Tuga Tugass Mata Mata Ku Kuli liah ah
: KTO KTO
Dosen Pengajar Pengajar
: Ibu Suhartatik, Suhartatik, S.Kep, Ns, M.Kes M.Kes
MAKALAH KETERGANTUNGAN OBAT “ Morfin“
Disusun oleh: ABDUL RAJAK SYAFAR NH0111 013 A1
PROGRAM STUD LMU K!P!RA"ATAN S!KOLAH TNGG LMU K!S!HATAN NAN HASANUDDN MAKASSAR #01$
1
KATA PENGANTAR
Alh%&'ulill%h( )u*i '%n s+u,u- s%+% )%n*%.,%n ,eh%'i-%. All%h S"T +%n/ .el%h &e&e-i,%n -%h&%. se-.% ,%-uni%N+% sehin//% s%+% e-h%sil &en+eles%i,%n &%,%l%h ini .e)%. )%'% 2%,.un+% M%,%l% M%,%l%h h ini 'iu%. 'iu%. un.u, un.u, &e&enu &e&enuhi hi s%l%h s%l%h s%.u .u/%s &%.% ,uli%h ,uli%h KTO KTO D%l%& D%l%& &%,%l%h ini %,%n 'i%h%s &en/en%i &en/en%i Mo-4in S%+% &en+%'%-i &en+%'%-i %h2% &%,%l%h ini &%sih *%uh '%-i se&)u-n%( oleh ,%-en% i.u ,-i.i, '%n '%n s%-% s%-%n n '%-i '%-i se&u se&u%% )ih% )ih%, , +%n/ %n/ e-s e-si4 i4%. %. &e& &e&%n %n/u /un n sel% sel%lu lu s%+ s%+% h%-% h%-%), ),%n %n 'e&i 'e&i ,ese&)u-n%%n &%,%l%h ini A,hi- ,%.%( s%+% s%&)%i,%n .e-i&% ,%sih ,e)%'% se&u% )ih%, +%n/ .el%h e-)e-%n se-.% '%l%& )en+usun%n )en+usun%n &%,%l%h ini '%-i %2%l s%&)%i %,hi- Se&o/% All%h S"T sen%n.i%s% sen%n.i%s% &e-i'hoi se/%l% us%h% ,i.% A&in
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b!ul "ajak S#afar
DAFTAR ISI 2
K%.% Pen/%n.%- Pen/%n.%- # # D%4.%- si si 3 3 BAB : P!NDAHULUAN A L%.%- Bel%,%n/ Bel%,%n/ $ $ B Ru&us%n M%s%l%h M%s%l%h $ $ 6 Tu*u%n Penulis%n Penulis%n 7 7 BAB : P!MBAHASAAN A Pen/e-.i%n Pen/e-.i%n &o-4in88 &o-4in8888888 88888888888 888888888888 888888888888 8888885 5 B Si4%. '%n -u&us -u&us %n/un %n/un '%-i &o-4in888 &o-4in88888888 88888888888 88888888889 88889 6 A.u-%n )en//un%%n )en//un%%nn+% n+% &o-4in88 &o-4in88888888 888888888888 88888888888 888888 8 D !4e, '%-i '%-i &o-4in888 &o-4in888888888 88888888888 88888888888 88888888888 88888; ; ! T%n'% '%n /e*%l%8888888 /e*%l%8888888888888 888888888888 888888888888 88888810 10 F Pen
BAB I PENDAHULUAN 3
. $atar %elakang
N%-,o.i,% %'%l%h =%. %.%u o%. +%n/ e-%s%l '%-i .%n%&%n %.%u u,%n .%n%&%n( %i, sin.e.is &%u)un se&i sin.e.is +%n/ '%)%. &en+e%,%n )enu-un%n %.%u )e-u%h%n ,es%'%-%n( hil%n/n+% -%s% n+e-i '%n '%)%. &eni&ul,%n ,e.e-/%n.un/%n >Un'%n/Un'%n/ No ## .%hun 1;;9? Y%n/ .e-&%su, *enis n%-,o.i,% %'%l%h .%n%&%n )%)%@e-( o)iu& &en.%h( o)iu& &%s%, ><%n'u( *i
Su*u'i( 1;;7?
%. "u&usan Masalah Masalah
A/%A/%- )enu )enuli lis%n s%n &%,%l &%,%l%h %h .i'% .i'%, , &en+ &en+i& i&)%n )%n/ / '%-i '%-i .u*u .u*u%n %n se&ul se&ul%( %( &%,% &%,% )enu )enuli liss &e-u&us,%n &%s%l%h )%'% : 1 Men*el% Men*el%s,% s,%n n .en.%n .en.%n/ / )en/e)en/e-.i% .i%n n &o-4in &o-4in # Men/i'en.i4i Men/i'en.i4i,%si ,%si si4%. si4%. '%n '%n -u&us -u&us %n/un %n/un '%-i &o-4in &o-4in 3 B%/%i& B%/%i&%n% %n% %.u-%n %.u-%n )en//u )en//un%% n%%nn+ nn+%% $ A)% A)% e4e, e4e, '%'%-ii o%. o%. .e-s .e-se eu. u. 7 B%/% B%/%i& i&%n %n%% .%n' .%n'%% '%n '%n /e*% /e*%l% l% 5 B%/%i& B%/%i&%n% %n% )en< )en
4
'. Tujuan
1 Tu*u% *u%n U& U&u& Un.u, &en/e.%hui .en.%n/ &o-4in # Tu*u Tu*u%n %n Khu Khusus sus 1 Men*el% Men*el%s,% s,%n n .en.%n .en.%n/ / )en/e)en/e-.i% .i%n n &o-4in &o-4in # Men*el% Men*el%s,% s,%n n .en.%n/ .en.%n/ Si4%. Si4%. '%n '%n -u&us -u&us '%-i &o-4 &o-4in in 3 Men*el% Men*el%s,% s,%n n .en.%n .en.%n/ / %.u-%n %.u-%n )en// )en//un% un%%n %n $ Men*el% Men*el%s,% s,%n n .en.%n .en.%n/ / e4e, '%-i '%-i o%. o%. .e-se .e-seu. u. 7 Men*el% Men*el%s,% s,%n n .en.% .en.%n/ n/ .%n' .%n'%% '%n '%n /e*%l /e*%l%% 5 Men*el% Men*el%s,% s,%n n .en.%n/ .en.%n/ )en
BAB II 5
PEMBAHASAAN
A. Peng Penger erti tian an
Mo-4in
&e-u)%,%n
)-o.o.i)e
'%-i
/olon/%n
o)ioi'
+%n/
)-e@%lensi
