MAKALAH ANTI FUNGI DITUJUKAN UNTUK MEMENUHI TUGAS FARMAKOLOGI KEMOTERAPETIKA
ZAHRA MILLATINA YUNIKA 260110120048
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I. DEFINISI Anti !n"i #$%!&'('n )*'t +'n" ,i"!n'('n !nt!( #$n"'t'-i in$(-i +'n" ,i-$*'*('n )$/ '#!% -$*'"'i '"$nn+'. In$(-i +'n" ,i-$*'*('n )$/ '#!% ini ,'&'t *$%-i't )(' #'!&!n -i-t$#i(. $%,'-'%('n '%in"'n ,i #'n' '"$n &$n"in$(-i '#!%3 t$%())ni-'-i in$(-i '#!% ,i*$,'('n #$n',i5
In$(-i -!&$%i7i'
A,''/ in$(-i '#!% +'n" /'n+' #$n"in'-i '%in"'n -!&$%i-i'i- +'n" t$%($%'tini-'-i -$&$%ti %'#*!t (!it ,'n (!(!. 9)nt)/ 5 in$(-i Tin$' 7'&iti- -$%t' M''--$:i' !%!% P!%*' 20123.
In$(-i -i-t$#i( in'-i3
A,''/ in$(-i '#!% +'n" #$n"in'-i )%"'n;)%"'n ,''# )(!- !t'##'n+' !#!#n+' ',''/ &'%!;&'%! ,'n #$n+$*'% ($ '%in"'n 'in *'/('n -'#&'i ($ -$'&!t )t'(. 9)nt)/ 5 in$(-i 9%+&t)7)77!- n$))%#'n- ,'n Hi-t)&'-#' 7'&-!'t!# P!%*' 20123.
S$,'n"('n *i' ,i,'-'%('n &',' $ti))"in+' in$(-i '#!% ,i*$,'('n #$n',i5
A-&$%"i)-i- 5 ,i-$*'*('n )$/ A-&$%"i!- -&. U#!#n+' #$%!&'('n
in$(-i -i-t$#i( +'n" t$%',i ,i &'%!;&'%!.
'-t)#i()-i- 5 ,i-$*'*('n )$/ '-t)#+7$- -&. In$(-in+' t$%',i
&$%t'#' ,i )'%!;&'%! '! #$n+$*'% ($ (!it.
9'n,i,i'-i- 5 ,i-$*'*('n )$/ '#!% -&$-i$- 9'n,i,'. In$(-in+' t$%',i ,i
&'%!;&'%! #!!t -$%t' '"in'.
9)77i,i),)#i()-i- 5 ,i-$*'*('n )$/ 9)77i,i)+,$- -&. In$(-in+' &$%t'#'
t$%',i ,i &'%! "$''n+' -$&$%ti ! n'#!n ($#!,i'n #$n+$*'% ($ -$!%!/ t!*!/.
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9%+&t)7)7)-i- 5 ,i-$*'*('n )$/ 9%+&t)7)77!- -&. In$(-in+' t$%',i ,i
-$'&!t )t'( (!it ,'n &'%!;&'%!.
Hi-t)&'-#)-i- 5 ,i-$*'*('n )$/ -&$-i$- Hi-t)&'-#'. In$(-in+' *$%!&'
&n$!#)ni' &',' &'%!;&'%!.
M!7)%#i()-i-
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5
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In$(-in+' &',' &'%!;&'%! -$%t' ,'%'/.
P'%'7)77i,i),)#i()-i- 5 ,i-$*'*('n )$/ -&$-i$- P'%'7)77i,i)i,$-.
In$(-in+' t$%',i &',' n),!- i#$.
S&)%)t%i7/)-i- 5 ,i-$*'*('n )$/ -&$-i$- S&)%)t/%i< . In$(-in+' t$%',i
&',' &$#*!!/ i#$ ,'n (!it.
Tin$'-i- 5 ,i-$*'*('n )$/ -&$-i$- Tin$'. U#!#n+' *$%!&' in$(-i (!it
)('.
