MCQs in Clinical Biochemistry

Series I-C

Model Paper

Basic Medical Science Time:80mins

Biochemistry

Author Email: [email protected] TotalMarks:100|PassMark:60

BIOCHEMISTRY Pleaseuseadarkpencil/pentocompl Pleaseuseadarkpencil/pentocompletethetest.Readtheinstruc etethetest.Readtheinstructionsatthe tionsatthe beginingcarefully.Thisisapracticetes beginingcarefully.ThisisapracticetestseriesinBiochemis tseriesinBiochemistry. try. PleaseNote:ThereisaNegativeMarkingof(-1)foreachincorrectresponse. 1. Given Givenbelow belowisa isalist listof ofVita Vitamin mins: s: (i)Cholecalciferol (i) Cholecalciferol(iii) (iii)Riboflavin Riboflavin(v) (v)Niacin Niacin (ii)VitaminB (ii)VitaminB12(iv) (vi)Pyridoxine (iv)Folicacid Folicacid(vi) Pyridoxine Whichoftheabovegivenvitaminsareinvolvedinenergy-releasingfunctions? A (iii),(vi)

C (ii),(iii),(v),(vi)

B (iii),(v)

D (v),(vi)

2. Assert Assertion( ion(A) A)&Re &Reaso ason( n(R): R): Assertion: Assertion:Cysteinecontainsdisulphidebondsformedfrom(-SH)groupoftwo Cysteinecontainsdisulphidebondsformedfrom(-SH)groupoftwo cystineresidues Reason:Disulphidegroups(-SH)confersstabilityandenhancessolubilityofthe Reason:Disulphidegroups(-SH)confersstabilityandenhancessolubilityofthe protein A BothAandRaretrueandRis thecorrectexplanationofA

Aistrue uebut butRis Risfa false lse C Aistr D BothAandRarefalse

B BothAandRaretrueandRis notthecorrectexplanationofA

3. CoenzymeFlavinnuc CoenzymeFlavinnucleotideisde leotideisderivedf rivedfrom rom:: A Vit.B3

C Vit.B6

B Vit.B2

D Vit.B1

4. Theenzym Theenzyme'xant e'xanthineoxidas hineoxidase'inphas e'inphaseIr eIreact eactionofd ionofdrugm rugmetabo etabolismisf lismisfoundin oundin A Lysosomes

C Cytosol

B Mitochondria

D Microsomes

5. Nicotinam Nicotinamideis ideisalso alsokn known ownas: as: A pyridine-3-carboxylicacid

C aminoimidazolecarboxamide

B pyridine-3-carboxamide

D N'-methyl-2-pyridone-5-carboxamide

Basic Medical Sciences

-1-

Series I-C

Model Paper

Biochemistry

6. Infolicacidsyn Infolicacidsynthes thesis,enz is,enzyme yme/sub /substra stratet tethatis hatisnotr notrequired: equired: A N-methyl-6-pyridine-3 carboxamide

C folylpoly-γ-glutamylsynthase D 6-hydroxymethyl-7,8-dihydropterin-pyrophosphate

B P-aminobenzoicacid

7. Fillin Fillinth the ebla blank nks: s: Aminoa Aminoacid cid1+E+E-PLP PLP [A]_ [A]____ _______ _______ ______ ____+ _+EE-PM PMP P 8. Nicotinamideinhum Nicotinamideinhumansis ansisprimar primarilymet ilymethylated hylatedtog togenera enerate te A Nicotinuricacid

C 5-methyl-H4PteGlun

B N'-methylnicotinamide

D N-methyl-2-pyridone-5-carboxamide

9. Sustainedcons Sustainedconsump umptionof tionofavidinre avidinresultsind sultsindeficiency eficiencyofwh ofwhichvitam ichvitamin? in? A Riboflavin

C Niacin

B Biotin

D Thiamine

10. Inanimals, Inanimals,thep thepyridinering yridineringofNADc ofNADcanbe anbesynt synthesized hesizedfrom from A asparticacid

