GPAT 14 P'cognosy

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A GLIMPSE ON MCQ OF PHARMACOGNOSY

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TEST ON PHARMACOGNOSY

Q1. Match the suitable diagnostic feature of alkaloidal drugs

1. 2. 3. 4. 5. 6. 7. 8. 9.

Spindle shaped phloem fibers, with with presence of lignified fibro fibro vascular bundles. Epidermis with smooth smooth cuticle, Anisocytic stomata and anomocytic anomocytic stomata, glandular and non glandular. Rhombo idal calcium oxalate crystals Ranuculaceous stomata and no calcium oxalate crystals, crystals, unicellular covering covering trichomes Lignified trichomes, collapsed cells, cells, no calcium oxalate crystals crystals and starch grains. Sunken stomata stomata and scaly leaves Leaves with rubiaceous stomata, no trichomes Cruciferous stomata, no calcium calcium oxalate crystals, presence of warty warty trichomes Stratified cork, stone cells and phloem fibers are absent.

a. Kurchi bark b. Rauwolfia root f.

Datura leaf g. Vinca

c. Cinchona bark d. Nux-vomica seed e. Eucalyptus leaf

i. Opium leaf

j. Coca

Q2. Match the suitable diagnostic feature for volatile oil containing drugs

1. Epidermis with unicellular unicellular conical thick walled warty trichomes, trichomes, rosette calcium oxalate crystals crystals and Reticulated parenchyma cells. 2. Acicular crystals with lignified lignified pericyclic fibers embedded in sheath of stone cells, abundant starch grains. 3. Presence of transverse wrinkles wrinkles or rugae , anatropous ovule, partially lignified fibro vascular bundles. 4. Epidermis with anomocytic anomocytic stomata with cluster of calcium oxalate, ellipsoidal schizogenous glands and absence of starch grains. 5. Pericarp with Anomocytic Anomocytic stomata, mesocarp contains lignified lignified reticulate parenchyma, rosette cryatals cryatals of calcium oxalate. 6. Coleospermic fruit, primary primary and secondary ridges in cremocarp cremocarp and vitamin A in leaves. a. Anise b. Clove f. Coriander

c. Cinnamon

d. Cardamom

Q3. Match the following biosynthetic precursors

1. Phenylalanine a. Reserpine 2. Tyrosine b. Atropine 3. Dopamine c. Quinine 4. Tryptophan d. Morphine 5. Ornithine e. Ephedrine 6. Lysine f. Lupine

e. Fennel


Q4. Match the following seeds outgrowth

1. Aril a. Colchicum 2. Arillode b. Strophanthus 3. Arista c. Cardamom 4. Strophile d. Nutmeg Q5. Match the following standard test for 1. Keller-Kiliani a. Tropane alkaloid s 2. Van-Urk’s b. Cinchona 3. Murexide c. Caffeine 4. Vitali-Morin d. Ergot alkaloids 5. Thalloquin e. Anthraquinone 6. Kluge’s f. Isobarbiloin 7. Dragendroff’s h. Alkaloids 8. Borntrager’s test i. Digitoxose Q6. Shikimic acid is a. 3,4,5-Trihydroxy benzoic acid b. 3,4,5-Trihydroxy hexenoic acid c. 3,4,5-Anthralinic acid d. 2,4-Dihydroxy-3-methy 2,4-Dihydroxy-3-methyll valeric acid Q7. Shikimic acid pathway is intermediate for all excluded

a. b. c. d.

Flavones Aromatic amino acids Coumarins Steroids

Q8. Mevalonic acid is

a. 3,5-Dihydroxy-3-methy 3,5-Dihydroxy-3-methyll valeric acid b. 2,5-Dihydroxy-3-methy 2,5-Dihydroxy-3-methyll valeric acid c. 2,4-Dihydroxy-2-methy 2,4-Dihydroxy-2-methyll valeric acid d. 3,5-Dihydroxy-2-methy 3,5-Dihydroxy-2-methyll valeric acid ] Q9. Anthranilic acid is used in biosynthesis of a. Phenylalanine b. Tyrosine c. Tryptophan d. Purine



Q10. Steroids are biosynthesized by

a. b. c. d.