)en+%l%h/un%%nn+% .in//i ,%-en% &o-4in %n+%, 'i/un%,%n 'i ,lini, se%/%i standard gold un.u, un.u, %n%l/e %n%l/esi, si, Sel%in Sel%in i.u &o-4in &o-4in &e&ili, &e&ili,ii e4e, eu4o-i eu4o-i%( %( -%s% -%s% 2%s)%'% 2%s)%'%(( -%s% n+%&%n n+%&%n(( )enu-un%n &o.ili.%s s%lu-%n Dalam jurnal Junaidi Khotib(1), Daning Irawati(2), Pagan Pambudi(3),
Toetik
r!ani(1)
" Prospek
Tipikal
ntagonis
Dopa&in
Sebagai
Penanggulangan
Ketergantungan Morfin # bagian Ilmu $iomedik $iomedik %armasi(1), %armasi(1), &ahasiswa '1(2), &ahasiswa &ahasiswa '2(3) %akultas
%armasi niersitas irlangga )
Mo-4in Mo-4in &e-u)% &e-u)%,%n ,%n %l,%lo %l,%loi'% i'% +%n/ +%n/ .e-'%) .e-'%)%. %. '%l%& '%l%& o)iu& o)iu&<%n <%n'u 'u +%n/ +%n/ e-%s%l e-%s%l '%-i '%-i .%n%&%n )%)%@e- so&ni4e-u& L Bil% 'i/un%,%n '%)%. &eni&ul,%n ,e.e-/%n.un/%n 4isi,( )si,is '%n .ole-%nsi sehin//% )en//un%%n '%l%& '%l% & )en/o%.%n s%n/%. 'i%.%si '%n &e-u)%,%n )ilih%n o%. .e-%,hi- Mo-4in e-u)% se-u, e-2%-n% )u.ih( 'i/un%,%n '%l%& )en/o%.%n un.u, un.u, &en/hi &en/hil%n l%n/,% /,%n n -%s% n+e-i n+e-i +%n/ +%n/ %&%. %&%. s%n/%. s%n/%. )%'% )%'% )en'e)en'e-i.% i.% ,%n,e,%n,e-(( o)e-%si o)e-%si '%n se%/%in+%( )e&e-i%n &o-4in ,e)%'% )%sien su'%h '%l%& en.u, sus.%ine' -ele%se .%le. >D%l%& *u-n%l Muhammad Taui!"#$ Ba%u!i &ir'(%ent(n()$ *u+ni Erma, - DETEKSI NARKOTIKA ENI ENIS S /ANN /ANNAB ABIN INOL OL DAN DAN MORF MORFIN IN DARI DARI SAMP SAMPEL EL URIN URINE E PENG PENGGU GUNA NA NARK NARKOT OTIK IKA A 0
1&ahas 1&ahasisw iswa a '3 Kimia Kimia nier niersita sitass 'umate 'umatera ra tara tara 2Dosen 2Dosen %&IP %&IP Kimia Kimia nier niersita sitass 'umate 'umatera ra tara tara 3Kasubbid *arkoba +aboratorium %orensik Polri abang &edan)
Mo-4in '%l%& %h%s% %sin/ 'i,en%l se%/%i &o-)hine %.%u &o-)hiu& 6%n'u +%n/ %i, &en/%n'un/ ;1$ E &o-4in Mo-4in 'i)e-oleh '%-i <%n'u 'en/%n <%-% e,s.-%si Mo-4in %'%l%h su%.u %&in% .e-sie-( .e-sie-( +%n/ s.-u,.u- ,i&i%n+% ,i&i%n+% &en/%n'u &en/%n'un/ n/ seu%h seu%h -%'i,%l -%'i,%l hi'-o,si hi'-o,si %l,oholi, '%n seu%h -%'i,%l hi'-o,si 4enoli, R%'i,%l 4enoli, inil%h +%n/ &en+e%,%n &o-4in '%)%. l%-u. '%l%& %l,%li '%n 'en/%n l%-u.%n 4e--i ,lo-i'% &e&en.u, sen+%2% +%n/ e-2%-n% > D%&in Su&%-'*o #005?
Mo-4in %.%u &o-4in% &e-u)%,%n %l,%loi' %n%l/esi, +%n/ s%n/%. ,u%. '%n &e-u)%,%n &e-u)%,%n %/en %,.i4 u.%&% +%n/ 'i.e&u,%n )%'% o)iu& Mo-4in% e,e-*% l%n/sun/ )%'% sis.e& s%-%4 )us%. un.u, &en/hil%n/,%n -%s% s%,i. !4e, s%&)in/ &o-4in% %n.%-% l%in %'%l%h )enu-un%n
6
,es%'%-%n( ,es%'%-%n( eu4o-i%( -%s% ,%n.u,( ,%n.u,( lesu( '%n )en/lih%.% )en/lih%.%n n ,%u- ,%u- Mo-4in% Mo-4in% *u/% &en/u-%n/i &en/u-%n/i -%s% l%)%-( &e-%n/s%n/ %.u,( '%n &e+e%,%n ,ons.i)%si
Mo-4in %'%l%h h%sil ol%h%n '%-i o)iu& %.%u <%n'u &en.%h '%n &e-u)%,% %l,%loi'% +%n/ +%n/ .e-'%)% .e-'%)%.. '%l%& '%l%& o)iu& o)iu& e-u)% e-u)% se-u, se-u, )u.ih )u.ih Konsu& Konsu&si si &o-4in &o-4in i%s%n i%s%n+% +% 'il%,u 'il%,u,%n ,%n 'en/%n <%-% 'ihis%) %.%u 'isun.i,,%n K%-en% &o-4in .e-/olon/ '%l%& *enis 'e)-es%n( &%,% i% e,e-*% 'en/%n <%-% &ene,%n susun%n s+%-%4 )us%.( &en+e%,%n .u-unn+% %,.i4i.%s neu-on( )usin/( )e-u%h%n )e-%s%%n '%n ,es%'%-%n e-,%lu. Konsu&si &o-4in se<%-% ,on.in+u &e&ili,i -esi,o .in//i e-u*un/ ,e&%.i%n
B. Siat Siat dan dan rumu rumu%% dari dari m(r m(rin in
Mo-4in &e&)un+%i li&% )us%. %si&e.-i, >,%-on 7(5(;(13( '%n 1$?( .e.%)i h%n+% 15 > )%s%n/%n -%se&i, 'i%s.e-eoiso&e-? 'i%s .e-eoiso&e-? '%n u,%n 3# >#7? iso&e- +%n/ &un/,in( ,%-en% %.o& 10 '%n 1# h%-us -is( -is( *%'i 1(3'i%,si%l( 1(3'i%,si%l( 'i%n'in/ 'i%n'in/,%n ,%n .e-h%'%) .e-h%'%) D? S.e-eo,i&i% S.e-eo,i&i% -el%.i4 )%'% ,eli&% )us%. i.u 'i-e'u,si se<%-% .e)%. oleh S.o-, )%'% .%hun 1;7# Pe-is.il%h%n ,l%si, >&is%ln+% &o-4in( ,o'ein? 'i/%n.i,%n oleh .%.%n%&% sis.e&i, +%n/ 'i'%s-,%n )%'% in.i &o-4in%n 'en/%n &e&)e-.%h%n,%n sis.e& )eno&o-%n 4en%n.-en J%'i &o-4in se,%-%n/ 'iseu. >emi-a emi-all
bstra bstra-t -t ?
