Pa Tho Physiology of Meningioma (Edited Version)

PATHOPHYSIOLOGY OF MENINGIOMA

Non modifiable risk factors:

Modifiable risk factors:

y

Gender (female)70%

y

Exposure

y

Age (above 50 up to 80 yrs old)

y

Previous head trauma

y

Hereditity

y

Cellphone use

y

virus

(nervous system disorders: disorders:

neurofibromastosis type 2) y

Monosomy

y

Female

to ionizing radiation

of chromosome 22 (70-80%)

hormones

Increase number and growth of  normal meningothelial cells.

presence of encapsulated tumors

Beni Beni n tumor tumor

Slow Slow rowth rowth

Increase ICP is less common

Arise from the

arachnoid cap cells

penetration in the inner dura at the venous sinuses

formation of mass Growth through the holes

at the base of the skull or outside the skull

Invasion at the bones

Leads to localized

Compresses

Indentation in the

thickening

the optic

brain parenchyma

Vision

May

extend to

structures

Production of 

osteoblastic reaction Focal

seizures

changes Increase ICP

Erosion

of cranial bone

the dural space

or other neurovascular

Hyperostosis

occu ies

dura

Increase growth and size

nerve

size adapts to the shape it

Attachment to the

Headache

Lesion seen on CT

Benign tumor formation in the occipital area

Craniotomy

Tissue

Open wound

trauma

Disruption of cell

Nociceptors on the dermis

membrane Impaired tissue

Risk for

integrity

infection

Starts of 

Send impulse to central nervous s stem

inflammatory process Pain

on surgical site

Release of  prostaglandin and bradykinin

Activity intolerance