Malonyl CoA Mevalonic acid Shikimic acid Tricarboxylic acid cycle

Q11. Isoprene unit is

a. 2-methyl-1,3-butadiene b. 3-methyl-1,3-butadiene c. 2-methyl-2,4-butadiene d. 2-chloro-1,3-butadiene Q12. HMG-COA is

a. b. c. d.

ß-hydroxy- ß-methyl glutaryl COA COA a-hydroxy- ß-methyl glutaryl COA COA ß-hydroxy- ß-methyl malonyl COA a-hydroxy- ß-methyl malonyl COA

Q13. Palthe Senna / C. Auriculata is differentiated from genuine Senna by

a. b. c. d.

presence of obvate shape leaves absence of Anthraquinones glycosides glycosides presence of papillose papillose cells in epidermis it is O-glycoside

Q14. Maximum amount of barbaloin is present in

a. b. c. d.

Curacao aloe Cape aloe Socotrine aloe Zanzibar aloe

Q15. Which of the following test of aloe is based upon the florescence?

a. b. c. d.

Cupraloin test Bromin e test Borax test Schoen teten’s test

Q16. Which of the following are test for Isobarbiloin? To receive free Pharma GPAT,NIPER, Preparation Sms/Guidance & ADMISSION NOTIFICATIONS on Mobile. Send ON BPHARMSTUFF to 09870807070

p. Cupraloin test q. Nitrous acid r. Nitric acid s. Schoen teten’s teten’s test a. P,Q b. Q,R c. P,R d. P,S Q17. Indian rhubarb is

a. b. c. d.

Rheum emodi R. Palmatum R. webbianum R. rhapnoticum

Q18. Which of the following is sesquiterpene?

a. Foskolin b. Berberine c. Zingiberine d. Citral Q19. Lysergic acid analogues are biosynthesized by

a. Phenylalanine b. Tyrosine c. Tryptophan d. Lysine Q20. Squalene has how many isoprene units?

a. 2 b. 3 c. 4 d. 5


Q21. Which of the following is not a microscopic characteristic of Senna?

a. b. c. d.

Presence of thick walled warty trichomes trichomes Presence of rubiaceous rubiaceous stomata Presence of cluster cluster sheath Presence of raphides

Q22. Identify the true statement about Senna?

a. b. c. d.

It have C-glycoside C-glycoside Will give modified Borntrager’s Borntrager’s test Sennoside A is meso form form and B is Trans form Sennoside C is trans form and D is meso meso form

Q23. Identify the false statement about rhubarb

a. b. c. d.

Indian rhubarb does not contain contain rhaponiticin Rhaponiticin is diphenyl diphenyl ethylene analogue having estrogenic estrogenic activity Rhapnoticum rhubarb give blue florescence while Indian Indian rhubarb give violet florescence Rhapnoticum rhubarb shows presence of rhein, emodin and aloe emodin.

Q24. Which of the following is not a test for digitalis?

a. b. c. d.

Baljet test Legal test Modified Borntager’s test Keller-Kiliani test

Q25. Match the following how the different variety are differentiated from digitalis?

1. 2. 3. 4.

Multi cellular cellular trichomes forming Hook at top a. Comfrey leaves Presence of large wooly trichomes b. Verbascum Thapus Trichomes 8-9 celled long c. Primose leaves Presence of calcium oxalate crystals d. D.Thapsi

Q26. Digoxin is cardenolide which is mainly used for rapid digitalization therapy have –OH grp at

a. 14 b. 14,16 c. 12,14,16 d. 12,16 Q27. Which of the lanatoside mainly give digoxin? To receive free Pharma GPAT,NIPER, Preparation Sms/Guidance & ADMISSION NOTIFICATIONS on Mobile. Send ON BPHARMSTUFF to 09870807070

a. A b. B c. C d. D Q28. Which of the following is not a microscopic characteristic of digitalis?

a. b. c. d.

