LAPORAN PERCOBAAN I PEMERIKSAAN BAHAN BAKU VITAMIN C
NAMA
: Zafira Zahrah
NPM
: 260110150022 260110150022
HARI HARI/T /TA ANGGA NGGAL L PRA PRAKT KTIK IKUM UM
: Kamis Kamis,, 15 Se! Se!em em"e "err 2016 2016
ASIST#N LA LA$%RAT%RIUM IUM
:1& :1& Mi Mi'hae( ae( )*a )*a*a *ase se +!ra 2& )ei S+r-a.i & e.a-a e.a-a Raha-+ Raha-+ A
LA$%RAT%RIUM LA$%RAT%RIUM ANALISIS ANALIS IS ARMASI AKULTAS ARMASI UNI#RSITAS PA)3A)3ARAN 3ATINANG%R 2016
I&
T+*+a. I&1& Me.e.!+4a. 4aar i!ami. asam as47r"a!8 e.9a. me.99+.a4a. me!7e !i!rasi i7ime!ri& I&2& Memahami 47.se asar rea4si re+4si a. 74siasi& I&& Me.9e!ah+i m+!+ "aha. "a4+ same( i!ami. -a.9 i9+.a4a.&
II& Pri.si II&1&
A.a(isis K+a.!i!a!if A.a(isis 4+a.!i!a!if "er4ai!a. e.9a. e.e!aa. "er+a "a.-a4 s+a!+ a! !er!e.!+ -a.9 !er4a.+.9 a(am s+a!+ same(& Za! -a.9 i!e!a4a. !erse"+!, -a.9 seri.94a(i i.-a!a4a. se"a9ai 47.s!i!+e. a!a+ a.a(i!, me.-+s+. e.!ah se"a9ia. 4e'i( a!a+ se"a9ai "esar same( -a.9
ia.a(isis )a- a. U.er;77, 20028& II&2& Rea4si Re+4si a. %4siasi Rea4si i.i aa! meme.9ar+hi se.-a;a
Ti!rasi I7ime!ri Ti!rasi i7ime!ri aa(ah a.a(isa !i!rime!ri +.!+4 a!<a! re+4!7r seer!i .a!ri+m !i7s+(fa!, arse.a! e.9a. me.99+.a4a. (ar+!a. i7i.e
"a4+ se'ara (a.9s+.9 Riai, 1==58& II&>& Asam As47r"a! Asam as47r"a! i!ami. 8 mer+a4a. a.!i74sia. -a.9 aa! me.'e9ah 74siasi& i!ami. mer+a4a. sa!+
III& Rea4si III&1&
i!ami. e.9a. I7i+m
Ke+s'h, 200?8& III&2& I7i+m I28 e.9a. ami(+m I2 @ ami(+m 47m(e4s I7
8& III&& I7i+m I28 e.9a. .a!ri+m !i7s+(fa! I2 @ 2Na2S2% Na2S>%6 @ 2NaI G7+'h, 1=8& I& Te7ri )asar i!ami. a!a+ L
*+9a !er74siasi !er+!ama "i(a !er(ar+! a(am s+a!+ e(ar+! misa(.-a air& Se"a9ai sa(ah sa!+ '7.!7h 4i!a aa! me.e.!+4a. 4aar i!ami. e.9a. 'ara me!7e !i!rasi& i!ami. mer+a4a. i!ami. -a.9 a(i.9 m+ah r+sa4, sehi.99a har+s i!a.9a.i e.9a. "ai4& i!ami. aa "+ah isi.!esa ari 9(+47sa, ima.a i!ami. a4a. me.9a(ami e.+r+.a. se(ama e.-ima.a.& Sa(ah sa!+ e.-e"a" e.+r+.a. 4a.+.9a. i!ami. ise"a"4a. aa.-a a4!ii!as e.im asam as47r"a! 74siase Sari 44, 20128& )asar ari me!7e i7ime!ri aa(ah "ersifa! mere+4si i!ami. & i!ami. asam as47r"a!8 mer+a4a. a! ere+4si -a.9 4+a! a. se'ara seerha.a aa! i!i!rasi e.9a. (ar+!a. "a4+ i7i+m& Pe.e!aa. 4aar i!ami. e.9a. me!7e i7ime!ri i.i mer+a4a. rea4si re+4si<74siasi re74s8& )a(am ha( i.i i!ami. "er!i.a4 se"a9ai a! ere+4si re+4!7r8 a. I 2 se"a9ai a! e.974siasi 74sia!7r8& )a(am rea4si i.i !er*ai !ra.sfer e(e4!r7. ari asa.9a. ere+4si 4e asa.9a. e.974siasi& Asam as47r"a! i 74siasi me.*ai asam ehir7as47r"a!, sea.94a. i7i+m ire+4si me.*ai i7ie Rahma;a!i, 44, 20168& 3i4a a(am (ar+!a. asam -a.9 me.9a.+.9 i!ami. a. 4ar"7hira! a!i se"a9ai i.i4a!7r8 i!am"ah4a. e.9a. i7i+m, i!ami. a4a. !er74siasi, a. i7i.e a4a. !ere+4si, sea.94a. (ar+!a. "er+"ah me.