GPS Safety Summary "et#a$ry%i$ a$id &"AA' (#e Produ$t Safety Summary is intended to provide a genera% overvie) of t#e $#emi$a% su*stan$e in t#e $onte+t of I,,A G%o*a% Produ$t Strategy- (#e information on t#e summary is *asi$ information and is not intended to provide emergen$y response. medi$a% or treatment informationSu*stan$e name "et#a$ry%i$ a$id &"AA' ,AS /1 Genera% statement ndi%uted or g%a$ia% met#a$ry%i$ a$id 4"AA5 is produ$ed for use as a *ui%ding *%o$k to make a )ide r ange of po%ymer*ased produ$ts t#at )e see and use every day %ike *inders in paints and $oatings *ut a%so )aterso%u*%e po%ymers. as an inter%evant in g%ass and. as an intermediate for t#e manufa$ture of met#a$ry%i$ a$id esters to name *ut a fe)- "AA is of %o) $on$ern to #uman #ea%t# and t#e environment- It is $%assified as #a6ardous &irritating to $orrosive upon $onta$t depending upon t#e $on$entration' *ut #as *een #and%ed safe%y *y industry and professiona%s for over !0 years"AA*ased po%ymers are inert in t#e environment and $an *e re$y$%ed *a$k to monomeri$ "AA-
,#emi$a% identity 7ame
"et#a$ry%i$ a$id &"AA'
8rand names
Visiomer9 G"AA
,#emi$a% name &IPA,'
2"et#y%propenoi$ a$id
,AS num*er
/1
"o%e$u%ar formu%a
,:!;2
Stru$ture Synonyms
A$ry%i$ a$id. 2met#y%
Evonik IIndustries ndustries AG | AG | GPS Safety Summary | June 2013 | Version 3 | page 1!
ses and app%i$ation "AA is produ$ed for t#e use as monomer for produ$tion of po%ymers and as a rea$tant for synt#esis of ot#er met#a$ry%ate esters- (#e su*stan$e is manufa$tured in industria% settings in $%osed systems and used *y industry for manufa$ture of po%ymers in $%osed and semi$%osed systems
P#ysi$a%$#emi$a% propertties P#ysi$a%$#emi$a% proper Property
Va%ue
P#ysi$a% state
%i=uid
,o%or
$o%or%ess
;dor
pungent
"o%e$u%ar )eig#t
>!-1 g mo%
?ater so%u*i%ity
> g% &20 @,'
1-01 g$m 3 &20 @,'
Vapor pressure
0-/ #Pa &20 @,'
"e%ting *oi%ing point
1- @, 1!2 @,
B%as#point
!/ @, at 1013 #Pa
;$tano%)ater partition
%og Po)C 0-3
$oeffi$ient Vis$osity
1-3> mPa s &20 @,'
:ea%t# effe$ts Effe$t Assessment
Desu%t
A$ute to+i$ity &ora%. derma%
"AA $auses severe adverse effe$ts at
and in#a%ation'
t#e site of app%i$ation. depending on t#e $on$entration and fre=uen$y or time of e+posure- ndi%uted "AA may #ave moderate to #ig# to+i$ity after ora%. derma% and in#a%ation e+posure-
Eye Skin irritation
,auses irritation$orrosion to t#e skin. eyes and respiratory system-
Sensiti6ation
7ot sensiti6ing *y skin $onta$t-
(o+i$ity after repeated
8y in#a%ation "AA $auses damage to
e+posure
mu$ous mem*ranes of t#e nose most pronoun$ed around t#e site of first $onta$t- ;t#er effe$ts in t#e *ody are nonspe$ifi$-
Evonik IIndustries ndustries AG | AG GPS Safety Summary | June 2013 | Version 3 | page 2!