II. PATOFISIOLOGI In$(-i '#!% ,i'='i ,$n"'n #'-!(n+' -&)%' '#!% ($ ,''# t!*!/ 't'! #$$('tn+' -&)%' t$%-$*!t &',' (!it. In$(-i -i-t$#i( !#!#n+' ,i'='i ,$n"'n t$%/i%!&n+' -&)%' ($ ,''# &'%!;&'%! 't'! &',' 7'n,i,i'-i- !)'"in' in$(-i ,'&'t t$%',i ('%$n' -&)%' #'-!( #$'!i !*'n" '"in' ('%$n' (!%'n"n+' ($*$%-i/'n. S$*$n'%n+' t!*!/ #$#ii(i &%)-$- &$%t'/'n'n t$%/','& in$(-i '#!% '('n t$t'&i ($(!'t'nn+' -'n"'t *$%'%i'-i 'nt'% in,ii,! t$%"'nt!n" tin"('t ,'+' t'/'nn+'. P',' &'-i$n ,$n"'n ()n,i-i i##!n)7)#&%)#i-$, in$(-i '#!% *'/('n +'n" -i'tn+' )&)%t!ni-ti( -'n"'t #!,'/ t$%',i. S$t$'/ -&)%' #'-!( ,'n #$$='ti ini &$%t'/'n'n t!*!/ ,$n"'n ()n,i-i t$%t$nt! -&)%' ,'&'t *$%($#*'n" #$n',i '#!% ,'n #$#*$nt!( ())ni ,i ,''# t!*!/ 't'! &',' '%in"'n -!&$%i-i'. H' t$%-$*!t '('n #$ni#*!('n "$'' )(' #'!&!n -i-t$#i( P!%*' 20123.
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III. PENGGOLONGAN OAT In$(-i '#!% -$7'%' !#!# ,i*$,'('n #$n',i in$(-i '#!% -i-t$#i( ,'n t)&i(' +'it! 5 1.Anti'#!% !nt!( in$(-i -i-t$#i( 5 '#)t$%i-in !-it)-in "%!& ':) ($t)()n':)!()n':) it%'()n':)3 ('i!# i),i,' Y'nt$-' 201>3. 2.Anti'#!% !nt!( in$(-i t)&i(' 5 "%i-$)!in i#i,':) t)n't't ni-t'tin ('n,i-i,in '-'# -'i-i't '-'# !n,$-iin't /')&%)"in n't'#i-in Y'nt$-' 201>3.
S$'in it! Anti!n"i !"' ,'&'t ,i('-ii('-i('n *$%,'-'%('n 7'%' ($%'n+' 't'!&!n -t%!(%!% (i#i'=in+' +'it! "))n"'n ':) &)i$n ,'n "))n"'n 'in. 1.G))n"'n A:) Din'#'('n ':) ('%$n' -$#!' 'n"")t'n+' #$#&!n+'i 7in7in ':) ':) ,$n"'n 2 't)# nit%)"$n N3 ,i-$*!t i#i,':) ,'n ,$n"'n > 't)# Nit%)"$n ,i-$*!t t%i':).G))n"'n ':) !"' *$($%' #$n"/'#*'t -int$-i- $%")-t$%). T%i':) $*i/ *'i( ,'%i -$"i ,i-t%i*!-i 't'! $$( -'#&in"n+' $*i/ -$,i(it. G))n"'n ':) !"' #$%!&'('n 'nti!n"i *$%-&$(t%!# !'- Y'nt$-' 201>3. 2.G))n"'n P)i$n A#)t$%i-in #$n+$*'*('n n$%)t)(-i( )$/ ('%$n' it! /'n+' ,i"!n'('n &',' ('-!-;('-!- *$%'t ,'n +'n" #$n"''#i "'n""!'n i#!nit'-. Ni-t'tin !"' -'n"'t t)(-i( -$/in""' /'n+' ,i"!n'('n !nt!( &$#'('i'n t)&i7'. ?''!&!n ,'&'t ,i&'('i &$%)%' ni-t'tinti,'( ,'&'t ,i'*-)%&-i. S''t ,i&'('i &$%)%' ni-t'tin /'n+' !nt!( #$n"'t'-i in$(-i 9'n,i,' '*i7'n ,i #!()-' GI ,'n &$#*$%i'n -$7%' )(' !nt!( t$%'&i in$(-i (!it ,'n '"in' Y'nt$-' 201>3.