C tryptophan

B dihydroacetonephosphate

D tyrosine

11. Cystathionineindex Cystathionineindexmay maybeem beemployedt ployedtoass oassessVita essVitaminB minB6status:Metabolismof whichaminoacidisinvolvedinitsloadtest? A Tryptophan

C Cysteine

B Methionine

D Histidine

12. Condition(s)inwhicht Condition(s)inwhichtrypt ryptophan ophanmet metabolism abolismisaltere isaltered d A sicklecellanemia

C pregnancy

B rheumaticfever

D rheumatoidarthritis

13. Matcht Matchthefo hefollowingaminoac llowingaminoacidsacc idsaccordingt ordingtothe otheircorr ircorrespond espondingpolarity ingpolarityand and charge: A.

Proline Proline

A. Charged Chargedpo positiv sitive( e(bas basic) ic)

B.

Valine

B. Polar uncharged

C.

Glutamine

C. Charged negative (acidic)

D.

Glutamate

D. Branched chain nonpolar

E.

Arginine

E. No N onpolar aliphatic


-2-

Series I-C

Model Paper

Biochemistry

14. Applicationofdithiothr Applicationofdithiothreitol(DTT) eitol(DTT)indete indeterm rminationof inationofprot proteinstr einstructur uctureisuse eisusedfor dfor:: A oxidationofdisulphidebonds

C modificationofreactive-SH groups

B reductionofdisulphidebonds

D identificationofCterminal residue

15. Tofragm Tofragmentp entpolypept olypeptidechains, idechains,the thereage reagentus ntusedat edatcleavag cleavagepoint epointPhe, Phe,Trp, Trp,Tyr Tyr atNterminalis: A Trypsin(porcinestomach)

C Chymotrypsin(bovinepancreas)

B Trypsin(bovinepancreas)

D Pepsin(porcinestomach)

16. Ox Oxidativedea idativedeaminat minationofh ionofhistidinepro istidineproduces duces A Urocanicacid

Anthranilica nilicacid cid C Anthra

B Histamine

D Kynurenicacid

17. Whichoft Whichofthefo hefollowingantibioticca llowingantibioticcausesr usesrenalinjuryif enalinjuryifinjected? injected? A PolymixinB

C Bacitracin

B Vancomycin

D Methicillin

18. Theendprod Theendproducto uctoft ftrypt ryptophan ophancatab catabolismis: olismis: A Alanine

C 3-hydroxy-anthralinate

B Kynurenine

D acetoacetate

19. Rearranget Rearrangethefo hefollowingureacy llowingureacycleinter cleintermed mediatesac iatesaccording cordingtot totheirco heircorrect rrectorder order offormation: A.

Arginine Arginine

B.

Argininosuccinate

C.

Carbamoyl phosphate

D.

Ornithine

E.

Citrulline

20. Whichoft Whichofthefo hefollowingaminoac llowingaminoacidisstr idisstrictlyket ictlyketogenic? ogenic? A Isoleucine

C Valine

B Leucine

D Tryptophan

21. Decarbo Decarboxyla xylation tionof ofhis histidine tidinere requir quires es A pyridoxamine-5'-phosphate

C pyridoxine-5'-phosphate

B pyridoxal-5'-phosphate

D histidinedecarboxylase


-3-

Series I-C

Model Paper

Biochemistry

22. Whichoft Whichofthefo hefollowingisnota llowingisnotapolyam polyamine? ine? A 1,4-Diaminobutane

C Spermidine

B Cadaverine

D Ornithine

23. Catalytictriadc Catalytictriadcharac haracterist teristicofs icofsome omeenzy enzymes mesare arefound foundin: in: A CarboxypeptidaseA

C Renin

B Chymotrypsin

D Pepsin

24. Matcht Matchthefo hefollowing'enzym llowing'enzymes'witht es'withtheirco heircorresp rrespondingf ondingfunct unctions: ions: A.

