GPAT 16 Medicinal Chemistry

MEDICINA MED ICINA L CHEMI CHE MI S TRY Q1. Identify the synthesis of following compound

(i ) NH3

a.

Acetyl choline

b.

Carbachol

c.

Methacholine

d. Neostigmine Q2. Identify the synthesis of following compound

CH3 Br

a.

Edrophonium

b.

Pyridostigmine

c.

Methacholine

d.

Neostigmine

Q3. Cyclohexyl nitrile and N, N-diethylamino is used as starting product in the synthesis of

a.

Glycopyrrolate

b.

Dicyclomine

c.

Homatropine

d.

Cyclopentolate

Q4. Xanthene 9-carboxylic acid N,N-diethylamino cholroethane is used in the synthesis of a.

Tropicamide

b.

Propantheline

c.

Procyclidine

d.

Dicyclomine

Q5. Which of the following is the structure of Tropicamide

a.

b.

c.

d.

Q6. Identify the synthesis of following compound

a.

Salbutamol

b.

Terbutaline

c.

Amphetamine

d.

Isoprenaline


a.

Salbutamol

b. Noradrenaline c.

Amphetamine

d.

Phenylephrine


a.

Salbutamol

b.

Phenoxybenzamine

c.

Tolazoline

d.

Naphthazoline


a.

Salbutamol

b.

Propranolol

c.

Prazocin

d.

Ephedrine


a.

Phenetolamine

b.

Phenoxybenzamine

c.

Prazocin

d.

Ephedrine


a.

Phenetolamine

b.

Phenoxybenzamine

c.

Prazocin

d.

Propranolol


a.

Diphenhydramine

b.

Doxylamine

c.

Mepyramine

d.

Pheniramine


a.

Diphenhydramine

b.

Doxylamine

c.

Mepyramine

d.

Pheniramine

NaH2


a.

Promethazine

b.

Cyclizine

c.

Pheniramine

d.

Methdilazine


a.

Promethazine

b.

Cyclizine

c.

Pheniramine

d.

Meclizine


a.

Phenindamine

b.

Cyproheptadine

c.

Triprolidine

d.

Indomethacin


a.

Cimetidine

b.

Ranitidine

c. Nizatidine d.

Famotidine

Q18. Which heterocyclic ring is present in Amiloride?

a.

Pyrimidine ring

b.

Pteridine ring

c.

Pyrazine ring

d.

Pyridine

Q19. Which diuretic have steroid nucleus?

a.

Amiloride

b.

Chlorthalidone

c.

Triamterene

d.

Spironolactone

Q20. Diphenhydramine belongs to antihistaminic class of

a.

Ethylene diamine

b.

Amino alkyl ether

c.

Alkyl amine

d.

Phenothiazine

Q21. Phenindamine belongs to class of a.

Piperidine

b.

Piperazine

c.

Ethylene diamine

d.

Amino alkyl ether


a.

Naproxen

b.

Ketoprofen

c. Naphthazoline d.

Phenacetin


a.

Sulindac

b.

Indomethacin

c.

Phenylbutazone

d.

Mefenamic acid


a.

Diclofenac

b.

Piroxicam

c.

Phenylbutazone

d.

Mefenamic acid


a.

Diclofenac

b.

Aminopyrine

c.

Phenylbutazone

d.

Mefenamic acid

Q26. Hydantoin posses the heterocyclic ring a.

Imidazoline 3,5-dione

b.

Imidazoline 2,4-dione

c.

Pyrazoline 3,5-dione

d.

Thiazoline 2,4-dione

Q27. Phenytoin is a.

5,5-diphenylimidazoline-2,4 5,5-diphenylimidazoline-2 ,4 dione

b.

4,4-diphenylimidazoline-2,4-dione

c.

4,4-diphenylimidazoline-3,5-dione

d.

5,5-diphenylpyrazoline-3,5-dione

Q28. Antipyretic activity of NASIDS is mostly exhibited due to inhibition of a.

PGE2

b.

PGD2

c.

PGI2

d.

PGF2α

Q29. Which enantiomers of profens are more active? a.

S(+)

b.

S(-)

c.

R(+)

d.

R(-)

Q30. Ephedrine how has many Chiral center a.

2

b.

3

c.

1

d.

0

Q31. Antazoline a NASID have a.

Imidazoline ring

b.

Pyrazoline ring

c.

Thiazoline ring

d.

Oxazoline ring

Q32. Which of the following is tertiary amine and crosses the BBB?

a.

Pyridostigmine

b.

Physostigmine

c. Neostigmine d.

Edrophonium

Q33. 4-chloro-6-amino-1,3-benzenesulfonamide 4-chloro-6-amino-1,3-benzenesulfonamide and formic acid are starting material for synthesis of

a.

