Organic Pharmaceutical Chemistry of 19 B
C C & C B & &
Page 1
1. The ratio ratio of disinfectant to the the dilution dilution of phenol required required to kill kill a given strain strain of of the bacterium Salmonella typhi: typhi: a. Phen Phenol ol numb number er b. Phen Phenol ol coef coeffi fici cien entt c. Phen Phenol ol valu valuee d. None None of the the abov abovee 2. The generic name of Nioral: a. !eco !econ naol aolee b. Clotr lotriimao maole le
c. "etoc etocon ona ao ole
d. Pota otassiu ssium m sorb sorbaate
#. $ulfonamides used for burn therap%: a. !afenide b. $ilver sulfadiaine
c. both a and b
d. none of the preceeding
'. The follo(ing are preservatives preservati ves e)cept: a. unde undec% c%le leni nicc acid acid b. !et !eth%l h%l para parabe ben n
c. ben beno oic acid
d. pot potassi assium um sor sorbate bate
*. The combination of trimethoprim and sulfametho)aole sulfametho)aole is also kno(n as: a. clotrima clotrimaole ole b. miconaol miconaolee c. co+trimo co+trimo)aol )aolee
d. cotrima cotrimaine ine
,. & pol%ene anti+fungal antibiotic: a. -riseofu -riseofulvin lvin b. N%statin N%statin
c. $alic%li $alic%licc acid
d. conaole conaole
/. Ben%l Be n%l penicillin penicilli n is also kno(n as: a. Peni Penici cill llin in b. Peni Penici cill llin in 0
c. )ac )acil illi lin n
d. &mpic mpicil illi lin n
3. 4irst generation urinar% tract anti+infective: anti+infective: a. salic%lic salic%lic acid b. -riseofu -riseofulvin lvin
c. Norflo)a Norflo)acin cin
d. Nalidi)ic Nalidi)ic acid
5. & fluoroquinolone: fluoroqui nolone: a. Norf Norflo lo)a )aci cin n
c. !eth !ethen enam amin inee
d. none none of the the abov abovee
b. Pipe Pipeme medi dicc acid acid
16. Combination therap% in the treatment of tuberculosis contain the follo(ing drugs7 e)cept: a. thambutol b. 8ifampin c. 9soniaid d. $treptom%cin
B
11. These drugs are used in treatment of amoebic d%senter%7 d%senter %7 e)cept: a. Tinidaole b. Chloroquine c. tofamide
d. !etronidaol ole
12. & fourth generation cephalosphorins: a. Cefalo)in b. Cefepime
c. Cefamandole
d. Cefuro)ime
1#. This drug is used in the treatment of chicken po): a. idovudine b. Chloroquine
c. &c%clovir
d. !etronidaole
1'. The drug of choice for t%phoid fever: a. Chloramphenicol b. ;incom%cin
c. Penicillin
d. Cephalosporins
B C &
1*. The generic name of alacin C (hich is often used to treat pimples: a. r%throm r%throm%cin %cin b. Tetrac% Tetrac%cline cline c. ;incom% ;incom%cin cin
d. Clindam% Clindam%cin cin
B
1,. The stud% of chemical agents (hich are selectivel% more to)ic to the invading organisms than the host: a. ther herapeut peutiics b. chem hemoth otherap erap% % c. org organic nic chem hemistr istr% % d. bioc bioche hemi mist str% r%
C
1/. Compounds that kill or prevent the gro(th of microorganisms microorganisms (hen applied to living tissues: tissues: a. disinfectant b. fungicides c. antiseptics d. s%st s%steemic anti+infectives
&
13. & combination combinatio n of non+ionic non+ioni c and cationic surfactants (ith iodine: a. P ov ovidone+9oduine b. $t $trong 92 solu soluti tion on c. 9odi 9odine ne Tinct inctur uree 15. The generic name of ne( !erthiolate is: a. Chorhe)idine gluconate b. Thimerosal
d. 92 in "9 solu soluti tion on
c. !e)achlorophene d. Benalkonium chloride chloride
Organic Pharmaceutical Chemistry of 19 B
B &
26. !echanism of action of quinolones: a. in in
Page 2
c. pr protein s%nthesis inhibition d. production of to)ic to)ic free radicals radicals
21. Prodrugs of active anti+malarial anti+malarial metabolites7 the dih%drotriaines: dih%drotriaines: a. quinolines b. biguanides c. beta+lactams
d. quinolones
22. / chloro+/+deo)% chloro+/+ deo)% lincom%cin: a. clindam%cin b. ro)ithrom%cin
d. ilot%cin
c. spectinom%cin
2#. The drug is effective against both e)oer%throc%tic and er%throc%tic forms of malaria: a. chlo chloro roqu quin inee b. quin quinin inee c. amod amodia iaqu quin inee d. c%cl c%clog ogua uani nill
B
2'. Ne(est and most potent quinoline derivative for malaria: a. amodiaquine b. mefloquine c. atabrine 2*. &n aromatic diamide derivative used for sleeping sickness: a. suramin b. pentamidine c. efflornithine 2,. !eth%lated er%throm%cin: er%throm%cin : a. clar clarit ithr hrom om% %cin b. aith ithro rom m%cin cin c. linco incom% m%ci cin n
B &
d. daraprim d. stibophen d. ilot ilot% %cin
B
2/. & semi+s%nthetic semi+s%nthetic aminogl%coside (hose structural protot%pe is kanam%cin: a. "antre) b. &mikin c. -aram%cin d. Nebcin
&
23. $tructural congener of $%mmetrel $%mmetrel (hich (hich is used for viral influena: a. ribavirin b. rimantadine c. ganc%clovir
d. foscarnet
25. !ore potent optical isomer of oflo)acin: a. levo b. de)tro
d. trans isomer
& B B
B C
B B C
c. cis isomer
#6. These group of drugs share the same mechanism of action as that of a. trimethoprim b. sulfones c. quinolones
sulfanilamide but are less effective: effective: d. none of the above
#1. !echanism of action of thiabendaole: a. paral%si paral%siss due to -&B& -&B& receptor receptor occupatio occupation n b. inhibition of cell division
c. phagoc%t phagoc%tic ic attack attack on (orms (orms d. decreased glucose glucose uptake
#2. This anti+burn therap% causes s%stemic acidosis: a. silvadene b. sulfam%lon
c. (hitfield
##. rug of choice for filarial infections: a. ivermectin b. praiquantel
c. dieth%lcarbamaine d. $tibophen
#'. &ctive form of the sulfonamide: a. non+ionied b. ionied
c. amphoteric
d. o)o ring
#*. =se of crotamiton: a. pediculicide
c.anthelmintic
d. antibacterial
b. scabicide
#,. !echanism of action of mebendaole: a. paral%si paral%siss due to e)cessive e)cessive loss of calcium calcium b. unkno(n mechanism mechanism of action
d. vandol
c. decreased decreased glucose glucose uptake uptake d. phagoc%tic attack attack on (orms
#/. & s%mpathomimetic s%mpathomimetic agent agent that bind to alpha receptors receptors found found centrall% centrall% that that cause cause suppression suppression of appetite: a. >enical b. -as+> c. &pokinon d. &difa)
B
#3. &n e)ample of a gl%cine con
c. no noradrenaline to epinephrine d. antabuse to dithiocarbamic dithiocarbamic acid acid
Organic Pharmaceutical Chemistry of 19
Page 3
B
#5. The follo(ing are characteristics characteristics of active transport7 e)cept: a. fo follo( saturation kinetics c. ca carrier mediated b. e)penditure of energ% energ% d. higher to lo(er lo(er concentration gradient gradient
B