19&e. 19&e.il9 il9( ('i' 'i'ehi ehi'-o '-o$(7 $(7e e)o, )o,si& si&o-4i o-4in%n n%n3( 3(5 5'io 'ioll
'i&%n% 'i&%n%
&enun*u,% &enun*u,%n n o-ien.%si o-ien.%si trans .e-h%'%) trans .e-h%'%) *e&%.%n 17( 15( 19 +%n/ e-huun/%n 'en/%n sis.e&
Sin.esis .o.%l &o-4in )e-.%&% ,%li 'i)%)%-,%n oleh G%.es '%n Tsehu'i >1;7#1;75? '%n oleh !l%' '%n Ginsu-/ >1;7$? H%l ini &ene/%s,%n hi)o.esis RoinsonS.o-, Bee-%)% sin.esi l%in +%n/ %i, &en+usul .e.%)i .%, s%.u )un sin.esis .o.%l '%)%. e-s%in/ se<%-% '%/%n/ 'en/%n 'en/%n h%sil su&e- %l%&i Pe&u,.i Pe&u,.i%n %n l%n/sun/ l%n/sun/ .en.%n/ s.e-eo,i&i% s.e-eo,i&i% -el%.i4 -el%.i4 )%'% ,%-on ,%-on 7(5(; '%n 13 'ie-i,%n oleh R%)o)o-. >1;701;73? )e-in1$?( 'ie-i,%n )%'% .%hun .%hun 1;77 1;77 &el%lu &el%luii .el%%h .el%%h 'i4-%, 'i4-%,si si sin%- sin%- K-is.%l K-is.%l .un//% .un//%ll .en.%n .en.%n/ / /%-%& /%-%& &o-4in &o-4in +%n/ +%n/ 'il%) l%)o-,%n
oleh
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Si4%. '%n -e%,si &o-4in se%/%i %l,%loi' e-si4%. %s% ,%-en% &en/%n'un/ /u/us %&in .e-sie- >)K% (1? '%n &e&en.u, /%-%& e-en.u, K-is.%l 'en/%n se'e-e.%n %s%& Y%n/ 'i/un% 'i/un%,%n ,%n %'%l%h %'%l%h /%-%& /%-%& hi'-o, hi'-o,si' si'%% +%n/ +%n/ &en/%n &en/%n'un 'un/ / .i/% .i/% &ole, &ole,ul ul %i- K-is.%l K-is.%l > &o-4in &o-4in hi'-o,si'% )H( !u-? Be-'%s%-,%n /u/us hi'-o,sil 4enoln+% &o-4in *u/% e-si4%. %s%& > )K% ;(;? '%n e-e%,si 'en/%n %l,%lihi'-o,si'% &e&en.u, 4enol%.( .e.%)i .i'%, e-e%,si 'en/%n l%-u.%n l%-u.%n %&&oni %&&oni% % Ti.i, Ti.i, isolis. isolis.-i, -i, .e-le.% .e-le.%, , )%'% )%'% )H ; Mo-4in Mo-4in +%n/ +%n/ .e-'%) .e-'%)%. %. '%l%& '%l%& %l%& &e&u.%- i'%n/ )ol%-is%si ,e ,i-i
/. Atura Aturan n 1engg 1engguna unaan an
Mo-4in 'i/un%,%n un.u, &en/h%&%. n+e-i +%n/ )%lin/ ,u%. Dosis %n%l/e.i, )%'% )en//un%n +%n/ 'iu.%&%,%n( +%i.u su,u.%n( %'%l%h 10 &/ )%'% 'osis ,e,e-*% %n.i.usi4? Pus%. -es)i-%si *u/% 'ih%&%. >,e-*%'e)-esi )%'% -es)i-%si? H%l ini .e-lih%. '%l%& -en.%n/ 'osis .e-%)i '%n )%'% 'osis +%n/ leih .in//i( %,hi-n+% &en+e%,%n ,elu&)uh%n )e-n%)%s%n !4e, sel%n*u.n+%( +%n/ &en+%n/,u. SSP +%i.u se'%si '%n )%'% se%/i%n )%sien eu)ho-i% Be-.%li%n e-%. 'en/%n ini( %'% ,e&un/,in%n un.u, &en/e&%n/,%n ,e.e-%n/%n )%'% &o-4in >,e.e-/%n.un/%n )si,is '%n 4isi, +%n/ ,u%.( )en/e&%n/%n .ole-%nsi '%n 'o-on/%n un.u, &en%i,,%n 'osis? Sel%in i.u( &o-4in *u/% &e&)un+%i si4%. &e-%n/s%n/ se<-% sen.-%l H%l ini &e-u)%,%n h%sil '%-i se-/%)%n )%'% %/i%n sen.-%l )%-%si&)%.i,us '%n %n.%-% l%in 'i2u*u',%n se%/%i &iosis Ke-*% s.i&ul%si ,e-*% '%-i %n%l/e.i,% *enis &o-4in( '%)%. 'i%&%.i se<%-% ,h%s )%'% &en
os.i os.i)% )%si si s)%s s)%s.i .i, , Se% Se%li li,n ,n+% +%(( o)iu o)iu& & +%n/ +%n/ '%)% '%)%.. 'i/u 'i/un% n%,% ,%n n un.u un.u, , &e-e' &e-e'%, %,%n %n usus usus(( &en+e%,%n os.i)%si o.oni, ,%-en% &en/%n'un/ )%)%@e-in
Mo-4in e,e-*% l%n/sun/ )%'% sis.e& s%-%4 )us%. un.u, &en/hil%n/,%n s%,i. !4e, s%&)in s%&)in/ / &o-4in &o-4in %n.%-% %n.%-% l%in %'%l%h %'%l%h )enu-u )enu-un%n n%n ,es%'% ,es%'%-%n -%n(( eu4o-i eu4o-i%( %( -%s% ,%n.u, ,%n.u,(( lesu( lesu( '%n )en/lih%.%n ,%u- Mo-4in *u/% &en/u-%n/i -%s% l%)%-( &e-%n/s%n/ %.u,( '%n &e+e%,%n ,ons.i)%si Mo-4in &eni&ul,%n ,e.e-/%n.un/%n .in//i 'i%n'in/,%n =%.=%. l%inn+% P%sien &o-4in *u/% 'il%)o-,%n &en'e-i.% inso&ni% '%n &i&)i u-u,
