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%$ EDAD GERIÁTRICA Deterioro de la función hepática y renal. Incremento del pH del jugo gástrico. Disminución de la motilidad intestinal y atrofia de la mucosa. Menor proporción de albúmina plasmática y otras proteínas transportadoras. Aumento del tejido adiposo y disminución de la masa muscular y el agua total.
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ESTADO DE SALUD Insuficiencia hepática (por reducción de la capacidad metabolizante general) Insuficiencia renal
+ Insuficiencia hepática Aumentan la vida media del tóxico al prolongar el tiempo de permanencia en el organismo
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