ ;a!7 ;a! !e"la"$! a/ a#". D#$"e!#k aala- $a!$ e#aa/ ,a/2 apa! me/#/2ka!ka/ la<$ $"#/a# a/ 6ol$me a#"  e/#. Pe/22$/aa/ #$"e!#k alam pe/2o4a!a/ me# #lak$ka/ $/!$k me/$"$/ka/ 6ol$me 9a#"a/ ek!"ael$le"3 k-$$/,a paa pe/,ak#! ,a/2 4e"-$4$/2a/ e/2a/ eema a/ -#pe"!e/#. D#$"e!#k <$2a #lapo"ka/ apa! #
#/"om /e5"#!#3 a/ !okem#a 2a2al 2#/
>$/2# $!ama a"# D#$"e!#k aala- $/!$k memo4#l#a# 9a#"a/ $em3 ,a/2 4e"a"!# me/2$4a- kee#m4a/2a/ 9a#"a/ eem#k#a/ "$pa e-#/22a 6ol$me 9a#"a/ ek!"a el kem4al# me/
T$<$a/ $!ama !e"ap# #$"e!#k aala- me/2$"a/2# eema3 ,a#!$. e/2a/ 9a"a me/2$"a/2# 6ol$me E@>. U/!$k me/9apa# -al #/#3 o$!p$! Na@l -a"$  #/p$!/,a.

7

D#$"e!#k !e"$!ama me/9e2a- ma$k/,a Na ke alam el !$4$l$

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Sem$a #$"e!#k ke9$al# p#"o/olak!o/ 4eke"
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D#$"e!#k ma$k ke alam 9a#"a/ !$4$l$ $pa,a ke"
Me"eka me/9apa# $"#/e melal$# ek"e# paa !$4$l$ p"ok#mal (#l!"a! ak-#" #al$"ka/ ke ka/$/2 kem#- a/ #!#m4$/ e4a2a# $"#/. Be"k$"a/2/,a al#"a/ a"a- ke 2#/
II.1.5 Gn$an T!a!*

D#$"e!#9 !$"$/a/ T#a;# aala- al$"e!#k3 ,a/2 apa! me/eka/ a4o"4# kem4al# #o/7#o/  Na3 @l7 a/ a#". T$"$/a/ #/# <$2a me/#/2ka!ka/ ekk"e# #o/7#o/ K 3 M2 a/ H@O 7 a/ me/$"$/ka/ ekk"e# aam $"a! (Sis&andono, "''). Se/,a8a !#a;# me/$/<$kka/ k$"6a o# ,a/2 e
E5ek 5a"mako#/am#ka !#a;# ,a/2 $!ama #ala- me/#/2ka!ka/ ekk"e# /a!"#$m3 klo"#a a/ e<$mla- a#". E5ek /a!"#$"e# a/ klo"$"e# #/# #e4a4ka/ ole- pe/2-am4a!a/ "ea4o"4# elek!"ol#! paa -$l$ !$4$l# #!al. Paa pe/e"#!a -#pe"!e/#3 !#a;# me/$"$/ka/ !eka/a/ a"a- 4$ka/ a
D#"e!#ka !$"$/a/ !#a;#a me/2a/$/2 $u$us su+a! e-#/22a apa! me/2-am4a! e;#m ka"4o/#k a/-#"ae. 0$2a #ke!a-$# 4a-8a e5ek al$"e!#k/,a !e"
A4o"4# !#a;# melal$# al$"a/ 9e"/a 4a#k ekal#. Um$m/,a e5ek o4a! !ampak e!ela- 1
1. Reak# ale"2# 4e"$pa kela#/a/ k$l#!3 p$"p$"a3 e"ma!#!# #e"!a# 5o!oe/#!#6#!a a/ kela#/a/ a"a-. %. Paa pe/22$/aa/ lama apa! !#m4$l -#pe"2l#kem#a3 !e"$!ama paa pe/e"#!a #a4e!e ,a/2 la!e/. Aa  5ak!o" ,a/2 me/,e4a4ka/ a/!a"a la#/ : 4e"k$"a/2/,a ek"e# #/$l#/ !e"-aap pe/#/22#a/ kaa" 2l$koa plama3 me/#/2ka!/,a 2l#ko2e/ol## a/ 4e"k$"a/2/,a 2l#ko2e/e#. . Me/,e4a4ka/ pe/#/2ka!a/ kaa" kole!e"ol a/ !"#2l#e"# plama e/2a/ meka/#me ,a/2 !#ak #ke!a-$#.

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I/apam#e •

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5,;/r,N,(2,e%/8,2<4,*!/8*r,1",!n*,1,8),4,su+a8#ena!*e A.01-2 

 3A. Na+e/ 5,;/r,N,(2,>%/8,2<4,*!/8*r,1",!n*,1,8),4,su+a8#ena!*e 4rench/

A.01-23A. Na+e/ ?aja%en 5rade na+e/ ?ena!*e< 4,(a!nsu+n8),5,/r,N,(2<4,*!/8*r,2,e%/8,1",!n*,1, 8), A.01-nde6 Na+e/ Fu*e= 5rade na+e/ (-!!p:888.9-emp#e".9om@-em#9al7S!"$9!$"e.*.-!ml)

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Pe#a/asan

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@I.

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@II.

Da+%ar Pus%a&a  No2"a,3 T-oma. 1%. 7i+ia edisinal8 pende%atan secara 9io%i+ia: ter$e+ahan Rasli+ Rasyid dan A+ir usadad . Ba/$/2: Pe/e"4#! ITB S#8a/o/o3 a/ Bam4a/2 Soeka"