HEMATOLOGY EXAMINATION NAME:______________________________ NAME:___ _________________________________________________ ______________________DA DATE:_______ TE:_______ 1. All of the following belong to the thrombin sensitive group of coagulation factors, except: a. Fibrinogen c. Proaccelerin b. Prothrombin d. Factor VIII . A blood smear is viewed through the microscope. In there, the er!throc!tes appear redder than normal, the neutrophils are barel! visible, and the eosinophils are bright orange. "hat is the most probable cause# a. $he slide was not stained. b. $he stain was too al%aline. c. $he slide was not rinsed sufficientl!. d. $he buffer was too acidic. &. $he intrinsic intrinsic coagulation s!stem s!stem is initiated when when this factor is exposed exposed to damaged epithelium: epithelium: a. III b. IV c. VII d. 'II (. $he prothrombin time )P$* screens for deficiencies of factors: a. III, VII c. I, II, V, VII, and ' b. I, II, V, VIII, I', ', 'I, and 'II d. I, II, V and ' +. After After centrifugation centrifuga tion of a blood specimen contained in a capillar! tube, the platelets and the leu%oc!tes ma! be found in the: a. $o $opp la!er c. $hird la!er b. econd la!er d. Fourth la!er -. Assa! of this en!me had become a routine procedure in anemic patients, especiall! if it occurs after administration of a drug or after consuming fava beans: a. /lucose0-0p /lucose0-0phosphate hosphate deh!drogenase c. /lutathion /lutathionee reductase b. /lutathione peroxidase d. P!ruvate %inase . $he term 23odg%in 4isease5 is preferred to 23odg%in 6!mphoma5 6!mphoma5 because: a. 7an! of the cells in nodes affected b! 34 are neoplastic in appearance, and onl! a minor population of cells have normal features. In contrast, the infiltrates of 836 are more uniforml! composed of similar0appearing normal cells. b. Fever and severe bacterial infection accompan! this form of malignanc!. c. 7an! of the cells in nodes affected b! 34 are normal in appearance, and onl! a minor population of cells have neoplastic features. In contrast, the infiltrates of 836 are more uniforml! composed of similar0appearing neoplastic cells. d. 3odg%in 4isease was the first form of l!mphoma discovered and in those times, the term 2l!mphoma5has not !et been made. 9. $art cell is different from a lupus er!thematosus )6* cell in that the ingesting cell is commonl! a: a. 6!mphoc!te c. 8eutrophi 8eutrophill b. 7onoc!te d. $hromboc!te ;. According to studies, persons who have sic%le cell trait are said to be resistant to: a. Plasmodium vivax c. Plasmodium %nowlesi b. Plasmodium ovale d. Plasmodium falciparum 1<. $he morpholog! of red cells that one would t!picall! t!picall! find in the blood smear of ic%le =ell 4isease patients is: a. 7ic 7icroc! roc!tic, tic, h!po h!pochro chromic mic c. 7acr 7acroc!t oc!tic, ic, norm normochr ochromic omic b. 8ormoc!tic 8ormoc!tic,, normochromic d. An! of these 11. In agranuloc!to agranuloc!tosis, sis, the usual finding is: a. 8e 8eut utro rope peni niaa b. 6eu eu%%oc oc!t !tos osiis c. 6!mph phoope peni niaa d. 8eu eutr trop ophi hillic met etam am!!el eloc oc!!te tess 1. "hich of the following >?= anomalies is detectable @86 b! examination of a blood smear# a. 3!pochromia b. 7icroc!tosis c. Anisoc!tosis d. Poi%iloc!tosis 1&. pheroc!tes are characteried b! the following, except: a. $he! are easil! deformed. b. $he defect in shape is caused b! cell membrane damage. c. $he! are round red blood cells lac%ing central pallor. pallor. d. $he! have diameters less than normal red blood cells. 1(. 