"utageni$ity
7ot mutageni$- ,%i$k #ere for a te$#ni$a% summary7o eviden$e of $ar$inogeni$ity- ,%i$k #ere for a te$#ni$a% summary-
,ar$inogeni$ity
7ot e+pe$ted to *e $ar$inogeni$-
(o+i$ity for reprodu$tion
Environmenta% effe$ts Effe$t Assessment
Desu%t
A=uati$ to+i$ity &a$utes#ort
"oderate%y to+i$ to a=uati$ organisms
term'
on an a$ute *asis-
Bate and 8e#avior
Desu%t
8iodegradation
Deadi%y *iodegrada*%e
8ioa$$umu%ation potentia%
7ot *ioa$$umu%ative
P8( vPv8 $on$%usion
7ot $onsidered to *e eit#er Persistent. or 8ioa$$umu%ative nor very Persistent or very 8ioa$$umu%ative &vPv8'-
Impa$t
n%ike%y to persist in. or #ave signifi$ant impa$t on t#e environment- ,%i$k #ere for a te$#ni$a% summary-
E+posure :uman #ea%t# "AA is produ$ed in essentia%%y $%osed systems so signifi$ant )orker e+posure during manufa$ture is un%ike%y- ?orkers may $ome into $onta$t )it# "AA during po%ymer produ$tion,onsumer e+posure to %i=uid monomer is un%ike%y due to t#e e+treme%y %o) %eve%s of residua% monomer in po%ymers used in $onsumer produ$ts &"AA is used as monomer in po%ymeri6ation'- se of "AA in artifi$ia% nai% produ$ts and ot#er nonmedi$a%denta% app%i$ations invo%ving dire$t skinnai% $onta$t )it# t#e %i=uid monomer is not re$ommended-
Environment (#e manufa$ture is a $%osed and automated pro$ess and no e+posure to t#e environment are intended- Any e+posures )i%% genera%%y *e %o)er t#an $on$ern %eve%s- Any )aste $ontaining residua% "AA #as to *e disposed in a$$ordan$e )it# %o$a%. state and fe dera% %a)s-
Evonik IIndustries ndustries AG | AG GPS Safety Summary | June 2013 | Version 3 | page 3!
Disk management re$ommendations Industry use. produ$tion and formu%ation E+posure may o$$ur eit#er in a g%a$ia% met#a$ry%i$ a$id manufa$turing fa$i%ity or in t#e various industria% or manufa$turing fa$i%ities t#at use t#is materia%?orkers s#ou%d fo%%o) t#e re$ommended safety measures as provided *y t#e manufa$turer in t#e Safety
State agen$y revie) 7G:S Ver- &2011' •
Degu%atory information$%assifi$ation and %a*e%% %a*e%%ing
G:S G:S,%assifi$ation Statutory *asis
"et#a$ry%i$ a$id &"AA'
7G:S Ver- &2011' B%amma*%e %i=uid
:a6ard $ategory
A$ute to+i$ity &ora%'
:a6ard $ategory
A$ute to+i$ity &in#a%ation'
:a6ard $ategory
A$ute to+i$ity &derma%'
:a6ard $ategory 3
Irritation$orrosion )it# spe$ifi$ $on$entration %imitsC ,on$entration &F' 10-0
Skin ,orr- 1A
,on$entration &F' 3-0 H
Skin Irrit- 2
10-0
Eye
,on$entration &F' 1-0 H
Skin Irrit- 2
3-0
Eye Irrit- 2A
Spe$ifi$ target organ to+i$ity
S(;( Sing%e E+p- 3 &respiratory tra$t.
sing%e e+posure
irritation'
:a6ardous to t#e a=uati$
:a6ard $ategory 3
environment A$ute :a6ard
7o )or%d)ide use of t#is $ategory- 7ot used in t#e European nion-
Evonik IIndustries ndustries AG | AG GPS Safety Summary | June 2013 | Version 3 | page !