Presence of anomocytic stomata stomata 3-5 celled celled long trichomes Collapsed celled celled covering trichomes Presence of calcium oxalate crystals

Q29. Carbenoloxone used as antiulcer is a derivative of

a. Dioscorea b. Liquorice c. Ginseng d. Safed musali Q30. Match the biological activity reported

1. 2. 3. 4. 5. 6. 7. 8. 9.

Antioxytocic a. Shatavari Precursor for steroid synthesis b. Dioscorea Immunomodulator c. Ginseng Heaptoprotective d. Silymarin Calculous affections e. Gokhru Vascular disorders f. Ginkgo Capillary fragility g. BucK-Wheat Angina pectoris h. Visnaga Antidiabetic i. Gymnema



Q31. Ophelic acid is present in

a. Picrorrhiza b. Gentian c. Chirata d. Kalmegh Q32. Match the following functional moiety present in volatile oil

1. 2. 3. 4. 5. 6. 7.

Ester Ester a. Gaultheria oil Ether b. Fennel Ketone c. Caraway Phenol d. Clove Oxide e. Chenopodium Alcohol f. Peppermint Aldehyde i. Lemon

Q33. Myrrh is

a. b. c. d.

Acid resin Ester acid Alcohol resin Carbohydrate

Q34. Wild cherry bark contains prunasin which is a

A) Phenolic glycoside (B) Isothiocyanate glycoside (C) Coumarin glycoside (D)Cyanogeneticglycoside Q35. Ephedra sinica and Ephedra equisetina can be distinguished by type of

(A) Branching (B) Stomata (C) Scaly leaves (D) Alkaloids

Q36. Acontitine belongs to the group of

A) Steroidal alkaloids (B) Terpenoidal alkaloids (C) Indole alkaloids (D) Quinoline alkaloids Q37. Crude fiber value of a drug is a measure of

A) Soft tissue matter (B) Woody matter (C) Mineral matter (D) Organic matter

Q38. Safranin is used as a reagent to detect (A) Gram-negative bacteria (B) Gram-positive bacteria Q39. Quercetin is

(C) Acid fast bacteria (D) Myxozoa


(A) 5, 7, 3-Trihydroxy flavones (B) 5, 7, 3, 4-Tetradydroxy flavones (C) 3, 5, 7, 3, 4-Pen tahydroxy flavonol (D) 3, 5, 7, 3, 4-Pentahydroxy flavonone Q40. A novel diterpenoid isolated from the bark of Taxus brevifolia is

A) Demecolcine Demecolcine (B) Paclitaxel Paclitaxel (C) Vinblasti Vinblastin n (D)Brevif (D)Brevifolici olicin n Q41.Myristica fragrans Houtt has two of the following characteristics.

(P) An indeciduous tree, which produces drupac eous, pale yellow fruits. (Q) Each fruit has several round seeds with smooth surface and lignaceous tegument, and the orange red fleshy aril — the mace, is present inside the seed. (R) A deciduous tall tree, which produces lignaceous capsu les. (S) Each fruit has a unique avoid seed, with lignified tegument, surrounded by orange red laciniate fleshly aril — the mace. A) Q, R (B) (B) P, P, R (C) (C) P.S P.S (D)Q, (D)Q, S Q42. Group I Lanatosides Group II Aglycone (P) Lanatoside A (1) Gitaxigenin (Q) LanatosideB (2) Diginatigenin (R) Lanatoside C (3) Digoxigenin (S) Lanatoside D (4) Digitoxigenin (A) P - 1 Q - 2 R-3 S-4 (B) p - 3 Q - 1 R -2 S-4 (C) P - 2 Q – 4 R-3 S-1 (D) P - 3 Q -3 R - 1 S-4 Q43. Clove stalks can be identified by the presence of (A) Starch grains (B) Cystolith s (C) Lignified sclereids (D) Acicular crystals of calcium oxalate ox alate Q44. Group I Specific chemical test (P) Thalleioquin Test (Q) Murexide Test (R) Vitali-Morin Test (s) Modified Borntrager’sTest (A) P - 4 Q – 1 R – 3 S - 2 (C) P - 3 Q – 4 R – 2 S - 1 (B) P - 1 Q – 3 R – 4 S - 1 (D) P - 2 Q - 2 R – 3 S - 4