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>.G))n"'n L'in T$%*in'in ,'n "%i-$)!in ,i"!n'('n -$7'%' )%' !nt!( in$(-i '#!% -!&$%i7i' ,i(!it %'#*!t ,'n (!(!. K$,!' )*'t t$%-$*!t ,'&'t -'#&'i ($ (!it (!(! %'#*!t +'n" -'n"'t #ini# '-(!'%i-'-in+'.T$%*in'in *$($%' #$n"/'#*'t -int$-i$%")-t$%) -$,'n"('n "%i-$)!in t$%i('t ,i($%'tin -$/in""' (!it %$-i-t$n t$%/','& in$(-i '#!% Y'nt$-' 201>3.
I@. PROFIL ANTI FUNGI P',' *'"i'n ini '('n ,i&'&'%('n #$n"$n'i #$('ni-#$ ($%' in,i('-i ()nt%' in,i('-i '%#'()(in$ti( -$%t' $$( -'#&in" ,'%i ti'& "))n"'n 'nti !n"i.
4.1 Anti !n"i !nt!( in$(-i -i-t$#i( AMFOTERISIN B
A#)t$%i-in A ,'n #$%!&'('n /'-i $%#$nt'-i -t%$&t)#+7$- n),)-!-. Mekanisme kerja
A#)t$%i-in *$%i('t'n (!'t ,$n"'n -t$%) +'n" t$%,'&'t &',' #$#*%'n -$ '#!% -$/in""' #$#*%'n -$ *)7)% ,'n ($/i'n"'n *$*$%'&' *'/'n int%'-$ ,'n #$n+$*'*('n ($%!-'('n +'n" t$t'& &',' -$. S''/ -'t! &$n+$*'* $$( t)(-i( +'n" ,iti#*!('n ,i-$*'*('n )$/ &$n"i('t'n ()$-t$%) &',' #$#*%'n -$ /$='n ,'n #'n!-i'. R$-i-t$n-i t$%/','& '#)t$%i-in #!n"(in ,i-$*'*('n )$/ t$%',in+' &$%!*'/'n %$-$&t)% -t$%) &',' #$#*%'n -$ Y'nt$-' 201>3 Farmakokinetik
A*-)%*-i 5 -$,i(it -$('i ,i-$%'& #$'!i -'!%'n 7$%n'.
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?'(t! &'%!/ (i%';(i%' 24;48 '# &',' ,)-i- '=' +'n" ,ii(!ti )$/ $i#in'-i '-$ ($,!' ,$n"'n ='(t! &'%!/ (i%';(i%' 1 /'%i -$/in""' (','% #'nt'&n+' '('n t$%7'&'i -$t$'/ *$*$%'&' *!'n -$t$'/ &$#*$%i'n Y'nt$-' 201>3. E(-(%$-i 5 )*'t ini #$'!i "in' *$%'n"-!n" '#*'t -$('i /'n+' > B ,'%i !#'/ ,)-i- +'n" ,i*$%i('n Y'nt$-' 201>3. Efek samping
In!- 5 (!it &'n'- ($%in"'t'n -'(it ($&'' ,$#'# #$n""i"i $-! 'n)%$(-i' n+$%i )t)t $*iti- ($'n" ,'n &$n!%!n'n '' "in'. 0B &$n,$%it' +'n" #$n,'&'t ,)-i- '=' -$7'%' I@ '('n #$n"''#i ,$#'# ,'n #$n""i"i. E$( t)(-i( t$%/','& "in' ,'&'t ,it$('n *i' '#)t$%i-in ,i*$%i('n *$%-'#' !-it)-in. Y'nt$-' 201>3. Indikasi
Unt!( &$n")*'t'n in$(-i '#!% -$&$%ti ()(-i,i)i,)#i()-i- '-&$%"i)-i- (%)#)*'-t)#i()-i- ,'n ('n,i,)-i-. A#)t$%i-in #$%!&'('n )*'t t$%&ii/ !nt!( *'-t)#i()-i-. A#)t$%i-in -$7'%' t)&i(' $$(ti t$%/','& ($%'titi- #i()ti(. Y'nt$-' 201>3 Sediaan
