Patho Physiology of Kawasaki Disease

Pathophysiology (Theoretical Based)

Non-Modifiable Non-Modifiable Factors

Modifiable Factors

 Age: < 5 years old

 Environment: Exposure to virus or bacteria

 Race: Asian (mostly in Japan/Korean/Chinese) Gender : Boys > Girls (2:1) Genetics: ITPKC gene (inositol-trisphosphate 3-kinase C)

RACE

AGE

GENDER

ENVIRONMENTAL

GENETIC

Asian

< 5 years old

Male

Infection: bacterial/viral

ITPKC ITPKC

inositol 1,4,5trisphosphate 3kinase C

Idiopathic

Impaired Immune System function

Trusted by over 1 million members

Try Scribd FREE for 30 days to access over 125 million titles without ads or interruptions! Start Free Trial Cancel Anytime.

Trusted by over 1 million members

Try Scribd FREE for 30 days to access over 125 million titles without ads or interruptions! Start Free Trial Cancel Anytime.

Exposure to bacteria and/or virus

Detection of foreign Body

Activation of Cell Immune Response

T-cells in thymus gland go in the lymph nodes

Regulator T-cells in lymph nodes are stimulated

Effector T-cells in lymph nodes are stimulated

Cytotoxic T-cell production

Widespread proliferation & activation of platelets

B-cells activation

Spontaneous production of cytotoxic antibodies and immune complexes Lymph nodes

Eyes

Lymphadenitis

Bilateral conjunctivitis, with or without pus or drainage

Palpable lymph nodes on the cervical area

Redness of the eyes