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•
•
•
Kon$ra in'i"a&i +
enyakit hati
Ginjal
Glaukoma
-etidak seimbangan elektrolit
In$era"&i O#a$ +
$lkohol
$ntihistamin
2arkotik
@ipnotik
edativ
ada pemeriksaan laboratorium dapat terjadi peningkatan en1im hati dan amilase serum.
. $dsorben
ekerja dengan cara menyerap air, racun dan gas pada saluran pencernaan , sehingga faeces menjadi lebih pekat. •
-aolin pekatin (kao 9 pek #tat) garam bismut $nti diare ringan , trmasuk obat bebas.
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•
4bat kausal antidiare # $dalah obat yang di berikan dengan tujuan menghilangkan penyebab diare :
•
•
"nfeksi : antibiotika dan antimikroba
•
tress : antiansietas
•
/umor /umor : tindakan operativ
•
-eracunan : antidotum
•
4bat : hentikan pengobatan
$ntimikroba diberikan apabila di dapatkan darah lekosit pada tinja.
/. O#a$ An$iee$i" An$iee$i"a a $ntiem $ntiemeti etik k adalah adalah obat#ob obat#obatan atan yang yang diguna digunakan kan dalam dalam penatal penatalaks aksana anaan an mual mual dan muntah. 4bat#obatan tersebut bekerja dengan cara mengurangi hiperaktifitas refleks muntah
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$ntiemetika diberikan kepada pasien dengan keluhan sebagai berikut : . 'abuk jalan0'abuk >arat ( Motion Sickness) Sickness) enyebab utama mabuk darat adalah pertentangan antara informasi yang disalurkan oleh organ keseimbangan otak disatu pihak dan informasi dari indera#indera lain di lain pihak. -hususnya -hususnya menyangkut menyangkut pertentangan pertentangan antara mata dan indera perasa, yang sebetulnya sebetulnya harus bekerja sama dengan organ keseimbangan (labirin). %. 'abuk kehamilan Menis muntah ini biasanya biasanya terjadi antara minggu ke#5 dan ke#< dari masa kehamilan kehamilan akibat kena kenaik ikan an pesat pesat dari @&G (Human (Human Chorion Chorion Gonadotr Gonadotropi opin). n).Gejala#g Gejala#gejala ejala pada umumnya umumnya tidak hebat dan hilang dengan sendirinya, maka sedapat mungkin jangan diobati agar tidak mengganggu perkembangan organ#organ janin. 3. 'ual atau muntah yang disebabkan penyakit tertentu seperti pada pengobatan dengan radiasi atau obat#obat sitostatik.
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neurologis dan setelah pembedahan.. 4bat ini biasanya jarang digunakan karena efek ekstrapiramidal yang luas dan efek sedatif. •
Derivate fenotiazin : proklorpe proklorperazin razin dan thietilperaz thietilperazin in (torecan). (torecan). bekerja bekerja di saluran
cerna sebagai prokinetik dan digunakan untuk pengobatan gangguan saluran cerna tetapi tidak cocok untuk pasien sesudah opersi dan keracunan obat. 3. $ntagonis reseptor #hydro?y#tryptamine #hydro?y#tryptamine $ntagonis $ntagonis reseptor reseptor #hydro?y #hydro?y#trypt #tryptamine amine yang menghambat menghambat reseptor reseptor serotonin serotonin di usunan yaraf usat () dan saluran cerna.. 4bat ini dapat digunakan untuk pengobatan post#operasi, dan gejala mual dan muntah akibat keracunan. eberapa contoh obat yang termasuk golongan ini adalah : •
>olasetron
•
Granisetron
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iasa iasany nyaa terap terapii kedu keduaa yang ang digu diguna naka kan n pada pada pasie pasien n mual mual dan dan munt muntah ah akib akibat at keracunan yang tidak peka terhadap obat yang lain. &ontohnya antara lain : marihuana, /@&. Ffektif pada dosis tinggi untuk sitostatika. 7. $ntihistamin ($ntagonis reseptor @ histamine ). 4bat ini efektif untuk berbagai kondisi seperti motion sickness, ataupun mual dan muntah pada ibu hamil. 4bat#obat dari golongan ini meliputi : •
&ycli1ine
•
>iphenhydramine
•
>imenhydrinate
•
'ecli1ine
•
rometha1ine (enta1ine, henergan, romacot)
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2. An$i An$ihi hi&$ &$a ain ini" i"a a 4bat ini terutama digunakan untuk mencegah dan mengobati mual dan muntah akibat mabuk
darat serta pada gangguan tujuh keliling (vertigo). Siklizin dan dimenhidrinat diresorpsi diresorpsi baik, kerjanya cepat dan dapat bertahan <# jam. Meklizin Meklizin baru berkerja setelah #% jam, tetapi efeknya lebih lama, antara % dan %< jam. In'i"a&i : mual, muntah, vertigo, mabuk perjalanan dan kelainan labirin • Kon$ra in'i"a&i : serangan asma akut, gagal jantung dan kehamilan • : perasaan mengantuk dan efek antikolinergis yang agak sering • ,-e" &a!ing dilaporkan pada dimenhidrinat, jarang pada sikli1in dan mekli1in.
