JC-2 Tutorial-1 Tutorial-1 Immunology Immunology Practice MCQ’s Dr. Dr. Patrick Walsh 1th !e". 2#1$ 1 Which of the following does not protect body surfaces: a. Skin. b. Mucus. c. Gastric acid. d. Salivary amylase e. Gut microflora. 2 Pattern recognition receptors (PRR) include: a. LPS. b. PAMPs. c. Lipoteichoic Lipoteichoic acid. d. Lectin-like molecules. e. nmethylated !pG se"uences. # The mononuclear phagocyte system does not include: a. Monocytes. Monocytes. b. $upffer cells. c. $idney mesan%ial cells. d. Lymph node medullary macropha%es. e. &ndothelial &ndothelial cells. ' A polymorphonuclear neutrophil (PMN): a. (s a bone bone marro) stem cell. b. (s closely closely similar to a mast cell. cell. c. !ontains microbicidal cytoplasmic %ranules. d. (s not a professional professional pha%ocytic pha%ocytic cell. cell. e. *as %ranules )hich stain )ith eosin. + Which of the following is not produced following actiation of the NA!P" o#idase microbicidal pathway
a. b. c. d.
,2 ,2 *2,2 ,
e. ,* / Neutrophil defensins are: a. Anti-to0ins. b. ,0y%en-dependent. c. &nymes. d. Glycolipids. e. Peptide antibiotics. . The membrane attac$ comple# consists of: a. ,* b. !olicins c. !#b#b34b d. !+b3/33536 e. Properdin 5. %&b: a. (s chemotactic. b. (s an anaphylato0in. c. ,psonies bacteria. d. 7irectly in8ures bacteria. e. (s the inactive form of !#. 6. Acute inflammation characteristically inoles: a. !onstriction !onstriction of arterioles. b. !apillary endothelial cell enlar%ement. c. (nflu0 of macropha%es. macropha%es. d. (nflu0 of mast mast cells. cells. e. (nflu0 of neutrophils. Which of the following is not an acute phase protein: 19. a. Serum amyloid amyloid P component. b. !hondroitin sulfate. c. !-reactive protein. d. Mannose bindin% lectin. e. :ibrino%en. 11. 11.
'nterferons:
a. b. c. d.
Are found only in mammalian species. Are divided into + main families. (nduce enyme synthesis in the tar%et cell. ,nly affect infected cells. cells.
e. Are specific for individual viruses. 12.
Natural $iller (N) cells do not:
a. b. c. d. e.
;espond to interferon. !ontain perforin. !ontain tumor necrosis factor <=:>. $ill only by dama%in% the tar%et cell outer membrane. !ontain serine proteases.
1#.
A complement component which is strongly chemotactic for neutrophils is:
a. b. c. d. e. 1'.
!6 !+a !# !#b !+b A ab fragment:
a. b. c. d. e. 1+.
(s produced by pepsin treatment. (s produced by separation of heavy and li%ht chains. 4inds anti%en. Lacks li%ht chains. *as no interchain disulfide bonds. The complementarity determining regions:
a. b. c. d. e.
Are restricted to li%ht chains. Are in the constant part of the (% molecule. 4ind to :c :c receptors. receptors. Are concerned in anti%en reco%nition. ,ccur at the !-terminal end of the (% peptide chains.
1/ * Which of the following gene clusters do not contribute to antigen binding:
a. b. c. d. e. 1.
?L !L ?* 7 @
Which of the following statements does not apply to 'g+,:
a. b. c. d. e. 15.
Appears early in the primary immune response. eutralies bacterial to0ins. !an fi0 complement. !rosses the human placenta. ,psonies bacteria. 'gA in sero-muc.us secretions:
a. b. c. d. e.
*as no @-chain. *as no secretory piece. (s dimeric. !annot bind to neutrophils. Activates the classical complement path)ay.
16 * 'gM: a. (s usually of hi%h affinity. b. (s most commonly tetrameric. c. *as the same number of constant domains as (%G. d. (s a )eak bacterial a%%lutinator. e. (s the main class of the natural antibodies. 29.
'g!:
a. b. c. d. e. 21.
'g/:
a. b. c. d. e. 22.
(s pentameric. (s resistant to proteolytic de%radation. (s present mainly as a surface receptor on 4-cells. (s present )ith unusual fre"uency in myelomas. (s abundant abundant in milk (s abundant in saliva. 4inds stron%ly to mast cells. !annot bind to macropha%es. Activates the complement cascade. *as an insi%nificant insi%nific ant role in )orm infestations A hapten is:
a. An epitope. b. A paratope. c. A small chemical %roupin% )hich reacts )ith preformed antibodies. d. A carrier. carri er. e. An immuno%en
2#.
0inding of antigen to antibody:
a. (s usually unaffected by molecular ri%idity. b. (s unaffected by the presence or absence of )ater molecules. c. (nvolves covalent bondin%. d. (s optimied by spatial complementarity. e. (s usually unaffected by p*. 2'.