A#)t$%i-in in$(-i t$%-$,i' ,''# i' +'n" #$n"'n,!n" 0 #" *!*!(
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Dosis
P',' !#!#n+' ,i#!'i ,$n"'n ,)-i- +'n" ($7i (!%'n" ,'%i 02 #"C("3 +'n" ,i'%!t('n ,''# ,$(-t%)-$ B ,'n ,itin"('t('n *$%t'/'& -'#&'i 04;06 #"C(" -$*'"'i ,)-i- &$#$i/'%''n. S$7'%' !#!# ,)-i- 0>;0 #"C(" 7!(!& $$(ti !nt!( *$%*'"'i in$(-i '#!% &$#*$%i'n ,i'(!('n -$'#' 6 #in""! ,'n *i' &$%! ,'&'t ,i'n!t('n -'#&'i >; 4 *!'n Y'nt$-' 201>3
FLUSITOSIN
F!-it)-in #$%!&'('n &i%i#i,in -int$ti- +'n" t$'/ #$n"''#i !)%in'-i Mekanisme kerja
F!-it)-in #'-!( ($ ,''# -$ '#!% ,$n"'n *'nt!'n -it)-in ,$'#in'-$ ,'n ,''# -it)&'-#' '('n *$%"'*!n" ,$n"'n RNA -$t$'/ #$n"''#i ,$'#in'-i #$n',i ; F!)%)!%'-i. Sint$-i- &%)t$in -$ '#!% t$%"'n""! '(i*'t &$n"/'#*'t'n 'n"-!n" -int$-i- DNA )$/ #$t'*)it !)%)!%'-i Y'nt$-' 201>3. Farmakokinetik
A*-)%*-i
5 ,i-$%'& ,$n"'n 7$&'t ,'n *'i( #$'!i -'!%'n 7$%n'.P$#*$%i'n
*$%-'#' #'('n'n #$#&$%'#*'t &$n+$%'&'n *$%(!%'n". P$n+$%'&'n !"' ,i&$%'#*'t &','
t'&i !#'/ +'n" ,i-$%'& ti,'( &$#*$%i'n *$%-'#' -!-&$n-i
'!#!ni!# /i,%)(-i,'C#'"n$-i!# /i,%)(-i,' ,'n ,$n"'n n$)#i-in. Di-t%i*!-i
5 ,i,i-t%i*!-i('n ,$n"'n *'i( ($ -$!%!/ '%in"'n ,$n"'n )!#$
,i-t%i*!-i #$n,$('ti t)t' 7'i%'n t!*!/.
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E(-(%$-i
5 0B !-it)-in '('n ,i($!'%('n *$%-'#' #$'!i it%'-i ")#$%!!
,''# *$nt!( !t!/ (','% ,''# !%in *$%(i-'% 'nt'%' 200;00"C#. K','% &!n7'( ,''# ,'%'/ -$t$'/ &$#*$%i'n &$%;)%' ,i7'&'i 1;2 '#. K','% ini $*i/ tin""i &',' &$n,$%it' in!-i$n-i "in'. M'-' &'%!/ )*'t ini ,''# -$%!# &',' )%'n" n)%#' 'nt'%' 24;4.8 '# ,'n -$,i(it #$#'n'n" &',' *'+i &%$#'t!% t$t'&i ,'&'t -'n"'t #$#'n'n" &',' &$n,$%it' in-!i-i$n-i "in'. Y'nt$-' 201>3 Efek samping
D'&'t #$ni#*!('n 'n$#i' $!()&$ni' ,'n t%)#*)-it)&$ni' t$%!t'#' &',' &$n,$%it' ,$n"'n ($'in'n /$#'t))"i( +'n" -$,'n" #$n,'&'t &$n")*'t'n %',i'-i 't'! )*'t +'n" #$n$('n !n"-i t!'n" ,'n &$n,$%it' ,$n"'n %i='+'t &$#'('i'n )*'t t$%-$*!t. M!'#!nt'/ ,i'%$ ,'n $nt$%)()iti- +'n" /$*'t. Ki%';(i%' B &$n,$%it' #$n"''#i &$nin""i'n $n:i# SGPT ,'n SGOT /$&'t)#$"'i. T$%',i -'(it ($&'' ($*in"!n"'n &!-in" #$n"'nt!( ,'n /'!-in'-i. Y'nt$-' 201>3 Indikasi