'6. These anti+diarrheals anti+diarrheals tend to decrease decrease pore sies of -9T -9T epithelial epithelial to prevent prevent formation formation of (ater% stools: stools: a. adsorbents b. astringents c. anti+motilit% anti+motilit% d. oresols
C
'1. This anti+histamine anti+histamine possesses the same indications as that of diphenh%dramine: a. mecliine mecliine b. h%oscine h%oscine c. dimenh%d dimenh%drinat rinatee d. celestam celestamine ine
&
'2. The metabolism of (arfarin is induced b% the follo(ing e)cept: a. tolbut tolbutami amide de b. halope haloperid ridol ol c. nitrog nitrogl% l%cer cerine ine
d. T T
'#. 4ertilit% vitamins: a. retinoic acid
d. biotin
C C & & B B
& & B
b. riboflavin
c. alpha tocopherol
''. Calcitriol7 a hormone hormone responsible responsible for for enhanced enhanced absorption absorption of calcium from the the intestines7 intestines7 is s%nthesied s%nthesied from: from: a. calcit calcitoni onin n b. vitami vitamin n 2 c. vitami vitamin n # d. caltr caltrate ate '*. & metabolite of chloral h%drate: a. trichloroacetic trichloroacetic acid b. acetaldeh%de acetaldeh%de
c. carbapenem ring
d. phenacetone
',. & sample drug e)creted via the saliva: a. lidocaine b. sulfonamide
c. sulfonamide
d. thiamine
'/. & vitamin & derivative derivativ e used in the management of psoriasis: a. 8etin+& b. Tegison c. &ccutane
d. ilatum
'3. $tructurall% $tructurall% specific drugs are those (hose activit% depends on: a. ph%sical characteristics c. both a and c b. abilit% to bind bind on a specific receptor d. none of the above '5. The most potent anti+bacterial anti+bacter ial alcohol: a. primar primar% % b. second secondar% ar% *6. Product of acid h%drol%sis of penicillins: a. penicillenic acid b. penicilloic acid
c. tertia tertiar% r%
d. quater quaternar nar% %
c. penicilloate Cl
d. pinecillic acid
*1. Cide): a. gamma ammabe ben nen eneehe)a he)acchlor hloriide
c. he)a he)acchlor hloro ophen phenee
d. car carbam bamo%l o%l pho phospha sphatte
b. glut lutarol arol
B
*2. Presence of electron electron (ithdra(ing (ithdra(ing groups attached attached to the alpha alpha carbon carbon of the amide amide side side chain chain in penicillins render: a. ac a ctivit% against Pseudomonas c. ac a ctivit% against -ram ?+@ bacteria b. acid stabilit% d. penicillinase resistance resistance
*#. &ttachment &ttachment of bulk% groups to the the alpha alpha carbon carbon of the amide side chain in penicillins render: a. ac a ctivit% against Pseudomonas c. ac a ctivit% against -ram ?+@ bacteria b. acid stabilit% d. penicillinase resistance resistance
B C
*'. & gl%copeptide gl%copept ide antibiotic: antibiotic : a. beta+lactam b. vancom%cin
c. pol%m%)in
d. probenecid
**. & tumor is benign if: a. meta metast stas asis is is evi evide dent nt b. cell originating originating from the tumor tumor ma% invade other tissues and and cause damage c. tumor tumor mass ma% ma% be removed removed b% surge surger% r% and regres regression sion of remai remaining ning cells cells occur occur d. cause cause dama damage ge to to surrou surroundi nding ng struc structur tures es
Organic Pharmaceutical Chemistry of 19 B C
Page 4
*,. 1 gram mass of tumor is equivalent to: a. 1667666 1667666 cancer cancer cells cells b. 1 billion billion cancer cancer cells cells
c. 1 million million cancer cancer cells cells d. none of the above
*/. The follo(ing are mucol%tics7 e)cept: a. bro bromhe mhe)ine )ine b. acet acet% %lc% lc%stei steine ne
c. car caramip amiph hen
d. none none of the above bove
C
*3. The side effects of steroids steroids used for asthma asthma are minimied (hen the the drug drug is given: a. orall% b. intravenousl% c. via inhalation d. rectall%
B
*5. & progesterone derivative (hich is used for the the treatment treatment of endometrial endometrial cancer: a. tamo)ifen b. depo+provera c. flutamide d. goserelin
B
,6. rug of choice for absence seiures: a. carbamaepine b. ethosu)imide
C
c. phen%toin
,1. &n anti+o)idant added in food products (hich are potent carcinogens: a. aspartame b. PCP c. BAT
d. primidone d. T&
&
,2. Pentavalent antimon% in the presence h%drochloric acid gives a violet precipitate (ith this pink d%e: a. rho rhodom domine ine B b. alum luminu inum rea reagent gent c. p+ni p+nittrobe roben neene ao+r o+res esor orccinol inol d. dime dimeth th% %lgl% lgl%o) o)iime
C
,#. )pectorant obtained from the phenol volatile oil of Fagus of Fagus grandiflora grandiflora: a. potass potassium ium iodide iodide b. t%lo) t%lo)apo apoll c. guaia guaiafen fenesi esin n
d. emetin emetinee
,'. !escaline is a derivative: a. indol ndolet eth% h%la lami mine ne b. phe phen%le n%leth th% %lam lamine ine
c. ster teroida oidall
d. )an )anthi thine
,*. &nesthetic of choice for labor: a. halo haloth than anee b. enfl enflur uran ance ce
c. nitr nitrou ouss o)id o)idee
d. meth metho)% o)%fl flur uran anee
B B C B B &
&
C C &
,,. The drug of choice for the acute attack of migraine: a. Codeine b. &vamigran c. ;itec
d. 9nderal
,/. &nesthetic &nesthetic of choice for patients (ith asthma: a. ketamine ketamine b. thiopenta thiopentall
c. enflurane enflurane
d. none of the above
,3. Propionic acid derivative: a. paracetamol b. dip%rone
c. piro)icam
d. napro)en
,5. &n e)ample of iodophor: a. iodine tincture b. povidone+iodine
c. ;ugols solution
d. all of the above
/6. Phen%lmethanol: Phen%lmethanol: a. chlore chloreton tonee
c. phen% phen%lal lalcoh cohol ol
d. carvac carvacrol rol
b. ben%l ben%l alcoho alcoholl
/1. & characteristic characteris tic of cancer cells: a. lack of normal normal gro(th gro(th controls controls b. s%nthesis of N& N& occurs in the ! phase
c. -6 phase is the resting resting phase for all cell t%pes t%pes d. None of the above
/2. Carcinogenic substances obtained from paper products: a. pol%chlorinated biphen%ls c. but%latedh%dro)%anisole b. acesulfame d. none of the above /#. Prostaglandins are also kno(n as: a. saturated fats b. compound lipids c. eicosanoids d. all of the above /'. Dhich of the follo(ing functional groups is the most basicE a. imide b. amide c. amine /*. erivatives of ben%lsulfon%lureas ben%lsulfon%lureas are: a. oral h%pogl%cemics b. diuretics
d. aniline
c. anti+inflammator% anti+inflammator% d. spasmol%tic
Organic Pharmaceutical Chemistry of 19 C B C & & C
Page 5
/,. & necessar% precursor of visual pigment is: a. tocopherol b. retinal
c. ergosterol
d. retinal
//. Paracetamol Paracetamol is aFan: a. salic%late
c. aniline derivative
d. aocine derivative
b. p%r p%raolone
