Pathophysiology Chronic Renal Failure

PATHOPHYSIOLOGY (Chronic Renal Failure)

Predisposing Factors  Ages 55 and above

Precipitating Factors

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Family History (Diabetes Mellitus,   Hypertension)

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Lifestyle - smoking - alcohol drinking

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Thickening and/or an in the amont of collagen in the basement membranes of the small vessels

!m"aired/slggish blood flo#

Certain Diseases (Hypertension, (Hypertension, Diabetes Mellitus, Recurrent infections

)ormal *+), creatinine

ore than .5 damage

Stage II R$#AL I#S&FFICI$#CY $F% '-5' *+), creatinine levels begin to rise

%emaining ne"hrons ndergo changes to com"ensate for  those damaged ne"hrons

Filtration of more concentrated blood by the remaining ne"hrons

Hy"ertro"hy of  ne"hrons !ntolerance and e0hastion of the

- %edction in renal ca"illaries -4carring of $lomerli - Atro"hy  Fibrosis of  %enal tbles

)itrogenos #astes im"airs "latelets

alfnction of  %AA4

6 2'  of  kidney damage

Decreased 8rythro"oietin 9rodction Continos decline in renal fnction

*leeding tendencies

 )a  H7 retention

 A)8!A

To0ins irritate "ericardial sac 9ericarditis

Cardiac Tam"onade

-fatige - #eakness

To0ins im"air  +rea immne de"osits system on the skin Decreased !mmne system %isk for  s"erinfection

 ┼  Decreased +rine 7t"t

!ncreased blood "ressre

8dema

9lmonary 8dema, 9eri"heral 8dema

+remic frost

Stage I% $#!'STAG$ R$#AL !IS$AS$ ($SR!) $F% :3'

4e"sis

To0ins affect C)4

7ligria Hy"ertension

Continos ltisystem  Affectation lti"le 7rgan Failre

Heart Failre

 ┼   ┼ 

!$ATH

 ┼ 

+remic 8nce"halo"athy -changes in mentation/ "sychiatric sym"toms -irritability -fatige -insomnia