in$(-i -i-t$#i( ('%$n' -$'in (!%'n" t)(-i( )*'t ini ,'&'t ,i*$%i('n &$% )%'. P$n""!n''nn+'
-$*'"'i
)*'t
t!n""'
/'n+'
,iin,i('-i('n
&','
(%)#)*'-t)#i()-iSediaan dan dosis
F!-it)-in t$%-$,i' ,''# *$nt!( ('&-! 20 ,'n 00 #"
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D)-i- +'n" *i'-'n+' ,i"!n'('n i''/ 0;10 #"C(" -$/'%i +'n" ,i*'"i ,''# 4 ,)-i-. Y'nt$-' 201>3
KETOKONAOL Mekanisme kerja
S$&$%ti ':)$ $ni- +'n" 'in ($t)7)n':)$ *$%int$%$%$n-i ,$n"'n *i)-int$-i$%")-t$%) -$/in""' #$n+$*'*('n &$%!*'/'n -$!#'/ !n"-i -$ +'n" *$%/!*!n"'n ,$n"'n #$#*%'n Y'nt$-' 201>3. Farmakokinetik
A*-)%*-i
5 ,i-$%'& *'i( #$'!i -'!%'n 7$%n' ,'n #$n"/'-i('n (','%
&'-#' +'n" 7!(!& !nt!( #$n$('n '(tiit'- *$%*'"'i $ni- '#!%. P$n+$%'&'n #$'!i -'!%'n 7$%n' '('n *$%(!%'n" &',' &$n,$%it' ,$n"'n &H '#*!n" +'n" tin""i&',' &$#*$%i'n *$%-'#' 'nt'-i,. Di-t%i*!-i E(-(%$-i !#$n !-!-
5 ($t)()n':) -$t$'/ ,i-$%'& *$!# *'n+'( ,i($t'/!i. 5 Di,!"' ($t)()n':) ,i$(-(%$-i('n *$%-'#' 7'i%'n $#&$,! ($ ,'n /'n+' -$*'"i'n ($7i -'' +'n" ,i($!'%('n *$%-'#' !%in
-$#!'n+' ,''# *$nt!( #$t'*)it +'n" ti,'( '(ti. Y'nt$-' 201>3 Efek samping
E$( t)(-i( $*i/ %in"'n ,'%i&',' A#)t$%i-in . M!' ,'n #!nt'/ #$%!&'('n $$( -'#&in" )*'t +'n" &'in" -$%in" ,i!#&'i E$( -'#&in" +'n" '%'n" ,it$#!i 5
-'(it ($&'' $%ti") n+$%i $&i"'-t%i(
)t))*i' &'%$-t$-i' "!-i *$%,'%'/ $%!&-i (!it ,'n t%)#*)-it)&$ni'.
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Indikasi
K$t)()n':) t$%!t'#' $$(ti !nt!( /i-t)&'-#)-i- &'%! t!'n" -$n,i ,'n '%in"'n $#'(. Kontra indikasi
K$/'#i'n ,'n '(t'-i. O*'t ini -$*'i(n+' ti,'( ,i*$%i('n &',' ='nit' /'#i ('%$n' &',' ti(!- ,)-i- 80 #"C("C/'%i #$ni#*!('n 7'7't &',' '%i /$='n 7)*' t$%-$*!t. Y'nt$-' 201>3
ITRAKONAOL Mekanisme kerja
S$&$%ti /'n+' ':)$ +'n" 'in it%'7)n':)$ *$%int$%$%$n-i ,$n"'n $n:i# +'n" ,i&$n"'%!/i
)$/
7+t)7/%)#$
P;40
14;,$#$t/+'-$.