/3. &ll of the follo(ing are progestins e)cept: a. norethindr norethindrone one b. testoster testosterone one
c. eth%nodiol eth%nodiol diacetat diacetatee
/5. &spirin is to salic%lic acid as morphine is to: a. codeine b. methadone
c. heroin
36. The functional group in p%rido)ine is: a. alcohol b. amine
c. carbo)%lic acid
31. &scorbic acid and tetrac%cline are: a. enols b. esters
c. ethers
d. amines
32. !& is classified as aFan: a. protei protein n inhibi inhibitor tor b. comple comple)in )ing g agent agent
c. en%m en%mee
d. hormon hormonee
d. progester progesterone one
d. pentaocine d. ketone
C
3#. Dhen used in pharmaceutic pharmaceutic preparations7 the purpose of h%droquinone7 h%droquinone7 lecithin and alpha alpha tocopherol tocopherol is: a. humectant c. oil soluble antio)idant b. demelaniing agent agent d. emulsif%ing agent agent
3'. Naturall% occurring alkaloids7 derivatives of tropane are: a. nasal decongestants b. analgesic c. vasoconstrictor
& C B B C
d. bronchodilator
3*. ;ocal anesthetics that is not a derivative of benoic acid is: a. lidoca lidocaine ine b. procai procaine ne c. dibuca dibucaine ine
d. bupiva bupivacai caine ne
3,. &ll of the follo(ing are macrolide antibiotics7 e)cept: a. er% er%thr throm% om%cin cin b. olea oleand ndom om% %cin cin c. vanc vancom om% %cin cin
d. spi spiram% ram%ci cin n
3/. &tivan has this generic name: a. tria triao ola lam m b. lora lorae epa pam m
c. flur flura aep epam am
d. tran trane) e)am amic ic acid acid
33. Plasil is: a. ac%clo ac%clovir vir
c. diclof diclofena enacc sodium sodium d. trane) trane)am amic ic acid acid
b. metocl metoclopr oprami amide de
35. The principal h%drol%tic degradation product of aspirin is: a. meth%l meth%l salic%la salic%late te b. acet%l acet%l chloride chloride c. salic%li salic%licc acid
d. salic%la salic%lamide mide
56. Barbiturates Barbiturates containing a sulfur atom are usuall%: a. short acting acting b. intermed intermediate iate acting acting
d. ultra ultra short short acting acting
c. long acting acting
51. <hough the prostaglandins are hormone+like7 the% ma% closel% closel% resemble (hich of the the follo(ing follo(ing chemicall%E a. en% en%me mess b. porp porph% h%ri rins ns c. prot protei eins ns d. lipi lipids ds
&
52. The onset and duration duration of barbiturate barbiturate action is mainl% a function function of its: its: a. lipid solubilit% c. plasma binding b. renal e)cretion d. method of administration administration
B
5#. The protot%pe narcotic antagonist is: a. nalo nalorp rphi hine ne b. nalo nalo)o )one ne
c. leva levall llor orph phan an
5'. ;%sergic acid dieth%lamide dieth%lamid e is: a. derived from mushroom b. a paras%mpathetic paras%mpathetic drug
c. histamine analog d. ergot derivative derivative
d. mepe meperi ridi dine ne
Organic Pharmaceutical Chemistry of 19 B B
C B B B C
Page 6
5*. rthoh%dro)%benoic rthoh%dro)%benoic acid is: a. acetic acid b. salic%lic acid
c. o)alic acid
d. citric acid
5,. iamo) has a generic name of: a. allopu allopurin rinol ol b. aceta acetaola olamid midee
c. dimeth dimeth%l %l)an )anthi thine ne
d. theoph theoph%l %llin linee
5/. ipheno)%late is a structural analog of: a. dilant dilantin in b. codein codeinee
c. meperi meperidin dinee
d. nalo)o nalo)one ne
53. Cevitamic acid is: a. folic acid
c. nicotinic acid
d. glacial acetic acid
55. Chloroquine is the generic name of: a. atabrine b. artane
c. aralen
d. akineton
166. "antre) belongs to this t%pe of antibiotics: a. penicilli penicillins ns b. cephalosph cephalosphorin orinss
c. macrolide macrolidess
d.. aminogl% aminogl%cosid cosides es
161. pinephrine is also kno(n as: a. tocoph tocophero eroll b. adrena adrenalin lin
c. emetin emetinee
d. levar levarter tereno enoll
162. 17#+dimeth%l)anthine 17#+dimeth%l)anthine is: a. caffeine b. theobromine
c. theoph%lline
d. aminoph%lline
b. ascorbic acid
C
16#. f the follo(ing penicillin congeners7 the one (ith (ith the broadest broadest spectrum of action action is: a. pen 0 b. methicillin c. carbenicillin d. o)acillin
C
16'. antac is: a. cimetidine
b. famotidine
c. ranitidine
d. niatidine
16*. C%totec C%totec is: a. sucral sucralfa fate te
b. misopr misoprost ostol ol
c. omepra omepraol olee
d. piren pirenepi epine ne
16,. !a huang is aFan: a. imidaole alkaloid
b. alkaloidal amine
c. purine
d. steroidal alkaloid
16/. Procaine Procaine is aFan: a. amine
b. ester
c. alcohol
d. ketone
B B B C & C
163. The functional group found in codeine and scopolamine is aFan: a. amine b. alcohol c. ester
d. ether
165. &ureom%cin is: a. kanam% kanam%cin cin
b. er%thr er%throm% om%cin cin
c. chlort chlortetr etrac% ac%cli cline ne
d. o)%tet o)%tetrac rac%c %clin linee
116. Bonamine is: a. mecliine
b. dramamine
c. scopolamine
d. aspirin
111. Pol%ene antibiotics include: 9. n%st n%stat atin in 99 . amph amphot oter eric icin in B a. 9 onl% b. 999 onl%
999. 99. -ris -riseo eofu fulv lvin in c. 9 and 99
d. 99 and 999
&
112. &mong the three )anthines7 it it is drug of choice for obtaining a stimulating effect of the CN$. a. caffeine b. theoph%lline c. theobromine d. all of the above
11#. & pol%saccharide pol%saccha ride that is used as plasma e)pander is: a. starch b. insulin c. de)trose
B
d. de)tran
11'. The combination t%pe oral contraceptive pill contains: a. an an androgen and a progestin c. an an androgen and an estrogen
Organic Pharmaceutical Chemistry of 19 b. an estrogen and progestin progestin
B
11*. $imethicone is chemicall% classified as aFan: a. (a) b. silicone
Page 7 d. 4$A and ;A ;A
c. sulfur
d. ketone
C
11,. &n acidif%ing agent emplo%ed in effervescent effervescent salts salts and refrigerant drinks: a. acetic acid b. lactic acid c. tartaric acid d. citric acid
11/. This is an analgesic analgesic agent that is used to lessen severit% of labor pains in obstetrics: a. colchicines b. codeine c. apomorphine d. emerol
B
113. Benaldeh%de Benaldeh %de is s%nthetic: a. cinnamon oil b. bitter almond oil
B C
c. corn oil
d. rose oil
115. The ring common among penicillins and cephalosphorins: a. benene ring b. B+lactam ring c. thiaole ring
d. phenothiaone
126. 8etin+& is: a. allt alltoi oin n
d. ben beno% o%ll pero pero)i )ide de
b. adap adapal alen enee
c. tret tretin inoi oin n
&
121. Barbiturates Barbiturates (ith an intermediate duration of action: a. amorbital b. Phenobarbital c. B 122. 0itamin 0itamin C is e)tremel% important in (ound healing. a. ma maturation of osteoblast c. b. collagen formation formation d.
