Immunology Questions 1903

Immunology Questions I M.Sc. 1.All of the following are true with respect to IgM antibodies EXCEPT which one A. B. C. D. E.

they they fix fix com comple pleme ment nt they they occur occur on the the surfac surfacee of lymph lymphocy ocytes tes they predominate predominate in the primary response response to antigen antigen they they are are glyc glycop opro rote tein inss they they medi mediate ate allerg allergic ic reacti reaction on

2. All of the following are true of antigen EXCEPT which one of the following? A. B. C. D. E.

They They con contai tain n epit epitop opes es.. They They will will reac reactt with with anti antibod bodies ies.. They They contain contain antigen antigenic ic deter determin minant ants. s. They They can can elicit elicit an an immun immunee respon response. se. They They cont contain ain para parato tope pes. s.

3. All of the following are true with respect to IgE molecules, EXCEPT which one? A. B. C. D. E.

They are the the principal principal immunoglobu immunoglobulin lin class class involved involved in allergic allergic reaction reactions. s. They are are involved involved in media mediating ting anti-par anti-parasiti asiticc immune immune responses responses.. They will cross the placenta placenta and and fix complement complement.. They can can effect effect the release release of histami histamine ne and other other chemical chemical mediato mediators. rs. They are the the least least abundant abundant immunogl immunoglobuli obulin n in the serum. serum.

4. Which of the following immunoglobulins is present normally in plasma at the highest concentration? A. B. C. D. E.

IgG IgM IgA IgD IgE

5. All of the following are true about antibodies, EXCEPT which one? A. B. C. D. E.

They They fix fix com comple pleme ment nt.. They They occur occur on the the surfa surface ce of B-ly B-lymph mphocy ocyte te They predominate predominate the primary primary immune response response to antigen. antigen. They They are are gly glyco copr prot otei eins ns.. They are molecul moleculee with a single, single, defined defined amino amino acid acid sequence sequence..

6. The major immunoglobulin family to which a particular immunoglobulin belongs can be determined by sequential analysis of the 110 amino acids beginning from the A. B. C. D. E.

Amino Amino term terminu inuss of the light light chain chain.. Carbox Carboxy y termin terminus us of of the light light chain chain.. Amino Amino term terminu inuss of the heavy heavy chai chain. n. Carbox Carboxy y termin terminus us of of the heavy heavy chai chain. n. None one of of the the abov abovee

7. The immunoglobulin Joining chain (J-chain) is A. B. C. D. E.

only only prod produce uced d by by T-Cells -Cells only only produc produced ed by neutrop neutrophil hilss associated associated with only multimeric multimeric forms of lgM and IgA associ associate ated d with IgE IgE for histami histamine ne releas releasee only only pro produ duce ced d by mast mast cell cellss

8. All of the following are true EXCEPT A. An epitope epitope is a small portion portion of a macromo macromolecule lecule B. the variabl variablee region region domains domains contain contain the the antigen antigen recogniti recognition on site site

C. an anti antigen genic ic deter determin minant ant is is a parat paratope ope D. The class class of an an immunoglobu immunoglobulin lin is determined determined by its heavy heavy chain chain E. An IgG IgG anti antibo body dy is is biv bival alen entt 9. Which immunoglobulin is the principal one found in secretions such as milk? A. B. C. D. E.

IgG IgM IgA IgD IgE

10. Individuals unable to make the J protein found in certain immunoglobulins would be expected to have frequent infections of the A. B. C. D. E.

brain. blood. liver. pancreas. inte intest stin inal al trac tract. t.

11. Which of the following statements best characterizes an antibody? A. An antibody antibody contains contains high molecula molecularr weight RNA as its basic basic structure. structure. B. An antibody antibody is composed composed of protein protein and cannot cannot be distingu distinguished ished from from the albumin albumin fraction fraction of the serum  proteins. C. An antibody antibody is composed composed of four identical identical protein protein subunits subunits which may be caused caused to dissociate dissociate by treatment treatment with urea. D. An antibody antibody contains contains protein protein as its major chemical chemical component component and its synthes synthesis is may be elicited elicited by the administration of a foreign protein or polysaccharide. E. An antibody antibody contains contains mucopolysa mucopolysacchari ccharides des as its major chemica chemicall component component and the synthesis synthesis of these may may  be elicited by the administration of a foreign protein or polysaccharide. 12. The immunoglobulin class which is the least abundant in the normal adult is A. B. C. D. E.