Int$%$%$n-i
ini
#$n+$*'*('n '(!#!'-i 14;#$t/+-t$%) ,'n #$n"!%'i('n $%")-t$%) ,i ,''# -$;-$ '#!% ,'n ($#!,i'n #$n""'nti -$!#'/ !n"-i -$ +'n" *$%/!*!n"'n ,$n"'n #$#*%'n Y'nt$-' 201>3. Farmakokinetik
It%'()n':) '('n ,i-$%'& $*i/ -$#&!%n' #$'!i -'!%'n 7$%n' *i' ,i*$%i('n *$%-'#' ,$n"'n #'('n'n. D)-i- 100 #"C/'%i -$'#' 1 /'%i '('n #$n"/'-i('n (','% &!n7'( -$*$-'% 0 "C# Y'nt$-' 201>3. ?'(t! &'%!/ $i#in'-i )*'t ini >6 '# -$t$'/ 1 /'%i &$#'('i'n3 Sediaan dan dosis
It%'()n':) t$%-$,i' ,''# ('&-! 100 #".
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Unt!( ,$%#'t)it)-i- ,i*$%i('n ,)-i- 1 < 100#"C/'%i -$'#' 2;8 #in""! K'n,i,i'-i- '"in' ,i)*'ti ,$n"'n ,)-i- 1 < 200 #"C/'%i -$'#' > /'%i. Piti%i'-i- $%-i())% #$#$%!('n ,)-i- 1 < 200 #"C/'%i -$'#' /'%i. In$(-i *$%'t #!n"(in #$#$%!('n ,)-i- /in""' 400 #" -$/'%i. Efek samping
K$#$%'/'n &%!%it!- $-! &!-in" $,$#' &'%$-t$-i' 10;1B &$n,$%it' #$n"$!/ #!' 't'! #!nt'/ t'&i &$n")*'t'n ti,'( &$%! ,i/$nti('n Indikasi
It%'()n':) #$#*$%i('n /'-i #$#!'-('n !nt!( in,i('-i +'n" -'#' ,$n"'n ($t)()n':)
'nt'%'
'in
t$%/','&
*'-t)#i()-i-
/i-t)&'-#)-i-
()(-i,i),i#i()-i- &'%'()(-i,i)i,)#i()-i- ('n,i,i'-i- #!!t ,'n t$n"")%)('n -$%t' tin$' $%-i())%. Y'nt$-' 201>3.
FLUKONAOL Farmakokinetik
O*'t ini ,i-$%'& -$#&!%n' #$'!i -'!%'n 7$%n' t'n&' ,i&$n"'%!/i ','n+' #'('n'n 't'!&!n ($'-'#'n '#*!n". K','% &!n7'( 4;8 " ,i7'&'i -$t$'/ *$*$%'&' ('i &$#*$%i'n 100 #". ?'(t! &'%!/ $i#in'-i 2 '# -$,'n"('n $(-(%$-i #$'!i "in' #$$*i/i 0B *$%-i/'n "in'. Sediaan dan dosis
11
F!()n':) t$%-$,i' !nt!( &$#'('i'n &$% )%' ,''# ('&-! +'n" #$n"'n,!n" 0 ,'n 10#". D)-i- +'n" ,i-'%'n('n 100;400 #" &$% /'%i. K'n,i-i'-i- '"in' ,'&'t ,i)*'ti ,$n"'n ,)-i- t!n""' 10 #". Efek samping
G'n""!'n -'!%'n 7$%n' #$%!&'('n $$( -'#&in" )*'t +'n" &'in" *'n+'( R$'(-i '$%"i &',' (!it $)-in)ii' -in,%)# -t$$n-J)/n-)n. Indikasi
F!()n':) ,'&'t #$n7$"'/ %$'&- #$nin"iti- )$/ (%i&t)()(!- &',' &$n,$%it' AIDS -$t$'/ &$n")*'t'n ,$n"'n A#)t$%i-in . O*'t ini !"' $$(ti !nt!( &$n")*'t'n ('n,i,i'-i- #!!t ,'n t$n"")%)('n &',' &$n,$%it' AIDS. Y'nt$-' 201>3.
KALIUM IODIDA
K'i!# I),i,' ',''/ )*'t t$%&ii/ !nt!( 9!t'n$)!- +#&/'ti7 -&)%)t%i7/)-iEfek samping
#!' %initi- -'i'-i '(%i#'-i %'-' t$%*'('% &',' #!!t ,'n t$n"")%)( i%it'-i &',' #'t' -i'),$niti- ,'n '(n$ &!-t!'%i- &',' *'"i'n 't'- *'/! Dosis
K'i!# i),i,' ,i*$%i('n ,$n"'n ,)-i- > ('i -$/'%i 1 # '%!t'n &$n!/ 1"C#3. D)-i- ,itin"('t('n 1 # -$/'%i -'#&'i #'(-i#' 12;1 #.