pentobarbital d. secobarbital 9ts principal effect is on the: re reduction of inflammation epithelial proliferation proliferation
12#. CN$ depressants (ith skeletal muscular rela)ant propert%7 propert%7 e)cept: a. !ethacarbamol7 =$P c. Baclofen e. !eprobamate b. Carisoprodol7 =$P d. Buspirone
C
12'. The drug drug of choice for for the treatment of genital genital herpes herpes being being potent against N& formation: a. $%mmetrel b. Aerple) c. &c%clovir d. 0idarabine
&
12*. The drug drug most effective against malarial malarial parasites parasites in in the liver but not effective effective against parasites parasites (ithin (ithin er%throc%tes: a. primaquine b. p%rimethamine c. quinacrine d. chloroquine
B
12,. 4eldene is: a. sulindac sulindac
b. piro)icam piro)icam
c. indometha indomethacin cin
d. ketoprofe ketoprofen n
12/. 0oltaren is: a. acemetacin
b. ibuprofen
c. diclofenac
d. napro)en
C C
B
&
123. epo+Provera is: a. c%proterone acetate b. nandrolene decanoate decanoate
c. medro)%progesterone acetate d. leuproreline acetate acetate
125. Dhich of the follo(ing actions of histamine is not blocked b% A1 antagonist: a. in increase in salivar% e)cretion c. va vasodilation b. increase in gastric gastric secretions secretions d. itchiness 1#6. pium p ium is an e)ample of: a. narcotic analgesic b. non+steroidal analgesic analgesic
c. antip%retic analgesic d. anti+inflammator% anti+inflammator% analgesic
1#1. Dhich of the the follo(ing follo(ing penicillin derivatives is both both acid+stable and resistant resistant to penicillinaseE penicillinaseE a. methicillin c. ampicillin e. pheno)%meth%l penicillin b. disodium carbenicillin carbenicillin d. o)acillin
Organic Pharmaceutical Chemistry of 19 B
&
&
Page 8
1#2. & diuretic that (ill manifest a competitive inhibition of the action of aldosterone: a. Triamterene b. $pirinolactone c. 4urosemide d. Chlorothiaide 1##. $ulfonamides $ulfonamide s are metabolied b% humans principall% principall % b%: a. acet%lation c. o)idation c. deamination d. con
e. meth%lation
1#'. $treptom%cin $treptom%cin and other aminogl%coside antibiotics are: a. ototo)ic c. h%pergl%cemic b. carcinogenic d. hepatoto)ic
e. goiterogenic
1#*. Benalkonium chloride is a germicidal surfactant (hich rendered inactive in the presence of: a. organic acid c. cationic surfactants e. inorganic salts b. gram+negative organisms organisms d. soaps
B
1#,. &cetaolamide &cetaolamide ?iamo)@ is rarel% the drug of choice for diuretic therap% because it: a. is to too po potent b. causes s%stemic s%stemic acidosis and alkaline alkaline urine c. is hab habit it formi orming ng d. does does not not e)hibi e)hibitt tach% tach%ph% ph%la)i la)iss e. induces induces en%mes7 en%mes7 especial especiall% l% carbonic carbonic anh%drase anh%drasess
C
1#/. The antips%chotic antips%chotic drug lo)apine succinate ?;o)itane@ is a compound: a. phenothiaine c. dibeno)aepine e. but%rophenone b. benodiaepine d. thio)anthene
B
1#3. ipheno)%late ?;omotil@ is an agent useful in the treatment of diarrhea. diarrhea. 9t is structurall% similar to: a. kaolin c. diphenh%dantoin e. o)alic acid b. meperidine d. pectin
&
1#5. Dhich of the the follo(ing follo(ing is classified as a broad+spectrum broad+spectrum antibioticE a. ampicillin c. sodium methicillin e. potassium phenethicillin b. penicillin d. sodium clo)acillin clo)acillin
B
1'6. &n &n antimanic agent: a. haloperidol
&
B
&
B
B
b. lithium salts
c. ;$
d. phenol
1'1. ;iquefied phenol7 =$P: a. ph p henol containing 16G (ater b. phenol as surgical surgical antiseptic antiseptic
c. ca c arbol+fuchsin solution d. treatment of tinea infection infection
1'2. Castellanis paint: a. ph p henol containing 16G (ater b. carbol+fuchsin solution solution
c. ph p henol as surgical antiseptic d. antibacterial antibacterial d%e
1'#. This is an effective antidote for the treatment of poisoning poisoning b% copper: copper: a. pen penicil icilllamin aminee b. dime dimerc rcaapro prol c. lugol ugols solu soluti tion on 1''. Tetrac%clin Tetrac%clinee is: a. an intermed intermediate iate spectrum7 spectrum7 bacterici bactericidal dal b. a broad spectrum7 spectrum7 bacteriostatic bacteriostatic
d. cast castel ella lani nis pai paint
c. a broad broad spectrum7 spectrum7 bacteric bactericidal idal d. an intermediate intermediate spectrum7 spectrum7 bacteriostatic bacteriostatic
1'*. Dhich of the the follo(ing follo(ing is not not soluble soluble in or or miscible miscible (ith alcohol7 =$PE a. ether b. acacia c. methanol d. Phenobarbital 1',. The drug used in all t%pes of tuberculosis is: a. ethambutol c. streptom%cin
e. p+aminosalic%lic acid
e. (ater
Organic Pharmaceutical Chemistry of 19 b. c%closerine B
1'/. ;evarterenol ;evarterenol ?;evophed@ is: a. ;+epinephrine b. ;+norepinephrine
Page 9
d. isoniaid c. 9soproterenol d. ;+dopa
e. ;+ephedrine
&
1'3. The most active aminogl%coside against Mycobacterium against Mycobacterium tuberculosis tuberculosis is: is: a. streptom%cin c. neom%cin e. kanam%cin b. amikacin d. tobram%cin
B
1'5. The most effective agent in the treatment of 8ickettsia7 !%coplasma and Chlam%dia infection is: a. penicillin c. vancom%cin e. bacitracin b. tetrac%cline d. gentamicin
1*6. &luminum &luminum and calcium salts inhibit inhibit the intestinal intestinal absorption of (hich (hich of the follo(ing follo(ing agentsE a. 9s 9soniaid c. Pheno)%meth%l penicillin e. Tetrac%cline b. Chloramphenicol d. r%throm%cin
C
1*1. Dhich of the follo(ing penicillins is resistant to penicillinaseE penicillinaseE a. Pol%m%)in B c. iclo)acillin b. Penicillin d. Carbenicillin
e. $treptom%cin
1*2. The quinolone derivative effective against P against P.. Aeruginosa is: Aeruginosa is: a. norflo)acin c. oflo)acin b. ciproflo)acin d. eno)acin
e. lomeflo)acin
1*#. Dhich of the follo(ing penicillins is resistant to penicillinaseE penicillinaseE a. &mpicillin c. Carbenicillin b. )acillin d. Ticarticillin Ticarticillin
e. !elocillin
1*'. 8ancidit% of fats ma% be due to: a. reduction to alcohols c. o)idation of double bonds b. impurities d. saponification
e. h%drogenation
B
B
C
& a b c d &
B
& B
C
1**. & thiaide diuretic can: a. enhance action of amphetamines b. antagonie action action of guanethidine guanethidine c. antagonie action action of digitalis digitalis drugs 1*,. $urfactants are characteried b%: a. the the pre prese senc ncee of (ate (ater+ r+so solu lubi bili lii ing ng grou groups ps b. negative charges c. positive charges
d. enhance action of oral h%pogl%cemics e. antagonie action action of tric%clic tric%clic antidepressants antidepressants
d. the the pre prese senc ncee of fat+ fat+so solu lubi bili lii ing ng grou groups ps e. the presence of (ater+solubiliing and fat+solubiliing groups in the same molecule
1*/. Piperaine citrate ?&ntepar@7 gentian violet7 p%rivinium pamoate ?Povan@ and thiabendaole ?!inteol@ are a. anthelmintics c. antiseptics e. anticholinergics b. d%es d. scabicides 1*3. &T or &idoth%midine &idoth%midine is used in the treatment of: a. "ochs infection b. A90 or &9$ c. carbuncle
d. ring(orm