D%l%& )en/o%.%n ,linis( &o-4in 'i%n//%) se%/%i s.%n'%- e&%s( %.%u )%.o,%n( '%-i %n%l/esi, 'i/un%,%n un.u, &e-in/%n,%n )en'e-i.%%n e-%. %.%u s%,i. '%n )en'e-i.%%n Se)e-.i o)iu& l%in( &is%ln+% o,si,o'on >O+6on.in( Pe-Dil%u'i'( P%ll%'one?( '%n 'i% he-oin ?( &o-4in l%n/sun/ &e&)en/%-uhi )%'% sis.e& s%-%4 s%-%4 )us%. )us%. >SSP? >SSP? un.u, un.u, &e-in/ &e-in/%n, %n,%n %n -%s% s%,i. Mo-4in Mo-4in &e&ili, &e&ili,ii )o.ens )o.ensii .in//i .in//i un.u, un.u, ,e<%n'u%n ( .ole-%nsi '%n )si,olo/is ,e.e-/%n.un/%n e-,e&%n/ 'en/%n
D. Ee! Ee! dari dari M(r M(ri in n
1 !4e, !4e, s%&)in/ s%&)in/ +%n/ 'i.i&u 'i.i&ul,% l,%n n Men/%l Men/%l%&i %&i )el%& )el%&%.%n %.%n '%n ,e,%<%u ,e,%<%u%n %n )%'% s%%. e-i<%-%( ,e-us%,%n )en/lih%.%n )%'% &%l%& h%-i( &en/%l%&i ,e-us%,%n )%'% li@e'%n /in*%l( )enin/,%.%n -esi,o .e-,en% @i-us H '%n he)%.i.is '%n )en+%,i. in4e,si l%inn+% &el%lui *%-u& sun.i, '%n )enu-un%n h%s-%. '%l%& huun/%n se( ,ein/un/%n '%l%& i'en.i.%s se,su%l( ,e&%.i%n ,%-en% o@e-'osis # !4e, !4e, u&u& u&u& %n.% %n.%-% -% l%in l%in : % Penu Penu-u -un% n%n n ,es% ,es%'% '%-% -%n n !u)ho-i% >-%s% /e&i-% lu%- i%s%? -%s% inil%h +%n/ se-in/ 'i<%-i oleh )en+%l%h/un% &o-4in < R%s% ,%n. ,%n.u,( u,( lesu lesu(( '%n )en/ )en/lih lih%.%n %.%n ,%u ,%u- - ' Mo-4 Mo-4in in *u/% *u/% &en/u en/u-% -%n/ n/ii -%s% -%s% l%)% l%)%-( -( &e-% &e-%n/ n/s% s%n/ n/ %.u %.u,( ,( '%n '%n &en+ &en+e e% %,% ,%n n ,ons.i)%si e Mo-4in &eni&ul,%n &eni&ul,%n ,e.e-/%n.un ,e.e-/%n.un/%n /%n .in//i( .in//i( inso& inso&ni% ni% '%n &i&)i &i&)i u-u, u-u, 4 R%s% %.inn %.inn+% +% +%n/ +%n/ .e-.e .e-.e,%n ,%n >'e)-e >'e)-esi? si? hil% hil%n/ n/ / D%+% ,onsen.-% ,onsen.-%si si )i,i-%n )i,i-%n .e-/%n//u .e-/%n//u &en+e &en+e%,%n %,%n su,%su,%- e-)i,ie-)i,i- '%n '%n %)%.is %)%.is 9
h Pu)i Pu)ill &%.% &%.% &en+ &en+e& e&)i )i.. > )in )in )oin )oin.. )u)i )u)ill ?( .e,% .e,%n% n%n n '%-%h '%-%h .u-un .u-un(( 'en+ 'en+u. u. n%'i n%'i l%&%.( suhu %'%n se'i,i. &enu-un( '%n o.o.o.o. &en*%'i le&%h i
Pe&% Pe&%,% ,%ii &o-4i &o-4in n %,%n %,%n &e-% &e-%s% s% &ulu &ulu.n .n+% +% ,e-i ,e-in/ n/(( seluselu-uh uh %'%nn %'%nn+ +% h%n/ h%n/%. %.(( '%n '%n %n//o.% %'%n .e-%s% e-%.(
*
M%l%s e-/e-%, '%n i<%-% <%'el
, P%'% o-%n/ o-%n/ +%n/ +%n/ elu& )e-n%h &e&%,%i &e&%,%i &o-4in &o-4in %.%u o)ioi'% o)ioi'% )%'% )%'% u&u&n+ u&u&n+%% se-.% se'%n/ .i'%, &en'e-i.% su%.u -%s% n+e-i( '%)%. .i&ul -e%,si +%n/ e-l%2%n%n( +%i.u .i&uln+% )e-%s%%n .i'%, en%, >'is4o-i%? +%i.u -%s% '%n >'%n *u/% o)ioi' o)ioi' )%'% u&u&n u&u&n+%? +%? -el%.i4e -el%.i4e sele,.i4( sele,.i4( +%,ni +%,ni .i'%, .i'%, e/i.u &e&)en/%-uhi unsu- senso-is l%in( +%i.u -%s% -%%( -%s% /e.%- >@i-%si?( )en/lih%.%n '%n )en'en/%-%n %h,%n )e-se)si n+e-i )un .i'%, sel%lu hil%n/ se.el%h )e&e-i%n &o-4in 'osis .e-%)i $ !4e, %n%l/esi, %n%l/esi, &o-4in &o-4in .i&ul .i&ul e-'%s%-, e-'%s%-,%n %n 3 &e,%nis&e &e,%nis&e % Mo-4in Mo-4in &enin &enin//i //i,%n ,%n %&%n %&%n/ / -%n/s%n -%n/s%n/ / n+e-i n+e-i Mo-4in '%)%. &e&)en/%h%-ui e&osi( %-.in+% &o-4in '%)%. &en/u%h -e%,si +%n/ .i&ul 'i,o-.e,s se-e-i )%'% 2%,.u )e-se)si n+e-i 'i.e-i&% oleh ,o-.e,s se-e-i '%-i .h%l%&us < Mo-4 Mo-4in in &e&u' e&u'%h %h,% ,%n n .i'u .i'u-- '%n '%n )%'% )%'% 2%,. 2%,.u u .i'u .i'u-- %&% %&%n/ n/ -%n/ -%n/s% s%n/ n/ n+en+e-ii &enin/,%.