7acroscopic examination examination of a capillar! hematocrit tube after spinning should include: a. ?uff! coat c. All of these b. >ed cell column d. Plasma la!er 1+. "hich of the following test results is expected on a patient with h!pofibrinogenemia# h!pofibrinogenemia# a. $hrombin time: Prolonged, >eptilase time: 8ormal c. $hrombin time: 8ormal, >eptilase time: Prolonged b. $hrombin time: Prolonged, >eptilase time: Prolonged d. $hrombin time: 8ormal, >eptilase time: 8ormal 1-. "hich of the following following stains is helpful in the diagnosis of suspected suspected er!throleu%emia# er!throleu%emia# a. Peroxidase c. PA b. 8onspecific esterase d. Acid phosphatase 1. "hich of the following following is a gl!coprotein gl!coprotein produced b! the liver liver and is considered as the the maBor inhibitor of blood coagulation# coagulation# a. Antithrombin III c. Protein = b. 3eparan sulfate d. Protein 19. "hich of the following situations below ma! lead to temporar! increase in a patientCs leu%oc!te count# 1. Do Dogg ggin ingg fo forr th thir irt! t! mi minu nute tess . x xpe peri rien enci cing ng a ve vehi hicu cula larr ac acci cide dent nt &. =i =iga gare rett ttee sm smo% o%in ingg a. 1 and b. and & c. 1 and & d. 1,,& 1;. A medical technologist was as%ed to determine the "?= count of a patient. 4uring the differential count procedure, the medtech observed 1 nucleated >?=s out of the 1<< leu%oc!tes he classified. $o determine the leu%oc!te count, he used the Improved 8eubauer
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and diluted the specimen 1:<. 3e was able to count 1;, +, &, and ( "?=s from the four large sEuares on one side of the hemoc!tometer. @n the other four large sEuares on the other side, he counted 19, (, , and 1 leu%oc!tes. Assuming that he performed the procedure correctl!, what is the real leu%oc!te count of this patient# a. (, (<<mm& b. &, ;;mm& c. &, ;; ' 1< ;6 d &, ;<< mm& <. our answer here should be the same as !our answer in number 1;. 1. $he AP$$ reagent consists of two components, which are: a. ?arium sulfate and aluminum h!droxide c. A platelet substitute and an activator b. $hromboplastin and calcium chloride d. $hromboplastin and an activator . If the anticipated "?= count of the patient is around 11< ' 1< ;6, then the recommended dilution and the t!pe of $homa pipet to use is: a. 1:<, "?= $homa pipet c. 1:<<, >?= $homa pipet b. 1:1<, "?= $homa pipet d. 1:1<<, >?= $homa pipet For numbers & to , select the best answer from the choices that follow.
&. $oxic granulations and Auer rods: 1.* ?oth ma! be seen in leu%oc!tes with severe malignant disorders .* ?oth leu%oc!tic inclusions are believed to be transformed aurophilic granules. (. 7a!03egglin inclusions and 4ohle0Amato bodies: 1.* ?oth of these inclusions are composed of >8A .* ?oth of these inclusions ma! be observed in neutrophils. +. Pernicious Anemia and Pelger03uet Anomal!: 1.* ?oth disorders affect the appearance of the neutrophil nucleus. .* $he nuclei in both disorders have a characteristic 2pince0ne5 appearance -. $he rubric!te: 1.* =onsidered as the first stage in the >?= maturation stages to produce hemoglobin .* =onsidered as the last stage in the >?= maturation stages to bear a nucleus . th!lenediaminetetraacetic acid )4$A*: 1.* Present onl! in lavender top blood collection tubes .* 7a! induce platelet clumping in some blood specimens 9. In the hematocrit determination procedure, one should seal the capillar! tubes at the: a. nd of the tube without the colored ring c. ither a or b b. nd of the tube with the colored ring d. 8either a nor b ;. ?urr cells are found in large numbers in which of the following conditions# a. 6iver disease b. Gremia c. r!throblastosis fetalis d. 6eu%emia &<. $he 3emoglobin and the 3emoglobin 4 can be distinguished from one another b! which test# a. Autohemol!sis test c. Acid serum test b. 3emoglobin electrophoresis at p3 9.d. olubilit! test &1. "hat is the primar! source of iron bound to transferrin in normal individuals# a. Absorption of iron from the small intestines b. ?rea%down of old red blood cells c. >elease of iron from the liver d. >elease of iron from muscle m!oglobin &. "hich of the following functions as the plasma transport protein for Vitamin ? 1# a. $ranscobalamin II b. Albumin c. $ransferrin d. 3emopexin &&. $he most common gl!col!tic en!me deficienc! associated with the aerobic pathwa! of >?= metabolism is: a. P!ruvate %inase b. 7ethemoglobin reductase deficienc! c. 3exo%inase deficienc! d. /lucose0-0phosphate deh!drogenase )/-P4* &(. In which stage of er!throc!tic maturation does hemoglobin formation begin# a. >eticuloc!te b. Pronormoblast c. ?asophilic normoblast d. Pol!chromatic normoblast &+. Parox!smal 8octurnal 3emoglobinuria episodes are commonl! associated with: a. =old temperatures b. 3ot tempeartures c. leep d. =ertain drugs &-. $he definitive techniEue for detecting hemoglobin in which the substitution of an amino acid leads to change in electrical charge is: a. 3emoglobin electrophoresis c. 3eat stabilit! test b. olubilit! test d. Hleihauer0?et%e &. In men and postmenopausal women whose diets are sufficient, iron deficienc! anemia most commonl! results from: a. Impaired absorption of iron in the small intestines