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P$n+$#*!/'n t$%',i ,''# 6;8 #in""! n'#!n t$%'&i #'-i/ ,i'n!t('n -'#&'i -$,i(itn+' 4 #in""! -$t$'/ $-i #$n"/i'n" 't'! ti,'( '(ti '"i Y'nt$-' 201>3.
4.2 Anti '#!% !nt!( in$(-i t)&i(' !RISEOFUL"IN
G%i-$)!in ',''/ 'nti*i)ti( 'nti '#!% +'n" ,i/'-i('n )$/ -$!#'/ -&$-i$P$ni7ii!# ,'n &$%t'#' ('i ,i&$%($n'('n ',''/ *$%*$nt!( )*'t )%' +'n" ,i&$%!nt!(('n *'"i &$n")*'t'n &$n+'(it ,$%#'t)&/+t)-i- Y'nt$-' 201>3. Mekanisme Kerja
G%i-$)!in ',''/ ($)#&)( )*'t !n"i-t'ti- +'n" #$n"i('t &%)t$in;&)t$in #i(%)t!*!'% ,'n *$%&$%'n !nt!( #$n"/'#*'t #it)-i- -$ '#!%. S$'in it! "%i-$)!in !"' in/i*it)% &$n"/'#*'t3 *'"i -int$n-i- '-'# n!($'t Y'nt$-' 201>3. Farmakokinetik
G%i-$)!in (!%'n" *'i( &$n+$%'&'nn+' &',' -'!%'n 7$%n' *'"i'n 't'- ('%$n' )*'t ini ti,'( '%!t ,''# 'i%.P$n+$%'&'n $*i/ #!,'/ *i' "%i-$)!in ,i*$%i('n *$%-'#' #'('n'n *$%$#'( D)-i- )%' 0. /'n+' '('n #$n"/'-i('n (','% &!n7'( ,''# &'-#' (i%';(i%' 1 "C# -$t$'/ 4 '#. O*'t ini #$n"''#i #$t'*)i-#$ ,i /'ti ,'n #$t'*)it !t'#'n+' ',''/ 6; #$ti"%i-$)!in. ?'(t! &'%!/ )*'t ini (i%';(i%' 24 '# 0B ,'%i ,)-i- )%' +'n" ,i*$%i('n ,i($!'%('n *$%-'#' !%in ,''# *$nt!( #$t'*)it -$'#' /'%i.
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Efek samping
L$!()&$ni' ,'n "%'n!)-it)&$ni' #$n"/i'n" *i' t$%'&i ,i'n!t('n. S'(it ($&'' ',''/ ($!/'n !t'#' &',' (i%';(i%' 1B &$n,$%it' +'n" *i'-'n+' /i'n" -$n,i%i -$('i&!n &$#'('i'n )*'t ,i'n!t('n. '%t%'"i' n$!%iti- &$%i$% ,$#'# &'n,'n"'n #$n"'*!% in-)#ni' *$%(!%'n"n+' ($7'('&'n &!-in" ,'n -in()& &',' -'!%'n 7$%n' ,'&'t t$%',i %'-' ($%in" #!!t #!' #!nt'/ ,i'%$ ,'n 't!$n-i. P',' (!it ,'&'t t$%',i !%ti('%i' %$'(-i )t)-$n-itiit'- $%it$#' #!ti)%# $-i(!' ,'n $%!&-i #$n+$%!&'i #)%*ii Y'nt$-' 201>3. Indikasi
E$(ti !nt!( in$(-i '#!% ,i (!it %'#*!t ,'n (!(! +'n" ,i-$*'*('n )$/ '#!% Mi7%)-&)%!# T%i7)&/+t)n ,'n E&i,$%#)&/+t)n Y'nt$-' 201>3. Sediaan dan dosis
G%i-$)!in t$%-$,i' ,''# *$nt!( t'*$t *$%i-i 12 ,'n 00 #" ,'n -!-&$-i #$n"'n,!n" 12 #"C#. P',' 'n'( "%i-$)!in ,i*$%i('n 10 #"C("C/'%i Unt!( ,$='-' 00;1000 #"C/'%i ,''# ,)-i- t!n""'. H'-i #$#!'-('n '('n t$%7'&'i *i' ,)-i- +'n" ,i*$%i('n ,i*'"i $#&'t ,'n ,i*$%i('n -$ti'& 6 '# Y'nt$-' 201>3. Kontraindikasi
G%i-$)!in *$%-i't ()nt%'in,i('-i &',' &'-i$n &$n,$%it' &$n+'(it i$% ('%$n' )*'t ini #$n+$*'*('n ($%!-'('n !n"-i /'ti Y'nt$-' 201>3.