Ornithine rnithinedec decarb arboxy oxylase lase

A. forma formation tionof ofhis histam tamine ine

B.

Aromatic L-amino acid decaboxylase

B. sperm sperminet inetop oput utres rescine cine

C.

Polyamine oxidase

C. formation of L-Dopa

D.

Tyrosine hydroxylase

D. formation of norepinephrine

E.

Dopamine β-oxidase

E. polyamine biosynthesis

25. Difluoromethy Difluoromethylornithine( lornithine(DFMO DFMO)isa )isadrug drugusedt usedtotr otreat eatwhichof whichofthef thefollowing ollowing disease(s)? Africansleep sleepings ingsickn ickness ess A African

C Kala-azar

B Yellowfever

D Dengue

26. Whichoft Whichofthefo hefollowingisasulphur llowingisasulphurcont containingam ainingaminoacidt inoacidthatc hatcontains ontainsa a disulphidebond(-S-S-)? A Serine

C Cysteine

B Methionine

D Cystine

27. Aminoacidtha Aminoacidthatcon tcontainsa tainsadoubler doubleringinitss inginitsstruc tructure ture:: A Proline

C Tryptophan

B Tyrosine

D Phenylalanine

28. Cyanogenbrom Cyanogenbromide(CNBr) ide(CNBr)isused isusedtos tosplitpolypept plitpolypeptidechains idechainson on A C-terminalofcysteineresidues

C C-terminalofarginineresidues

B C-terminalofmethionineresidues

D C-terminaloflysineresidues

29. Nanogramc Nanogramconcent oncentration rationofa ofaminoa minoacidscan cidscanbede bedetect tectedby edbyusingwhich usingwhichoft ofthe he followingreagents? A Ninhydrin

C Fluorodinitrobenzene(FDNB)

B Fluorescamine

D Dansylchloride


-4-

Series I-C

Model Paper

Biochemistry

30. Whichoneof Whichoneofthe thefollowingagen followingagentss tsstimulat timulatesTSHs esTSHsecret ecretion? ion? A Dopamine

C Glucocorticoids

B somatostatin

D propylthiouracil

31. Thesiteofe Thesiteofentry ntryof ofthre threonineinto onineintoTCAcycle TCAcyclefor forform formationof ationofglucose glucose:: A Succinyl-CoA

C α-ketoglutarate

B Pyruvate

D Oxaloacetate

32. About Abouttr triiodot iiodothyr hyronine onine(T (T3): A ismostlyboundtoTBG B freeformofT3isgreaterthanthe freeformofT4

C itsbiologichalf-lifeislongerthan T4 D 80%ofT3isformedfrom deiodinationofT 4

33. Broads Broadspec pectr trum uman antibiot tibiotics icsinclud include: e: A Erythromycin

C Penicillin

B Streptomycin

D Trimethoprim

34. Ureotelic Ureotelican anima imalsinc lsinclude: lude: A Sharks

C reptiles

B birds

D bonyfishes

35. Duringureabiosy Duringureabiosynthes nthesisinhum isinhumans, ans,carba carbamoy moylphospha lphosphatedo tedonates natesitsc itscarbam arbamoyl oyl groupsto: A Citrulline

Argininosucc uccinat inate e C Argininos

B Ornithine

D Urea

36. Anuncomm Anuncommonam onaminoacidr inoacidresiduef esiduefoundinc oundincollagen: ollagen: A dehydrohydroxylisinonorleucine

C 5-hydroxylysine

B 4-hydroxyproline

D alloftheabove

37. Avitaminthat Avitaminthatact actsas sasacof acofacto actorinser rinserineme inemetabolism tabolism:: A Riboflavin

C Thiamine

B Folicacid

D Pyridoxine


-5-

Series I-C

Model Paper

Biochemistry

38. Whichoneof Whichoneofthe thefollowingisan followingisanexam exampleof pleofaser aserineprot ineprotease? ease? A Plasminogen

C Plasmin

B α1-AT(antitrypsin)

