Data Stabilitas Kemo

DATA DATA KELARUTAN KELARU TAN DAN STABILITAS OBAT KANKER DI INSTALASI FARMASI RUMAH SAKIT SANTA MARIA (berdasarkan data stabilitas RS Kanker 'Dharais'!

SEDIAAN A"AL NO

DATA KELARUTAN

NAMA OBAT KONSENTRASI

KONDISI #EN.IM#ANAN

#ELARUT

$OLUME

KONSENTRASI

STABILITAS #EN.IM#ANAN SETELAH DILARUTKAN

%&& )

%%&%*& )

STABILITAS #EN.IM#ANAN SETELAH DILARRUTKAN DALAM INFUS

METODE #EMBERIAN

RUTE/LAMA #ELARUT #EMBERIAN .AN0 )O)OK

$OLUME LARUTAN

%&& )

INFORMASI TAMBAHAN

%%&%*& )

Alk+latin, A,ent

Carboplatin 1

Kemobotin Carboplatin DBL

50 mg/5ml, 150 mg/15 ml, !50 Suhu Ruangan mg/!5 ml, 00 mg/0 ml

D5, NS

5 ml, 15 ml, !5 ml

10 mg/ml

"#toplatin

-

Carmu$tine 

%

!

100 mg/ %ml

:-8: C4 terlinung ari #ahaa

&'(

) ml

%*% mg/ml

10 mg/.ial, 50 mg/.ial

Suhu Ruangan

&'(

10 ml, 5 ml, 50 ml

1 mg/ml

no2an

00 mg/.ial, 1 gr/.ial

Suhu Ruangan

10 ml, 5 ml, 50 ml

0 mg/ml

De#arba3ine

00 mg/0 ml

BiCN+

Ci Ci$platin C#lo.i

-

&'( NS

! jam4 8 hari / .ial, ( Drip 15 5 hari / menit- ! jam $puit

D5, NS

100- 00 ml 67on$entra$i minimal 0*5 mg/ml

8 j am

! jam4 8 jam / NS4 9 hari / 9 hari D5 alam D5 8 jam ! jam -

8 jam 7e#epatan inu$ ma2* % mg/m;/menit

( Drip 1- jam

D5,NS

500 ml

! jam

0 jam

inu$ 1-8 jam

D5, NS, D5NS

1000 ml-000 ml< 7on$entra$i 0*5 -  mg/ml

-

1 jam terlinung #ahaa

 hari

! jam

-

 j am

! jam

! jam

( Drip 1- jam

-

! jam

! jam

&'(, &'(, NS, NS, D5 &'(, &'(, NS, NS, D5

terlin terlinun un ari ari

5

D=(C

:-8: C4 100 mg/10 ml, terlinung ari #ahaa 00 mg/0 ml

&'(

10 ml, 0 ml

10 mg/ml

(o$amie 

>olo2an

! jam

-

( rip %0-0 menit

-

rp $elama %0 menit atau inu$ berlanjut $elama 5 hari

15-0 menit

( bolu$4 ( rip #epat

D5

( rip 15-0 menit4 ( 90 menit bolu$ -0 menit

1 hari 500 mg, 1 g,  g Suhu Ruangan

1*5 ml, 5 &'(, NS ml, 50 ml

!0 mg/ml

! jam

D5, NS

50 ml-500 ml

-

 minggu

) hari

! jam

-

150-50 ml

-

15-0 menit

NS

50-500 ml

-

0 menit

( rip - jam

D5

50-500 ml

! jam

 jam

$erbu7 7ering tia7 boleh ma$u7 peningin, jangan guna7an NS terlinung ari #ahaa

D5, NS

50-1000 ml

?e#hlorethamine )

