Seminario_ Función de Los Neutrófilos

S O L I F Ó R T U E N S O L E D S E N O I C N U F

MARTINO

GRUPO III TAFUR IRMA

SHEILA

SELENE MEDINA ROJAS JOSÉ LUIS MENDOZA CHAVEZ RICARDO MENDOZA FERNÁNDEZ JORDY MENDOZA MACO, MIGUEL ANGELs ANGEL s MONTALBÁN TORRES DIEGO ALEJANDRO MONZON RODAS JOSE ALMANZOR MORALES GONZÁLES RICK OSCAR MORE TERÁN JORGE LUIS MUGUERZA HUAMÁN JHON MUNDACA MANAY MARÍA YSAURA 1 • •

ME N D O Z A C H AV E Z , RI C A R D O ME N D O Z A F E R N Á N D E Z , J O R DY


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DETERMINANTES DEL MOVIMIENTO L.s -&/).)*%.s ?.-*6.'.$/)-&('&s $&/%'+0-.s s.$ /$. & -.s '&s?.$s(-&s ?'*6('*.s &$ -(s &&$s(s ).$%'( -.s 6*)'..'4($*s6.s *$9(s.'&s ?'.)&s.s (4/.s! Es%>$ )(?()*%(.s ?('( s&-&))*.$(', *$4&'*'  &s%'/*' -( 6(.'( & -.s *$9(s.'&s &<%'(.s &<%'()&-/-('&s, -. )/(- '&=/*&'& /$( s&'*& & ?(s.s 6*4'()*+$ *'*4*( 7()*( -(s S O L I F Ó R T U E N S O L E D S E N O I C N U F

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INTERACCIÓN DE LOS NEUTRÓFILOS Y LAS CÉLULAS ENDOTELIALES L( *$(6()*+$ s& )('()%&'*@( 7*s%.-+4*)(6&$%& ?.' -( ()/6/-()*+$ & -&/).)*%.s &$ &s*%*. & *$(6()*+$ &*. ( -( 6*4'()*+$ *'&))*.$(- & -.s -&/).)*%.s )*')/-($%&s! L( S O L I F Ó R T U E N S O L E D S E N O I C N U F

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"3

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#

7& '&)&? '&)&?%.' %.' FML FML!! A- *4/(*4/(- =/& ).$ ).$ %..s %..s -.s '&)&? '&)&?%.' %.'&s &s & =/*6*. =/*6*.(%' (%'(& (&$%& $%&ss &$).$%'(.s &$ -.s $&/%'+0-.s, &- '&)&?%.' & ML &6/&s%'( =/& &?&$&$ &%*&6?. )*$2%*)( & /$*+$ s(%/'(-&  /$( (0$*( (-%( ).$s%($%& & *s.)*()*+$ K &0$*. ).6. -( ).$)&$%'()*+$ '&=/&'*( ?('( .-*4(' ( /$ #  & '&)&?%.'&s *s?.$*-&s ?('( &- =/*6*.(%'(&$%& &s?&)0).! L.s &s%/*.s /%*-*@($. $&/%'+0-.s 7/6($.s *$%()%.s '&9&-($ -( ?'&s&$)*( & (?'.<*6((6&$%& #! '&)&?%.'&s & S O L I F Ó R T U E N S O L E D S E N O I C N U F

#1

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−

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#

Lo# rece)tore# de +(i!iocina# L.s $&/%'+0-.s &
−

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#"

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#

FUNCIONES DIFERENTES AL MOVIMIENTO L.s $&/%'+0-.s ?.-*6.'.$/)-&('&s . s&46&$%(.s, ).$.'6($ -( -%*6( &%(?( & ?-&$( 6(/'()*+$ & -.s 4'($/-.)*%.s! S.$ -.s -&/).)*%.s 6>s ).6/$&s  %(6*2$ -.s 4'($/-.)*%.s 6>s (/$($%&s! L.s $&/%'+0-.s ()%($ ).6. -( ?'*6&'( -$&( & &&$s( &- 7/2s?& '&$%& ( -( *$&))*+$ )&-/-(' ()%&'*($(  s.$ ).$s%*%/&$%&s )&-/-('&s S O L I F Ó R T U E N S O L E D S E N O I C N U F