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b. 6ow transferrin levels c. Increased resistance to hoo%worm infections d. =hronic gastrointestinal bleeding
For nos. &9 to &;, use the data below:
&9. "hat is the 7=V# a. ;+ ( f6 &;. "hat is the 7=3=# a. & &( gd6
b. 1& f6 b. 9 +; pg
c. < ;+(- f6
d. 9 +; f6
c. ; ;+ gd6
d. &,<<< gd6
(<. Falsel! decreased > can result from: a. $ilted > tube b. xcess anticoagulant c. Vibration of test area d. < minutes standing (1. An abnormal red cell with a thin rim of hemoglobin and a large central area is called: a. Anuloc!te b. pheroc!te c. 7eniscoc!te d. 4repanoc!te (. "hich of the following test results is expectedl! abnormal in =hristmas disease# a. Platelet count c. Prothrombin time )P$* b. $ourniEuet test d. Activated partial thromboplastin time )AP$$* (&. $he tourniEuet should be securel! wrapped around the unclothed arm about how man! centimeters above the selected site# a. 1+01b. &0( c. .+01< d. 10 ((. All of the following tests will demonstrate normal results in a patient with Factor VII deficienc!, except: a. Activated Partial $hromboplastin $ime c. $hrombin time b. Prothrombin time d. Platelet count (+. =!anide0resistant Peroxidase stain ma! be used to detect: a. 3air! =ell 6eu%emia b. 3odg%inCs 6!mphoma c. =hronic 7!elogenous 6eu%emia d. osinophilic leu%emia (-. $he medical technologist stained a blood smear. 3e then held it up to the light and noticed that the smear is bluer than normal. "hat abnormalit! ma! be expected on this smear# a. 6eptoc!tes b. 6!mphoc!tosis c. >ouleaux d. ic%le cells (. From the following choices, identif! which one will demonstrate a low serum ferritin test result. 1. Plumbism . $halassemia &. ,ideroblastic anemia (. Iron deficienc! anemia a. 1 and c. 1,,& b. and ( d. ( onl! (9. $he most common clinical application of flow c!tometr! is: a. 4iagnosis of ic%le =ell 4isease b. 4etection of fetomaternal hemorrhage c. 4iagnosis of leu%emias and l!mphomas d. 4ifferentiation of anemias (;. $he coagulation factors that reEuire vitamin H for their production include all of these, except: a. tuart factor b. Factor I' c. Fibrinogen d. Proconvertin +<. A blood specimen showed an elevated 7=V with an increased >4". $hese results would suggest that the patient has: a. Iron deficienc! anemia b. ic%le cell anemia c. 8ormal blood specimen d. Vitamin ? or folate deficienc! +1. "hich of the following will 8@$ increase the ># a. >ouleaux b. Increased globulins c. Poi%iloc!tosis d. Increased fibrinogen +. Parox!smal 8octurnal 3emoglobinuria ma! be detected through: a. 3amCs Acidified erum $est c. Flow c!tometr! b. ugar "ater $est d. All of these +&. $he sol0gel one lies directl! beneath the platelet membrane and is composed of: a. 7icrofilaments c. ?oth A and ? b. 7icrotubules d. 8either A nor ? +(. $o properl! mix the blood and the anticoagulant in the light blue top tube, the medtech must invert the tube: a. Five to eight times c. ight times b. $hree to four times d. $wice ++. $he P$ is most sensitive to a deficienc! of which clotting factor# a. Fibrinogen b. VII c. VIII d. 'I +-. 6ipemia ma! affect which of the following hematologic parameters# 1. 3emoglobin . 7=3 &. 3ematocrit a. 1 and c. 1 and & b. and & d. 1,, and & +. Inactivation of factors Va and VIIIa is caused b!: a. $hrombin b. Protein
c. t0PA
d. Activated protein =