E. Tand Tanda a dan dan ge'a ge'a+a +a
Un.u, /e*%l% +%n/ 'i.i&ul, 'i.i&ul,%n %n %,i%. %,i%. )e&%,%i%n )e&%,%i%n Mo-4in +%n/ +%n/ 'ihen.i,%n 'ihen.i,%n >/e*%l% )u.us o%.? se<%-% &en'%'%, )%'% )e<%n'u +%i.u %,%n &en/%l%&i S+n'-o&% As.inensi%( +%i.u /e*%l% +%n/ .i&ul ,%-en% )e&%,%i%n o%. +%n/ 'ihen.i,%n se<%-% &en'%'%,
S+n'-o&% As.inensi% %,%n &unu%n/ %i- es%- 50 ,%li seh%-i? Ke-in/%. %,%n ,elu% e-
sel%&% 910 h%-i ( ,e&un/,in%nn+% %'% 'u% Se&uh .o.%l 'en/%n 'ise-.%i -%s% ,%)o, un.u, &e&%,%in+% l%/i %.%u &enin//%l 'uni%
Sel%in /e*%l% S+n'-o&% As.inensi%( %'% /e*%l% l%in +%n/ leih u&u& 'i.un*u,,%n oleh )e<%n'u +%n/ &en/%l%&i &en/%l%&i /e*%l% )u.us o%.)en/he o%.)en/hen.i%n n.i%n )en//un%%n )en//un%%n Mo-4in se<%-% &en'%'%, +%i.u Ke-in/%. e-leih( ,e*%n/ o.o.( &en//i/il( /elis%h( &en/u%)( .i'u- .e-/%n//u( le,%s &%-%h(
F. Pen2e Pen2egah gahan an dan dan 1eng(3 1eng(3ata atan n
". Dengan (IPNOT)"PI : Un.u, Un.u, )e<%n' )e<%n'u u n%-,o n%-,o%% +%n/ +%n/ &%sih &%sih .e-/%n .e-/%n.un .un/ / se<%-% se<%-%
iolo/is .e-h%'%) =%. %'i,.i4 .e-.en.u( se%i,n+% &en/i,u.i hi)no.e-%)i 'i%2%h )en/%2%s%n 'o,.e- Mes,i)un 'en/%n )e&-o/-%&%n )i,i-%n is% &e&u%. )e<%n'u n%-, n%-,o o%% >Mo-4i >Mo-4in n '%n '%n se*en se*enis is? ? &en* &en*%' %'ii s%&% s%&% se,%l se,%lii .i'% .i'%, , in/i in/in n '%n '%n .i'% .i'%, , &%u &%u &en/,o &en/,onsu nsu&si &si n%-,o n%-,o%% l%/i l%/i '%l%& '%l%& se,%li se,%li .e-%)i( .e-%)i( n%&un n%&un &en/he &en/hen.i n.i,%n ,%n ,onsu& ,onsu&si si n%-,o n%-,o%% se<%-% se<%-% &en'%' &en'%'%, %, &un/,i &un/,in n is% is% &en+e &en+e%, %,%n %n ,e&%.i% ,e&%.i%n n M%,% M%,% &in.%l% &in.%l%h h )en'%)%. 'o,.e-( %)%,%h leih %i, hi)no.e-%)i un.u, &e&u%. )e<%n'u se'i,i. 'e&i se'i,i se'i,i.. &enin/ &enin//%l, /%l,%n %n n%-,o n%-,o%( %( %.%u %.%u se,e.i, se,e.i,%% e-hen e-hen.i .iSe, Se,%li %li l%/i( l%/i( %)%)un %)%)un *enis *enis ,e<%n' ,e<%n'u%n u%n +%n/ +%n/ 'i %l%&i( %l%&i( )e<%n' )e<%n'u u h%n+% h%n+% is% is% e-u% e-u%h h .o.%l .o.%l 'en/%n 'en/%n hi)no. hi)no.e-%) e-%)ii %)%il% )e
Me.%'on 'i/un%,% 'i/un%,%n n '%l%& '%l%& )e-%2%. )e-%2%.%n %n ). Dengan Therap# "u&atan Metha!on : Me.%'on ,e<%n' ,e<%n'u%n u%n &o-4in &o-4in Me.h%' Me.h%'one one %'%l%h %'%l%h s%-%n% s%-%n% )en/%l )en/%lih% ih%n n %.%u %.%u su.i. su.i.usi usi %/i %/i )%-% )%-% Pe<%n'u Pe<%n'u n%)=% n%)=%
+%n/ Ke.e-/%n Ke.e-/%n.un/% .un/%n n O)i%. %.%u %.%u Mo-4in Mo-4in Me.h%'one Me.h%'one &e&)un+ &e&)un+%i %i
e4e, .ole-%nsi sil%n/ +%n/ %i, 'en/%n /olon/%n o)ioi' l%inn+% se)e-.i he-oin %.%u &o-)hine '%n oleh ,%-en%n+% &e.h%'one
un.u, un.u, &en/,onsu& &en/,onsu&si si sus.%nsi sus.%nsi he-oin( he-oin( &o-4in &o-4in %.%u o%. se*enisn+% se*enisn+% &el%lui sun.i,%n sun.i,%n *u/% %,%n e-,u-%n/
G. /ara 1em3erian 1em3erian a%uhan a%uhan !e1era4atan !e1era4atan 1ada 1ada 1engguna 1engguna m(rin m(rin *. Pengkajian