G:S G:SKa*e%% Ka*e%%ing Statutory *asis
"et#a$ry%i$ a$id &"AA'
7G:S Ver- &2011' Sym*o%&s'
Signa% )ord
:a6ard statement
:22/ ,om*usti*%e %i=uid :302 :armfu% if s)a%%o)ed :311 (o+i$ in $onta$t )it# skin:332 :armfu% if in#a%ed:31 ,auses severe skin *urns and eye damage:33 "ay $ause respiratory irritation:02 :armfu% to a=uati$ %ife
Pre$autionary statementsC
Pre$aution statements and more information a*out "AA $an *e found on t#e Safety
Prevention
Avoid *reat#ing dustfumegasmistvaporsspray,ontaminated )ork $%ot#ing must not *e a%%o)ed out of t#e )orkp%a$e?ear prote$tive g%oves-
Desponse
If on skinC ?as# )it# p%enty of )aterIf skin irritation or ras# o$$ursC Get medi$a% advi$eattention?as# $ontaminated $%ot#ing *efore reuse-
Evonik IIndustries ndustries AG | AG GPS Safety Summary | June 2013 | Version 3 | page !
G%ossary A$ute to+i$ity
#armfu% effe$ts after a sing%e e+posure
8iodegrada*%e
*reakdo)n of materia%s *y a p#ysio%ogi$a% environment
8ioa$$umu%ation
a$$umu%ation of su*stan$es in t#e environment
,ar$inogeni$ity
effe$ts $ausing $an$er
,#roni$ to+i$ity
#armfu% effe$ts after repeated e+posures
G:S
G%o*a% :armoni6ed System on ,%assifi$ation and Ka*e%ing
"utageni$ity
effe$ts t#at $#ange genes
P8(
Persistent 8ioa$$umu%ative (o+i$
Deproto+i$ity
teratogeni$ity. em*ryoto+i$ity and #armfu% effe$ts on ferti%ity
Sensiti6ing
a%%ergeni$
(eratogeni$
effe$ts on foeta% morp#o%ogy
vPv8
very Persistent very 8ioa$$umu%ative
,onta$t information )it#in $ompany Emai% address E $mdaLevonik-$om Emai% address SA produ$t-regu%atory-servi$esLevonik-$om Bor more produ$t safety summaries. p%ease visitC "et#a$ry%ates Produ$ers Asso$iation
(#is GPS Safety Summary is *ased on EvonikMs present kno)%edge and e+perien$e as of t#e date of issue- :o)ever. it imp%ies no %ia*i%ity or ot#er %ega% responsi*i%ity on t#e part of Evonik. in$%uding )it# regards to e+isting t#ird party inte%%e$tua% property rig#ts. espe$ia%%y patent rig#ts- In no event s#a%% Evonik *e responsi*%e for damages of any nature )#atsoever resu%ting from t#e use of or re%ian$e upon t#e information #erein or t#e $#emi$a% to )#i$# t#at information refers- In parti$u%ar. no )arranty. )#et#er e+press or imp%ied. or gu arantee in t#e %ega% sense is intended or imp%ied *y Evonik(#is GPS Safety Summary is on%y intended to provide genera% information a*out t#e $#emi$a% referred to #erein *ut not any indept# #ea%t# and safety information- (#e information in t#is GPS Safety Summary is supp%ied on t#e $ondition t#at t#e persons re$eiving t#e same )i%% make t#eir o)n determination as to its suita*i%ity for t#eir purposes prior to use- ( #is GPS Safety Summary does not supersede or rep%a$e re=uired regu%atory andor %ega% $ommuni$ation do$umentsPerforman$e of t#e $#emi$a% des$ri*ed #erein s#ou%d *e verified *y tes ting )#i$# s#ou%d *e $arried out on%y *y =ua%ified e+pertsEvonik reserves t#e rig#t to make any $#anges to t#is GPS Safety Summary in a$$ordan$e )it# te$#no%ogi$a% progress or furt#er deve%opments- Deferen$e to trade names used *y ot#er $ompanies is neit#er a re$ommendation. nor does it imp%y. t#at simi%ar produ$ts $ou%d not *e used-
June 2013
