1. •
azithromycin
•
ondansetron
Serious - Use Alternative azithromycin + ondansetron
azithromycin and ondansetron both increase QTc interval. Possible serious or lifethreatening interaction. Monitor closely. Use alternatives if available. Avoid Avoid with congenital long QT syndrome !"# monitoring recommended with con comitant medications that $rolong QT interval% electrolyte abnormalities% "&'% or bradyarrhythmias. (. •
albuterol)i$ratro$ium * "ombivent +es$imat
•
$seudoe$hedrine)loratadine
Significant - Monitor Closely albuterol + pseudoephedrine
albuterol and $seudoe$hedrine both decrease sedation. Potential for interaction% monitor. albuterol + pseudoephedrine
albuterol and $seudoe$hedrine both increase sym$athetic ,adrenergic effects% including increased blood $ressure and heart rate. Potential for interaction% monitor. . •
•
ondansetron levoflo/acin
Serious - Use Alternative levofloxacin + ondansetron
levoflo/acin and ondansetron both increase QTc interval. Possible serious or lifethreatening interaction. Monitor closely. Use alternatives if available. Avoid with congenital long QT syndrome !"# monitoring recommended with con comitant medications that $rolong QT interval% electrolyte abnormalities% "&'% or bradyarrhythmias. 0. •
gliuidone
•
ca$to$ril
•
as$irin
Significant - Monitor Closely aspirin + gliquidone
as$irin increases effects of gliuidone by un2nown mechanism. 3ignificant interaction $ossible% monitor closely. +is2 of hy$oglycemia. captopril + gliquidone
ca$to$ril increases effects of gliuidone by $harmacodynamic synergism. 3ignificant interaction $ossible% monitor closely. captopril + aspirin
ca$to$ril% as$irin. !ither increases to/icity of the other by 4ther ,see comment. 3ignificant interaction $ossible% monitor closely. "omment5 May result in renal function deterioration% $articularly in elderly or volume de$leted individuals. aspirin + captopril
as$irin decreases effects of ca$to$ril by $harmacodynamic antagonism. Potential for dangerous interaction. Use with caution and monitor closely. 63A78s decrease synthesis of vasodilating renal $rostaglandins% and thus affect fluid homeostasis and may diminish antihy$ertensive effect. Minor aspirin + gliquidone
as$irin increases effects of gliuidone by $lasma $rotein binding com$etition. Minor or non-significant interaction. 9arge dose of salicylate.
:. •
•
levofoxacin methylprednisolone
Signicant - Monitor Closely •
methylprednisolone + levofoxacin
methyl$rednisolone and levoflo/acin both increase 4ther ,see comment. 3ignificant interaction $ossible% monitor closely. "oadministration of uinolone antibiotics and corticosteroids may increase ris2 of tendon ru$ture. ;. •
•
pseudoephedrine/loratadine methylprednisolone
Signicant - Monitor Closely •
methylprednisolone + loratadine
methyl$rednisolone will decrease the level or effect of loratadine by affecting he$atic)intestinal enzyme "
loratadine + methylprednisolone
loratadine will increase the level or effect of methyl$rednisolone by P-glyco$rotein ,M8+1 efflu/ trans$orter. 3ignificant interaction $ossible% monitor closely. =. •
pseudoephedrine/loratadine
•
codeine
•
methylprednisolone
•
cetirizine
•
levofoxacin
Signicant - Monitor Closely
•
methylprednisolone + loratadine
methyl$rednisolone will decrease the level or effect of loratadine by affecting he$atic)intestinal enzyme "
loratadine + methylprednisolone
loratadine will increase the level or effect of methyl$rednisolone by P-glyco$rotein ,M8+1 efflu/ trans$orter. 3ignificant interaction $ossible% monitor closely. •
methylprednisolone + levofoxacin
methyl$rednisolone and levoflo/acin both increase 4ther ,see comment. 3ignificant interaction $ossible% monitor closely. "oadministration of uinolone antibiotics and corticosteroids may increase ris2 of tendon ru$ture. •
codeine + pseudoephedrine
codeine increases and $seudoe$hedrine decreases sedation. !ffect of interaction is not clear% use caution. Potential for interaction% monitor.