Group II Phytoconstituents (1) Hyoscyamine (2) Barbaloin (3) Quinine (4) Theobromine

Q45. Presence of one of the following characteristics show that the Rauwolfia serpentine is adulterated with other species of Rauwolfia. To receive free Pharma GPAT,NIPER, Preparation Sms/Guidance & ADMISSION NOTIFICATIONS on Mobile. Send ON BPHARMSTUFF to 09870807070

(A) Compound starch starch grains (B) Cluster crystals of calcium oxalate (C) Lignified sclereids sclereids (D) Unlignified pericyclic fibres

Q46. Chinese rhapontic rhubarb can be distinguished from Indian rhubarb by fluorescence developed in UV light which is: (A) Deep yellow (B) Deep violet (C) Green (D)Blue

Q47. Citrus flavonoids are rich in

A) Aesculetin Aesculetin (B) Fraxin Fraxin (C) Hesperidin Hesperidin (D)Scopole (D)Scopoletin tin

Q48. The alkaloid which inhibits the cholinesterase undergoes hydrolysis in solution to give methyl carbamic acid and eseroline is: A) Scopolamine Scopolamine (B) Pyridost Pyridostigmin igminee (C) Neostigmi Neostigmine ne (D) Physostigm Physostigmine ine Q49. Eegonine, a hydrolytic product of cocaine on treatment with chromium trioxide gives a keto acid, which on thermal decarboxylation results in

A) Atropic Atropic acid (B) Tropic Tropic acid (C) Pseudo Pseudo cocaine cocaine (D)Tropinone (D)Tropinone Q50. A natural product derivative developed as an antimalarial is A) Artemether Artemether (B) Paludrine Paludrine (C) Pyrimetha Pyrimethamine mine (D) Haloffantr Haloffantrine ine Q51. Predict the product obtained by treating 6-chloro-3, 5-diamino pyrazin-2-methyl carboxylate with Guanidine

A) Amiloride Amiloride (B) Hydrochlor Hydrochlorothiaz othiazide ide (C) Triamterene Triamterene (D) Furosemid Furosemidee

Q52. Glycyrrhizin, a sweet principle of liquorice is

(A) K and Mg salts of glycyrrhizin ic acid (B) Na and Mg salts of glycyrrhetinic acid

SEND ANY PHARMA MATERIAL & GPAT MATERIAL TO :[email protected] (C) K and Ca salts of glycyrrhizinic acid (D) Na and Ca salts of glycyrrhetinic acid Q53. Alloploids are polyploids derived from (A) a single parental species genome (B) more than one parental species genomes (C) a plant with haploid number of chromosomes (D) a plant with diploic number of chromosomes Q54. The colour and flavour of Saffron are due to -(P) Crocin (Q) Crocetin (R) Safranal (S) Crepenyic acid (A) R, S (B) P, R (C) Q, S (D)Q, P

Q56. Group I Umbelliferous fruit Group II Diagnostic character (P) Fenel (1) Wavy scierenchyma (Q) Indian Dill (2) Bran ched and unbranched vittae (R) Coriander (3) Reticulaterly lignified parenchyma (S) Anise (4) Lateral ridges with vascular bundles

(A) P-1Q-4R-35-2 (B) P-2Q-3R-4S-1 P-2Q-3R-4S-1 (C) P-4Q-2R-1S-3 P-4Q-2R-1S-3 (D) P-3Q-2R-45-1 P-3Q-2R-45-1

Q57. The quantitative values determined for the identification of leaf drugs remain constant throughout the age of the plant EXCEPT A) Stomatal number (B) Veinlet termination number (C) Veinislet number (D) Stomatal index

Q58. A sample of Cinnamomum zeylanicum purchased from the market was evaluated for its authenticity. It shows (A) presence of cork and cortex (B) absence of cork and cortex (C) absence of phloem fibres (D) presence of xylem parenchyma