Fisi, D%.% 4isi, +%n/ &un/,in 'i.e&u,%n )%'% ,lien 'en/%n )en//un%%%n NAPA )%'% s%%. )en/,%*i%n %'%l%h se%/%i e-i,u. : N+e-i( /%n//u%n )ol% .i'u-( &enu-u &enu-unn+ nn+%% sele-% sele-% &%,%n( &%,%n( ,ons.i) ,ons.i)%si( %si( 'i%-e( 'i%-e( )e-il% )e-il%,u ,u se,s &el%n/ &el%n//%/%- no-&%( no-&%( ,e&un' ,e&un'u-%n u-%n '%l%& '%l%& ,ee-si ,ee-sih%n h%n 'i-i( 'i-i( )o.ensi )o.ensi%l %l ,o&)li ,o&)li,%si ,%si ( *%n.un *%n.un/( /( h%.i h%.i 's 's n4e,si )%'% )%-u)%-u Se'%n/,%n s%s%-%n +%n/ in/in 'i<%)%i %'%l%h %/%- ,lien &%&)u un.u, .e-%.u- '%l%& )ol% hi'u)n+%
!&osion%l Pe-%s%% Pe-%s%%n n /elis%h /elis%h >.%,u. >.%,u. ,%l%u ,%l%u 'i,e.% 'i,e.%hui hui?( ?( .i'%, .i'%, )e-<%+ )e-<%+%% 'i-i( 'i-i(
Sosi%l Lin/ Lin/,u ,un/ n/%n %n sosi% sosi%ll +%n/ +%n/ i%s i%s%% %,-% %,-% 'en/ 'en/%n %n ,lie ,lien n i%s% i%s%n+ n+%% %'%l %'%l%h %h .e&%n .e&%n )en//un% =%.( %n//o.% ,elu%-/% l%in )en//un% =%.( lin/,un/%n se,ol%h %.%u ,%&)us +%n/ 'i/un%,%n oleh )%-% )en/e'%-
n.ele,.u%l Pi,i-%n +%n/ sel%lu in/in &en//un%,%n =%. %'i,i.i4( )e-%s%%n -%/u un.u, e-hen.i( %,.i@i.%s se,ol%h %.%u ,uli%h &enu-un s%&)%i e-hen.i( )e,e-*%%n .e-hen.i S%s%-%n +%n/ in/in 'i<%)%i %'%l%h %/%- ,lien &%&)u un.u, ,onsen.-%si '%n &enin/,%.,%n '%+% )i,i- ,e h%lh%l +%n/ )osis.i4
S)i-i.u%l Ke/i%.%n ,e%/%&%%n .i'%, %'%( nil%inil%i ,e%i,%n 'i.in//%l,%n ,%-en% )e-u%h%n )e-il%,u >.i'%, *u*u-( &en
Kelu%-/% Ke.%, Ke.%,u. u.%n %n %,%n %,%n )e-i )e-il% l%,u ,u ,lie ,lien( n( &%lu &%lu )%'% )%'% &%s+ &%s+%-% %-%,% ,%.( .( )en/ )en/h% h%& &uu-%n %n '%n '%n )en/u-%s%n se<%-% e,ono&i oleh ,lien( ,o&uni,%si '%n )ol% %suh .i'%, e4e,.i4( 'u,un/ 'u,un/%n %n &o-il &o-il .e-h%'% .e-h%'%) ) ,lien ,lien .i'%, .i'%, .e-)enu .e-)enuhi hi S%s%-% S%s%-%n n +%n/ +%n/ hen'%, hen'%, 'i<%)% 'i<%)%ii %'%l%h ,elu%-/% &%&)u &e-%2%. ,lien +%n/ )%'% %,hi-n+% &en<%)%i .u*u%n u.%&% +%i.u &en/%n.isi)%si .e-*%'in+% ,e,%&uh%n >-el%)s?
+. Diag Diagno nosa sa Ke Kepe pera raa ata tan n
% Ko)i Ko)in/ n/ in'i in'i@i @i'u 'u .i'% .i'%, , e4e, e4e,.i .i44 ' ' .i'% .i'%, , &%&) &%&)u u &en/ &en/%. %.%s %sii ,ein ,ein/i /in% n%n n &en//un%,%n =%. %'i,.i4 Dis.-ess s)i-i.u%l ' ,u-%n/n+% )en/e.%hu%n < Pe-u% Pe-u%h%n h%n )e&e )e&elih lih%-%% %-%%n n ,eseh% ,eseh%.%n .%n '%n '%n ADL ADL ' Ko)in/ Ko)in/ ,elu%-/ ,elu%-/%% .i'%, .i'%, e4e,.i4 e4e,.i4 ' ' )ol% )ol% %suh %suh +%n/ +%n/ s%l%h s%l%h e G%n//u%n G%n//u%n ,es%'%-%n ,es%'%-%n so&nolen. so&nolen. ' ' in.o,si, in.o,si,%si %si o%. se'%.i@e se'%.i@e hi)no.i, hi)no.i,
-. Interensi
in'i@i'u .i'%, e4e,.i4 ' .i'%, .i'%, &%&)u &en/%.%si &en/%.%si D5 Ke1era4atan " : Ko)in/ in'i@i'u ,ein/in%n &en//un%,%n =%. %'i,.i4 Tu'uan- ,lien &%&)u un.u, &en/%.%si ,ein/in%n &en//un%,%n =%. %'i,.i4 Inter6en%i *. In!ii!u
%? 'en.i4i,%si 'en.i4i,%si si.u%si +%n/ &en+e%,% &en+e%,%n n .i&uln+ .i&uln+%% su/es.i su/es.i ? 'en.i4i,%si )e-il%,u ,e.i,% su/es.i '%.in/ Dis,usi,%n Dis,usi,%n <%-% <%-% &en/%lih, &en/%lih,%n %n )i,i-%n )i,i-%n '%-i '%-i su/es.i su/es.i +%n/ +%n/ leih leih )osi.i4 )osi.i4 '? B%n.u B%n.u ,lien ,lien &en/e,s) &en/e,s)-esi -esi,%n ,%n )e-%s%% )e-%s%%nn+ nn+%%
+. Kelo&pok
%? Dis,usi,%n Dis,usi,%n )en/%l% )en/%l%&%n &%n &en/u<%) &en/u<%),%n ,%n ,%.%,%.% ,%.%,%.% +%n/ +%n/ &en/%n'u &en/%n'un/ n/ se&%n/%. se&%n/%. &en/hin'%-i =%. %'i,.i4