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+9. In the granuloc!tic series of maturation, what is the last stage to undergo mitosis# a. 7!eloblast b. Prom!eloc!te c. 7!eloc!te d. 7etam!eloc!te +;. If the medtech multiplies the >?= count of a normal individual b! three, the resulting value will most probabl! reflect the: a. 3emoglobin of the patient c. 7ean cell volume of the patient b. 3ematocrit of the patient d. "eight of the patient -<. $he nuclear parachromatin of the l!mphoc!te tends to stain light purple with deep purple heterochromatin, giving the appearance of: a. Purple nec%lace pattern c. =rushed velvet b. Violet ca%e d. =hec%erboard -1. $he primar! inhibitor of the fibrinol!tic s!stem is: a. Antithrombin III b. K0antiplasmin c. Protein = d. K 0macroglobulin -. $he first factor to be affected b! warfarin is: a. Factor V b. Factor VII c. Factor VIII d. Factor I' -&. =linical conditions associated with 4I= include: a. na%e bites b. Acute infections )such as malaria* c. Acute prom!eloc!tic leu%emia d. All of these -(. @ne can expect an increased > result in all of the following conditions, except: 1. >heumatic fever (. ,ic%le cell anemia . 3ereditar! spheroc!tosis +. 7!ocardial infarction &. $uberculosis a. 1,,&,( b. , &, and ( c. 1, &, and + d. and ( -+. $hromboc!topenia ma! be observed in all of the following conditions, except: a.=hronic m!elogenous leu%emia c. $A> s!ndrome b. /aucherCs disease d. 4I= --. From the choices below, select the ones which are found in the alpha granules of the platelets. 1. ?eta0thromboglobulin &. Fibrinogen . $hrombospondin (. Factor V a. 1,,&,( b. 1 and c. 1, and & d. 1 onl! -. $he patientCs AP$$ failed to correct after addition of normal fresh plasma. "hat would be the most probable cause# a. Factor 'II deficienc! b. Factor VIII deficienc! c. Afibrinogenemia d. =irculating anticoagulants -9. "hich of the following tests can be used to differentiate vitamin H deficienc! from hepatic disease# a. Factor V assa! c. Factor VII assa! b. P$ d. ?leeding time -;. $his is the term used to describe a condition where the red cells var! in sie greatl!. a. Anisoc!tosis c. ?oth A and ? b. Poi%iloc!tosis d. Pol!chromasia <. "hat is the critical value for the hemoglobin level# a. L +< g6 and M 1<< g6 c. L +< g6 and M 11< g6 b. L < g6 and M &<< g6 d. L < g6 and M << g6 1. $his red cell inclusion is composed of ferric iron and appear as bluish green0staining bodies in Prussian blue reaction: a. iderotic granules b. 3b 3 c. =abot rings d. 3ein bodies . $he 2pince0ne5 appearance of neutrophil nucleus ma! be seen in: a. Pernicious anemia b. 3!persplenism c. Pelger03uet anomal! d. Alder0>eill! anomal! &. $he critical value for reticuloc!te counts )adults*: a. <.9N b. +.9
eill! anomal! c. Pelger03uet anomal! b. 7a!03egglin anomal! d. $oxic granulations -. "hich of the descriptions below properl! depict 3b = cr!stals# a. 3exagonal, elongated cr!stals c. Formed within cell membrane b. 2"ashington 7onument5 d. 8one of these . >?= basophilic stippling ma! be found in which of the following conditions# 1. P!rimidine0+C08ucleotidase )P8* 4eficienc! . $halassemia &. 6ead poisoning a. 1 and & b. 1,, and & c. and & d. & onl! 9. "hich of the following is considered as the storage site for v"F in the blood vessel cells# a. Platelet alpha granules b. "eibel0Palade bodies c. ?oth A and ? d. 8either A nor ? ;. $he mean plasma concentration of fibrinogen is: a. 9 to 1< mgd6 b. 1 mgd6 c. << to (<< mgd6 d. + mgd6 9<. In an electronic cell counter, clumped platelets ma! interfere with which of the following laborator! results# 1. "?= count . 3emoglobin &. Platelet count (. 3ematocrit a. 1,,& b. 1 and & c. and & d. & onl! 91. $he primar! granules of the neutrophils contain all of the following, except: a. 6actoferrin c. ?oth A and ? b. 7!eloperoxidase d. 8either A nor ? 9. A diluting solution for manual platelet count is: a. 3a!emCs solution c. <.1 8 3=l
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b. 1N aEueous solution of ammonium oxalate
d. N acetic acid