##

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#3

 .'6(' /$( 9&s)/-( &$.)%*)( &$.6*$(( (4.s.6(, &- )/(- (- /s*.$('s& ).$ -.s 4'>$/-.s $&/%'+0-.s, ?('%*)/-('6&$%& ).$ -.s 4'>$/-.s ?'*6('*.s, &s)('4($ s/ ).$%&$*., &$.s& /$ )/&'?. '&s*/(- =/& ).$%*&$& &- 6(%&'*(- &4'((.! U$( 9&@ %&'6*$(. &?'.)&s. (4.)%*)., -.s $&/%'+0-.s 6/&'&$! INTERACCIÓN ENTRE NEUTRÓFILOS Y MICROORGANISMOS U$( 9&@ =/& &- $&/%'+0-. 7( ())&*. (- s*%*. & *$&))*+$, &s /$(6&$%(- =/& &s?-*&4/& s/ ?.%&$)*(- 6*)'.*)*( ?('( &9*%(' -( *s&6*$()*+$ & -.s ?(%+4&$.s! E$ S O L I F Ó R T U E N S O L E D S E N O I C N U F

#5

(-4/$.s )(s.s s/ *$%&'9&$)*+$ ?.'> &''(*)(' -( *$&))*+$, 6*&$%'(s =/& &$ .%'.s ?&'6*%*'> ).$%&$&'-( 7(s%( =/& s& &s(''.--& /$( '&s?/&s%( *$6/$& ((?%(%*9(! E$&/%'+0-. )/&$%( ).$ *s%*$%.s '&)&?%.'&s & '&).$.)*6*&$%. ?('( ?.&' &s?-&4(' s/ ?.%&$)*(- 6*)'.*)*( &$ .'6( '&-(%*9(6&$%& &s?&)0)([ &9*%($. ((' -.s %&*.s &7/2s?&! E--.s s.$ -.s '&)&?%.'&s ?('( ).6?.$&$%&s &- ).6?-&6&$%., -.s '&)&?%.'&s ?('( -( ?.')*+$ F) & -( )(&$(  RF)  -.s '&)&?%.'&s & %*?. T.--! L.s .s ?'*6&'.s %*?.s & '&)&?%.'&s '&).$.)&$ 6.-2)/-(s &?.s*%((s s.'& &- 6*)'..'4($*s6. ).6. S O L I F Ó R T U E N S O L E D S E N O I C N U F

#8

).$s&)/&$)*( & s/ *$%&'())*+$ ).$ &- s*s%&6( *$6/$& &- 7/2s?&, &$.6*$((s ).-&)%*9(6&$%& .?s.$*$(s! O?s.$*@()*+$ s& '&0&'& ( -( /$*+$  -( (-%&'()*+$ & -( s/?&'0)*& 6*)'.*($( ?.' *$6/$.4-./-*$(s  ).6?.$&$%&s &- ).6?-&6&$%., -. =/& '&s/-%( &$ &- '&).$.)*6*&$%. ?.' '&)&?%.'&s &s?&)0).s s*%/(.s &$ -.s $&/%'+0-.s! Es%& '&).$.)*6*&$%. s& %'(/)& &$ -( (7&'&$)*( *$6/$&, =/& &s%> ).6$6&$%& s&4/*. ?.' (4.)*%.s*s &- 6*)'.*.!


