Konsep Radiobiologi Dan Prinsip Dasarnya

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Konsep Radiobiologi Dan Prinsip Dasarnya

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arteriografi femoralis

Interaksi Radiasi Dengan Materi

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Kedokteran Kedokteran Nuklir Nuklir

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Konsep Radiobiologi dan Prinsip

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ISI •

Pengenalan

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Efek Stokastik dan Efek non-Stokastik  Sign up to vote on this title 

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Respon Sel dan Kelangsungan Hidupnya Hidupnya

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Pengenalan KASUS 1

Elihu Thomson (seorang fisik  Sign up to vote on this title  Useful  Not useful Amerika) sengaja mengenakan sinar-X ke You're Reading a Preview kelingking kirinya selama beberapa hari (u

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KASUS 2

William Herbert Rollins (seorang dokte dari Boston) menunjukkan penelitiannya Sinar-X bisa membunuh babi guinea  mengakibatkan kematian keturunan Sign up to vote on this title saat guinea diiradiasi saat hamil.  Useful  Not useful You're Reading a Preview KASUS 3

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Efek Stokastik dan Efek non-Stokas •

Ada 2 kategori efek radiasi pada manusia: 


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Efek non-Stokastik (efek deterministik) Useful Not useful 

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→ adalah efek yang umumnya dia You're Reading a Preview

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contoh efek non-Stokastik :  Eritema (kemerahan pada kulit)  Pencukuran bulu (kehilangan rambut)  Mual, muntah, diare (NVD) sering

setelah paparan akut radiasi

diamati pada


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 Sistem saraf pusat (SSP) kerusakan You're Reading a Preview  Kerusakan pada janin (cacat fisik)

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Efek stokastik

(umumnya akan timbul setelah beberapa tahun setelah terjadinya paparan) Sign up to vote on this title  cirinya :

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You're Reading a Preview

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Kurva Survival

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Kurva s biasanya dinya dalam bentuk  kurva logartimik Sign up to vote on this title  Useful  Not useful Kurva survival You're Reading a Preview dinyatakan

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Kurva Survival: Logaritmik •

Ada dua alasan mengapa biasanya kurva digambarkan dalam bentuk logaritmik:


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Pertama, pembunuhan sel You're Reading a Preview adalah peristiwa random yang

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Secara umum, partikel dengan transfer en linear tinggi (LET) akan menunjukkan ben kurva survival,

 up to voterendah on this title sementara partikel denganSignLET ak  Useful  Not useful memiliki kurva lebih rumit dan membentu


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Model linear-kuadratik •

•

Model linear-kuadratik, mengandaikan bahwa kurva survival mempunyai dua komponen, satu sebanding dengan dosis Sign up to vote on this title dan yang lain tergantung pada dosis  Useful  Not useful kuadrat. You're Reading a Preview Ekspresi model linear-kuadratik dapat

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Kurva Survival •

•

α merupakan kemiringan awal kurva, berhubungan dengan pembunuhan dengan sasaran tunggal Sign up to vote on this title β menentukan komponen kuadratik  Useful  Not useful representasi pembunuhan sel dengan multi sasaran. You're Reading a Preview

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The biologically effective dose (BED) dosis efek biologi

Dapat dinyatakan dalam persamaan sebaga berikut :  Sign up to vote on this title  lnUseful   Not useful  = You're Reading a Preview

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The biologically effective dose (BE dosis efek biologi pada therapy w radiopharmaceuticals Sign up to vote on this title

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 Useful  Not usefulberikut Dapat dinyatakan dalam persamaan sebagai You're Reading a Preview  

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Macam-macam interaksi radiasi deng tubuh Macam macam interaksi radiasi: Sign up to vote on this title

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 Useful  Not useful 1. Interaksi radiasi dengan molekul air (rad You're Reading a Preview air)

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Interaksi radiasi dengan molekul a (radiolisis air)

ion radikal ( 10− ) 2  → 2  +   − ∗  2 + →  +   Sign up to vote on this title Useful   −  2  →  −   ∗ Not useful Ion radikal


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Interaksi radiasi dengan DNA

Akibat :perubahan struktur molekul gula/ putusnya ikatan hydrogen antar basa, hilangnya  Sign up to vote on this title useful  Not parah dan lainnya. Kerusakan yang Useful lebih a putusnya salah satu untai DNA . You're Reading a Preview

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Interaksi radiasi dengan kromos

Akibat : perubahan pada jumlah / struktur kromosom (a kromosom), Kerusakan struktur kromosom ( patahnya kromosom).  Sign up to vote on this title

fragmen  Useful  Not useful asentrik(patahnya lengan kromosom yang You're Reading a Preview

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Interaksi radiasi dengan sel Akibat : kematian Sel yang paling sensitive terhadap pengaruh radiasi adalah sel yang paling aktif melakukan pembelahan dan tingkat differensiasi (perkembangan/

SEL

sel yang tidak muda rusak akibat pengar radiasi adalah sel  Sign up to vote on this title tingkat dengan Not useful  Useful differensiasi yang tinggi


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Efek Bystander •

Efek biologi yang timbul pada sel yang  Sign up to vote on this title dilintas radiasi secara langsung tetapi be useful  Useful  Not berdekatan dengan sela Preview yang secara lang You're Reading

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Agustina,Sri.2012.Radiasi dan efek biologi p  Sign up to vote on this title manusia. http://tina Useful  Not useful tin0t.blogspot.com/2012/03/radiasi-efekYou're Reading a Preview

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Konsep Radiobiologi Dan Prinsip Dasarnya

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