Summer 2009
Institute of Chemistry College of Science University of the Philippines Diliman, Quezon City 1101
Course Syllabus and Schedule
Course number: Chem 40 Course Title: Titl e: Introduction to Biochemistry Biochemistr y Course credit: 3 units Class schedule: 7 ± 9 AM,MTWThF, PH 1209 Course Pre-requisites Pre -requisites:: Chem 17 or Chem 26 and Chem 26.1 AND Chem 31 and Chem 31.1
Instructor: Evangeline C. Amor Consultation Hours: 12 ± 2 PM MTWThF, PH 1210 E-mail consultation is encouraged E-mail:
[email protected]
Course description: The course focuses on the discussion of the structure -function -f unction relationship of the four biomolecules: biomolecules: proteins, nucleic acids, carbohydrates and lipids and their metabolis m. Course goals:
Understand and appreciate the relationship relati onship of the structure struct ure and chemistry of the four biomolecules to their function includin g their metabolism and regulation.
Course Objectives: 1. 2. 3. 4.
to compare the basic biochemical principles in prokaryotes and eukaryotes. to illustrate the structure-function relationship of biomolecules in living systems. to describe metabolism, its organization and regulation. to give examples of the applications of b iochemistry in related fields. th
Main reference: refer ence: Biochemistry, 5 edition by Campbell and Farrell Other References: Refer ences: Biochemistry by Garrett and Grisham; Biochemistry by Mathews and Van Van Holde; Principles of Biochemistry by Lehninger; Biochemistry by Hort on. R eminders: eminders:
1. 2. 3. 4.
th
On the 5 meeting, please submit four (4) bluebooks with your name written at the back. Prepare a Quiz bluebook. Read ahead on the topics to be covered. Short quizzes will be given r egularly on the topics covered. ¥
Evangeline Evangeline Amor, 200 9
Summe Summerr 2009
Cours Coursee sc e ule
Day
10 27 Apr up to Day 13 30Apr
Day
Course Course obje objec ive
To disc discu uss and desc descr r ibe the processes processes that compr ise ise the cen centr al al dogma dogma of bi biology in molecu lecular lar te ter r ms ms
Topic opic /or c ivi The Cen Centr al al Dogma ogma Replication lication & Rep Rep air air A. DNA Rep B. Tr anscr scr iption tion C. Tr anslation slation Techn Technii ues in Nucleic Nucleic Acid cid Anal Analy ysis (r ead eading assign assignme men nt) In Foc Focus: Viruses ruses and Can Cancer cer (r ead eading assign assignme men nt) Group Acti Activ vity it y 4 From From Genes to Protei Protein ns Group Acti Activ vity it y 5WhoDunIt unIt
Re ere ce
/ or requ requireme
Chapter ter 10 of te of te Chapter ter 11 of te of te Chapter ter 12 of te of te Chapter ter 13 of te of te Chapter ter 14 of te of te Group out output put Group out output put
tbook tbook tbook tbook tbook
st
11
1 Long E am
28 Apr
(Tuesd esda y)
1 May May
Labor Labor Day ± No Classes To analy al yze the ther modynamics odynamics of meta of metabo bolism; lism; to escr ibe metabo metabolism lism descr To r ecall ecall stru struct ctur ur es es and char acter acter istics istics of monosacc onosacch har ides and disacc disacch har ides; To desc descr r ib e the prope proper tied tied of ca of carbohydr rbohydr ates; ates; To compar e the stru struct ctur ur e and functi function on of di diff er ent glycoconj onjugates; ugates; To r elate elate the functi function on of sam of samp ple carbohydr carbohydr ates ates to their eir st stru ruct ctur ur e and prope proper ties ties
Day
14 04 May May up to Day 18 08 May May
To disc discu uss in detail detail carbohydr carbohydr ate ate metabo metabolism lism and its r egulati gulation on;; To disc discu uss in detail detail the main main oxi oxidativ ative pathw athwaa y and its connecti onnection on to cellu cell ular lar r esp espir ation ation includ cludiing their eir r egulati gulation on;;