?u$tine

10 mg/.ial

Suhu Ruangan

&'(

10 ml

1 mg/ml

-

?elphalan 8

"l7eran

50 mg/.ial

Suhu Ruangan


@2aliplatin 9

lo2atin Re2ta Strepto3o#in

10

Aano$ar

11 =hiotepa

1 g/.ial

NS

10 ml

Suhu Ruangan, =erlinung Cahaa

D5, &'(

10 ml, 0 ml

:-8: C4 terlinung ari #ahaa

NS, &'(

10 ml

&'(

1*5 ml, %*0 ml

&'(

100 mg/5ml, 0 mg/ml, 500 50mg/ml, 100 mg/10ml, 1 mg/ml g/10ml

:-8: C4 15 mg/.ial, %0 terlinung ari mg/.ial #ahaa

5 mg/ml

-

! jam

-

! jam

 jam

!8 jam

-

100 mg/ml

9 jam

!8 jam

( rip %0-0 menit

D5, NS

500 ml

9 jam

!8 jam

10 mg/ml

8 hari

) hari

( rip 10-0 menit

D5

50-100ml

1! hari

% hari

5 mg/ml

#ahaa4 $erbu7 .ial paa $uhu ruangan hana $tabil ! minggu

! jam

Har2s di,2nakan se,era setelah disia3kan

Antietab1lit

1

Ctarabine

1 g/.ial, 100 mg/.ial

"le2an


$uhu ruangan

8 hari

(=, ( rip 1% jam

NS,D5NS

50-1000ml

8 hari 6rip4 ) hari 6(=/$ringe 

terlinung ari #ahaa

Ctarabine DBL


Suhu Ruangan

&'(

100 mg/5 ml, 500 mg/10 ml

0 mg/ml, 50mg/ml, 100 mg/ml

! jam

(

NS,D5NS

50-1000ml

tablet 150 mg, tablet 500 mg

Suhu Ruangan

&'(

00 ml

000mg/00ml

-

oral

&'(

00 ml

50 mg/5ml, 500 mg/10ml

Suhu Ruangan, =erlinung Cahaa

NS,D5

( bolu$ 5-15 menit, ( rip

NS, D5

50-1000 ml

50 mg/.ial

:-8: C

&'(

( rip 15-%0 menit

NS, D5

100-15 ml

NS, D5, RL

7on$entra$i *5-5 mg/ml

NS,D5

100 ml

! jam

Cepe#itabine 1%

eloa 5-'luoroura#il

1!

15

Cura#il 'luarabine 'luara

50 mg/ml

 ml

5 mg/ml

! jam

?ethotre2ate 1

1)

mthe2ate emetre2e "limta

50 mg/ml, 50 mg/5 ml, 5mg/5ml

Suhu Ruangan

NS,D5


Suhu Ruangan

NS

! ml4 0 ml

50 mg/ml, 50 mg/5 ml, 5mg/ml

% bulan

5 mg/ml

! jam

8 jam

(?4 (=4 ( bolu$4 ( ! minggu inu$ berlanjut !! jam ! jam -

( rip 10 menit

iminum $egera $egera $etelah prepara$i, $etelah %0 menit $etelah ilarut7an ma7an  jam NS, %% jam D5

