Interaksi Obat Dan Makanan

INTERAKSI OBAT DAN MAKANAN Farmakologi Susunan Saraf Pusat (SSP) dan NSAID (Anti Rmatik)

OLEH :

 NI WA WAYAN ERMIYANTI ERMIYANTI

P07131215010

PANDE PUTU DIAN PRATIWI

P07131215011

KADEK AMBARA SIDI MA MANTRI

P07131215026

KEMENTRIAN KESE!ATAN REP"B#IK INDONESIA $"R"SAN %I&I PO#TEKKES DENPASAR (A) TA!"N '*

KATA PEN%ANTAR 

Puji su!u" !#$i %#&j#'!#& !()#*i"#' Tu)#& Y#&+ M#)# Es# !#"(&# *(&+#& "#)$#', !#"u&i#, s("'# '#u-i! *#& )i*##).N# !#$i *#%#' $(&(/(s#i!#& $#!#/#) '(&'#&+ #"$#!/+i Susu&#& s#"#- Pus#' SSP4 *#& NSAID #&'i "($#'i!4 i&i *(&+#& #i! $(s!i%u& #&#! !(!u"#&+#& *i*#/#$&# K#$i s#&+#' (")#"#% $#!#/#) i&i *#%#' ("+u&# *#/#$ "#&+!# $(&#$#) 8#8#s#& s("'# %(&+('#)u#& !i'#K#$i ju+# $(&#*#"i s(%(&u)&# #)8# *i *#/#$ $#!#/#) i&i '("*#%#' !(!u"#&+#& *#& j#u) *#"i !#'# s($%u"&# O/() s(# i'u, !#$i (")#"#% #*#&# !"i'i!, s#"#& *#& usu/#& *($i %("#i!#& $#!#/#) #&+ '(/#) !#$i u#' *i $#s# #&+ #!#& *#'#&+, $(&+i&+#' 'i*#! #*# s(su#'u #&+ s($%u"&# '#&%# s#"#& #&+ $($#&+u& S($+# $#!#/#) s(*(")#&# i&i *#%#' *i%#)#$i #+i si#%#%u& #&+ $($#9#&#S(!i"#&# $#!#/#) #&+ '(/#) *isusu& i&i *#%#' ("+u&# #+i !#$i s(&*i"i $#u%u& "#&+ #&+ $($#9#&# S((/u$&# !#$i $)& $##- #%#i/# '("*#%#' !(s#/#)#& !#'#. !#'# #&+ !u"#&+ ("!(&#& *#& !#$i $($)& !"i'i! *#& s#"#& #&+ $($#&+u& *($i %("#i!#& *i $#s# *(%#&

D(&%#s#", 6 ("u#"i 201 P(&usu&

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i

Daftar Isi

K#'# P(&+#&'#"

i

D#-'#" Isi

ii

BAB I PENDAHULUAN 11 P(&*#)u/u#&

1

12 Ru$us#& M#s#/#)

2

13 Tuju#&

2

BAB II PEMBAHASAN 21 D(-i&isi j(&is #' *#& $(!#&is$( #!si #' sis'($ s#"#- %us#' *#& NSAID 3 22 #"$#!!i&('i!, *sis, *u"#si #' *#& (-(! s#$%i&+ #' sis'($ s#"#- %us#' *#& NSAID 5 23 I&'("#!si #' *#& $#!#&#& *#"i %(&#!i' susu&#& s#"#- %us#' *#& NSAID BAB III PENUTUP 31 K(si$%u/#& 32 S#"#& D#-'#" Pus'#!#

;

10 10 11

ii

iii

BAB I PENDA!"#"AN + #atar Blakang P#*# $#&usi# sis'($ s#"#-, !)usus&# '#! $($%u&#i !($#$%u#&

-u&+si #&+ j#u) /(i) ("!($#&+ *#"i sis'($ s#"#- %#*# $#!)/u! /#i& u&+si sis'($ s#"#- #i'u $(&("i$# "#&+s#&+#& *#"i /i&+!u&+#& #'#u *#"i *#/#$ 'uu) s(&*i"i, $($%"s(s *#& $(&+)#&'#" "#&+s#&+#&."#&+s#&+#&, s("# $(&+!"*i&#si!#& *#& $(&+#'u" -u&+si.-u&+si 'uu) $(/#/ui i$%u/s.i$%u/s #&+ *i(#s!#& *#"i %us#' !( %("i-(" D#/#$ sis'($ s#"#- %us#' ("/#&+su&+ s($u# %"s(s.%"s(s !(ji8##& *#& %si!is O#'.#'#& *#%#' $($%(&+#"u)i susu&#& s#"#- %us#' *(&+#& $("#&+s#&+ s'i$u/us4 #'#u $(&(!#& *(%"(si4, *#& #*# %u/# #' #&+ *#%#' $(&(!#& s(su#'u -u&+si s(!#/i+us $("#&+s#&+ -u&+si #&+ /#i& s(%("'i %i#' #&+ $(&(!#& %us#' %("&#-#s#&, '('#%i $("#&+s#&+ %us#' $u&'#)4 E-(! #'.#' '("+#&'u&+ %#*# j(&is *#& s(&si'i
U&'u! $(&+)i&*#"i '("j#*i&# i&'("#!si #' *#&