Q59. A transverse section of the root fo Glycyrrhiza glabra when treated with 80% sulphuric acid gave A) Deep yellow yellow colour (B) No reaction, reaction, but only charring charring (C) Deep blue colour colour (D) Deep red colour Q60. Microscopy of the bulbs of Urginea Indica family Liliaceae shows (A) Prisms of calcium oxalate (B) Calcium carbonate and silica (C) Rosettes of calcium oxalate (D) Raphides of To receive free Pharma GPAT,NIPER, Preparation Sms/Guidance & ADMISSION NOTIFICATIONS on Mobile. Send ON BPHARMSTUFF to 09870807070

calcium oxalate Q61. The antihistamine with diphenyl methyl group is A) Methdilazin Methdilazinee (B) Cyclizine Cyclizine hydrochloride hydrochloride (C) Pheniramine Pheniramine (D) Phenindamine Phenindamine Q62. Heterocyclic rings present in pilocarpine are (A) Imidazole and Quinoline (B) Imidazole and Thiazole (C) Quinoline and Phenanthrene (D) Imidazole and Dihydrofuran

Q63. T he most important microbial virulence factor in the etiology of bacterial meningitis is A) Exotoxin Exotoxin (B) Components Components of the capsule capsule (C) Coagulase Coagulase (D) Hyaluronida Hyaluronidase se Q64. Commonly used tetanus vaccine is produced by (A) treatment of the causative organism with heat or UV light and finally obtaining the toxoid (B) sub-culuring the virus at pH 10.4 (C) artificially generating antibodies to viral glycoproteins (D) isolating the antigenicity genes from the causative organism

Q65. (-) – Hyoscyamine is (A) 15-20 times more active as a mydriatic than (+)- hyoscyamine (B) Inactive as a mydriatic (C) 3-5 times less active as a mydriatic than (+)- hyoscyamine (D) 100 times more active as a mydriatic than (+)- h yoscyamine Q66. Gram positive bacteria typically contain (A) cell walls that lack peptidoglycans (B) repeating un its of arabinogalactan and an d mycolates in their cell walls (C) Peptidoglycan containing muramic acid and D-amino acids in their cell walls (D) cell walls containing predominantly polysaccharides and glycoprotein Q67. Two tests for ephedrine are

(P) A solution in dilute HCl, treated with copper sulphate and sodium hydroxide gives a violet colour (Q) An alcoholic alcoholic solution gives a red colour colour with FeCl3 (R) On shaking with solvent ether, the organic layer shows purple while the aqueous layer bec omes blue in colour (S) A solution of vanillin gives a violet-red colour (A) Q, S (B) P, S (C) P, R (D) Q, R Q68. Dried fruits of sweet fennel has two of the following properties (P) 80% of E-anethole, 10% of methyl chavicol an d 5% (+) – fenchone as constitutents (Q) 65-75% (+)- Lin alool as a constitutent (R) The fruit is a diakene, almost cylindrical and surrounded by large stylopod (S) The fru it is elongated an d surrounded b y calyculus (A) P, R (B) Q, S (C) P, S (D) Q, R


Q69. Two of the following facts are associated with Ethylene oxide gas

(P) It is non toxic and non inflammable and used for sterilization (Q) It is a colourless inflammable gas, toxic in nature and used for sterilization (R) It is diluted with CO2 (S) It cannot penetrate plastic and paper packaging (A) P, R (B) P, S (C) R, S (D) Q, R Q70. Match Group I and Group-II and identify the correct combinations Group-I Group-IIPlant Source (P) Thorn apple (1) Dried leaves and flowering tops of Hyoscyamus niger (Q) Henbane (2) Dried leaves and flowering tops of Datura Stramonium (R) Deadly nightshade (3) Leaves of Digitalis purpurea dried at a temperature temperature below 60ºC 60ºC (S) Foxglove leaves (4) Dried leaves and other aerialparts of Atropa acuminate (A) P - 2 Q - 1 R - 4 S - 3 (B) P - 1 Q - 2 R - 3 S – 4 (C) P - 3Q - 4 R - 2 S - 1 (D) P - 2 Q - 3 R - 4 S - 1 Q71. Extracts of Chondrodendron tomentosum, family menispermaceae contains several alkaloids One of the important alkaloid is A) (-) Phyllandrene Phyllandrene (B) (+) Holarrhenine Holarrhenine (C) (+) (+) Tubocurarine (D) (±) Colchicine Q72. This alkaloid has A) Bis benzyl tetrahydro tetrahydro isoquinoline ring ring (B) Quinoline Quinoline ring (C) Phenanthrene ring (D) Pyrido pyrimidine pyrimidine ring Q73. Microscopic characters of ginger rhizome are (A) Spindle shaped lignified fibres and sclereids (B) Cluster crystals of calcium oxalate and sclereids (C) Non-lignified vessels and sac shaped starch grains (D) Non-lignified fibres and sclereids