*ai +.9+& Per+"aha. ;ar.a i.i me.*ai asar ari rea4si !i!rasi, a. +.9+ me.+.*+44a. a4hir ari r7ses rea4si !i!rasi S7;a a. K7.7, 2008& Ti!rasi re74s aa(ah !i!rasi -a.9 me(i"a!4a. r7ses 74siasi a. re+4si& Ke+a r7ses i.i se(a(+ !er*ai se'ara "ersamaa.& )a(am !i!rasi re74s "iasa.-a me.99+.a4a. 7!e.si7me!ri +.!+4 me.e!e4si !i!i4 a4hir& U.!+4 me.9e!ah+i 4aar i!ami. me!7e !i!rasi re74s -a.9 i9+.a4a. aa(ah !i!rasi (a.9s+.9 -a.9 me.99+.a4a. i7i+m& I7i+m a4a. me.974siasi se.-a;a
Ti!rasi i77me!ri a. i7ime!ri aa(ah sa(ah sa!+ me!7e !i!rasi -a.9 iasar4a. aa rea4si 74siasi re+4si& Me!7e i.i (e"ih "a.-a4 i9+.a4a. a(am a.a(isa *i4a i"a.i.94a. e.9a. me!7e (ai.& A(asa. ii(ih.-a me!7e i.i 4are.a er"a.i.9a. s!74i7me!ri -a.9 seerha.a e(a4sa.aa..-a, ra4!is a. !ia4 "a.-a4 masa(ah a. m+ah& I7ime!ri aa(ah *i4a !i!rasi !erhaa a!<a! re+4!7r e.9a. !i!rasi (a.9s+.9 a. !ia4 (a.9s+.9& )i(a4+4a. er'7"aa. i.i +.!+4 me.e.!+4a. 4aar<4aar a! 74sia!7r se'ara (a.9s+.9, seer!i 4aar -a.9 !eraa! aa ser"+4 i!ami. & )a(am "ia.9 farmasi me!7e i.i i9+.a4a. +.!+4 me.e.!+4a. 4aar a!<a! -a.9 me.9a.+.9 74sia!7r, misa(.-a ( 2 , eIII8, +II8 a. se"a9ai.-a& Sehi.99a me.9e!ah+i 4aar s+a!+ a! "erar!i me.9e!ah+i m+!+ a. 4+a(i!as.-aS+a!+ a! e.9a. 7!e.sia( re+4si -a.9 (e"ih !i.99i a4a. me.974siasi a! -a.9 7!e.sia( re+4si.-a (e"ih re.ah& Per"eaa. 7!e.sia( a.!ara +a a! mer+a4a. 7!e.sia( rea4si a. (e"ih 4+ra.9 mer+a4a. er"eaa. 7!e.sia( -a.9 a4a. i+4+r *i4a a! !erse"+! !eriri a!as +a se!e.9ah ari s+a!+ se( (is!ri4 )ai, 20108& & A(a! a. $aha. &1& A(a!: 1& $a!a.9 e.9a+4 2& $7!7( '74(a! & $+re! >& 7r7.9 5& Ge(as 4imia 6& Ge(as +4+r ?& Ka'a ar(7*i & Ker!as er4ame. =& K(em 10& La"+ #r(e.me-er 11& La"+ +4+r 12& Nera'a a.a(i!i4 1& Pe.a.9as air 1>& Pie! !e!es 15& Pie! 7(+me 16& Sa!e( 1?& S!a!if &2& $aha.: 1& Ami(+m 0,5C
2& & >& 5& 6& ?&
AD+aes Asam as47r"a! i!ami. 8 Ka(i+m i4r7ma! 0,1 N Ka(i+m I7ia 1C Lar+!a. I7i+m 0,005 N Na!ri+m !i7s+(fa! 0,1 N
I& )a!a Pe.9ama!a. I&1& Pemeri4saa. M+!+ $aha. $a4+ N7& 1&
Pr7se+r
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7!7
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)i!am"ah4a.
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aa s+h+ >0 &
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150 m( aD+aes < Lar+!a. i7i.e a. KI < )i!im"a.9 1, 9ram i7i.e a. !er'am+r h7m79e., a. me.am"ah4a. 4e (ar+!a. KI "er;ar.a 4e'74(a!a. sei4i! emi sei4i! hi.99a h7m79e.& < Lar+!a. "eraa a(am (a"+ < )ie.'er4a..-a samai 1000 +4+r mL a(am (a"+ +4+r < )ii.ah4a. (ar+!a. 4e a(am < Lar+!a. i7i+m "eraa "7!7( '74(a! e.9a. "a.!+a. 2&
a(am "7!7( '74(a!
