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Pathophysiology of Acute Myelogenous Leukemia Fab m4
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PATHOPHYSIOLOGY OF ACUTE MYELOGENOUS LEUKEMIA FAB M4
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Predisposing Factors: Age <65 y.o Gender: Male Race: European American Hereditary: 1st degree relatives Congenital Disorders: Down Syndrome, fanconi anemia, Bloom syndrome, and ataxia telangiectasia
Precipitating Factors: Exposure to Radiat Exposure to chemic Cigarette Smoking Drugs: Alkylating a epipodophyllotoxin hracyclines, hracyclines, chloramphenicol an phenylbutazone isorders: myelodyspla syndrome or myelo
Etiology: UNKOWN
Disruption in the function of transcription factor which plays an important part for gene expression and regulation
Faulty transcription creates genetic damage to stem cells
Disruption of growth control & differentiation pathway of pluripotent myeloid stem cells
Blockage in cell maturation Faulty myelocytic and monocytic cell
