Farmacologia - Oxitócicos

FARMACOS ESTIMULANTES UTERINOS

Oxitócicos Dr. Miguel Ángel Marcelo ereau C!te"ra "e Far#acolog$a USM%

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Motili"a" uterina &or#onas' #e"ia"ores locales Iner(ación si#)!tica * )arasi#)!tica +rece)tores ,- * /0 C1lulas #usculares lisas +#io#etrio0 C

i" " "

A t i i" "

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Motili"a" uterina Utero no gestante2 Contracciones espontáneas (mayor intensidad durante la fase lútea y la menstruación)

Utero gestante2 

Primeras etapas: etapas: depresión de contracciones por progestero por progesterona na (hipoexcitabilidad) (hipoexcitabilidad)

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F!r#acos esti#ula"ores "e la #otili"a" uterina +oxitócicos0 1.-xitocina !.-"rosta#landinas

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Oxitocina

Est$#ulos2  

&st'mulos sensitios del cuello del útero (distensión cerical) ucción mamaria por el lactante

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Oxitocina2 e3ectos 3isio3ar#acológicos Contracciones r'tmicas desde el fundus hasta el cuello

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Oxitocina2 #ecanis#o "e acción +eceptores ,* acoplados a prote'nas 

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Oxitocina2 otros e3ectos 3isio3ar#acológicos 

Esti#ulación "e la secreción "e

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Oxitocina2 as)ectos 3ar#acocin1ticos 

00 o 02: 2onitoriación.

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Oxitocina2 in"icaciones tera)1uticas 

In"ucción "el )arto (infusión i..)

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Oxitocina2 e3ectos a"(ersos 

fecto contráctil (a dosis elevadas)! ;iperton'a y rotura de útero

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%rostaglan"inas2 e3ectos

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%rostaglan"inas In"icaciones *

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%rostaglan"inas2 %rostaglan"inas2 e3ectos

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Alcaloi"es ergóticos

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