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MIKONAOL
Mi()n':) #$%!&'('n t!%!n'n i#i,':) -int$ti( +'n" %$'ti -t'*i #$#&!n+'i -&$(t%!# 'ni '#!% +'n" $*'% *'i( t$%/','& '#!% -i-t$#i( #'!&!n '#!% ,$%#'t)it Y'nt$-' 201>3. Mekanisme Kerja
Mi()n':) #$n"/'#*'t -int$-i- $%")-t$%) +'n" #$n+$*'*('n &$%#$'*iit'#$#*%'n -$ '#!% #$nin"('t Y'nt$-' 201>3. Farmakokinetik
D'+' '*-)%*-i Mi7)n':)$ #$'!i &$n")*'t'n )%' (!%'n" *'i(.. Mi7)n':)$ -'n"'t t$%i('t )$/ &%)t$in ,i ,''# -$%!#. K)n-$nt%'-i ,i ,''# 9SF ti,'( *$"it! *'n+'( t$t'&i #'#&! #$'(!('n &$n$t%'-i +'n" *'i( ($ ,''# &$%it)n$' ,'n 7'i%'n &$%-$n,i'n. K!%'n" ,'%i 1B ,)-i- &'%$nt$%' ,i$(-(%$-i ,i ,''# !%in ,$n"'n ()#&)-i-i +'n" ti,'( *$%!*'/ n'#!n 40B ,'%i t)t' ,)-i- )%' ,i$i#in'-i #$'!i ()t)%'n ,$n"'n ()#&)-i-i +'n" ti,'( *$%!*'/ &!'. Mi7)n':)$ ,i#$t'*)i-#$ )$/ i$% ,'n #$t'*)itn+' ,i$(-(%$-i ,i ,''# !-!,'n !%in. Ti,'( -'t!&!n ,'%i #$t'*)it +'n" ,i/'-i('n *$%-i 't '(ti Y'nt$-' 201>3. Indikasi
Diin,i('-i('n !nt!( ,$%#'t)it)-i- tin$' $%-i())% ,'n ('n,i,i'-i- #!()(!t'n. Efek samping
$%!&' i%it'-i ,'n %'-' t$%*'('% ,'n #'-$%'-i #$#$%!('n &$n"/$nti'n t$%'&i Y'nt$-' 201>3.
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Sediaan dan dosis
O*'t ini t$%-$,i' ,''# *$nt!( (%$# 2B ,'n *$,'( t'*!% +'n" ,i"!n'('n 2 ('i -$/'%i -$'#' 2;4 #in""! Y'nt$-' 201>3. Indikasi
K%$# 2 B !nt!( &$n""!n''n int%''"in' ,i*$%i('n -$('i -$/'%i &',' #''# /'%i !nt!( #$n,'&'t('n %$t$n-i -$'#' /'%i. G$ 2B t$%-$,i' &!' !nt!( ('n,i,i'-i- )%' Y'nt$-' 201>3.
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DAFTAR PUSTAKA
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2012.
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/tt&-5CCi,.-7%i*,.7)#C,)7C114>4160Cin$(-i;'#!%,)=n)', ,i'(-$- 20 N)$#*$% 201 11503 Y'nt$-'
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201>.
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/tt&-5CCi,.-7%i*,.7)#C,)7C1>12224CMAKALAH;FARMAKOLOGI ,i'(-$- 20 N)$#*$% 201 125023
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