-. Keluarga
%? Mo.i@%si Mo.i@%si ,elu%-/% ,elu%-/% un.u, un.u, &e&%n.u &e&%n.u ,lien ,lien &%&)u &%&)u *u*u*u*u- il% su/es.in+ su/es.in+%% '%.%n/ 13
? Dis,usi,%n u)%+% ,elu%-/% &e&%n.u ,lien &en/u-%n/i &en/u-%n/i su/es.i B%n.u B%n.u su%s%n% su%s%n% &en' &en'u,u u,un/ n/ ,e%,-% ,e%,-%%n %n 'i -u&%h -u&%h
D5 Ke1era4atan ) - Dis.-ess Dis.- ess s)i-i.u%l ' ,u-%n/n+% )en/e.%hu%n )en/e.% hu%n Tu'uan- ,lien &enin/,%.,%n ,e/i%.%n s)i-i.u%l Inter6en%i */
In!ii!u
%? B%n.u B%n.u &en/i' &en/i'en. en.i4i, i4i,%si %si ,eu.u ,eu.uh%n h%n s)i-i. s)i-i.u%l u%l ? 'en.i4i,%si %-.i ,e+%,in%n ,e%/%&%%n Mo.i@% Mo.i@%si si &en*%l% &en*%l%n,% n,%n n ,e%/%& ,e%/%&%%n %%n
+/
Kelo&pok
%? Dis,us Dis,usi,% i,%n n nil% nil%ini inil%i l%i ,e%i, ,e%i,%n %n ? L%,u,%n ,e/i%.%n i%'%h e-s%&%
-/
Keluarga
%? Dis,us Dis,usi,% i,%n n )en.in/ )en.in/n+ n+%% ,e/i%.%n ,e/i%.%n ,e%/%& ,e%/%&%%n %%n ? B%n.u &en+i%),%n ,e/i%.%n ,e%/%&%%n 'i -u&%h -u&%h Mo.i@%si Mo.i@%si o-%n/ o-%n/ .u% .u% se%/%i se%/%i
e-u%h% n )e&elih%-%%n )e&elih %-%%n ,eseh%. , eseh%.%n %n '%n ADL D5 Ke1era4atan , - Pe-u%h%n Tu'uan - ,lien &%&)u &en/%&il ,e)u.us%n &e-u%h '%n &e&)e-%i,i /%+%
hi'u)n+% Inter6en%i */
In!ii!u
%? 'en.i4i,%si 'en.i4i,%si /%+% hi'u) hi'u) sel%&% sel%&% &en//u &en//un%,%n n%,%n =%. %'i,.i4 %'i,.i4 ? Dis,usi,%n ,e-u/i%n /%+% hi'u) )en//un% )en//un% =%. %'i,.i4 B%n.u ,ei%s%%n ,ei%s%%n &en/on.-o &en/on.-oll )en//u )en//un%%n n%%n =%.&e-o,o, =%.&e-o,o, '? B%n.u l%.ih%n l%.ih%n /%+% /%+% hi'u) seh%. : &%,%n( &%,%n( &%n'i &%n'i '%n '%n .i'u.i'u- .e-%.u- .e-%.u-
+/
Kelo&pok
%? Dis,us Dis,usi,% i,%n n /%+% /%+% hi'u) seh%. seh%. '%n '%n &%n4%%. &%n4%%.n+ n+%%
-/
Keluarga 14
%? 'en.i 'en.i4i, 4i,%si %si /%+% /%+% hi'u) hi'u) ,elu%,elu%-/% /% ? Dis,usi,%n ,elu%-/% se%/%i &o'el '%n .e&)%. e-l%.ih un.u, hi'u) hi'u) seh%.
D5 Ke1era4atan 7 - Ko)in/ ,elu%-/% .i'%, .i' %, e4e,.i4 ' )ol% %suh +%n/ s%l%h Tu'uan - ,elu%-/% &%&)u &e&e-i,%n ,en+%&%n%n )%'% ,lien sehin//% &%&)u
e-hen.i &en//un%,%n =%. %'i,.i4 Inter6en%i */
Kelo&pok
%? Be-i Be-i ,ese&)%.% ,ese&)%.%n n un.u, un.u, &en/e,s &en/e,s)-e )-esi, si,%n %n )e-%s%%n )e-%s%%n ? Dis,usi,%n <%-% &en/h%'%)i )e-il%,u ,lien '%n -en<%n% seelu& )ul%n/ B%n.u &en<%)%i &en<%)%i ,ese)%,%. ,ese)%,%.%n %n .n'%, .n'%, l%n*u. l%n*u. )e-%2%.%n )e-%2%.%n -eh%ili. -eh%ili.%si %si &en.%l &en.%l
+/
Keluarga
%? 'en.i 'en.i4i, 4i,%si %si )ene-i& )ene-i&%%n %%n ,elu%,elu%-/% /% .e-h%'%) .e-h%'%) &%s%l%h &%s%l%h ? B%n.u &ene-i&% &%s%l%h 'en.i 'en.i4i, 4i,%si %si h%-%)% h%-%)%n n un.u, un.u, se& se&uh uh .o.%l .o.%l '? B%n.u -es)on ,elu%-/% ,elu%-/% il% il% ,lien &en//un%, &en//un%,%n %n =%. %'i,.i4 %'i,.i4 e? B%n. B%n.u u ,elu ,elu%%-/% /% l%.i l%.ih% h%n n &en/ &en/u< u<%) %),% ,%n n ,%.% ,%.%, ,%. %.%% +%n/ %n/ &en/h en/h%%-/% /%ii '%n '%n &en'u,un/ ,lien un.u, e-hen.i
G%n//u%n ,es%'%-%n so&nolen. ' in.o,si,%si in.o,si,%si o%. D5 Ke Ke1e 1era ra4a 4ata tan n 8 - G%n//u%n se'%.i@e hi)no.i, Tu'uan - ,lien &%&)u &el%,u,%n in.e-%,si '%n &e&e-i,%n -es)on .e-h%'%)
s.i&ulus se<%-% o).i&%l Inter6en%i -
*.
