CNS Pharmacology General anesthetics 1. The state state of “general anesthesia” usually includes: includes: a) Analgesi Analgesia a b) Loss of consciousness, consciousness, inhibition of sensory and autonomic autonomic reflexes c) Amne Amnesi sia a d) All of the the above above 2. Inhaled anesthetics anesthetics and and intravenous agents having general anesthetic anesthetic properties: properties: a) Directly activate GABA GABA receptors receptors b) Facilitate GABA action action but have no direct action on GABAA GABAA receptors c) Reduce the excitatory excitatory glutamatergic glutamatergic neurotransmission neurotransmission d) Increase the duration of opening of nicotine-activated nicotine-activated potassium potassium channels 3. The anesthetic anesthetic agent agent , which is an inhibitor of NMDA glutamate glutamate receptors receptors is : a) Thiopenta Thiopentall b) Halothane Halothane c) Ketami Ketamine ne d) Sevoflur Sevoflurane ane 4. An ideal ideal anesth anesthetic etic drug would: would: a) Induces anesthesia anesthesia smoothly and rapidly and secure rapid recovery recovery b) Posses a wide wide margin of safety safety c) Has a minimal minimal adverse adverse effects d) All of the the above above 5. Which of the following following general general anesthetics anesthetics belongs belongs to inhalants? a) Thiopenta Thiopentall b) Desflura Desfluran n c) Ketami Ketamine ne d) Propofol Propofol 6. The anesthe anesthetic, tic, which which is used used intravenou intravenously sly is : a) Propo Propofol fol b) Halothane Halothane c) Desflu Desflura rane ne d) Nitrous Nitrous oxide oxide 7. Sevoflurane has largely largely replaced replaced halothane halothane and isoflurane isoflurane as an inhalation anesthetic of choice because: a) Induction of anesthesia anesthesia is achieved more more rapidly and smoothly b) Recovery is more rapid rapid c) It has low low post- anesthetic anesthetic organ organ toxicity d) All of the the above above 8. The limit limitation ation of sevoflu sevoflurane rane is: is: a) High incidence incidence of coughing and laryngospasm laryngospasm b) Chemically unstable c) Centrally mediated sympathetic sympathetic activation leading leading to a rise of BP and HR d) Hepatoto Hepatotoxicit xicity y
CNS Pharmacology General anesthetics 9. Which of these anesthetics lacks sufficient potency to produce surgical anesthesia by itself and is commonly used with another anesthetic? a) Haloth Halothane ane b) Sevoflur Sevoflurane ane c) Nitrous Nitrous oxide d) Desflura Desflurane ne
10. The inhale inhaled d anesthet anesthetic, ic, which which reduce reduces s arterial arterial press pressure ure and heart heart rate rate is : a) Isoflura Isoflurane ne b) Halothane Halothane c) Desflu Desflura rane ne d) Nitrous Nitrous oxide oxide 11. Which of the following causes centrally mediated sympathetic activation leading to a rise in BP & HR? a) Desflura Desflurane ne b) Sevoflurane c) Nitrous Nitrous oxide d) Isofuran Isofurane e 12. The inhaled anesthetic, which decreases the ventilatory response to hypoxia is : a) Sevoflur Sevoflurane ane b) Nitrous Nitrous oxide oxide c) Desflu Desflura rane ne d) Halothane Halothane
13. Which Which of the follow following ing inhaled inhaled anestheti anesthetics cs is an an induction induction agent agent of choic choice e in patient with airway problems? a) Desflura Desflurane ne b) Nitrous Nitrous oxide oxide c) Haloth Halothane ane d) Isoflura Isoflurane ne anesthetic, which causes causes the airway airway irritation is : 14.The inhaled anesthetic, a) Nitrous Nitrous oxide oxide b) Sevoflur Sevoflurane ane c) Haloth Halothane ane d) Desflura Desflurane ne 15. Which Which of the followin following g inhaled inhaled anesthe anesthetics tics increa increases ses cerebr cerebral al blood blood flow least least of all? a) Sevoflur Sevoflurane ane b) Nitrous Nitrous oxide oxide c) Isofl Isoflura urane ne d) Desflura Desflurane ne anesthetic, which should be avoided avoided in patients with a history of 16.The inhaled anesthetic, seizure disorders is : a) Enflu nflura rane ne b) Nitr Nitrou ous s oxid oxide e c) Sevof evoflu lura rane ne
CNS Pharmacology General anesthetics d) Desf Desflu lura rane ne
17. Which Which of the followin following g inhaled inhaled anesthe anesthetics tics can can produce produce hepati hepatic c necrosis necrosis? ? a) Soveflur Soveflurane ane b) Desflura Desflurane ne c) Haloth Halothane ane d) Nitrous Nitrous oxide oxide 18. Which of the following anesthetics decreases metheonine synthase activity and causes megaloblastic anemia? a) Desflura Desflurane ne b) Halothane Halothane c) Nitrous Nitrous oxide d) Soveflur Soveflurane ane 19.Unlike inhaled anesthetics, intravenous agents such as thiopental, etomidate, and propofol: a) Have a faster onset onset and rate of recovery recovery b) Provide a state state of conscious conscious sedation c) Are commonly used used for induction induction of anesthesia anesthesia d) All of the the above above
anesthetic, which is an ultra-short-acting ultra-short-acting barbiturate is : 20.The intravenous anesthetic, a) Fenta Fentanyl nyl b) Thiopenta Thiopentall c) Midazo Midazolam lam d) Ketamine Ketamine 21. Which of the following agents is used to accelerate recovery from the sedative actions of intravenous BDZ? a) Nalox Naloxon one e b) Flumazen Flumazenil il c) Ketami Ketamine ne d) Fomepizo Fomepizole le
22. Which Which of the follow following ing intrave intravenous nous anest anestheti hetics cs has has antiemetic antiemetic actions? actions? a) Thiopenta Thiopentall b) Propofol Propofol c) Ketami Ketamine ne d) Fentanyl Fentanyl anesthetic, which causes causes minimal cardiovascular cardiovascular and respiratory 23.The intravenous anesthetic, depressant effects is: a) Propo Propofol fol b) Thiopenta Thiopentall c) Etomi Etomidat date e d) Midazola Midazolam m 24. The intravenous anesthetic, which produces dissociative anesthesia is : a) Midazola Midazolam m b) Ketamine Ketamine
CNS Pharmacology General anesthetics c) Fenta Fentanyl nyl d) Thiopenta Thiopentall
25. 25. Ketam Ketamine ine anes anesthe thesia sia is is assoc associat iated ed with with:: a) Cardiovascular Cardiovascular stimulation b) Increased cerebral blood flow, oxygen consumption and intracranial intracranial pressure c) Disorientation, Disorientation, sensory and perceptual illusions, illusions, and vivid dreams following anesthesia anesthesia d) All of the the above above
Inhalation Anesthetics : ♣ ♣ ♣ ♣ ♣ ♣
EEG changes ( Epilepsy - like seizures ) Enflurane . Reflex tachycardia Isoflurane & Desflurane ( I.D. I.D.)) . Myocardial suppression Halothane & Enflurane ( he he)) . Airway irritation Enflurane , Isoflurane & Desflurane ( eid or die ) . Hepatotoxicity Halothane ( in adults ONLY ) Sensitizes the Heart to catecholamine Halothane .
Answe rs: 1.d 2.a 3.c 4.d 5.b 6.a 7.d 8.b 9.c 10.b 11.a 12.b
13.c 14.d 15.b 16.a 17.c 18.c 19.d 20.b 21.b 22.b 23.c 24.b 25.d