#:

A&6>s & 6-%*?-&s 6&)($*s6.s ?('( -( *$*)*()*+$ & -( '&s?/&s%( *$(6(%.'*(, 7( '&())*.$&s '&4/-((s =/& *$7*&$  &$ -%*6( *$s%($)*(, %&'6*$($ &- ?'.)&s.! R&)&?%.'&s & '&).$.)*6*&$%. & ?(%'.$&s S.$ -.s '&)&?%.'&s & %*?. T.-- \6($.s( CD3, CD1, '&)&?%.' s)(9&$4&' A CD], &
3

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31

OPSONI2ACIÓN FACTORES OPSON3NICOS L.s ?'*$)*?(-&s ()%.'&s & -( .?s.$*@()*+$ s.$ -(s .?s.$*$(s *$6/$.4-./-*$( I4G1 & I4G", 6*&$%'(s =/& I4A1  I4A %(6*2$ '&(-*@($ &s%( /$)*+$ &$ &- %'()%. '&s?*'(%.'*.! L.s ).6?.$&$%&s *62'*).s &- ).6?-&6&$%., C"  C, ?'.?.')*.$(' -( /$)*+$ .?s+$*). (*)*.$(- , /$%. ).$ C"*, ?'.?.')*.$($ -( (4.)*%.s*s & *s?('.! L( I4G  C" S O L I F Ó R T U E N S O L E D S E N O I C N U F

3

).''&s?.$&$ ( -( )->s*)(6&$%& --(6(( .?s.$*$( %&'6.&s%(-&  %&'6.->*-[, '&s?&)%*9(6&$%&! O)#onina# e#ta4$e#


3"

−

Inmunoglobulina G"

L( I4G ).$s%*%/& &- 8# &- %.%(- & -(s I4s ?'&s&$%&s &$ &- ?-(s6(! L( 6(.' ?('%& & -.s A)s ?'./)*.s ).$%'( ()%&'*(s 4'(6?.s*%*9(s, 9*'/s  %.<*$(s, ).''&s?.$&$ ( &s%( )-(s& & I4! S/ ).$)&$%'()*+$ ?-(s6>%*)( 9('*( & 5 ( 18 6416-! T*&$& /$( 9*( 6&*( =/& 9('( & 1#"# (s! S O L I F Ó R T U E N S O L E D S E N O I C N U F

3

−

Inmunoglobulina A.

R&?'&s&$%( &- 1 &- %.%(- & -(s 4-./-*$(s 7/6($(s! Es%( *$6/$.4-./-*$( ?.s&& )(?()*( $&/%'(-*@($%&  ?'&)*?*%($%&, 6*&$%'(s =/& s/ )(?()*( & 0(' ).6?-&6&$%.  & .?s.$*@()*+$ s.$ 6/ 2*-&s, -*6*%>$.s& s/ &&)%. ( $&/%'+0-.s  $. ( 6()'+(4.s!


3#

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33

&$%'(( (- 6*s6., ).6. s.$ ..s, .)(, (?('(%. *4&s%*9., s*s%&6( '&s?*'(%.'*., 9(4*$(, &%)!

O)#onina# $,4i$e#


35

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El complemento

C.$ -( &$.6*$()*+$ ).6?-&6&$%. s& &s*4$( /$ ).$/$%. ).6?-&. & (-'&&.' " ?'.%&$(s, =/& /$%. ).$ -( ).(4/-()*+$ s($4/$&(, -( 0'*$+-*s*s  -( .'6()*+$ & )*$*$(s ).$s%*%/&$ /$. & -.s s*s%&6(s & &$@*6(s ()%*9(.'(s &s&$)(&$($%&s &$).$%'((s &$ &- ?-(s6(! Es%.s s*s%&6(s s& )('()%&'*@($ ?.' ?'./)*' /$( '&s?/&s%( '>?*(  6/


38

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3:

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O?s.$*@()*+$ & -(s ()%&'*(s

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L*s*s & ()%&'*(s

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5

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D&&$s*$(s S&'?'.)**$(s, *$)-/&$. -( )(%&?s*$( G  -( (@/'.)**$( GA "5 '.%&$( ()%&'*($( & 6(.' ?&'6&(*-*( BI