$#!#&#&, u!#& ("#"'i $(&+)i&*#"i $#!#&#& '("s(u'

Y#&+

u&'u! $(&+!&su$si #'

#'#u

s(#i!&# *i/#!u!#& #*#/#) %(&+#'u"#& 8#!'u

#&'#"# #' *#& $#!#&#& u&'u! *i!&su$si *#/#$ 8#!'u #&+ ("(*# D(&+#& $($%u&#i i&-"$#si #&+ 9u!u% $(&+(&#i #' #&+ *i+u&#!#& s("'# !#%#& 8#!'u #&+ '(%#' u&'u! $(&+!&su$si&#, $#!# !i'# *#%#' $(&+)i&*#"i '("j#*i&# i&'("#!si #&'#"# #' *(&+#& $#!#&#&

+' Rumusan Masala,

1

121

A%#!#) *(-i&isi, j(&is #' *#& $(!#&is$( #!si #'

sis'($ s#"#- 

 %us#' *#& NSAID = 122 B#+#i$#&# -#"$#!!i&('i!, *sis, *u"#si #' *#& (-(! s#$%i&+ #' 123

sis'($ s#"#- %us#' *#& NSAID = B#+#i$#&# i&'("#!si #' *#& $#!#&#& *#"i %(&#!i' susu&#& s#"#- 

 %us#' *#& NSAID = +- Tu.uan 131 M(&+('#)ui *(-i&isi, j(&is #' *#& $(!#&is$( #!si #' sis'($ s#"#-   %us#' *#& NSAID 132 M(&+('#)ui -#"$#!!i&('i!, *sis, *u"#si #' *#& (-(! s#$%i&+ #' 133

sis'($ s#"#- %us#' *#& NSAID M(&+('#)ui i&'("#!si #' *#& $#!#&#& *#"i %(&#!i' susu&#& s#"#-   %us#' *#& NSAID

2

BAB II PEMBA!ASAN '+ Dfinisi/ $nis O0at/ dan Mkanism Aksi O0at Sistm Saraf Pusat dan NSAID P#*# $#&usi# sis'($ s#"#-, !)usus&# '#! $($%u&#i !($#$%u#&

-u&+si #&+ j#u) /(i) ("!($#&+ *#"i sis'($ s#"#- %#*# $#!)/u! /#i& O#'.#'#& *#%#' $($%(&+#"u)i susu&#& s#"#- %us#' *(&+#& $("#&+s#&+ s'i$u/#si4 #'#u $(&(!#& *(%"(si4 *#& #*# %u/# #' #&+ *#%#' $(&(!#& su#'u -u&+si s(!#/i+us $("#&+s#&+ -u&+si #&+ /#i& P#*# sis'($ s#"#- %us#' "#&+s#&+#& s(%("'i s#!i', %#&#s, "#s#, 9#)## *#& su#"# $u/#.$u/# *i'("i$# /() "(s(%'", !($u*i#& *i'("us!#& !( '#! *#& su$su$ 'u/#&+ (/#!#&+ Sis'($ s#"#- %us#' $($i/i!i (("#%# j(&is #', #&'#"# /#i&: 1 A&#/+('i!# A&#/+('i! #'#u #&#/+(si! #*#/#) #' #&+ *i+u&#!#& u&'u! $(&+u"#&+i #'#u $(&+)i/#&+!#& "#s# s#!i' #'#u #'.#' %(&+)i/#&+ &("i '#&%# $(&+)i/#&+!#& !(s#*#"#& *#& #!)i"&# #!#& $($("i!#& "#s# &#$#&  %#*# %(&*("i'# O#' #&#/+('i! '("*i"i *#"i 2 #i'u : # A&#/+('i! &#"!'i!#, $("u%#!#& +/&+#& #' #&+ *i+u&#!#& u&'u!  $("(*#!#& #'#u $(&+)i/#&+!#& "#s# &("i s(%("'i %#*# -"#9'u"# *#& !#&!(" >&') #' #&#/+('i! &#"!'i!# #i'u $"-i&, !*(i&, -(&'#&i/, &('#*&, '"#$#*/, /!s&, !#&#is, *#& %(&'#?si&   O#' #&#/+(si! &&.&#"!'i! $#$%u $(&+)i/#&+!#&