1*5. 9s a folate+reductase folate+reductase inhibitor: a. Trimethoprim b. $ulfonamides c. Penicillin d. Tetrac%cline 1,6. The structure structure of this this class of antibiotic antibiotic has a beta+lactam ring and a thiaolidine thiaolidine ring. a. Taobactam b. Penicillin c. Cephalosporins d. !onobactam 1,1. The generic generic name of uracef: uracef:
all:
Organic Pharmaceutical Chemistry 10 of 19 a. Cephradine
B
B
b. Cephaoline
1,2. The preparation is used as pediculicide: a. =ltralan cream b. Trim%cin ointment
Page c. Cephadro)il
d. Cephale)in
c. Betronavate ointment
d. "(ell lotion
1,#. &n antibiotic that is obtained from Streptomyces noursei: noursei: a. &mphotericin B b. N%statin c. -riseofulvin
d. Clindam%cin
1,'. The plant containing the anticancer drug7 vincristine and vnblastine: a. !a%apple b. Peri(inkle c. uropean %ear
d. Datura alba
&
1,*. & ver% common common adverse adverse reaction reaction of alk%lating agents used used in the treatment treatment of cancer: cancer: a. alopecia b. miosis c. m%driasis d. ata)ia
C
1,,. These are calcium channel blockers7 e)cept: a. 0erapamil b. Nifedipine
c. &tenolol
d. iltiaem
1,/. The generic name of the brand iabinese: a. Chlorpropramide b. -libenclamide
c. !etformin
d. &cetohe)amide
1,3. & loop or high+ceiling diuretic: a. 4urosemide b. $orbitol
c. $pirinolactone
d. A%drochlorothiaide
c. 9sopropanol
d. -l%citol
1/6. These drugs are narcotic analgesics7 e)cept: a. morphine b. codeine
c. nalbuphine
d. mefenamic acid
1/1. This is used as an inhalation anesthetic: a. droperidol b. thiopental
c. halothane
d. midaolam
1/2. ;evodopa is used in the treatment of: a. leukemia b. Parkinsons disease
c. &lheimers disease
1/#. The generic name of Nubain: a. Nalbuphine b. Nalo)one
c. Pentaocine
d. !ethadone
1/'. !ethenam !ethenamine ine is also called: called: a. =ridine b. =racil
c. =ric acid
d. =rothropin
&
&
& 1,5. This drug is is used as an osmotic diuretic: a. !annitol b. thanol
C
B
&
B
1/*. Neuroto)icit% caused b% 9soniaid can be treated (ith: a. thiamine b. p%rido)ine c. menaquinone
d. Ta% $achs disease
d. ergocalciferol
1/,. & broad+spectrum anthelmintic that is effective effective against a variet% of nematode nematode infestations infestations and is the generic generic name of &ntio): a. Piperaine b. Thiabendaole c. P%rantel pamoate d. !ebendaole B
1//. & common agent in smoking cessation programs providing patches: a. lobeline b. nicotine c. emetine
d. coal tar
C
1/3. Thiabendaole ?!inteol@7 a benimidaole benimidaole derivative7 is an anthelmintic drug used used primaril% primaril% to treat infections caused b%: a. Ascaris a. Ascaris c. Strongyloides e. Taenia saginata ?flat(orm@ saginata ?flat(orm@ b. Necator b. Necator americanus americanus ?hook(orm@d. Entero ?hook(orm@d. Enterobios bios vermicularis vermicularis
B
1/5. ne of the reasons reasons (h% aminogl%cosides aminogl%cosides are are frequentl% frequentl% combined (ith (ith other antibiotics in treating treating certain
Organic Pharmaceutical Chemistry 11 of 19 infections is to: a. prevent drug infections b. prevent drug emergence emergence of resistant resistant bacteria bacteria c. increase renal e)cretion
Page
d. increase oral absorption e. decrease s%stemic s%stemic to)icities to)icities
136. &ngiotensin+conver &ngiotensin+converting ting en%mes ?&C@ ?&C@ inhibitors inhibitors are associated associated (ith a high incidence incidence of (hich (hich of the follo(ing adverse reactionsE a. hepatitis c. agranuloc%tosis e. hirsutism b. h%pokalemia d. proteinuria
131. Dhich of of the follo(ing chemotherapeutic agents has has a good penetrabilit% penetrabilit% into the the cerebrospinal cerebrospinal fluidE a. streptom%cin c. tobram%cin e. cephale)in b. gentamicin gentamicin d. chloramphenicol chloramphenicol
C
132. The scientist (ho can la% claim claim to the title title of 4ather 4ather of Chemotherap%: Chemotherap%: a. 8obert "och c. Paul hrlich e. -iuseppe Brotu b. Hoseph ;ister ;ister d. &le)ander &le)ander 4leming 4leming
&
13#. ffective ffective administration administration routes of nitrogl%cerin nitrogl%cerin for angina angina pectoris pectoris include include all all of the follo(ing7 follo(ing7 e)cept: a. oral b. inravenous c. transdermal d. sublingual
&
13'. This group is is responsible responsible for the bone bone marro( marro( to)icit% of chloramphenicol: chloramphenicol: a. N2 gr group c. A group e. benene group b. NA2 group d. CA group
13*. iaepam is used in in the treatment of all all of the follo(ing7 e)cept: a. an)iet% c. skeletal muscle spasm e. preoperative sedation b. status epilepticus epilepticus d. analgesia
13,. Dhich is not true regarding ceftria)one: a. a #rd gene genera rati tion on cep cepha halo losp spor orin in c. adm admin inis iste tere red d pare parent nter eral all% l% b. resistant to to B+lactamase B+lactamase d. once dail% dosing dosing
e. res resis ista tant nt to to aci acid d
13/. &ll of the follo(ing substances are present in opium7 e)cept: a. thebaine c. codeine b. methadone d. morphine
e. papaverine
B
B
133. &n antip%retic aniline derivative (ith (eak anti+inflammator% anti+inflammator% activit%: a. acet%lsalic%lic acid c. mefenamic acid e. sulindac b. acetaminophen acetaminophen d. indomethacin
&
135. The most potent of the inhalation anesthetic agents: a. metho)%flurane c. enflurane b. halothane d. nitrous o)ide
e. isoflurane
C
156. Dhich of the follo(ing antineoplastics is not considered an antimetaboliteE antimetaboliteE a. methotre)ate c. etoposide e. c%tarabine b. thioguanine d. fluorouracil fluorouracil
151. Dhich of the follo(ing statements is not true regarding the aminogl%coside aminogl%coside antibioticsE a. the% are highl% ionied in solution d. the% are ototo)ic and nephroto)ic b. the% are bactericidal bactericidal e. the% are easil% easil% absorbed after after oral administration administration c. the% are more effective in alkaline medium
Organic Pharmaceutical Chemistry 12 of 19 &
152. Baclofen7 a derivative of -&B& is used in: a. spast spastici icit% t% in in patie patients nts (ith (ith mult multipl iplee scle scleros rosis is b. parkinsonism
Page
c. manage managemen mentt of spasti spasticit cit% % in in rheu rheumat matic ic disord disorder erss d. spasticit% of cerebral pals% pals%
C
15#. ;ong ;ong term use of tetrac%clines tetrac%clines in pregnant pregnant (omen (omen should be avoided avoided due to to several reasons. Dhich of these is not trueE a. the% chelate calcium ions b. the% ma% predispose predispose to discoloration discoloration of deciduous deciduous teeth in the the infant c. the% are to)ic to the fetus and ma% cause abortion d. the% can cause %ello( atroph% of the liver in the mother e. the% get deposited in gro(ing bones
&
15'. &ll of the follo(ing antibiotics produce neuromuscular blockade7 e)cept: a. ampicillin c. streptom%cin e. amikacin b. kanam%cin d. neom%cin
B
15*. 4or 4or the treatment of s%stemic s%stemic m%cosis7 m%cosis7 (hich (hich of the follo(ing follo(ing antifungal agents can be administered b% intravenous routeE a. miconaole c. ketoconaole e. n%statin b. amphotericin amphotericin B d. clioquinol
C