! jam

8 jam

! jam

! jam

! jam -

em#itabine 18

em3ar em#i7al

1 g/.ial4 00 mg/.ial

Suhu Ruangan

NS

5 ml-5 ml

%8mg/ml

-

! jam

( rip %0 menit

NS

50-500 ml

15 mg

Suhu Ruangan

NS, D5

5 ml

% mg/ml

8 hari

! jam terlinung #ahaa

(?, SC, (", ( bolu$

NS, D5, D5NS

10 ml

500 mg

Suhu Ruangan

&'(

1*1 ml

500 m#g/ml

-

! jam

(?, ( bolu$, ( rip 10-15 menit

&'(, NS, D5&

50 ml

terlinung #ahaa

-

! jam

'on7ogem

>inari penimpanan i $uhu :-8: C 7arena apat meng7ri$tal

Antibi1tik

Bleom#in >Cl 19

Bleo#in

0 Da#tinom#in

1! hari 9 jam terlinung terlinung #ahaa #ahaa -

! jam


1 ?itom#in-C

Cael2

D5&

$uhu ruangan terlinung #ahaa

NS,&'(

 mg/! ml, 10 mg/0ml

0*5 mg/ml

1! hari

10 mg, 50 mg

:-8: C

$eiaan bentu7 larutan

5 ml, 5 ml

 mg/ml

! jam

( rip tanpa $aringan

-

(?,( bolu$, ( rip 15-%0 menit

Daunorubi#in >Cl %

NS, D5, D5NS

 mg, 10 mg

Do2orubi#in lipo$omal 

( pelan 6510 menit, rip 6%0-0 menit, (", intraperitonial , (ntra.e$i7al

0 mg

Suhu Ruangan

&'(, D5&, RL, NS

! ml

5 mg/ml

) hari

! jam

NS, D5&

500 ml, 0-!0 ml

1 jam / terlinung #ahaa, 1! hari NS, ! jam hinari /Na la7tat e7$tra.a$a$i

! jam 6no.ell, ! hari 6D(>

100 ml

Dauno#in

! jam

Do2orubi#in >CL ! Sinro2o#in

10 mg, 50 mg

:-8: C

bentu7 larutan

5 ml, 5 ml

 mg/ml

Kemoo2in pirubi#in 5

pi$inan

hinari penimpanan i ree3e, inu$ tia7 boleh i$aring

! jam

10 mg, 50 mg

:-8: C

$eiaan bentu7 larutan

5 ml, 5 ml

 mg/ml

-

!8 jam

! jam

-

! jam

! jam

-

!8 jam

! jam

!8 jam ( bolu$4 ( rip ( bolu$ %-10 menit an rip 15-0 menit

NS,D5&

NS, D5&

50-1000 ml

50-50 ml

) hari

!8 jam

! jam

-

! jam

! jam

! jam

!8 jam

! jam

Antib1di 1n1kl1nal

Be.a#i3umab 

".a$tin

Cetu2imab

100 mg

:-8: C

NS

! ml

5 mg/ml

! jam

$egera

( rip tia7 boleh bolu$

NS

100 ml

! jam

$egera

1 jam

8 jam

tia7 boleh i$impan alam ree3e, tia7 boleh i7o#o7, terlinung #ahaa

tia7 boleh

)

rbitu2

100 mg

:-8: C4 tia7 100 mg/50 terlinung ari memerlu7a ml #ahaa m pelarut

5 mg/ml

! jam

-

( rip

$e$ua tia7 perlu $eiaanna itambah7an alam pembaEa 7ema$an NS 7o$ong

! jam

-

i7o#o7, tia7 boleh ilarut7an, tia7 boleh i$impan alam ree3e terlinung matahari lang$ung, ilarang i7o#o7, tia7 boleh i$impan alam ree3e