D Tissueplasminogenactivator (TPA)

39. Drugthatis Drugthatisgivent giventoprev opreventt entthrom hrombosisinpa bosisinpatients tientswhoar whoarepro eproneto netodevelop developclots: clots: A Dicoumarol

C Desmopressin

B VitaminK

D Ethamsylate

40. Anexampleof Anexampleofaser aserineprot ineproteaseinhibitor easeinhibitor:: A Thromboplastin

Antithrom ombinI binIII II C Antithr

B Thrombin

D Plasmin

41. Match atcht the hefo followin llowing: g: A.

Ehlers-D Ehlers-Danlos anlossy syndr ndrom ome e

A. chronic chroniccon conjugat jugated ed hyperbilirubinemia

B.

Osteogenesis imperfecta

B. loose joints

C.

Rotor syndrome

C. abnormal fragility and bone formation

D.

Alport syndrome

D. degeneration of joint cartilage

E.

Stickler syndrome

E. end-stage renal disease

42. Achilddiagnosedwithh Achilddiagnosedwithhomo omocyst cystinuriahas inuriahasmen mentalre talretarda tardationand tionandfau faulty lty developmentofbones.Thebiochemicalbasisofthisdiseaseisduetodefective enzyme A Kynureninase

C Homogentisate1,2dioxygenase

B Homoserinedeaminase

D Cystathionineβ-synthase

43. Apyrido Apyridoxal xalphos phosphat phatee eenzy nzyme me:: A Tryptophanoxygenase

C Kynureninase

B α-ketoaciddecarboxylase

D Kynurenineformylase

44. Allofthefollowingare Allofthefollowingarephenylalaninec phenylalaninecatabo atabolitesexc litesexcept: ept: A phenylacetate

C phenyllactate

B p-hydroxyphenyllactate

D phenylacetylglutamine

45. Conversionof Conversionofphenylalaninet phenylalaninetotyr otyrosineisc osineiscatalyzed atalyzedby: by: A phenylalaninehydroxylase

C tyrosinedecarboxylase

B tyrosinase

D dopadecarboxylase


-6-

Series I-C

Model Paper

Biochemistry

46. VitaminDresist VitaminDresistantr antrickets ickets(VDRR)isc (VDRR)ischarac haracterized terizedby: by: A lackofparathyroidhormone (PTH)

C nephrocalcinosis D hyperphosphataemia

B hypophosphataemia

47. Whichvitam Whichvitaminacts inactsasa asacoenz coenzyme ymefor forreac reactiont tionthaty hatyieldsme ieldsmethioninef thioninefrom rom homocysteine? A Biotin

C Pyridoxine

B Thiamine

D Cobalamin

48. Adrugthat Adrugthatinhibitsm inhibitsmonoam onoamineoxidase ineoxidasethus thusprolong prolongingthe ingtheaction actionofs ofserot erotonin: onin: A iproniazid

C prazosin

B imipramine

D fluoxetine

49. Whichoft Whichofthefo hefollowingcompo llowingcompoundise undisessent ssentialforgr ialforgrowtha owthanddiff nddifferent erentiationof iationof epithelialcells? A Retinol

C Retinoicacid

B Retinal

D Retinylpalmitate

50. β-pleatedsh β-pleatedsheets eetsthat thatoccur occurinsom insomepro eproteinsisd teinsisdueto ueto A covalentbonding

C disulphidelinkages

B hydrogenbonding

D prolineresidues

51. Nottrueab Nottrueabouta outaprot proteinat einatisoelectr isoelectricpH(t icpH(thepI hepI)) A hasanetchargeofzero

C R-groupsreflectsthenature isoelectricpHofaprotein

B theydonotmigrateinan electricalfield

D isoelectricpHofglycineis4.97

52. Whichoft Whichofthefo hefollowingstate llowingstatemen mentsab tsaboutγoutγ-Aminobu Aminobutyric tyricacid(G acid(GABA)is/a ABA)is/arenot renot true? A isformedbydecarboxylationof glutamate