Int Introducti roduction on to Metabo Metabolism: lism: Types ypes,, Pat Pathw hwaa ys and Bio Bioenergetics rgetics Carbohydr Carbohydr ates ates Int Introducti roduction on Rev Review iew of wr iting iting stru struct ctur ur es; es; iso isomer mer ism; ism; gl ycosid si dic bond A. Monosacc onosacch har ides and Disacch isacchar ides Glucose, se, fruct fructo ose, se, galact galacto ose, se, manno mannose se,, etc. etc.; r eactiv eactivity ity of m of monosacca onosaccah har ides; sucrose rose,, lacto lactose, se, malto maltose, se, cellob cell obiiose; Pol Polysacch sacchar ides (stru struct ctur ur efuncti function) on);; cellu cellulose and its prope proper ties; ties; star star ch; amy amylose; amy amylopecti opectin n; glycoge ogen; chitin itin; peptidog tidogll ycan cans; mucopol opol ysacch sacchar ides; prote proteog ogll ycan cans; gl ycoprotei oprotein ns; glucosaminog sami nogll ycan cans Carbohydr Carbohydr ate ate Metabo Metabolism: lism: Glycol ysis; Glucone oneoge ogenesis; Glycoge ogen Metabo Metabolism; lism; PPP The TCA TCA Cycle The ETC & OP Group Acti Activ vity it y 6 Carbohydr Carbohydr ate ate Puzzle Puzzle
Day 16 06 May May
2 Long Exam
08 May May
Last da y of droppi dropping (Remind Remindeer : Don¶t on¶t forget forget to submit ubmit the instru struct ctor¶ or¶ss copy of t of the droppi dropping slip) slip)
Chapter ter 15 of te of texbook xbook Chapter ter 16 of te of tex xtbook
Chapter ter 17 of te of tex xtbook Chapter ter 18 of te of tex xtbook Chapter ter 19 of te of tex xtbook Chapter ter 20 of Te of Tex xtbook Group out output put
nd
¥
Evangeli ngelin ne Amor, 2009
Summe Summerr 2009
Cours Coursee sc e ule
Course Course obje objec ive
Topic opic rd 3 Long Exam (We (Wednes dnesd da y)
Day
21 13 May May To desc descr r ib e and compar e the stru struct ctur ur e, prope proper ties, ties, and functi function on of di diff er ent lip lipid classes;
Day 19 11 May May up to Day 22 14 May May
Day 23 15 May May up to Day 24 18 May May
To desc descr r ib e the stru struct ctur ur e, prope proper ties ties and char acter acter istics istics of bi biological ogical membr membr anes; To compar e diff er ent tr anspor t processes processes To disc discu uss in detail detail lip lipid metabo metabolism lism with ith emph emphasis asis on f atty atty acid acids and choleste holestero roll
To desc descr r ib e protei protein n and nucleic nucleic acid acid metabo metabolism lism and its r egulati gulation on;; To r elate elate the diff er ent metabo metabolic lic pathw athwaa ys discu iscussed ssed and see its unit unity y
/ or requ requireme
Lip Lipids Types ypes and Prope Proper ties ties of Li of Lip pids Satur atur ated ated and unsat unsatur ur ated ated f atty att y acid acids; Eico Eicosano sanoiids and isopr isopr enoi noids; Stero teroiids and stero sterols; ls; Sphi Sphingophos ngophospholi pholip pids; Glyceropho cerophosspholi pholip pids Membr Membr anes and Membr Membr ane Tr anspor t Compositi position on and Prope Proper ties; ties; K inds nds of T of Tr anspor t; t; Membr Membr ane Pote Poten ntial Lip Lipid Metabo Metabolism lism Fatty atty Aci Acid d Synt Synthesis & Degr adation ation;; K eton etonee Body For mation mation;; Choleste holestero roll Synt Synthesis
Chapter ter 8 of te of tex xtbook
Protei Protein n Metabo Metabolism lism Nucleic Nucleic Acid cid Metabo Metabolism lism Inte Integr gr ation ation of Meta of Metabo bolism lism Group Acti Activ vity it y 7 Metabo Metabolic lic Disord isordeer s
Chapter ter 23 of te of tex xtbook
Chapter ter 21 of te of tex xtbook
Chapter ter 24 of te of tex xtbook 5 Minu Minute te Group Repor Repor t
th
FINAL FINAL EXA EXAM
To be be Announce Announced d
(Eith Either 21 May May or 22 May) May)
i g c e me:
Quizzes Quizzes 4 Long Exams Final Exam Total:
Re ere ce
Last da y of classes of classes 4 Long Exam (We (Wednes dnesd da y)
Day 25 19 May May
Gr
/or c ivi
Gr
± 100 ± 400 ± 150 650 pts
i g c le:
1.0 1.25 1.5 1.75 2.0
92 ± 100 87 ± 91 83 ± 86 79 ± 82 75 ± 78 Exempt emptiion
gr
2.25 2.5 2.75 3.0 4.0
70 ± 74 65 ± 69 60 ± 64 55 ± 59 50 ± 54
e provi e that all 4 long ong exams are passe passe .
Policies
1. St Stude udents with ith 5 or mor e absen sences will get a gr ade of 5.0 unless unless they drop the cour se. se. 2. No mak mak e-up quizzes quizzes will be given. 3. St Stude udents who miss one one exam will get a scor scor e of ze of zero ro in that exam. am. 4. St Stude udents who miss two exams will get a gr ade of 5.0. ¥
Evangeli ngelin ne Amor, 2009
