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/5<;FK 6G< !), Medication
Dose
Indication
Aspirin
75-90 mg/kg/day
Control of pain, stiffness, and inflammation
Nonsteroidal antiinflammatory agent
Varies with drug
Control of pain, stiffness, and inflammation
Hydroxychloroquine
7 mg/kg/day
Selective use for arthritis
Gold salt
0.75 m /k month
D-Penicillamine
10 mg/kg/day
Sulfasalazine
40-60 mg/kg.day
Polyarthritis unresponsive to nonsteroidal anti-inflammatory agents Polyarthritis unresponsive to other regimens Polyarthritis unresponsive to other regimens
Corticosteroid drug Systemic Ophthalmic Intra-articular Immunosuppressive agent
Prednisone 1 mg/kg/day (aslow a dose as possible) 4 drops/day 30 mg prednisolone-TBA Varies with drug
Life-threatening systemic disease, chronic uveitis Chronic uveitis Selective use for arthritis Life-threatening systemic disease
Toxicity
Salicylism (lethargy, hyperpnea, tinnitus), gastrointestinal irritation, bleeding, hepatitis Gastrointestinal irritation, hepatitis, decreased renal function Dermatitis, keratopathy, retinopathy Dermatitis, nephritis, stomatitis, bone marrow suppression Dermatitis, nephritis, lupuslike syndrome Bone marrow suppression, dermatitis, gastrointestinal irritation Growth retardation, infection, Cushing's syndrome Cataracts, glaucoma Infection Infectio, bone marrow suppression, sterility, oncogenesis
28
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Rheumatoid arthritis
30
Rheumatoid arthritis
Therapy NSAID gold penicillamine methotrexate hydroxychloroquine Anti-TNF 31
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= "5 6$%F7 " "%O 5 " 6$%D" O 6$/ /""% 6$%D" 2$6"4" 6"53$% 4"% "%FF70" 2$#="/F"
36 36
37 37
38 38
39 39
