Pathophysiology in Liver Cirrhosis

Liver insult  Alcoholic Ingestion, Viral hepatitis

Hepatocyte Increase

damage

pain

wbc fatigue

fever  liver  Inflammation

Nausea

anorexia

vomiting

Alterations in blood and lymph flow

Liver necrosis

LIVER FAILURE

ascite s

Delayed

Anemia

Liver fibrosis

Thrombocyt openia splenomegaly

LIVER FIBROSIS AND SCARRING

edema

Wound

bleeding

Superficial

Esophageal healing infection Abdominal

hemorrhoids

bleeding

Decrease ADH edema

Dec.androgen/ Estrogen p.

Loss of 

Palmar 

Spider 

Erythema

angiomas

Plasm a

Testicul ar 

Gyneco

CHON

atrophy

mastia

Menstru al change s

Dec.met.of CHON  And Carb./ Dec.Fat

Hypoglycemia

Edema

 Acites Vit.k absop.

Bleeding Clay colored stool

bile

tendencies

Bilirubin excretion Dark urine

In urine

 jaundice Bilirubin metabolism hyperbilirubinemi

Body hair 

Increase

 Alterations Foul breath

In

serum

sleep

ammonia

Inability to Metabolize Liver failure

ammonia

Hepatic encephalopath y

Confusion to Hepatic coma Respiratory  Asterexis

acidosis

DEATH