C requirepyridoxalphosphate (PLP)

B isinhibitedbydruglamotrigine

D isanexcitatoryneurotransmitter


-7-

Series I-C

Model Paper

Biochemistry

53. Assert Assertion( ion(A) A)&Re &Reaso ason( n(R): R): Assertion: Assertion:Inelectrophoresis,aproteinwillmovetowardcathodeifthepIisbelow Inelectrophoresis,aproteinwillmovetowardcathodeifthepIisbelow isoelectricpoint Reason:Theproteinhasanetnegativechargeandsowillmigratetowardsthe Reason:Theproteinhasanetnegativechargeandsowillmigratetowardsthe cathode A BothAandRaretrueandRis thecorrectexplanationofA



54. Whichoft Whichofthefo hefollowingenzym llowingenzymeisabs eisabsentinh entinhuma umanbeings nbeings? ? A aldehydedehydrogenase

C lactatedehydrogenase

B pyruvatedecarboxylase

D pyruvatecarboxylase

55. Aregulatorye Aregulatoryenzym nzymetha ethatisinhibited tisinhibitedbyNADH byNADH A isocitratedehydrogenase

C aldehydedehydrogenase

B malatedehydrogenase

D D-β-hydroxybutyrate dehydrogenase

56. Whatisno Whatisnottr ttrueabo ueaboutt utthepy hepyruvat ruvatedehy edehydrogen drogenasec asecomp omplex? lex? A providessubstratesfor gluconeogenesis

C areversiblereaction D sourceofacetylCoAforKrebs cycle

B inhibitedbyacetylCoA

57. Oneof Oneofthef thefollowingisnota ollowingisnotanurea nureacyc cycleinterm leintermediate: ediate: Argininosucc uccinat inate e A Argininos

C glutamate

B Ornithine

D Carbamoylphosphate

58. Anexam Anexampleo pleof fser serinee ineendo ndopept peptidas idase: e: A CarboxypeptidaseA

C Chymotrypsin

Aminopeptid ptidase ase B Aminope

D Enteropeptidase

59. Regardingbindingof RegardingbindingofDNAaroun DNAaroundhisto dhistone,s ne,spott pottheincor heincorrect rectsta statem tement( ent(s): s): A Unboundnegativesupercoilis plectonemic

C requirescompressionofthe minorgrooveofDNAhelix

B bindingdependsonabundance ofA=Tbasepairs

D topoisomerasecausesrelaxation ofpositivesupercoil


-8-

Series I-C

Model Paper

Biochemistry

60. Match atcht the hefo followin llowing: g: A.

Fibrinoge Fibrinogen n

A. lysine-glu lysine-glutam taminea ineamid mideb ebond ond

B.

Fibrin clot

B. γ-carboxyglutamate

C.

Prothrombin

C. α-ketoglutarate

D.

Ornithine transamination

D. arginine-glycine peptide bond

E.

Glutamate transamination

E. glutamate γ-semialdehyde

61. Vitaminwhichisac Vitaminwhichisacomp omponent onentofAc ofAcylCarrier ylCarrierProt Protein(ACP): ein(ACP): A VitaminA

C Pantothenicacid

B Thiamine

D Niacin

62. Aminoacidtha Aminoacidthatisun tisunableto abletofurn furnishcarb ishcarbonf onforgluco orglucosesy sesynthes nthesis is (nonglucogenic/nonketogenic): A Leucine

C Isoleucine

B Cysteine

D Tyrosine

63. Whichoneof Whichoneofthe thefollowingfun followingfunctions ctionsaslubrica aslubricants ntsinsynov insynovialfluidofjoints ialfluidofjoints? ? A Chondroitinsulphate