'7r7.9 Pem"+a!a. i.i4a!7r ami(+m 0,5C < )i!im"a.9 ami(+m se"a.-a4 < Ter"e.!+4 (ar+!a. ami(+m 0,25 9ram a. i(ar+!4a. a(am 50 m( aD+aes a.as, (ar+!a.
&
ia+4
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m(
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a.as < Lar+!a. !er'am+r h7m79e.
h7m79e., 4em+ia. isari.9& Pem"+a!a. (ar+!a. .a!ri+m !i7s+(fa! 0,1 N < )i!im"a.9
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9ram
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>
hi.99a h7m79e.& Pem"+a!a. Lar+!a.
Ka(i+m
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se"a.-a4
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9ram a. i(ar+!4a. a(am aD+aes
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4a(i+m
i4r7ma! a(am 100 m( aD+aes
e.9a.
me.99+.a4a. (a"+ +4+r 100 mL hi.99a !a.a "a!as < La(+ i47'74 hi.99a h7m79e.&
I&&
Ti!rasi Pem"a4+a.
N7& 1&
< Lar+!a. !er'am+r h7m79e.
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i (a"+ #r(e.me-er < < Lar+!a.
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.a!ri+m !i7s+(fa! hi.99a "er+"ah ;ar.a me.*ai '74(a!& < )i!am"ah4a.
< Lar+!a.
me.*ai
"er;ar.a "ir+, se!e(ah i !i!rasi ;ar.a "ir+
me.*ai hi(a.9& < 1 B 10,5 mL ami(+m 2 B 10, mL
se"a.-a4 2 m( 4em+ia.
ra!a mL
i !i!rasi 4em"a(i hi.99a ;ar.a "ir+ me.9hi(a.9 < )i'a!a! 7(+me .a!ri+m 2&
!i7s+(fa! -a.9 !era4ai& Pem"a4+a. (ar+!a. I7i+m < )iie!
10
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i7i+m 4e a(am (a"+
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B
!i7s+(fa! -a.9 !era4ai& 12,5 + 10,4 + 11,2 3
B 11,66 mL
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Ti!rasi e.e.!+a. 4aar i!ami.
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m9
i!ami.
asam as47r"a!8 (ar+! a(am 100 m( aD+aes "e"as %2
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i!i!rasi
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II& Perhi!+.9a. II&1& Ti!rasi Pem"a4+a. Na!ri+m Ti7s+(fa! 1 B 10,5 m( Na m( Ka(i+m i4r7ma! B 10 m( N Ka(i+m i4r7ma! B 0,1 N • N7rma(i!as Na!ri+m Ti7s+(fa!
1 F N1 B 2 F N2 Na m( F N1 B 10 m( F 0,1 N 1
N1 B
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II&2&
•
Ti!rasi Pem"a4+a. I7i+m 1 B 12,5 m( 2 B 10,> m( Na
N1 B
10
B 0,11 N
II&&
•
Ti!rasi Pe.e.!+a. Kaar i!ami. 1 B ?,> m( 2 B ?,> m( I7i+m ra!a5,6= m9
•
C Kaar B
massahitung massatimbang F 100C 145,69 mg
B
401,4 mg
B 6,2=C
III& Pem"ahasa.