$he following data were obtained from a &0!ear old Filipino female who is currentl! admitted in a public hospital. "?= count J 1&,;<<mm& 4ifferential count: 8eutro: 1N 6!mpho: +N osinophils: N 7onoc!tes: N 9&. In the case given, there is: 1. Absolute l!mphoc!tosis &. Absolute neutrophilia +. Absolute eosinophilia . >elative eosinophilia (. Absolute monoc!topenia -. >elative neutrophilia a. 1,&,+ b. 1,,& c. & and + d. & and -
9(. Infection with $richinella spiralis ma! cause: a. 8eutrophilia b. 7onoc!tosis c. osinophilia d. 7onoc!tosis 9+. $he earl! normoblast ma! otherwise be called as: a. >ubriblast b. Prorubric!te c. >ubric!te d. 7etarubric!te 9-. Faggot cells are most commonl! encountered in: a. Acute prom!eloc!tic leu%emia c. =hronic m!elogenous leu%emia b. Acute m!elomonoc!tic leu%emia d. Acute er!throleu%emia 9. =omplete the following statement: 2"hen Factor 'III is present, the fibrin clot formed is OOOOOOOOOOOOOOO in + 7 Grea and OOOOOOOOOOO when left standing for OOOOOOOOOOOO.5 a. Insoluble, 1N 3!drochloric acid, ( hours c. oluble, 1N 7onochloroacetic acid, (9 hours b. Insoluble, 1N 7onochloroacetic acid, ( hours d. Insoluble, 1N 7onochloroacetic acid, hours 99. "hich of the following is produced b! the liver and is considered as the maBor inhibitor of thrombin# a. Antithrombin III c. Protein = b. 3eparan sulfate d. Protein 9;. $esting an old blood sample will demonstrate the following results: a. 7=V, 7PV, QPlatelet count c. Q7=V, Q7PV, Platelet count b. 7=V, 7PV, Platelet count d. Q7=V, Q7PV, QPlatelet count ;<. "hich of the following conditions will produce a falsel! decreased >?= count# a. 3emol!sis b. 7icroc!tosis c. Increased numbers of schistoc!tes d. All of these ;1. "hich of the following is improperl! matched# a. =4(: 3elperinducer $ cells b. =41-: 8H cells c. =4&(: =!totoxic $ cells d. =41(: 7onoc!tes ;. $he last stage to s!nthesie hemoglobin is the: a. Pol!chromatophilic normoblast c. >eticuloc!te b. @rthochromic normoblast d. 7ature er!throc!te ;&. $he infective stage of the malaria parasites to humans is: a. porooites b. 7erooites c. $rophooites d. /ametoc!tes ;(. "hich of the following stains is least helpful in differentiating the subt!pes of acute l!mphoblastic leu%emias# a. PA b. @>@ c. udan ?lac% d. All of these ;+. "hich of the following conditions will produce a falsel! increased "?= count# a. Presence of l!sis0resistant >?=s containing abnormal hemoglobins b. Increased numbers of nucleated >?=s c. ?oth A and ? d. 6ipemia ;-. "hat is the correct order of draw for the s%in puncture procedure# a. 4$A microcollection tube erum microcollection tube @ther microcollection tubes with anticoagulants lides $ube for blood gas anal!sis b. $ube for blood gas anal!sis lides 4$A microcollection tube @ther microcollection tubes with anticoagulants erum microcollection tube c. 4$A microcollection tube @ther microcollection tubes with anticoagulants erum microcollection tube lides$ube for blood gas anal!sis d. $ube for blood gas anal!sis 4$A microcollection tube @ther microcollection tubes with anticoagulants erum microcollection tube lides
"For nos. ; to 1<<, anal!e the following laborator! test results and identif! the most probable factor deficienc!.
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)P$ J prolonged and AP$$ J prolonged* Aged plasmaJ 8@$ =@>>=$4 Aged serum J 8@$ =@>>=$4 Adsorbed plasma J =@>>=$4 )P$ J normal and AP$$ J prolonged* Aged plasmaJ =@>>=$4 Aged serum J =@>>=$4 Adsorbed plasma J 8@$ =@>>=$4 )P$ J normal and AP$$ J prolonged* Aged plasmaJ 8@$ =@>>=$4 Aged serum J 8@$ =@>>=$4 Adsorbed plasma J =@>>=$4 )P$ J prolonged and AP$$ J normal* Aged plasmaJ =@>>=$4 Aged serum J =@>>=$4 Adsorbed plasma J 8@$ =@>>=$4
1. . &. (. +. -. .
;. OOOOOOO
;9. OOOOOOOO
;;. OOOOOOOO
1<<. OOOOOOOOO
AlbaCs 7edical $echnolog! ?oard xamination >eview =ompiled 7edical $echnolog! 6icensure xamination )7arch 1;;< to 7arch 1;;9* P> Ruestions and Answers ?oo% )A >eview 7anual For =linical 6aborator! xaminations* 7edical $echnolog! 3ematolog! >eview b!: 7ar! >ose $e xamination >eview for 7edical $echnolog! b!: 8eville D. ?r!ant 3ematolog! 6ecture /uide b!: >ene D.A.>. 4inglasan @ther references )reliable websites and boo%s* related to the medical technolog! profession
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