Sintesa Aspirin dengan Reaksi Esterifikasi FenolDeskripsi lengkap
Sintesa Aspirin dengan Reaksi Esterifikasi FenolFull description
Deskripsi lengkap
qweryu,ljFull description
sintesis aspirinFull description
Deskripsi lengkap
Full description
About aspirinDeskripsi lengkap
ASPIRIN CAPSULES •
Capsules – Capsules – solid dosage dosage forms n which medicinal agents and/or inert substances are enclosed within a small shell of gelatin - Made up of gelatin but may also be made from starch or other suitable substances TYPES: 1. Hard shell/ gelatin or dry!illed "apsules – "apsules – made up up of gelatin, gelatin, sugar sugar and water o Clear, colorless and essentially tasteless o Colored with various FDC and DC dyes and made opa!ue by adding agents such as titanium dio"ide to conceal solid contents o Consists of two pieces, a body and a cap o #and$filled with powder contents by punch method or filling machines %. So!t #elatin Capsules – Capsules – made up of gelatin but more pliable due to the presence of glycerine or a polyhydric alcohol such as sorbitol, each of which act as a plastici&er o 'sually filled with li!uid or a solid active ingredient suspended in a li!uid vehicle approved for oral use such as vegetable oil or a non$ a!ueous, water miscible glycol such as polyethylene glycol ()) or polyethylene glycol o *!uipment re!uired in preparing soft gelatin is not usually available in pharmacies, so this dosage form is not prepared e"temporaneously - +reservatives methyl propylparabens, sorbic acid- – to retard microbial growth - Cotton – used to absorb mi"ture preferred when administered administered orally by - re preferred adults 1. Conv Conven enie ient ntly ly carri carried ed %. 0ead 0eadily ily iden identi tifi fied ed . *asily sily ta2 ta2en - 3ariety of dosage strengths, providing 1. Fle"ib Fle"ibili ility ty to the pres prescri cribe ber r %. ccurate ccurate individu individuali&e ali&ed d dosage dosage for the patient $isad%antages: 1. 4wallowi 4wallowing ng for children children and elderly elderly %. Formu Formulat lation ion diff difficu iculti lties es
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. 4ome have poor poor oral oral bioava bioavailab ilability ility// poor poor water solubility (. 4ome have irritant irritant effe effect ct on the git git when when ta2en orally #elatin $ obtained by partial hydrolysis of collagen from the s2in, white connective tissue, and bones of animals Properties: - 4table in air - 4ub5ect to microbial decomposition - 6nsoluble in cold water, softens through absorption of up to 1) times its weight of water - 4oluble in hot water digested by proteolylic proteolylic en&yme - protein, digested and absorbed #67# #'M6D689 dditional moisture in absorbed absorbed - dditional - :ecomes distorted and lose their rigid shape - 0*M*D9 use desiccant material silica gel, clay or activated charcoal *;80*M* D09<*44 - Moisture is lost - :ecomes brittle and crumbled when handled *;M+=* >F F6== 6< #0D 7*=86< C+4'=*4 - +owder or granules - +ellet mi"ture - +aste - Capsule - 8ablet 4oft gelatin capsules o Characteristics Contains more moisture >blong, oral or mound *legant 4ingle color or two toned ?ith identifying mar2ings *asily swallowed o 'ses to encapsulate and hermetically seal =i!uids 4uspensions Dry powder +reformed tablets +asty materials o Drugs prepared Digo"in@ 3itamin ,* Capsule 4i&e )))