F 100C
Pra4!i4+m 4a(i i.i -ai!+ emeri4saa. m+!+ ari "aha. "a4+ i!ami. asam as47r"a!8& Pemeri4saa. m+!+ har+s i(a4+4a. a9ar 4i!a me.9e!ah+i 4+a(i!as ari "aha.<"aha. -a.9 i.9i. 4i!a a4a. i9+.a4a.& )a. ari emeri4saa. m+!+ 4i!a aa! me(iha! se"eraa "a9+s 4+a(i!as ari s+a!+ "aha. e.9a. mem"a.i.94a. sifa! as(i ari "aha./a! !erse"+! "erasar4a. arma47e I.7.esia& )a(am emeri4saa. m+!+ aa "e"eraa ha( -a.9 har+s i(a4+4a.& Per!ama i(a4+4a. iie.!ifi4asi se'ara 7r9a.7(e!is, (a(+ iie.!ifi4asi "erasar4a. rea4si 4imia, a. e.e.!+a. 4aar e.9a. !i!rasi& Paa emeri4saa. m+!+ "aha. "a4+ i!ami. i.i er!ama !e!es me!i(e. "(+e a. ia.as4a. aa s+h+ >0 &
Ke!i4a i!am"ah4a. me!i(e. "(+e (ar+!a. as47r"a! me.*ai "er;ar.a "ir+& Kem+ia. (ar+!a. 'am+ra. !erse"+! ia.as4a. i a!as e.a.9as air aa s+h+ >0 & Se!e(ah 5 me.i! (ar+!a. "er+"ah ;ar.a me.*ai "er;ar.a "e.i.9
4em"a(i& Ha( !erse"+! aa! !er*ai i4are.a4a. asam as47r"a! "erea4si e.9a. me!i(e. "(+e& Asam as47r"a! !ere+4si 7(eh me!i(e. "(+e, a. "er+"ah me.*ai se.-a;a (e+'7 (e+'7
ari asam as47r"a! aa "a.-a4, sa(ah sa!+.-a aa(ah e.9a. 'ara !i!rasi i7ime!ri& Ti!rasi i7ime!ri mer+a4a. 'ara -a.9 a(i.9 seerha.a a. !er*a.94a+& Paa !i!rasi i7ime!ri ri.si.-a aa(ah !i!rasi (a.9s+.9, e.9a. asam as47r"a! se"a9ai a.a(i! a. (ar+!a. i7i+m se"a9ai e.!i!er& )ise"+! !i!rasi
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Kesim+(a. IJ&1& Kaar i!ami. ihi!+.9 e.9a. !i!rasi i7ime!ri aa(ah 6,2=C IJ&2& )aa! memahami 47.se asar rea4si re+4si a. 74siasi IJ&& )aa! me.9e!ah+i m+!+ "aha. "a4+ same( i!ami. -a.9 i9+.a4a.&
)ATAR PUSTAKA $asse!, 3& 1==>& Buku Ajar Vogel: Kimia Analisis Kuantitatif Anorganik & 3a4ar!a: Pe.er"i! #r(a.99a& )ai& 2010& Analisis farmasi& 3a4ar!a: Pe.er"i! $+4+ Ke74!era. #G& )a-, R&A a. L, U.er;77& 2002& Analisis Kimia Kuantitat if& 3a4ar!a: #r(a.99a& Ga.*ar, I".+& 200?& Kimia Farmasi Analisis& 79-a4ar!a: P+s!a4a Pe(a*ar& G7+'h, A& 1=& Estimation of Manganese Oxides and Potassium Bichromate& UK: R7-a( S7'ie!- 7f hemis!r-& I+a9ie, A&A a. I+a9ie, &%& 200?& I7ime!ri' )e!ermi.a!i7. 7f As'7r"i' A'i i!ami. 8 i. i!r+s r+i!s& Research ournal Agriculture and Biological !ciences& Ni9eria: Ae-emi 7((e9e 7f #+'a!i7.& Kari.a, M7.a(isa, a!ima;a(i a. Ga-a!ri i!ra.i.9!-as& 201& Per"a.i.9a. Hasi( Pe.e!aa. Kaar i!ami. Ma.99a )77( e.9a. me.99+.a4a. Me!7e Se4!r7f7!7me!ri U<is a. I77me!ri& urnal "lmiah Farmasi 7(& 2 N7& 01& Ke+s'h, G&T& 200?& #lo$al %ealth: &essons from Ba'h (ole in "ntelectual Pro)ert' Management in %ealth and Agricultural "nno*ation& UK: %Ff7r& Rahma;a!i, a. Ha.a, h7iri(& 2016& Pe.e!aa. Kaar i!ami. Paa $a;a.9 P+!ih A((i+m sa!i+m, L8 )e.9a. Me!7e I7ime!ri& +ERA,A urnal "lmu Farmasi -ournal of Pharmac' !cience./ 7( >& N7 1& Rie.7iar, a. Nahria.!7, H+sai.& 2010& Pe.99+.aa. Asam As47r"a! i!ami. 8 U.!+4 Me.i.94a!4a. )a-a Sima. Sir+ R7se(a Hi"is'+s sa"ariffa Li..&8& urnal %asil Penelitian "ndustri& 7( 2& N7 1& <1& Riai, H& 1==5& Asas Pemeri4saa. Kimia& 3a4ar!a: UI Press& Sari, #(74, S+.ari, Ari a. Arif H+!ama& 2012& Pr7ses Pe.9a;e!a. Sari $+ah Ae( Ma((+ss-(es!ris mi((&8 se'ara N7. Terma( $er"asis Te4.7(79i %s'i((a!i.9 Ma9.e!i.9 ie( %M8& urnal ,eknologi Pertanian 7(& 1 N7& 2&
S7;a, S a. A& #, K7.7& 200& Sai(i.9 %. The : A i!ami. Ti!ra!i7. Ei!h A T;is!/ ournal +hemical Education& 7( 0& N7 5& 550<551 S+mar*7, )ami.& 2006& Pengantar Kimia& 3a4ar!a: Pe.er"i! $+4+ Ke74!era. #G&