15,. Dhich of the follo(ing agents is not used for local candidiasisE a. n%statin c. griseofulvin e. clotrimaole b. gentian violet violet d. miconaole
B
15/. &ll of the follo(ing are effective effective and clinicall% clinicall% useful useful against against (orm (orm infestation infestation caused b% Ascaris b% Ascaris umbricoides7 umbricoides7 e)cept: a. piperaine c. mebendaole e. thiabendaole b. niridaole d. p%rantel pamoate pamoate
C
153. & good local local anesthetic should have all all of the follo(ing follo(ing properties7 e)cept: a. s%stemic to)icit% should be lo( b. effective effective at bod% fluid pA c. onset of anesthesia should be gradual and short duration of action to avoid to)icit% d. must be effective regardless of the site of application e. not irritant to the tissue and should not cause an% permanent structural damage to nerves
155. 4rom 4rom the list given given belo(7 belo(7 identif% identif% the the drug possessing Itriad Itriad of featuresJ (hich includes includes antiamebic. antiamebic. antigiardiasis7 antigiardiasis7 and antitrichomonal: antitrichomonal: a. iodoquinol c. emetine e. piperaine b. chloroquine d. metronidaole
&
266. Aeparin Aeparin is aFan: aFan: a. e)tract of animal tissue b. e)tract of plant plant
e
c. metal d. hormone
e. en%me
B
261. &mongst &mongst the follo(ing7 the drug of choice for acute attack of Plasmodium of Plasmodium viva! malaria viva! malaria is: a. amodiaquine c. primaquine e. mefloquine b. chloroquine d. quinine
B
262. rugs (hich act on er%throc%tic er%throc%tic c%cle c%cle of malarial parasite: a. (ill be effective for radical cure c. (ill not be clinicall% effective
Organic Pharmaceutical Chemistry 13 of 19 b. (ill be effective effective for for suppressive proph%la)is proph%la)is
Page d. (ill both be effective effective for proph%la)is proph%la)is and radical use
B
26#. &ll statements regarding antip%retic analgesics are false7 e)cept: a. produc producee fall fall in blood blood pressu pressure re c. develo develop p drug drug depend dependenc encee e. produc producee gene genera rall CN$ CN$ depres depressio sion n b. raise the pain threshold d. relieve visceral visceral pain
C
26'. rug of choice for ring(orm infection is: a. n%statin c. griseofulvin b. ketoconaole d. neom%cin
e. amphotericin B
&
26*. &cetaminophen &cetaminophen is preferred over aspirin in follo(ing conditions7 e)cept: a. rheumatic disease d. children (ith influena b. patients (ith (ith peptic ulcer ulcer e. children (ith (ith chicken po) c. patients (ith bronchial asthma
&
26,. ral ral neom%cin neom%cin and streptom%cin are used used for steriliation steriliation of bo(el and for d%senter% because: a. the% are at least absorbed from oral route b. the peak concentration concentration in blood is achieved quickl% quickl% c. the% are least to)ic to -9T d. the% are destro%ed b% the gastric
26/. Dhich of the follo(ing follo(ing is the the most most appropriate appropriate statement about indomethacinE a. it is a po(erful analgesic onl% b. it is a po(er po(er anti+inflammator% anti+inflammator% onl% c. it is onl% analgesic and anti+inflammator% anti+inflammator% (ithout antip%retic effect d. it is a po(erful analgesic and anti+inflammator% anti+inflammator% agent (ith antip%retic and uricosuric actions e. it is po(erful antip%retic onl%
B
263. Dhich of the follo(ing is a depot penicillin preparationE a. pheno)%meth%lpenicillin c. ben%l penicillin b. benathine penicillin penicillin d. clo)acillin
e. methicillin
B
265. &ll of the follo(ing drugs interfere (ith platelet activit%7 activit%7 e)cept: a. aspirin c. protamine e. anisindione b. dimercaprol dimercaprol d. (arfarin
C
216. ,+aminopen ,+aminopenicil icillanic lanic acid is: a. ma
&
211. ipheno)%late7 an effective effective antidiarrheal antidiarrheal drug is: a. related to meperidine c. a narcotic antagonist b. atropine+like atropine+like drug d. a ganglion+blocking ganglion+blocking drug
e. anticholinergic action
212. Class Class 9 antiarrh%thmic antiarrh%thmic drugs result in decrease decrease in heart rate rate of the accelerated accelerated heart and and usuall% reduce the the rate of conduction of cardiac impulse. The% include the follo(ing7 e)cept: a.quinidine c. disop%ramide e. amiodarone b. procainamide procainamide d. phen%toin
B
21#. Dhich of the follo(ing drugs does not reduce blood cholesterol levelE a. clofibrate c. destroth%ro)ine e. colestipol b. epinephrine d. cholest%ramine cholest%ramine
21'. Dhich of the follo(ing is the longest+acting nitrateE
Organic Pharmaceutical Chemistry 14 of 19 a. gl%cer%l trinitrate b. am%l nitrite nitrite
c. er%thritol tetranitrate d. pentaer%thritol pentaer%thritol tetranitrate tetranitrate
Page e. isosorbide dinitrate
&
21*. Dhich of of the follo(ing is considered considered a primar% primar% drug drug for the treatment treatment of all seiure t%pes e)cept e)cept absenceE absenceE a. carbamaepine c. valproic acid e. phenobarbital b. ethosu)imide d. diaepam
C
21,. Dhich of the follo(ing follo(ing penicillins is acid stable and therefore therefore orall% effective: a. benathine penicillin c. clo)acillin e. piperacillin b. procaine penicillin penicillin d. tricarcillin tricarcillin
21/. & monoamine o)idase inhibitor used as an antidepressant drug: a. amitr%ptiline c. cloapine e. fluo)etine b. thioridaine thioridaine d. tran%lc%promine tran%lc%promine
213. Dhich of the follo(ing follo(ing is not used for topical application on e)ternal e)ternal surfacesE a. mafenide c. sodium sulfacetamide e. resorcinol b. silver sulfadiaine sulfadiaine d. sulfiso)aole
B
215. &ll of the follo(ing benodiaepines are commonl% commonl% used used in the treatment treatment of an)iet%7 an)iet%7 e)cept: a. chlordiaepo)ide c. alpraolam e. diaepam b. clonaepam d. loraepam
226. Dhich of the follo(ing chemotherapeutic agents is not bactericidalE bactericidalE a. carbenicillin c. cefuro)ime e. vancom%cin b. gentamicin gentamicin d. er%throm%cin er%throm%cin
221. &ll of the the follo(ing follo(ing statements are true concerning the penicillins7 e)cept: a. this class of antibacterials acts b% damaging the cell (alls of bacteria b. piperacillin piperacillin and ticarcillin ticarcillin have activit% activit% against Pseudomonas against Pseudomonas species species c. use of an% penicillin is contraindicated contraindicated in a patient (ho has had an allergic reaction reaction to an% one penicillin d. the% are obtained from the genus of Streptomyces e. the addition of clavulanic acid to amo)icillin preparations preparations protects the drug from penicillinase
B
222. 9n choosing choosing a specific benodiaepine for the the treatment treatment of insomnia7 all of the the follo(ing follo(ing are considerations7 considerations7 e)cept: a. age of the patient c. the half life of the drug b. mental status status of the patient patient d. the absorption absorption of the drug c. the underl%ing sleep disorder being treated
22#. &n antibiotic most commonl% used in topical preparations: a. clotrimaole c. griseofulvin b. vidarabine d. bacitracin bacitracin
e. foscarnet