Hydrochlorthiazide

b.

Chlorthiazide

c.

Benzthiazide

d.

Polythiazide

Q34. 2,4-dichloro benzoic acid and furfurylamine are starting product for synthesis of a.

Furosemide

b.

Bumetanide

c.

Chlorthalidone

d.

Chlorthiazide

Q35. Pthalic anhydride and chlorobenzene are starting product for synthesis of

a.

Phenindamine

b.

Cyproheptadine

c.

Chlorthalidone

d.

Chlorthiazide

Q36. 2,3-dichlorophenoxyacetic and butrylchloride are stating product for the synthesis of a.

Ethacrynic acid

b.

Triamterene

c.

Amiloride

d.

Furosemide

Q37. Pteridine ring is present in

a.

Amiloride

b.

Triamterene

c.

Chlorthalidone

d.

Spirolactone

Q38. Benzylnitrile and nitrosopyrimidine are the starting product for

a.

Amiloride

b.

Triamterene

c.

Chlorpheniramine

d. Naphthazoline Q39. 2,6-dichloro5-formylpyrimidine and hydrazine are starting product of a.

Allopurinol

b.

Colchicine

c.

Probenecid

d.

Sulfinpyrazone

Q40. 4-hydroxy-3-hydroxymethyl Benzaldehyde and tertiary butylbenzylamine are involved in the synthesis of

a.

Terbutaline

b.

Salbutamol

c.

Isoprenaline

d.

Albuterol


a.

Halothane

b.

Enflurane

c.

Isoflurane

d.

Methoxyflurane


a.

Phenobarbitone

b.

Mephobarbitone

c.

Secobarbitone

d.

Pentobarbitone

Q43. Identify the synthesis of following compound a.

Amobarbitone

b.

Secobarbitone

c.

Pentobarbitone

d.

Phenobarbitone

Ethylisopentylethylmalonate


a.

Glutethimide

b.

Methqualone

c.

Meprobamate

d.

Paraldehyde


a.

Diazepam

b. Nitrazepam c.

Flurazepam

d.

Alprazolam

urea


a.

Phenytoin

b.

Trimethadione

c.

Phensuximide

d.

Primidone


a.

Imipramine

b.

Carbamazepine

c.

Amitriptyline

d.

Primidone

Q1. Which of the following anthelmintics is not a carbamic methyl ester?

1.

Cyclobendazole 2. Thiabendazole 3. Albendazole 4. Parbendazole

Q2. Acyclovir is a analogue of

1.

Uracil

2. Adenine

3. Guanine

4. Thymidine

Q3. Sulfamethoxazole is having

1.

Isoxazole ring

2. Oxazole ring

3. 1, 3, 4 thiadiazole

4. Imidazole

Q4. Which of the following drug is amphoteric in nature?

1.

Chloramphenicol

2. Amphotericin Amphotericin B

3. Macrolides

4. Penicillins

Q5. Which isomer of Chloramphenicol is more active?

1.

R, R

2. R, S 3. S, S

4. All are equally active

Q6. Which of the following is not true about cycloserine?

1.

It is derived from amino acids

2. It inhibits cell wall synthesis

3. Having oxazolidine ring

nephrotoxic Q7. How many chiral centers are present in oxytetracycline?

1.

4

2. 5

3. 6

4. 7

Q8. Which of the following drug is para-hydroxy acetanilide derivative?

1. Niclosamide

2. Diloxanide

3. Pyrazinamide Pyrazinamide

4. Teclozan

Q9. How many chiral centers centers are present in steroid steroid nucleus?

1.

4

2. 5

3. 6

4. 7

Q10. Primaquine is derivative of-

1.

8-aminoquinoline

2. 4-aminoquinoline

3. Biguanides

4. Napthaquinone

Q11. In steroid nucleus A/B, B/C, C/D rings are fused in the manner of-

1.

Cis- Cis -Trans

2. Trans-Cis-trans Trans-Cis-trans

3. Cis-Trans-Cis Cis-Trans-Cis

Q12. Which of the following is not having steroid nucleus?

4. Trans-Cis-Cis Trans-Cis-Cis

4. Highly

1.

Finastride

2. Nondrolone

3. Flutamide

4. Megestrol

Q13. 9α 9α fluoro - 11β 11β,17,21-trihydroxy -16α -16α-methyl pregna1,4-diene 3,20 dione is

1.

Paramethsone

2. Triamcinolone

3. Prednesolone

4. Betamethasone

Q14. . 9α fluoro - 11β 11β,16α ,16α,17,21-tetrahydroxy pregna1,4-diene 3,20 dione is

1.