The intermolecular forces which contribute to the interaction between antibody and antigen:
a. Are all electrostatic. electrostatic . b. Are all van der Baals. Baals. c. Are all hydrophobic. d. Are all hydro%en hydro%en bonds. e ;ely on a combination of the above. 2+.
The antigen moiety on an antigen-presenting cell recogni1ed by the alpha beta T-cell receptor is:
a. ative protein protein anti%en plus plus ma8or histocompatibility histocompatibility comple0
molecule. b. Processed anti%en plus M*!. c. Processed peptide anti%en. d. ative anti%en. e. M*! alone. 2/.
The initial complement component that is bound by complement-fi#ing antibodies is:
a. b. c. d. e. 2.
!1" !1s !#b !+a !6 2eeral of the complement components are:
a. b. c. d. e.
Glycolipids !ytokines &nymes *ormones Antibodies
25.
The classical and alternatie pathways meet at complement component:
a. b. c. d. e. 26.
!' !'b :actor 7 !+ !# %lonal selection occurs when antigen is encountered
by:
a. b. c. d. e. #9.
eutrophils Mast cells =-cells 4asophils &osinophils Plasma cells:
a. b. c. d. e.
*ave a thin layer of cytoplasm Are derived from =-cells =-cells 7evelop into 4-cells Secrete lar%e amounts of %amma interferon *ave a hi%hly developed rou%h endoplasmic reticulum
#1.
2pecific antibodies are readily detectable in serum following primary contact with antigen after:
a. b. c. d. e.
19 min 1h + days #+ )eeks ,nly follo)in% a second contact )ith anti%en
#2.
Adoptie transfer of ac3uired immune responsieness inoles the transfer of:
a. Antibody b. !omplement c. Pha%ocytes d. Lymphocytes e. Serum
##.
The main reason an e#perimental animal treated with 4-rays can act as a liing test tube for lymphocyte transfer e#periments is because:
a. b. c. d. e. #'.
(t is microbiolo%ically microbiolo%ically sterile sterile !omplement components )ill be inactivated =he host lymphocytes are destroyed or unable to divide ,nly non-dividin% cells are affected =he re"uirement for =-cell =-cell help is overcome
'mmunological unresponsieness to self antigens is called:
a. b. c. d. e.
=olerance =olero%en Memory Ac"uired immunity A7!!
#+.
Protectie antibodies against infectious agents are often:
a. Autoantibodies b. eutraliin% c. =o0oids d. atural $iller e. on-specific 'ntracellular parasites within macrophages are $illed #/. more readily in the presence of:
a. Antibody b. $inins c. Properdin d. Gamma-interferon e. Anaphylato0in T cell surface receptors for antigen partly recogni1e: #. a. !ytokines b. M*! c. A7!! d. Antibody e. (L-2 #5. An immune response against grass pollen often inoles:
a. Patho%en-associated Patho%en-associ ated molecular patterns patterns b. 4reakdo)n of self tolerance c. A hypersensitivity hypersensitiv ity reaction
d. ;eaction a%ainst M*! e. Persistent infection by the pollen #6.
2econdary antibody responses are better because:
a. b. c. d. e.
=hey provide defense a%ainst unrelated anti%ens =he antibody can be made by both = and 4 cells !omplement-fi0in% !omplement-f i0in% antibodies are made =hey do not re"uire =-cell =-cell help =hey are stron%er and faster
'9.
%lonal selection occurs when a 0-lymphocyte encounters:
a. b. c. d. e.
!ytokines Anti%en =-lymphocytes !omplement !hemotactic factors
'1.
The secondary5 but not the primary5 immune immune response is based on:
a. b. c. d. e.
Memory =he bonus effect of multivalency multival ency !omplement activation Mast cell de%ranulation !lonal selection
'2.
Protection against microorganisms inside cells is proided by:
a. b. c. d. e.