C Heparansulphate

B Hyaluronicacid

D Keratansulphate

64. Leastt Leasttoxic oxicam among ongt the hefollow following: ing: A ammonia

C urea

B glutamine

D uricacid

65. Abas Abasic icam amino inoa acid cid:: A Glutamate

C citrulline

B hydroxyproline

D selenocysteine

66. Animinoacidtha Animinoacidthatisa tisaconst constituent ituentoff offibrouss ibrousstruc tructure tureofco ofcollagen llagen A Lysine

C Proline

B Histidine

Arginine D Arginine

67. Givenbelowisalist Givenbelowisalistofc ofclottingf lottingfactor actorsof softhe thecoagulat coagulationcasc ioncascade. ade. (i)FactorI (i) FactorI(iii) (iii)FactorV FactorV(v) (v)FactorVIII FactorVIII (ii)FactorXI (ii)FactorXI(iv) (iv)FactorII FactorII(vi) (vi)FactorXII FactorXII Whichoftheabovegivenfactorsareactivatedbythrombin? A (i),(ii),(iv)

C (iii),(v),(vi)

B (iv),(v),(vi)

D (i),(iii),(vi)


-9-

Series I-C

Model Paper

Biochemistry

68. Considerthefo Considerthefollowingstatem llowingstatements entsabout aboutinsulin: insulin: Statement1:ThenumberofGLUT1transportersinerythrocytesareincreasedby Statement1:ThenumberofGLUT1transportersinerythrocytesareincreasedby insulin Statement2:Elevatedinsulinlevelsinwell-fedstatecauseanincreasein Statement2:Elevatedinsulinlevelsinwell-fedstatecauseanincreasein fructose2,6-bisphosphate Statement3:Highinsulinlevelsinwell-fedstatedepressespyruvatekinasein Statement3:Highinsulinlevelsinwell-fedstatedepressespyruvatekinasein liver Statement4:ThenumberofGLUT4transportersinskeletalmuscleandadipose Statement4:ThenumberofGLUT4transportersinskeletalmuscleandadipose tissueareincreasedbyinsulin Whichofthestatementsgivenabovearecorrect? A 2and4

C 3and4

B 1and3

D 2and3

69. Assert Assertion( ion(A) A)&Re &Reaso ason( n(R): R): Assertion: Assertion:PreproinsuliniscleavedinsecretorygranulesreleasingtheC-peptide PreproinsuliniscleavedinsecretorygranulesreleasingtheC-peptide thatformstheactiveglycoproteinhormoneinsulin Reason:ElevatedC-peptidelevelisadiagnosticmarkerfortumorsofpancreatic Reason:ElevatedC-peptidelevelisadiagnosticmarkerfortumorsofpancreatic β-cellsandNIDDM A BothAandRaretrueandRis thecorrectexplanationofA



70. Therea Thereactio ction'G n'Glucos lucoset eto o Glucose-6phosphate'inmusclesismediatedby A aldosereductase

C phosphoglucomutase

B Hexokinase

D Glucokinase

71. Pyruvateisc Pyruvateisconver onvertedt tedtoacet oacetylCoAinm ylCoAinmitochond itochondriaby riaby A pyruvatekinase

C pyruvatedehydrogenase

B pyruvatecarboxylase

D acetylCoAcarboxylase

72. β-alanineisacon β-alanineisaconstituen stituentof tofwhichVitam whichVitamin? in? A Retinoicacid

Ascorbica icacid cid C Ascorb

B Nicotinicacid

D Pantothenicacid

73. Allofthefollowingsta Allofthefollowingstatem tements entsregar regardingtr dingtriiodothyr iiodothyronine(T onine(T3)areincorrectexcept: A deiodinaseD3isthemainsource ofT3intheblood

C fastingincreasestheplasmaT3 levelsby10-20%

B seleniumdeficiencycausesafall inplasmaT3level

D T3istheprimaryfeedback regulatorofTSHsecretion


- 10 -

Series I-C

Model Paper

Biochemistry

74. Ox Oxidat idationo ionofio fiodide dideism ismediat ediated edby: by: A thyroidperoxidase

C iodinase

B iodotyrosinedeiodinase

D Botha&c

75. Tyrosineisapr Tyrosineisaprecurs ecursorof orofalloft allofthefo hefollowinghormo llowinghormonese nesexcept xcept:: A thyroxine