#'#u

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*(&+#& $#!#&#& *#%#' $(&+u"#&+i "(si! '("j#*i&# i"i'#si s#/u"#& 9("&# &#$u& *#%#' $(&+u"#&+i #s"si&# A%#i/# *ii&+i&!#& (-(! #&+ 9(%#'  j#&+#& *i!&su$si ("s#$# #/!)/ !#"(&# *#%#' $(&i&+!#'!#& "(si!  %(&*#"#)#& O#'.#' i&i #%#i/# s("i&+ *i+u&#!#& *#%#' $(&u"u&!#& #s"si #s#$ -/#' *#&  B(("#%# 9&') i&'("#!si #' #&#/+(si! #&'i%i"('i! *#& NSAID *(&+#& $#!#&#& #i'u : 1 P#"#s('#$/ *i!&su$si ("s#$# !%i, '(), $i&u$#& 9/# !#&*u&+#& !#-(i&4 #!#& $(&i$u/!#& (-(! %'(&si#si *#& $(&i&+!#'!#& "(si! '!si! *#"i %#"#s('#$/ 2 NSAID #%#i/# ("i&'("#!si *(&+#& !u&i' !#&*u&+#& !u"!u$i&4 #!#& $(&i$u/!#& (-(! si&("+(s'i! *#& $(&i&+!#'!#& #!'i-i'#s #&#/+('i! #&'i i&-/#$#si *#/#$ 'uu) 3 As%i"i& #%#i/# ("i&'("#!si *(&+#& +i&s(&+ *#& #8#&+ %u'i) #!#& $(&i$u/!#& (-(! si&("+(s'i! *#& $(&i&+!#'!#& #!'i-i'#s #&'i!#+u/#& #s%i"i& *#& "(si! %(&*#"#)#&

8

BAB III PEN"T"P -+ Ksim1ulan P#*# $#&usi# sis'($ s#"#-, !)usus&# '#! $($%u&#i !($#$%u#&

-u&+si #&+ j#u) /(i) ("!($#&+ *#"i sis'($ s#"#- %#*# $#!)/u! /#i& O#'.#'#& *#%#' $($%(&+#"u)i susu&#& s#"#- %us#' *(&+#& $("#&+s#&+ s'i$u/#si4 #'#u $(&(!#& *(%"(si4 *#& #*# %u/# #' #&+ *#%#' $(&(!#& su#'u -u&+si s(!#/i+us $("#&+s#&+ -u&+si #&+ /#i& P#*# sis'($ s#"#- %us#' "#&+s#&+#& s(%("'i s#!i', %#&#s, "#s#, 9#)## *#& su#"# $u/#.$u/# *i'("i$# /() "(s(%'", !($u*i#& *i'("us!#& !( '#! *#& su$su$ 'u/#&+ (/#!#&+ Sis'($ s#"#- %us#' $($i/i!i (("#%# j(&is #', #&'#"# /#i&: A&#/+('i!#, A&'i%i"('i! *#& NSAID N& S'("i*#/ A&'i I&-/#$$#'" D"u+s4 M#si&+. $#si&+ #' '("s(u' $($i/i!i -#"$#!!i&('i!, *sis, s("'# (-(! s#$%i&+ #&+  ("(*#.(*# s("'# '("*#%#' i&'("#!si *(&+#& $#!#&#& #&+ ("si-#' $($%("9(%#' #'#u $($%("/#$#' #s"si *#"i #' #'#u $#!#&#& i'u s(&*i"i -+' Saran A*#%u& s#"#& #&+ i&+i& *is#$%#i!#& %(&u/is #i'u: 1 K(%#*# %(&+#j#" #+#" $#$%u $($("i!#& i$i&+#& *#& $#su!#& #&+ $($#&+u& $(&+(&#i -#"$#!/+i susu&#& s#"#- %us#' *#&  NSAID 2 K(%#*# %($#9# *#& $#)#sis8# #+#" $#$%u $($#)#$i $(&+(&#i -#"$#!/+i susu&#& s#"#- %us#' *#& NSAID

9

DAFTAR P"STAKA

A&&i$ 2013 Farmakologi Ibuprofen )''%s:FF(

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