DEFENSINAS L(s &&$s*$(s s.$ ?2?%*.s )(%*+$*).s & "W"" (6*$.>)*.s '*).s &$ )*s%&$(  ('4*$*$( =/& s& 7($ &%&)%(. &$ (4.)*%.s, %(-&s ).6. -.s $&/%'+0-.s, & -.s =/& ).$s%*%/&$ & S O L I F Ó R T U E N S O L E D S E N O I C N U F

13

"# & -(s ?'.%&$(s =/& ).$%*&$&$ -.s 4'>$/-.s! L(s &&$s*$(s .'6($ ?('%& & -.s 6&)($*s6.s *$%'()&-/-('&s & -( *$6/$*( *$$(%(! H( .s 4'/?.s ?'*$)*?(-&s & &&$s*$(s -(s &&$s*$(s =/& s& &$)/&$%'($ &$ -.s 4'>$/-.s & $&/%'+*-.s  &$ -(s )2-/-(s & ($&%7 &- *$%&s%*$. &-4(.,  -(s &&$s*$(sf =/& s.$ s&)'&%((s ?.' -(s )2-/-(s &?*%&-*(-&s & -( ?*&-, & -( 6/).s( '&s?*'(%.'*(  ?.' -(s 4->$/-(s s(-*9(-&s!


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*s/-/'.*$%'()(%&$('*.sP s.$ 6.-2)/-(s )('4((s ?.s*%*9(6&$%&  ?.' ).$s*4/*&$%& *$%&'()%($ ).$ 6.-2)/-(s )('4((s $&4(%*9(6&$%& ?'&s&$%&s &$ -(s 6&6'($(s & -.s 6*)'..'4($*s6.s, ).6. &- LS & -(s ()%&'*(s G'(6 $&4(%*9(s  &- >)*. -*?.%&*).*). & -(s ()%&'*(s G'(6 ?.s*%*9(s!


13

L(s &&$s*$(s s& (4'&4($ ?('( .'6(' ?.'.s &$ -( ?('& & -(s ()%&'*(s G'(6 ?.s*%*9(sP &$ -(s ()%&'*(s G'($ $&4(%*9(s, -( (0$*( &-&9(( & -(s &&$s*$(s ?.' &- LS 7()& =/& s& &s?-()&$ -.s *.$&s & )(-)*.  6(4$&s*., --&9($. ( &s&s%(*-*@()*+$  '/?%/'( & -( 6&6'($(! L(s &&$s*$(s %(6*2$ &s%*6/-($ -( =/*6*.%(<*s & -.s 6.$.)*%.s, -(s )2-/-(s &$'%*)(s  -.s -*$.)*%.s TP *$7*&$ -( 0'*$+-*s*s 6./-($. &- ()%.' ()%*9(.' &- ?-(s6*$+4&$.! S O L I F Ó R T U E N S O L E D S E N O I C N U F

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L(s &&$s*$(s &s%'/&$ .'4($*s6.s 6/ *9&'s.s, &$%'& -.s =/& s& &$)/&$%'($ S%(?7-.).))/s(/'&/s, s&/.6.$(s(&/'.4*$.s(, E! ).-*, C'?%.).))/s$&..'6($s  &9*'/s '&)/*&'%. &- 7&'?&s s*6?-&! L(s &&$s*$(s %(6*2$ %*&$&$ *6?.'%($%&s ?'.?*&(&s *$6/$.6./-(.'(s − −