In!ii!u
%? Ose-@ Ose-@%si %si .%n'%. .%n'%.%n' %n'%% @i.%l .e-u.% .e-u.%&% &% ,es%'%,es%'%-%n %n ? Be,e-*% s%&% 'en/%n 'o,.e- '%l%& )e&e-i%n .e-%)i &e'iS
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1. )aluasi
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BAB III PENUTUP
A. Ke Ke%i %im1 m1u+ u+an an
N%-,o.i,% %'%l%h =%. %.%u o%. +%n/ e-%s%l '%-i .%n%&%n %.%u u,%n .%n%&%n( %i, sin.e.is &%u)un se&i sin.e.is +%n/ '%)%. &en+e%,%n )enu-un%n %.%u )e-u%h%n ,es%'%-%n( hil%n/n+% -%s% n+e-i '%n '%)%. &eni&ul,%n ,e.e-/%n.un/%n >Un'%n/Un'%n/ No ## .%hun 1;;9? Y%n/ .e-&%su, *enis n%-,o.i,% %'%l%h .%n%&%n )%)%@e-( o)iu& &en.%h( o)iu& &%s%, 16
><%n'u( *i D%&in Su&%-'*o #005?
Mo-4in Mo-4in &e-u)% &e-u)%,%n ,%n %l,%lo %l,%loi'% i'% +%n/ +%n/ .e-'%)% .e-'%)%.. '%l%& '%l%& o)iu& o)iu&<%n <%n'u 'u +%n/ +%n/ e-%s%l e-%s%l '%-i '%-i .%n%&%n .%n%&%n )%)%@e)%)%@e- so&ni4e-u& so&ni4e-u& L Bil% 'i/un%,%n 'i/un%,%n '%)%. &eni&ul,%n &eni&ul,%n ,e.e-/%n.un/%n ,e.e-/%n.un/%n 4isi,( )si,is '%n .ole-%nsi sehin//% )en//un%%n '%l%& '%l% & )en/o%.%n s%n/%. 'i%.%si '%n &e-u)%,%n )ilih%n o%. .e-%,hi- Mo-4in e-u)% se-u, e-2%-n% )u.ih( 'i/un%,%n '%l%& )en/o%.%n un.u, un.u, &en/hi &en/hil%n l%n/,% /,%n n -%s% n+e-i n+e-i +%n/ +%n/ %&%. %&%. s%n/%. s%n/%. )%'% )%'% )en'e)en'e-i.% i.% ,%n,e,%n,e-(( o)e-%si o)e-%si '%n se%/%in+%( )e&e-i%n &o-4in ,e)%'% )%sien su'%h '%l%& en.u, sus.%ine' -ele%se .%le.
Mo-4in e,e-*% l%n/sun/ )%'% sis.e& s%-%4 )us%. un.u, &en/hil%n/,%n s%,i. !4e, s%&)in s%&)in/ / &o-4in &o-4in %n.%-% %n.%-% l%in %'%l%h %'%l%h )enu-u )enu-un%n n%n ,es%'% ,es%'%-%n -%n(( eu4o-i eu4o-i%( %( -%s% ,%n.u, ,%n.u,(( lesu( lesu( '%n )en/lih%.%n ,%u- Mo-4in *u/% &en/u-%n/i -%s% l%)%-( &e-%n/s%n/ %.u,( '%n &e+e%,%n ,ons.i)%si Mo-4in &eni&ul,%n ,e.e-/%n.un/%n .in//i 'i%n'in/,%n =%.=%. l%inn+% P%sien &o-4in *u/% 'il%)o-,%n &en'e-i.% inso&ni% '%n &i&)i u-u,
A'% # <%-% )en/o%.%n '%n )en
Mel%l Mel%lui ui &%,% &%,%l% l%h h ini( ini( )enu )enuli liss &en+ &en+%-% %-%n, n,%n %n ,e)% ,e)%'% '% )enu )enuli liss sen' sen'i-i i-i '%n '%n ,e)% ,e)%'% '% si%)%)un %/%- sosi%lis%si %,%n %h%+% n%-,o% ,hususn+% n%-,o.i,% .e-us 'il%,u,%n .e-u.%&% ,e)%'% /ene-%si &u'% +%n/ e-)o.ensi &en+%l%h/un%,%n o%. *enis ini
17
DAFTAR PUSTAKA
Su&%-' Su&%-'*o( *o( D%&in D%&in #005 #005 Pengantar Ki&ia %uku Pan!uan Kuliah Mahasisa Ke!okteran J%,%-.% : Pene-i. u,u ,e'o,.e-%n !G6
N M Su%ni.i '%n M A Hi.%)-e.i2i Su-+%'hi : PENENTUAN KUANTITATIF MORFI MORFIN N DALAM DALAM URIN URIN SE/ARA SE/ARA SPEKTR SPEKTROFO OFOTOD TODENS ENSITO ITOME METRI TRI Jurusan
Kimia %&IP niersitas da!ana, $ukit $ukit Jimbaran
Junaidi Khotib, Daning Irawati), Pagan Pambudi), Pambudi), Toetik r!ani " 18
Pr(%1e! Ti1i!a+ Antag(ni% D(1amin Se3agai Penanggu+angan Penanggu+angan Ketergantungan M(rin
%/i%n l&u Bio&e'i, F%-&%si( M%h%sis2% S1( M%h%sis2% S# F%,ul.%s F%-&%si Uni@e-si.%s Ai-l%n//%
Muhammad Taui!"$ Ba%u!i &ir'(%ent(n($ *u+ni Erma - DETEKSI NARKOTIKA ENIS /ANNABINOL DAN MORFIN DARI SAMPEL URINE
'umatera tara, Dosen PENGGUNA NARKOTIKA 0 &ahasiswa '3 Kimia niersitas 'umatera %&IP Kimia niersitas 'umatera tara, Kasubbid Kasubbid *arkoba +aboratorium +aboratorium %orensik Polri abang &edan
h..):i'2i,i)e'i%o-/2i,iMo-4in% diakses .ada hari &inggu 22 Juni 2/10 .ukul /1 h..):u*i%ns&%
888 19
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