C epinephrine

B melanin

D serotonin

76. Whichoft Whichofthefo hefollowingisthebe llowingisthebests stsource ourceofa ofascor scorbicacid( bicacid(Vit.C)? Vit.C)? A Currant,black

C Brussels,sprout

B Rosehips

D Parsley

77. Oneof Oneofthef thefollowingisusefu ollowingisusefulintreat lintreatingleukem ingleukemicpatient icpatients: s: A aspartate

C asparagine

B asparaginase

D arginase

78. Essentia Essentialam laminoa inoacid( cid(s) s)includ include: e: A Threonine

C Serine

B Phenylalanine

D Tyrosine

79. Dailynitrogenexcr Dailynitrogenexcretionb etionbyhum yhumanbeings anbeingsisabou isabout: t: A 16.5gm

C 8-25mg

B 4.5gm

D 7.5mg

80. Oneof Oneofthef thefollowingenzym ollowingenzymesisno esisnotinvolved tinvolvedinurea inureabiosynt biosynthesis: hesis: A L-ornithinetranscarbamoylase

C CarbamoylphosphatesynthaseII

B CarbamoylphosphatesynthaseI

Argininosucc uccinase inase D Argininos

81. Phosphateex Phosphateexcret cretionbyt ionbythekidne hekidneysisau ysisaugme gmented nted(enha (enhanced) nced)by: by: A Insulin

C Calcitonin

B Parathyroidhormone(PTH)

D 1,25-dihydroxyvitaminD


- 11 -

Series I-C

Model Paper

Biochemistry

82. Assert Assertion( ion(A) A)&Re &Reaso ason( n(R): R): Assertion: Assertion:FolicaciddeficiencycanbediagnosedbyFIGluexcretiontest. FolicaciddeficiencycanbediagnosedbyFIGluexcretiontest. Reason: Accu Reason: Accum mulationo ulationofN fN-f -form ormimin iminoglut oglutam amate ateis isdue dueto toinc increa reased sedca catab tabolism olismof of uronicacid. A BothAandRaretrueandRis thecorrectexplanationofA



83. Onethat Onethatisnot isnotaco aconstitu nstituento entofglyco fglycosam saminoglycans inoglycans(G (GAG) AG):: A Neuraminicacid

C Uronicacid

Aminosuga ugars rs B Aminos

D Hexosamines

84. RespiratoryQ RespiratoryQuotient uotientof offat fatandpr andproteinar oteinareres erespective pectively: ly: A 1.0,0.8

C 0.7,0.8

B 0.7,1

D 0.8,0.7

85. BMRis BMRishigh highint inthe hefollow followinge ingexce xcept: pt: A Coldclimate

C Graves'disease

B Fever

D Myxedema

86. Inwhichoft Inwhichofthefo hefollowingconditionsp llowingconditionsplasma lasmapotas potassium siumconcen concentrat trationisincrea ionisincreased? sed? A metabolicalkalosis

C followinginsulininjection

B metabolicacidosis

D Conn'ssyndrome

87. Ureaclearanceb Ureaclearancebynor ynormalk malkidneysis idneysisabout about:: A 70ml/min

C 125ml/min

B 100ml/min

D 225ml/min

88. Neteffect Neteffectof ofParat Parathyroidh hyroidhorm ormone( one(PTH)on PTH)onbonea boneandkidney ndkidneyis: is: A increasesECFcalcium concentration

C PTHincreasesrenalclearance ofcalcium

B PTHdecreasesrenalclearance ofphosphate

D decreasesECFphosphate concentration

89. Aproteinresp Aproteinresponsiblefor onsibleforoxidat oxidationofiro ionofiron n A Hemosiderin

Apoferritin itin C Apoferr

B Ceruloplasmin

D Siderophyllin


- 12 -

Series I-C

Model Paper

Biochemistry

90. Mostof Mostofthe thefiltered filteredloadof loadofphosp phosphate hate(about (about80% 80%)isr )isreabsor eabsorbedf bedfrom romthe: the: A proximaltubule