133

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SEPROCIDINAS L( )(%&?s*$( G &s /$( s&'*$( ?'.%&(s( =/& 6(%( ( -(s ()%&'*(s 4'(6$&4(%*9(s  4'(6?.s*%*9(s 6&*($%& -( /$*+$ ( -(s ?'.%&$(s & /$*+$ ( -( ?&$*)*-*$( & -(s ()%&'*(s %(-&s ).6. -(s &- S%(?7-.).))/s (/'&/s, -. =/& *$%&'0&'& ).$ -( s$%&s*s & ?&?%*.4-*)($.s! L( (@/'.)**$( &s .%'( s&'*$( ?'.%&(s( =/& 6(%( ( -( Es)7&'*)7*( ).-*, S O L I F Ó R T U E N S O L E D S E N O I C N U F

135

S%'&?%.).))/s(&)(-*s  C($*( (-*)($s &$ 6&*. >)*., &s%. &s '&(-*@(-& 6&*($%& -.s (4.-*s.s.6(s & -.s $&/%'+0-.s! ?PI 5PROTE3NA ?ACTERICIDA DE LA PERMEA?ILIDAD8 Es /$( ?'.%&$( )(%*+$*)( & #8 QDA ?'&s&$%& &$ -.s 4'>$/-.s (@/'.0-.s, =/& &&')& s/ ()%*9*( ()%&'*)*( s&-&)%*9( ).$%'( -(s ()%&'*(s 4'(6 $&4(%*9(s ( %'(92s & /$ 6&)($*s6. $. &$@*6>%*).! S O L I F Ó R T U E N S O L E D S E N O I C N U F

138

L( ?2'*( & -( 9*(*-*( ()%&'*($( s& ().6?(( &

(-%&'()*.$&s /$)*.$(-&s '&s%'*$4*(s ( -( 6&6'($( &<%&'$(, ).6. *$)'&6&$%. &$ -( ?&'6&(*-*( ( 6.-2)/-(s 7*'.+*)(s  ()%*9()*+$ s&-&)%*9( & &$@*6(s =/& &4'(($ &- ?&?%*.4-*)($.  -.s .s.-?*.s & -( 6&6'($( &<%&'$(! L( 9*(*-*( 9*(*-*( & -(s ()%&'*(s ()%&'*(s ).6. ).6. -( E!).-*, s& ).6?'.6&% ).6?'.6&%& & ?.' &- '&$*6 '&$*6*&$%. *&$%. & -( ?&'6&(*-*( =/& &s%( ?'.%&$( ?'./)& &$ s/ 6&6'($(, ()%/($., (- ?('&)&' &$ .s &%(?(s ?'*6&'. ?'./)& /$( ?&'6&(*-*@()*+$ '&9&'s*-& & -( 6&6'($( &<%&'*.' & S O L I F Ó R T U E N S O L E D S E N O I C N U F

13:

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15

).$*)*.$&s ( ($(&'.*(s, & &s%& 6.. s&(-(6.s -( *6?.'%($)*( )-$*)( & -( ?'.%&$( BI &$ -( 6/&'%& $. .<*(%*9(! L.s 4'>$/-.s &s?&)0).s 6(')(.s ).$ -()%.&''*$( s.$ ($%*()%&'*($. ).$%'( (-4/$.s 4'(6 $&4(%*9.s ?.' -( 4&$&'()*+$ & '(*)(-&s -*'&s &- 7*&''.! L(s -*s.@*6( ?'&s&$%&s &$ 4'>$/-.s &s?&)0).s ?'*6('*.s (@/'+0-.s, ?'.(-&6&$%& ).$%'*/($ &$ -( *4&s%*+$ &


151

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15

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H(''*s.$! '*$)*?*.s & M&*)*$( I$%&'$(, D($ L! L.$4., D&$$*s L! K(s?&', J! L(''

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J(6&s.$, A$%7.$ S! F(/)*, S%&?7&$ L! H(/s&', J.s&?7 L.s)(-@.! 18& I$6/$.-.4(! R.(s e*--*(6 M! 15%( &*)*+$! C.'?.'()*+$ ?('( I$9&s%*4()*.$&s B*.-+4*)(s F.$. E*%.'*(-! C.-.6*(! 1#!


15"

Seminario_ Función de Los Neutrófilos

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