Paramethsone

2. Triamcinolone

3. Fludrocortisone

4. Betamethasone

Q15. Which of the following is antiandrogenic?

1.

Tamoxifen

2. Mifepristone 3. Clomiphene

4. Flutamide

Q16. Which heterocyclic ring is present in Amiloride?

1.

Pyrimidine ring 2. Pteridine ring 3. Pyrazine ring 4. Pyridine

Q17. Which diuretic have steroid nucleus?

1.

Amiloride

2. Chlorthalidone

3. Triamterene

4. Spironolactone

Q18. Benorylate is condensation product of ………………………………………………………………. Q19. Diphenhydramine belongs to antihistaminic class of

1.

Ethylene diamine

2. Amino alkyl ether

3. Alkyl amine

4. Phenothiazine

Q20. Match the following heterocyclic ring present in drugs-

1.

Imidazole

a. Cimetidine

1.

2.

Thiazole

b. Ranitidine

2.

3.

Furan

c. Astemizole

3.

4.

Benzimidazole

d. Terfenadine

4.

5.

1,1 dioxothiazine

e. Thiazolidine

5.

6.

Sulbactam

f. Oxazolidine

6.

7.

Clavulinic acid

g. Albendazole

7.

h. Piroxicam Q21. Choose the correct statement for estrogen

1.

Ring D is benzenoid and have OH grp at C 17 Phenolic

2.

Ring A is quinonoid and have OH grp at C 3 alcoholic

3.

Ring A is benzenoid and have OH grp at C 3 Phenolic

4.

Ring D is quinonoid and have OH grp at C 17 alcoholic

Q22. Phenindamine belongs to class of

1.

Piperidine

2. Piperazines

3. Ethylene diamine

4. Amino alkyl ether

Q23. Match the following

1.

1.

Benzimidazole

Zalcitabine

2.

Imidazole

Metronidazole

3.

Thymidine

Stavudine

4.

17β 17β hydroxy- 17α 17α methyl 3 oxo androst-4ene

Meconazol

5.

Salicylic acid derivative

Nondrolone

2. 3. 4. 5. 6.

6.

Piperazine ring

Mthyltestosterone Mthyltestosterone 7.

7.

Morpholino

Diloxanide 8.

8.

Ethanol derivative

Niclosamide 9.

9.

Acetanilide derivative

Nitrofurazone 10.

10. Oxazolidine

Nimorazole Citerizine Mebendazole

Q24. Which of the moiety is responsible for diuretic activity in acetazolamide?

1.

1, 3, 4-thiazole ring

2. N-acetyl grp

3. Sulphamoyl grp

Q25. Which isomer of diethyl stilbosterol is more active?

1.

Cis

2. Trans

3. E

Q26. Identify True/False (T/F) statement

4. Z

4. Secondary amino grp

1.

In steroid nucleus confirmation is boat shape

(T/F)

2.

Paramethsone have 9α 9α fluoro, 16α 16α-methyl-17α -methyl-17α-hydroxy grp

(T/F)

3.

Halofantrine is quinoline methanol

(T/F)

4.

Sesquiterpene lactone is artimisnin

(T/F)

5.

Ciprofloxacin have Piperazine ring attached to 1st position

(T/F)

6.

Vidarabine is adenine analogue

(T/F)

7.

Pyrantel is pyridine analogue

(T/F)

8.

Trimethoprim is pyrimidine analogue

(T/F)

9.

Sulphalene have Pyrazine ring

(T/F)

10. Azteonam is monobactam

(T/F)

11. Clavulinic acid thiazolidine ring

(T/F)

12. Active anti inflammatory metabolite of sulfasalazine is pyridyl sulphanilamide sulphanilamide

(T/F)

13. Phenyl butazone is synthesized from hydrazine derivative

(T/F)

14. Fenbufen is carbonyl propionic acid

(T/F)

15. Mefenamic acid is arylacetic acid derivative

(T/F)

16. Oxicams are N-heteroaryl N-heteroaryl carboxamide carboxamide derivatives

(T/F)

17. Chlorthiazide have 1,1 dioxo 1,2 thiazine ring

(T/F)

Sy n t h e s i s o f s o m e i m p o r t a n t d r u g s 1.

Acetazolamide

14. Allopurinol

2.

Polythiazide

15. Phenylbutazone

3.

Mebendazole

16. Indomethacin

4.

Niclosamide

17. Mepyramine

5.

Metronidazole

18. Promethazine

6.

Diloxanide

19. Cimetidine

7.

Mefenide

20. Nalixidic acid

8.

Meconazol

9.

Proquanil

10. Trimethoprim 11. Clofazimine 12. Chlorthalidone 13. Mefenamic acid

GPAT 16 Medicinal Chemistry

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