=-cells Antibody !#b !1" =he membrane attack attack comple0
6&* What are the two types of immunity,
a. active3 adaptive b. adaptive3 innate c. ac"uired3 inactive d. inactive3 innate e. adaptive3 ac"uired 66* Which of these are the most abundant in circulation,
a. basophils b. dendritic cells
c. neutrophils d. mast cells e. eosinophils 67* Which of these is a professional antigen presenting cell (AP%),
a. dendritic cells b. erythrocytes c. eosinophils d. mast cells 68* Which of these is a secondary lymphoid organ,
a. $idney b. 4rain c. Spleen d. *eart e. =hymus 69* T cells re3uire two signals to be actiated* ne signal is the binding of the antigen presented by the antigen presenting cell (AP%)* The other is the binding of:
a. interferin% molecules b. partner molecules c. helper molecules d. co-stimulators co-stimulators e. =oll =oll receptors 6;* "ow are the different isotypes of antibodies produced,
a. somatic hypermutation b. evolution c. randomly produced d. class s)itchin% 6<* Which of these is an autoimmune disease,
a. Systemic Lupus &rythematosus &rythematosus b. ;heumatoid Arthritis c. Graves 7isease d. All of these 7.* What is hypersensitiity,
a. &0cessive emotions
b. &levated levels of hormones c. A sensitive character d. Aller%ic reactions +1. Bhen the innate immune system encounters a forei%n anti%en3 )hat cell-surface cell-surface molecule plays the role of reco%niin% the presence of a forei%n anti%enC a. Antibody b. = cell receptor c. =he membrane attack comple0 of complement d. =oll-like =oll-like receptor e. *LA !lass (( +2. 4indin% of mannose-bindin% lectin to mannose-containin% molecules on an anti%enDs surface EEEEE. a. inactivates the complement cascade before it can do dama%e to host cells. b. activates = cell proliferation and differentiation. c. activates 4 cell proliferation and differentiation. d. directly causes the release of histamine. e. is an e0ample of pattern reco%nition. +#. aFve !7'H = cells EEEEE. a. are also kno)n as cytoto0ic = cells. b. respond to (L-1 H (L-12 to become =1 helper = cells. c. respond to anti%en presented by *LA !lass ( molecules. d. are stimulated to rearran%e the 7A for their = cell receptors in the bone marro). e. stron%ly respond to polysaccharide anti%ens. +'. =he part of an anti%en that is reco%nied by the adaptive immune system is called EEEEE. a. an epitope. b. an isotype. c. a paratope. d. a cytokine.
e. a chemokine. ++. Bhich part of the (%& antibody is responsible for bindin% to mast cells and basophilsC a. Li%ht chain b. (mmuno%lobulin fold c. :c re%ion d. !omplementarity-determin !omplementarity-determinin% in% re%ion e. !omplement bindin% site +/. Bhich of the follo)in% bonds is ,= responsible for linkin% an antibody to its co%nate re%ion of an anti%enC a. ?an der Baals forces b. *ydrophobic forces c. *ydro%en bonds d. (onic bonds e. 7isulfide bonds +. Antibodies to Streptococcus pyo%enes attack certain proteins in the heart valves3 causin% rheumatic fever. =his is an e0ample of EEEEE. a. an autoimmune disease. b. cross-reactivity. c. passive immuniation. d. neutraliation of anti%ens. e. an immunodeficiency disease. +5. =)o antibodies that have the same anti%enic reco%nition se"uence are called EEEEE. a. isotypes. b. allotypes. c. haptens. d. idiotypes. e. autotypes.
+6. (dentify the =;& statement about M*! molecules. a. = cells can reco%nie anti%en bound to either self or non-self M*!. b. M*! !lass (( is composed of one uni"ue alpha chain and the common beta2 micro%lobulin chain. c. M*! !lass (( is reco%nied by !75H = cells. d. M*! !lass ( has the primary role of reco%nition of selfpeptides. e. M*! !lass ( is e0pressed on a %iven = cell as either the cassette of M*! inherited from mom or as the cassette of M*! inherited from dad.
/9. 7endritic cells EEEEE. a. constitutively constitutively e0press !lass !lass (( anti%ens anti%ens and 4. 4. b. constitutively constitutiv ely e0press !lass ( anti%ens but not 4. c. constitutively e0press !lass !lass (( anti%ens anti%ens but not 4. d. constitutively constitutively e0press 4 4 but not !lass !lass (( anti%ens. anti%ens. e. constitutively constitutively e0press !lass !lass (( anti%ens anti%ens but not not !lass ( anti%ens. /1. = cells mature in the thymus. =heir maturation is driven by the EEEEEE protein that is e0pressed by stromal cells in the thymus. a. b. c. d. e.
eta protein of !7# !7'' (L-2 otch :-IJ4
/2. Bhich of the follo)in% procedures or tests allo)s the identification and collectin% of a particular type of cell that has been reco%nied by labeled antibodyC a. Bestern blot b. &lectrophoresis
c. :luorescence-activated :luorescence -activated cell sortin% d. (mmunofluorescence e. (mmunofi0ation (mmunofi0ation test /#. A %iven macropha%e producin% (L-1 can induce cells in the brain to reset the body thermostat to a hi%her temperature. =his represents EEEEEE action of a cytokine. a. b. c. d. e.
autocrine endocrine e0ocrine paracrine orthocrine
/'. =he ability of several different cytokines to e0ert a similar activity is called EEEEEE. a. b. c. d. e.
redundancy pleiotropy syner%ism additivity transmembrane transmembrane alteration
/+. (dentify the cytokine that is responsible for early development of 4 cells in the bone marro). marro). (n its absence3 4 cells do not develop. a. b. c. d. e.
(L-1 (L-2 (L-' (L- (L-19
88* Which immunoglobulin has the following properties,
A is bactericidal bactericidal a%ainst Gram ne%ative ne%ative or%anisms or%anisms in the presence of lysoyme 4 is present in mucous secretions ! does not bind complement 7 does not bind to immune cells by its :c re%ion & is an efficient antiviral antibody
