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CNS Pharmacology Anti-epileptic drugs 1. The mechanism of action of antiepileptic drugs is : a) Enha Enhanc ncem emen entt of GABA GABA-er -ergi gic c (inh (inhib ibit itor ory) y) tran transm smis issi sion on b) inhi inhibi biti tion on of of excit excitat ator ory y (usu (usual ally ly glu gluta tama mate te-er -ergi gic) c) tra trans nsmi miss ssio ion n c) Modification of of io ionic co conductance d) All of the above . 2. which of the following has an impotent effect on the T-type calcium channels in thalamic neurons? a) Carbamazepine b) Lamotrigine c) Ethosuximide d) Phenytoin . 3. The drug which does not produce a voltage-dependent inactivation of sodium channels is : a) Lamotrigine b) Carbamazepine c) Phenytoin d) Vigabatrine .
inhibiti on of the central effects of excitatory 4. The antiepileptic drug, which produce inhibition amino acids is : a) Ethosuximide b) Lamotrigine c) Diazepam d) Tiagabine . 5. The drug which is not used for partial and generalized tonic-clonic seizures is : a) Carbamazepine b) Valproate c) Phenytoin d) Vigabatrine . 6. The drug which is used for absence seizures is : a) Sodium valproate b) Phenobarbital c) Carbamazepine d) Phenytoin . 7. The drug which is used for myoclonic seizures is: a) Primidone b) Carbamazepine c) Clonazepam d) Phenytoin . 8. The most effective drug in status epilepticus in adults is : a) Carbamazepine b) Ethosuximide c) Diazepam d) Zonisamide .
CNS Pharmacology Anti-epileptic drugs 9. Regarding phenytoin: a) It effects on Ca 2+ currents, reducing the low-threshold (T-type) current b) It blocks Na+ channels c) It inh inhib ibit its s GABA GABA-tr -tran ansa sami mina nase se,, whic which h cata cataly lyze zes s the the brea breakd kdow own n of GAB GABA A d) None of the above .
10. 10.
Phen Phenyt ytoi oin n is is use used d in in the the trea treatm tmen entt of: of: a) Petit mal epilepsy b) Grand mal epilepsy c) Myoclonic seizures d) None of the above .
11.
Dose-r Dose-rela elated ted advers adverse e eff effect ect caus caused ed by by phen phenyto ytoin in is: is: a) Phys hysical cal and and psych ycholog logical ical depe depen ndenc ence b) Gingival h hy yperplasia c) Exacerbated grand mal epilepsy d) Steven-Johnson syndrome .
Granulocytopenia Granulocytopenia , GI irritation and facial hirsutism hirsutism are possible adverse adverse effects 12. of: a) Phenobarbital b) Ethosuximide c) Phenytoin d) Carbamazepine . 13.
which of the following does not induce hepatic microsomal enzymes ? a) Carbamazepine b) Phenytoin c) Phenobarbital d) Sodium valproate .
14. 14.
The The dru drug g of choi choice ce for for part partia iall seiz seizur ures es is: is: a) Carbamazepine b) Diazepam c) Ethosuximide d) Phenytoin .
15.
The mechanism of action of Carbamazepine appears to be similar to that of: a) Benzodiazepines b) Sodium valproate c) Phenytoin d) Ethosuximide .
16.
Which Which of the followin following g is also effecti effective ve in in treatin treating g trigem trigeminal inal neuralgi neuralgia? a? a) Carbamazepine b) Phenytoin c) Vigabatrine d) Lamotrigine .
17.
The most common adverse effects of Carbamazepine are:
CNS Pharmacology Anti-epileptic drugs a) b) c) d)
Diplopia, at ataxia, an and na nausea Gingival hy hyperplasia, hi hirsutism Sedat edatio ion, n, phys physic ical al and and psy psych chol olog ogic ical al depe depend nden ence ce All of the above .
18.
Phe Phenoba obarbi rbital tal ca cause uses : a) Phys hysical cal and and phyc hycholo hologi gic cal dep depen ende den nce b) Exacerbated petit mal epilepsy c) Sedation d) All of the above .
19.
Lamotrigine can be used alone in the treatment of all the following except : a) Partial seizures b) Absence c) Myoclonic seizures d) Gener eneral aliized ton tonic - c clo loni nic c seizu eizurres .
20. The mechanism mechanism of action of vigabatrine vigabatrine is : a) Dire Direct ct acti action on on the the GAB GABA A rec recep epto torr-ch chlo lori ride de chan channe nell com compl plex ex b) Inhi nhibit bition ion of of GA GABA ami amino notr tra ans nsfe ferrase c) NMDA NMDA rece recept ptor or bloc blocka kade de via via the the glyc glycin ine e bin bindi ding ng site site d) Inhi Inhibi biti tion on of of GABA GABA neu neuro rona nall reup reupta take ke fro from m syna synaps pses es . 21.
The mechanism of topiramate’s action is: a) Redu Reduct ctio ion n of exci excita tato tory ry glu gluta tama mate te-er -ergi gic c neu neuro rotr tran ansm smis issi sion on + b) Inhi nhibit bition ion of volt volta age sens nsit itiv ive e Na channels c) Pote Potent ntia iati tion on of GABA GABA-e -erg rgic ic neur neuron onal al tran transm smis issi sion on d) All of the above .
22.
The drug of choic choice e in the treatmen treatmentt of petit petit mal mal (absenc (absence e seizur seizures) es) is: is: a) Phenytoin b) Ethosuximide c) Phenobarbital d) Carbamazepine .
23.
adverse effects of ethosuximide are all the following except : a) Gast Gastri ric c upse upsett such such as anor anorex exia ia,, pain pain,, naus nausea ea and and vomi vomiti ting ng b) Exacerbated grand mal epilepsy c) Fatigue , Dizziness and headache d) Aggressive be behavior .
24.
Sodium valproate is very effective against all the following except : a) Absence seizures b) Myoclonic s se eizures c) Generalized to tonic-clonic se seizures d) Partial seizures .
25.
The drug drug of choic choice e in the the trea treatme tment nt of of myoc myoclon lonic ic seiz seizure ures s is: is: a) Sodium valproate b) Phenobarbital c) Phenytoin
CNS Pharmacology Anti-epileptic drugs d)
Ethosuximide .
antiepilepti c drugs may produce teratogenicity? 26.Which of the following antiepileptic a) Phenytoin b) Valproate c) Topiramate d) All of the above . 27.
The most dangerous effect of antiepileptic antiepilepti c drugs after large overdoses is: a) Respiratory d de epression b) Gastrointestinal irritation c) Alopecia d) Sedation