22'. The preferred agent for h%pertensive emergencies: emergencies: a. propranolol c. captopril b. clonidine d. diao)ide
e. sodium nitroprusside
C
22*. $uperior to ac%clovir ac%clovir in the treatment treatment of herpes herpes viruses viruses in the the CN$ CN$ in in neonates: neonates: a. ido)uridine c. vidarabine e. idovudine b. ribavirin d. amantadine
22,. Dhich of the follo(ing follo(ing bases is is most most susceptible to alk%lating alk%lating agentsE a. adenosine c. th%midine e. uridine b. c%tosine d. guanine
&
22/. 0incristine 0incristine is used primaril% primaril% in the the treatment treatment of (hich (hich of the the follo(ingE follo(ingE
Organic Pharmaceutical Chemistry 15 of 19 a. Aodgkins disease b. lung cancer
c. liver cancer d. melanoma
Page e. prostate cancer
B
223. 4or 4or the treatment of s%stemic s%stemic m%coses7 m%coses7 (hich (hich of the follo(ing follo(ing antifungal agents can can be administered administered b% intravenous routeE a. miconaole c. ketoconaole e. n%statin b. amphotericin amphotericin B d. clioquinol
225. Penicillin is the drug of choice for the follo(ing infective conditions7 e)cept: a. gonococcal infection d. streptococcal infection b. pneumococcal infection infection e. pseudomonal infection infection c. treponema pallidum infection
B
2#6. &ll &ll of the follo(ing follo(ing drugs drugs act as prodrugs prodrugs and need need to be converted converted in the the bod% to active active compound7 e)cept: a. levodopa c. prednisone e. c%clophosphamide b. salbutamol d. bacampicillin bacampicillin
C
2#1. &mongst &mongst the follo(ing the drug of choice for scabies is: a. sulfur c. ben%l benoate b. crotamiton d. amodiaquine
e. tannic acid
2#2. $ensitivit% of gram negative bacilli to amo)icillin is due to its: a. carbo)%l group c. h%dro)%l group b. nitro group group d. amino group group
e. carbon%l group
&
2##. Bone Bone marro( marro( depression depression resulting resulting in panc%topenia panc%topenia is the characteristic characteristic to)ic effect effect of all all the follo(ing drugs7 e)cept: a. o)%tetrac%cline c. methotre)ate e. dactinom%cin b. chloramphenicol chloramphenicol d. mitom%cin mitom%cin
C
2#'. The follo(ing antibiotic possess clinicall% useful antimalignant antimalignant propert% propert%77 e)cept: a. mitom%cin c. streptom%cin e. plicam%cin b. bleom%cin d. daunorubicin
&
2#*. This is the the process process utilied b% 4lore% 4lore% and Chain Chain in in isolating isolating penicillin: a. freee+dr%ing c. chromatograph% e. distillation b. e)traction d. )+ra%
C
2#,. The metabolite of the red red d%e7 d%e7 prontosil7 prontosil7 responsible for its antimicrobial antimicrobial propert%: propert%: a. sulfiso)aole c. sulfanilamide e. sulfap%ridine b. sulfametho)aole sulfametho)aole d. sulfacetamide sulfacetamide
B
2#/. Dhich of of the follo(ing antiviral agents is not not useful for the treatment of herpes herpes virus infectionE a. vidarabine c. trifluridine e. ido)uridine b. interferon interferon d. ac%clovir
B
2#3. &ll of the the follo(ing follo(ing chemotherapeutic chemotherapeutic agents agents are are useful useful for proph%la)is against infections caused b% b% specific microorganisms7 e)cept: a. amantadine against influena & virus d. tetrac%cline against rickettsial infection chlo chlora ramp mphe heni nico coll aga again inst st t%ph t%phoi oid d fev fever er e. p%ri p%rime meth tham amin inee aga again inst st mala malari riaa in in end endem emic ic area areass c. isoniaid against tubercular infection
2#5. The The therapeutic therapeutic uses of amphetamines amphetamines does not include include (hich of the follo(ing: a. in h%perkinetic children c. obesit% e. h%pertension b. narcoleps% d. parkinsonism
B
2'6. Nitrous Nitrous o)ide7 a general general anesthetic anesthetic agent7 is characteried characteried b% all of the features of (hich of the follo(ing follo(ing
b.
Organic Pharmaceutical Chemistry 16 of 19
Page
groupsE a. high potenc%7 good analgesia7 good skeletal muscle rela)ation b. lo( potenc%7 potenc%7 good analgesia7 analgesia7 poor skeletal skeletal muscle rela)ation rela)ation c. high potenc%7 poor analgesia7 good skeletal muscle rela)ation d. high potenc%7 good analgesia7 poor skeletal muscle rela)ation e. lo( potenc%7 good analgesia7 good skeletal muscle rela)ation
2'1. & drug receptor ma% be all of the follo(ing7 e)cept: a. isolable en%me c. protein or a nucleic acid b. functional component component of a cell cell membrane d. chelates
B
2'2. !echanism of action of trimethoprim: trimethoprim: a. compet competitiv itivee inhibito inhibitorr for the incor incorporat poration ion of P&B& P&B& b. folate reductase reductase inhibitor
&
c. inhibit inhibitss protein protein s%nth s%nthesis esis d. destruction of bacterial cell cell (all
2'#. & drug molecule (hich possesses both intrinsic intrinsic activit% and affinit%: affinit%: a. agonist b. antagonist c. poison
d. none of the above
C
2''. Chelating Chelating agent that that is an effective effective antidote foe copper copper poisoning poisoning and used in the treatment treatment of Dilsons Dilsons disease: a. defero)amine mes%late b. dimercaprol c. penicillamine d. T&
&
2'*. Dhich is not a chelating agentE a. 3+!e 3+!eth tho)% o)%qu quin inol olin inee b. 3+!e 3+!erc rcap apto toqu quin inol olin inee
c. 3+A% 3+A%dr dro)% o)%qu quin inol olin inee
2',. imercap imercaprol rol is also kno(n as: a. B&; b. ithiogl%cerol
c. both a K b
C
d. '+& '+&&+ &+) )im imee
d. none of the above
&
2'/. $%nthesied $%nthesied from from dr% h%drogen chloride chloride and carbon carbon mono)ide at #66 degrees and 266 atm pressure: a. tetrachloroeth%lene b. piperaine c. both d. none
B
2'3. Passive diffusion includes (hat drugE a. ;ipid soluble b. ;ipid insoluble
B
B
c. &mphoteric
d. A%drophilic
2'5. 9t is the tendenc% of the drug to combine (ith the receptor: a. fficac% b. 9ntrinsic activit% c. Bonding
d. &ffinit%
2*6. Brand Brand name of Bisacod% Bisacod%l: l: a. -elusin !P> b. ulcola)
c. Aaloperidol
d. 4leet
2*1. Penicill Penicillin in a. !ethicillin
c. both
d. none
b. Ben%l penicillin
&
2*2. rgano+$ilicon rgano+$ilicon pol%mers containing containing and and $i atoms atoms (ith a substituent substituent organic organic groups: a. silicons b. alk%nes c. esters d. ethers
2*#. & phenol primaril% obtained from clove oil: a. resorcinol b. cresol
&
c. he)%lresorcinol
d. eugenol
2*'. Dhich of the follo(ing follo(ing is used used in the treatment of pernicious pernicious anemiaE a. thiamine b. niacin c. riboflavin
d. c%anocobalamin
2**. Classified as a macrolide antibiotic7 e)cept: a. Bacitracin b. r%throm%cin
d. leandom%cin
c. $piram%cin
Organic Pharmaceutical Chemistry 17 of 19 C
&
C
C
Page
2*,. & macrolide antibiotic (hich (as found in in the soil of 9loilo: a. &chrom%cin b. &lbam%cin c. r%throm%cin 2*/. The follo(ing antimalarials antimalarials are s%nthetic drugs7 e)cept: a. &tabrine b. &ralen c. Camoquin
d. 0iom%cin
d. Luinine
2*3. Pol%ene antibiotics for fungi: a. amphotericin B b. miconaole
c. ketoconaole d. both a K b
e. both b K c
2*5. &lso &lso kno(n kno(n as solvent solvent shift: shift: a. facilitated transport b. ion+pair transport transport