Ritu2imab 8

9

?abthera

=ra$tu3umab >er#eptin

100 mg, 500 mg

:-8: C

$eiaan #air

100 mg/10 ml, 500 mg/50 ml

 mg/ml

! jam

1 jam

( rip

NS, D5

1-! mg/ml

! jam

1 jam

!!0 mg

:-8: C

&'( G antimi7roba

0 ml

10 mg/ml

8 hari

! jam

( rip

NS

50 ml

! jam

! jam

5 mg/10 ml

:-8: C

NS

10 ml

5 mg/ml

-


NS

50 ml

-

) jam

50 mg, 100mg/! ml

:-8: C

&'(

*% ml

5 mg/ml

! jam

 jam


NS, D5

50 ml

! jam

 jam

50 mg/.ial

:-8: C

&'(

10*5 ml

5 mg/ml

! jam

-

( rip

NS, D5, RL

100 ml

! jam

-

-

! jam

-

! jam

:-8: C

1%H ethanol/ &'(

10 mg/ml

!8 jam

 jam

! jam

 jam

! jam

! jam

-

! jam

-

8 jam

-

8 jam

Nimotu3umab %0

%1

=hera#im embroli3umab Ketrua Brentu2imab

%

"#etri$

tia7 boleh i7o#o7 an tia7 boleh i$impan alam ree3e

tia7 boleh i$impan alam ree3e, terlinung #ahaa

#r1d2k alaiah Antii4r1t2b2lar

Do#eta2el %%

=a2oter Bre2el =a#eeo a#lita2el

0 mg, 80 mg

 ml, 8 ml

( rip

NS, D5&

50-1000ml

terlinung #ahaa, 7on$entra$i inu$ 0*%-0*9 mg/ml, 7ema$an non C

a2u$ %! Sina2el 'on#opa#

%0 mg/5ml, 100 mg/1*) ml, %00 mg/50 ml

F 5:C

$eiaan #air

"n3ata2 %5

ribulin >ala.en

0*88 mg/ ml

F5:C

ml, 100 mg/1*) ml, 0 mg/!%*%% ml

 mg/ml

-

) jam

( rip 1-% jam

D5&, NS, D5NS, RL

-

!8 jam

$eiaan #air

! jam

) jam !8 jam

! jam

( rip

NS

100 ml

! jam

! jam

NS,D5

0-50 ml

-

8 jam

1 hari

1 hari

Alkal1id $inka

% in#ri$tine

1 mg/ml,  mg/ml

:-8: C

%) inbla$tine

10 mg

:-8: C

NS

10 mg/ml, 50 mg/5 ml

:-8: C

$eiaan larutan

1 mg/ml

$e$uai D

-

( rip 10-15 menit* ( inu$ berlanjut ! jam

10 ml

1 mg/ml

$e$uai D

8 hari

( bolu$4 rip 5-15 menit

NS,D5

50 ml

1 ml, 5 ml

10 mg/ml

! jam

( bolu$ -10 menit, rip

NS, D5

10-50 ml

$eiaan #air 1 ml, ml

inorelbine %8 Na.elbin inorel$in

! jam

-

Tidak b1leh diberikan IT

! jam

! jam

Deri5at #1d13h+ll1t16in

! jam

( bolu$ !50 menit4 ( inu$ berlanjut ! jam

% jam

(?4 (ntraermal4 ( rip %0-0 menit

topo$ie %9 o$

100 mg/5ml, 500 mg/5 ml

Suhu Ruangan

$eiaan larutan

5 ml, 5 ml

0 mg/ml

topul

D5, NS

7on$entra$i 0*-0*! mg/ml

-

0* mg/ml I 9 jam4 terlinung #ahaa 0*! mg/ml I ! jam

En7+

L-"$paragina$e !0

Leuna$e

Deri5at )a3h1the4in

10000 unit/.ial

:-8: C

NS,&'(

5 ml

000 unit/ml

) jam

D5, NS

50-50 ml

) jam

% jam

enggunaan ( menng7at7an re$i7o alregi, hinari bila memung7in7an

(ritote#an !1 Campto

!0 mg/ ml, 100 mg/5 ml

Suhu Ruangan Seiaan #air  ml, 5ml

0 mg/ml

"#tate#an

! jam

 jam

!8 jam

! jam

( bolu$, ( rip %0-90 menit

D5, NS

50-500 ml

! jam

 jam

!8 jam

! jam

Kon$entra$i a7hir 0*1-*8 mg/ml, terlinung #ahaa

Inhibit1r #r1teas1e

!

Borte3omib el#ae

%*5 mg/ml

Suhu Ruangan

NS

%*5 ml

1 mg/ml

8 jam

( bolu$ #epat %-5 eti7

-

-

-

8 jam

1%*5 ml

50 mg/ml

!8 jam

( rip 0-90 menit

D5

500 ml

! jam

) jam

1 bulan

! jam

tia7 boleh alam ree3er, tia7 boleh i7o#o7

5 hari

5 hari

7on$entra$i ma7$* 10 mg/ml


Inhibit1r T131is1erase

!%

"m$a#rine "m$iine

)5 mg/1*5 ml

Suhu Ruangan L-la#ti# a#i

I2n1re,2lat1r

(ntereron "la " !!

(ntron "

% juta,  juta, 9 juta unit

:-8: C

&'(, NS, D5

0*5 ml

1*5 juta unit/ml, % juta unit/ml, !*5 juta unit/ml

1 bulan

! jam

$ub#utan

500 mg/ml

Suhu Ruangan

&'(

10 ml

10 mg/ml

-

1 jam

( rip 1 jam

-

8 hari 6alam $puit

( rip #epat 15-%0 menit4 ( inu$ berlanjut ! jam

-

(?, ( 7e#epatan ma7$* 10 mg/menit

7on$entra$i &'(, NS, D5 ma7$* % juta unit/ml

Anti5iral

!5 an#i#lo.ir

D5, NS

50-1000ml

Antid1t2 ke1tera3i Ur13r1te4tant

?e$na !

+romite2an

100 mg/ 10 ml, Suhu Ruangan !00 mg/!ml

$eiaan larutan

10 ml, 50 ml

10 mg/ml

NS, D5, RL

50-1000 ml

-

?e$na G !8 jam (o$amie/$i7loo 6D5, RL, $ami alam ! jam RL/D5 $tabil ! 6NS jam

F1lini4 A4id

!) Leu#o.orin

50 mg/5ml, 100 mg/10 ml

:-8: C

$eiaan larutan

10 mg/ml

! jam

NS, D5

50-1000 ml

! jam

-

jangan i#ampur engan bahan o7$iator ataupun menganung logam

Ad82n4t )he13r1te4ti5e A,ent

!8

"mio$tine thol

500 mg

Suhu Ruangan

NS

10 ml

50 mg/ml

! jam

5 jam

( bolu$ 15 menit

NS

Reeren$i< 1* Bragalone, D*L*, 01* Drug >anboo7 or @n#olog, * 1! th, "meri#an harma#i$t "$$o#iation, Le2i#omp, &olter$ KluEer Clini#al Drug (normation, (n#* * LaEren#e, "*= et al, 009, >anboo7 an (nje#table Drug$,  15 h, "meri#an So#iet o >ealth S$tem harma#i$t, ?arlan, +*S* %* Bro$ur terlampir ma$ing-ma$ing obat

100 ml

! jam

5 jam

Data Stabilitas Kemo

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