C corticalcollectingduct

B distaltubule

D LoopofHenle

91. Cerebra Cerebralfu lfunct nction ionislea isleast stim impair paired edin in A Respiratoryalkalosis

C Metabolicacidosis

B Respiratoryacidosis

D Metabolicalkalosis

92. Anexampleof Anexampleoforalphos oralphosphate phatebinder: binder: A Echothiophate

C calciumcarbonate

B sodiumphosphate

D Diisopropyl-fluoro-phoshate

93. VitaminDdeficiency VitaminDdeficiencyisdiagnos isdiagnosedwhen edwhenplasm plasma25-( a25-(OH) OH)D D3concentrationis below: A 50nmol/L

C 60nmol/l

B 57nmol/l

D 40nmol/l

94. Regardin Regardingc gconv onvers ersion ionof ofCO CO2intoHCO3-inerythrocytescatalyzedbytheenzyme carbonicanhydrase,whichofthefollowingactsasasubstrate(s)? A Sunlight

C Glucose

B H2O

D H2CO3-

95. Molecularweight Molecularweightofhu ofhuman manhem hemoglobinisabo oglobinisabout: ut: A 21,600

C 68,000

B 16,890

D 64,000

96. Zincisaprost Zincisaprostheticc heticcomp omponent onentofe ofenzym nzyme(s) e(s):: A carboxypeptidaseA

C carbonicanhydrase

B alcoholdehydrogenase

D succinatedehydrogenase

97. Notan Notaniron ironcon contain tainingp ingprot rotein: ein: A lactoferrin

C hemosiderin

B transferrin

D ceruloplasmin

98. Onemo Onemoleculeof leculeofglucose glucoseform formationf ationfrom rompyru pyruvate vaterequire requires s A 6ATP,4GTP,and2NADH

C 4ATP,2GTP,and2NADH

B 2ATP,2GTP,and1NADH

D 2ATP,2GTP,and1NADH


- 13 -

Series I-C

Model Paper

Biochemistry

99. Hypophosphatem Hypophosphatemiaisseen iaisseeninallofth inallofthefollowingco efollowingconditionsex nditionsexcept: cept: A respiratoryalkalosis

C metabolicalkalosis

B malabsorption

D alcoholabuse

100. Pickthecorr Pickthecorrectp ectpathway athwayof ofhem hemoglobindegr oglobindegradation adationfrom fromthe thegivenbe givenbelow: low: A Heme->hb->biliverdin-> bilirubin->stercobilinogen-> urobilinogen

C Heme->hb->urobilinogen-> biliverdin->bilirubin-> stercobilinogen

B Hb->heme->biliverdin-> bilirubin->urobilinogen-> stercobilinogen

D Hb->heme->bilirubin-> biliverdin->urobilinogen-> stercobilinogen


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Series I-C

Model Paper

Biochemistry

Disclaimer:Everyattempthasbeenmadetovalidateeachandevery Disclaimer:Everyattempthasbeenmadetovalidateeachandevery question/answers.Anyremainingerrorisregretted.Authorwillnotbeheldresponsible foranyerrors.Pleaseconsultstandardtextbooksgiveninthereferencesectionforany discrepancy.Questionswithwronganswersmaybetterbeleftunattempted/ unanswered.ThisisapracticeMCQseriesinBiochemistryavailablefreetodownload designedforthebenefitofprospectivePGcandidatesandUGmedicalstudents. ReferenceTextbooks: 1.PrinciplesofBiochemistry,Lehninger4thEdition 2.StryerBiochemistry,5thEdition,Berg,TymoczkoandStryer 3.Lippincott'sIllustratedReviews:Biochemistry,Harvey&Ferrier,5thEdition


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MCQs in Clinical Biochemistry

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