Q74. Klunge’s test is for the identification of A) Barbaloin Barbaloin (B) Isobarbal Isobarbaloin oin (C) Aloinosi Aloinosides des (D) Aloesin Aloesin Q75. Group I Group II Glycoside Type P. Gentisin 1. Flavonol Q. Genistein 2. Flavone R. Apigenin 3. Xanthone S. Quercetin 4. Isoflavone (A) P-4,Q-3,R-1,S-2 (B) P-1,Q-2,R-4,S-3 (C) P-3,Q-4,R-2,S-1 (D) P-2,Q-1,R-3,S-4

Q76. Group I Group II Bark Diagnostic Microscopically Characters P. Kurch i 1. Heavily lignified phloem fibers with Y-shaped pits, secretory canals, micro crystals of calcium To receive free Pharma GPAT,NIPER, Preparation Sms/Guidance & ADMISSION NOTIFICATIONS on Mobile. Send ON BPHARMSTUFF to 09870807070

oxalate Q. Cascara Cascara 2. Pericycl Pericyclee with stone cells having horse-shoe horse-shoe Shaped thickening, thickening, oil cells, cells, minute minute needles needles ofcalcium oxalate R. Cinnamon 3. Alternating layers of stone cells and phloem, nonlignified pericyclic fibres, prismatic crystals of calcium oxalate S. Cinchona 4. Wavy medullary rays, groups of heavily lig nified sclereids, crystal sheath of calcium oxalate (A) P-2,Q-1,R-4,S-3 (B) P-4,Q-3,R-1,S-2 (C) P-3,Q-4,R-2,S-1 (D) P-1,Q-2,R-3,S-4

Q77. In Podophyllum toxin the lactone grp which is essential for the antimiotic activity must be

a. b. c. d.

Trans position Cis position E type Z type

Q78. Identify the True / False statement and fill in the blanks

1. Anthranol are more active than Anthraquinones 2. Anthranol gives strong strong florescence in alkali while Anthraquinones donot 3. GPP is formed formed from two units of IPP. 4. Starting material for Shikimic acid is PEP and Erythrose Erythrose -4-P 5. Shikimic acid gives C C units 6. Naphthalene glycosides present in Senna are ………………………… ……………………………. …. 7. Microscopic characteristics of Rhubarb is ………………………… ………………………………. ……. 8. ……………………… have haemotoxic and foaming properties. 9. …………………… is is used as reference standard for bioassay of cardiac glycosides. glycosides. 10. Microscopic characteristics of Quillaria bark is …………………………… …………………………………….. ……….. 11. Wild chery bark have …………………………… …………………………… type of glycosides glycosides 12. ………………….. is man like root 13. ………………… root have odour of methyl salicylate salicylate 14. ………………… is used in in treatment of leucoderma 15. Khellin is smooth smooth muscle relaxant is important important constituent of ……………………. ……………………. 16. ………………………… ………………………… is pentacyclic pentacyclic Triterpenoids saponin 17. ……………………… bark is used as cardiotonic. 18. ……………………… bark is uterine tonic tonic cause uterine contractions. 19. ………………………. ………………………. Bark is used to treat treat dysentery 20. Tannin’s that donot give goldbeater’s goldbeater’s skin test are called called as ……………….. 21. …………………………. …………………………. Anthelmintic Anthelmintic for tapeworms. tapeworms. 22. …………………… alkaloidal drug on boiling with water produce acetophenone like smell. 23. …………………… benzaldehyde smell production on treatment with with KMnO4. 24. …………………… Guggulosterone are used as an antihyperlipidamic



GPAT 14 P'cognosy

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