c. bulk transport d. passive diffusion diffusion
e. none of the above
2,6. )ternall%7 )ternall%7 eth%l alcohol is emplo%ed as: a. refrigerant b. rubefacient 2,1. Carbonic Carbonic acid gas: a. o)%gen b. nitrogen
c. astringent
c. carbon dio)ide d. ammonia
d. all of the above
e. helium
&
2,2. 4or patients allergic to penicillins7 penicillins7 this drug is used used as as alternative: alternative: a. er%throm%cin c. aureom%cin e. none of the above b. spectinom%cin spectinom%cin d. lincom%cin lincom%cin
&
2,#. These anti+diarrheals anti+diarrheals trap trap the to)ins and flushes flushes them out of %our %our s%stem: s%stem: a. adsorbents b. anti+motilit% agents c. astringents d. oral reh%dration salts
&
2,'. rug of choice for urinar% tract infections: a. co+trimo)aole b. gentamicin
c. naprofen
d. all of the above
2,*. 0oltaren: ltaren: a. tolmetin
c. diclofenac
d. piro)icam
C
C
b. sulindac
2,,. The chemical name of Phenethicillin: Phenethicillin: a. Ben%l penicillin b. Pheno)%meth%l Pheno)%meth%l penicillin
c. Pheno)%eth%l penicillin d. Pheno)%prop%l Pheno)%prop%l penicillin
C
2,/. The follo(ing are the uses of meth%lene blue7 e)cept: a. antidote for c%anide poisoning c. antidote for barbiturate poisoning b. antidote for for nitrate poisoning poisoning d. none of the above
B
2,3. !echanism of action action of of this this anti+tubercula anti+tubercularr agent agent is to inhibit inhibit protein s%nthesis: a. P& b. $treptom%cin c. 9NA d. thambutol
&
2,5. Compounds Compounds that result from from a combination of electron electron donors (ith a metal ion ion to form a ring structure: structure: a. chelates b. ligands c. both d. none
&
2/6. Transport Transport of drug molecules molecules from the the site of administration administration to the s%stemic circulation: a. absorption c. metabolism e. to)icolog% b. adsorption d. e)cretion
2/1. !eth%lsalic%late !eth%lsalic%late is also kno(n as : a. toothache drop b. oil of Hasmine
B
2/2. &gents &gents that facilitate the evacuation of bo(els: a. anti+motilit% agents c. astringents
c. oil of rose
d. oil of (intergreen
e. none of the above
Organic Pharmaceutical Chemistry 18 of 19 b. cathartics cathartics C
B
&
C
C
B
B
Page
d. antacids
2/#. &bsolute &bsolute alcohol is commerciall% prepared b%: a. direct distillation b. fermentation
c. aeotropic distillations d. none
2/'. 2/'. Nubain Nubain:: a. meperidine b. nalbuphine
c. methadone d. fentan%l
e. pentaocine
2/*. "aopecta "aopectate: te: a. activated charcoal b. attaulgite attaulgite
c. resol d. kaolin M pectin pectin
e. atropine sulfate
2/,. The least stable of all vitamins: a. ascorbic acid c. thiamine b. folic acid d. retinoic acid acid 2//. & change in structure of isoniaid causes: a. an increase in in the potenc% of the drug b. an increase in the duration of of drug action
e. menadione
c. decrease in the potenc% of the drug d. none of the above
2/3. The most to)ic vitamin: vitamin: a. folic acid b. pantothenic acid acid
c. retinoic acid d. thiamine
e. p%rido)ine
2/5. !a
c. skin d. small intestines intestines
e. none of the above
236. -eneric -eneric name of Benadr%l Benadr%l &A: &A: a. guaiafenesin b. diphenh%dramine
c. apomorphine
d. benonatate
a &
231. & bright red d%e d%e that (as found to create remarkable remarkable cures of streptococcal streptococcal infections: infections: a. prontosil b. meth%l red c. both d. none
C
232. Aalaone Aalaone is aFan: a. iodophor d. o)idiing agent b. mercur% containing containing anti+infective anti+infective e. none of the above above c. chlorine containing anti+infective 23#. rug of choice choice for lepros%: lepros%: a. rifampicin c. prothionamide e. dapsone b. ethonamide d. clofaimine
B
B
B
C
23'. The metabolic function of niacin: a. decarbo)%lation b. redo) reactions
c. differentiation of epithelial tissues d. maturation maturation of er%throc%tes er%throc%tes
23*. $unshine $unshine vitamin: vitamin: a. &
c.
d. "
c.
d.
b.
23,. The follo(ing are fat+soluble vitamins7 e)cept: a. & b. B2 23/. 9n terms of pA7 aspirin is absorbed in the: a. mouth c. stomach
e. rectum
e. "
Organic Pharmaceutical Chemistry 19 of 19 b. small intestines intestines B
C
Page
d. large intestines intestines
233. Therapeutic gas used as a gas diluentFcarrier: diluentFcarrier: a. o)%gen b. helium
c. nitrogen
d. carbon dio)ide
235. The follo(ing drugs are e)tensivel% metabolied in the liver7 e)cept: a. 9soproterenol b. Propranolol c. ;idocaine
d. Paracetamol
256. & d%e used in vital nerve staining: a. malachite green b. gentian violet
d. basic fuchsin
c. meth%lene blue
251. The e)cretion e)cretion of (eakl% (eakl% basic drug (ill (ill be more rapid rapid in acidic acidic urine than in in basic urine because: a. all drugs are e)creted more rapidl% in acidic urine b. the drug (ill (ill e)ist primaril% primaril% in the unionied unionied form7 (hich (hich cannot easil% be reabsorbed c. (eak bases cannot be reabsorbed from the kidne% tubules d. the drug (ill e)ist primaril% in the ionied form7 (hich cannot be easil% reabsorbed
&
252. $uperinfection $uperinfection is common (ith: a. anti antibi biot otic icss (hi (hich ch are are giv given en pare parent nter eral all% l% b. those (hich (hich are used for prolonged prolonged period
&
C
c. thos thosee (hi (hich ch supp suppre ress ss the the nor norma mall bac bacte teri rial al flor floraa d. those (hich (hich are given as a depot preparation preparation
25#. & potentiall% fatal aplastic anemia is a to)icit% associated (ith: a. chloramphenicol b. nitrofurantoin c. clindam%cin 25'. Dhich is not true for cephalosporinsE a. broad spectrum b. bactericidal
d. cephalothin
c. affected b% penicillinases
d. acid+stable
25*. Bactrim and $eptrim are trade names for a fi)ed+dose combination of: a. sulfamethiole and trimetho)aole c. sulfametho)aole and phenaop%ridine b. sulfiso)aole and methenamine methenamine d. sulfametho)aole sulfametho)aole and trimethoprim trimethoprim
C
25,. Dhich of of the follo(ing is most most likel% likel% to cause tinnitus tinnitus and hearing hearing loss in high dosesE a. ibuprofen b. phen%lbutaone c. acet%lsalic%lic acid d. indomethacin
B
25/. Pharmacologic Pharmacologic effects effects of the classic classic antihistamines antihistamines include include all all of the follo(ing7 e)cept: a. sedation (ith lo( doses c. an antipruritic effect b. inhibition of gastric acid acid secretion d. dr%ing of salivar% salivar% and bronchial bronchial secretion
&
253. &n e)ample of a commercial commercial product product that is pro+drug: a. ;asi) b. -eocillin c. !orphine
d. 0alium
B
255. &ll of the follo(ing statements are correct7 e)cept: a. sulfonamides increase the risk of neonatal kernicterus b. ketoconaole penetrates penetrates into the the C$4 c. metronidaole is effective against Entero against Enterobacter bacter histolytica histolytica d. mebendaole is the drug of choice choice in the treatment treatment of (hip(orm infections infections
B
#66. ;arge overdose of acetaminophen are likel% to cause: a. tinnitus b. hepatic necrosis c. agranuloc%tosis
d. renal tubular acidosis