/. Ne%r Ne%rol ole! e!$i $i"a "a ejumlah ejumlah neuroleptika neuroleptika juga berday anti#emetis anti#emetis khususny
deriate fenotiazin !, seperti
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•
,-e" &a!ingn*a yang terpenting adalah sedasi dan gelisah berhubung rintangan
darah otak.Ffek otak.Ffek samping samping lainnya lainnya berupa berupa gangguan gangguan lambung usus serta gangguan •
ekstrapiramidal, terutama pada anak#anak kecil. 4o&i& : 3#< dd #8 #8 mg, anak#anak maksimal 8, mg0kg0sehari. =ectal %#3 dd %8 mg. mg.
. 4o!eri'on: motilium enyaa ben1imda1olinum ini adalah propulsivum yang berkhasiat menstimulasi peristalstik
dan pengosongan pengosongan lambun, selian berdaya anti emetis, digunakan digunakan pada relflu?#esofagus dan pada muntah akibat khemoterapi dan pada migraine. 4o&i& : 3#< dd 8#%8 mg a.c; anak#anak 3#< dd8,3 mg0kg, mg0kg, rectal anak#anak anak#anak sampai % • tahun%#< dd 8 mg; i.m0i.v 8, #8,% mg per kg berat badan dengan maksimum
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Kon$ra in'i"a&i
-ehami -ehamilan lan0me 0meny nyusu usui, i, hipote hipotensi nsi dan seranga serangan n
,-e" &a!ing
asma Gejala ekstra piramidal, piramidal, mengantuk, mengantuk, sakit kepala,
Se'iaan
dll &innari1ine (generik) tablet % mg
10. 4ienhi'rina$ In'i"a&i
'ual, muntah, vertigo, mabuk perjalanan perjalanan dan
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. OBAT OBAT ANTI:I,RT,NSI ANTI:I,RT,NSI ening eningkat katan an tekana tekanan n darah darah di dalam dalam arteri arteri (pembu (pembuluh luh darah darah nadi) nadi) di atas atas angka normal. ering kali tanpa gejala, sehingga penderita tidak merasa sakit.
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C. alfa#receptor blocker D. beta#receptor blocker E. 4bat# obat F. $ntagonis &a(-alsium A. 4i%re$i"
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Golongan ini lebih efektif dari penghambat $&F $&F karena jalur kedua melalui en1ym &himase juga dirintangi. 4bat#obatnya: Losartan, valsartan, ibesartan, candesartan dan eprosartan. C. al-a(>)ree!$or #lo"er
mekanisme kerjanya:
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yang bersifat sementara (beberapa minggu), menggangu mekanisme homeostase untuk homeostase untuk memelihara kadar#glukosa dalam darah ( e-e" hi!ogli"ei& )
O#a$ ; o#a$n*a &e#agai #eri"%$ + 1. O# O#a$ a$ 4i%r 4i%re$ e$i" i" Tia< Tia
tebal dan aal tubulus distal. @ilangnya -S, 2aS, dan &l# menyebabkan peningkatan pengeluaran
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tubulus kontortus distal.
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sebagai Hneurotransmitter palsuI simpatomimetik lemah yang menurunkan aliran keluar simpatis
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pelepasan norepinefrin.
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curah jantung dan penurunan pelepasan rennin. ronkokonstriksi melalui antagonisme reseptor
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eritomatosis sistemik.
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