IgG IgA IgM IgD IgE.

13. Class switching of immunoglobulins occurs A. B. C. D. E.

Usually Usually with with booster booster immunizatio immunizations, ns, going going from from IgM to IgG bind bindss com compl plem emen entt causes causes the histam histamine ine releas releasee mediat mediates es immunogl immunoglobu obulin lin class class switchi switching ng result resultss in the glyco glycosyl sylati ation on of immuno immunoglo globul bulins ins

14. The class of an immunoglobulin A. B. C. D. E.

is determined determined by Class Class I and Class Class II major histocom histocompatibi patibility lity complex complex proteins proteins is determine determined d by the the carbohydra carbohydrate te attached attached to the light light chain chain is dete determ rmin ined ed by by the the anti antige gen n is dete determi rmined ned by by the the heavy heavy chai chain n type type Is det deter ermin mined ed by by the the J-ch J-chai ain n

15. The class of an immunoglobulin is determined by A. B. C. D.

the the vari variab able le regi region on the J-chain the the hea heavy vy cha chain the the car carbo bohy hydr drat atee

E.

the the T3 poly polype pept ptid idee comp comple lex x

16. Light chains are A. B. C. D. E.

specif specific ic for for each each clas classs of anti antibod body y not specif specific ic for for each each clas classs of anti antibod body y reac reacti tive ve with with anti antige gen n have have only only a cons constan tantt regio region n are compos composed ed onl only y of of carb carbohy ohydra drate te

17. IgE is 1. 2. 3. 4.

An allerg allergy y asso associa ciated ted immuno immunoglo globul bulin in the leas leastt abunda abundant nt immun immunoglo oglobul bulin in in the the plasm plasmaa bind bindss to to mas mastt ce cells lls can can cros crosss the the plac placen enta tall barri barrier  er 

1. 2. 3. 4.

is prod produc uced ed by mast mast cell cellss is prod produc uced ed by B-ce B-cell llss is pro prod duced uced by by T-c T-cel ells ls bind bindss to to mas mastt ce cells lls

18. IgE

19. Which of of the followi following ng are true true statemen statements ts 1. 2. 3. 4. 20. IgE is is a.  b.

21. 21.

22.

23.

24.

25. 25.

IgM IgM and and IgG IgG can can fix fix com compl plem emen entt IgA is a secret secretory ory immunog immunoglob lobuli ulin n IgE mediat mediates es imme immedia diate te hype hyperse rsensi nsitiv tivity ity IgD provi provides des most most passiv passively ely acqui acquired red mater maternal nal immun immunity ity

An immunog immunoglobuli lobulin n associa associated ted with with some some kinds kinds of allerg allergic ic reactio reactions ns the leas leastt abundan abundantt typo typo at antibo antibody dy synth synthesi esized zed c. associated with the mast cell for histamine release d. produced produced during during the the primary primary immune response response before class class switching switching Antib Antibod odie iess are are a. Immu Immuno nogl glob obul ulin inss  b. compos composed ed of variab variable le and and constan constantt region region domai domains ns c. made made of heav heavy y and and ligh lightt cha chain inss d. glycoprotei teins The antige antigenic nic determ determina inate te a. is the the com combi bini ning ng sit sitee of an an anti antibo body dy  b. is usually usually no more more than than five or six amino acids of the the antigen antigen c. is the par paratope d. Consis Consists ts of a small small topol topologic ogical al featu feature re of the the antige antigen n A critical critical property property of of an antigen antigen is is a. Its abilit ability y to stimul stimulate ate an immu immune ne resp respons onsee  b. a unique unique topo topotog togica icall featur featuree called called an an parato paratope pe c. a uniqu uniquee topol topologi ogical cal featur featuree calle called d an epit epitope ope d. not a unique unique topological topological feature feature called called an antige antigenic nic determi determinant nant An antige antigenic nic deter determin minant ant is a. a small small topological topological feature feature of of a large macrom macromolecu olecule le such as as A protein protein or carbohydrat carbohydratee  b. specif specifica ically lly recogni recognized zed by a epitop epitopee c. specif specifica ically lly recogni recognized zed by a para paratop topee d. specif specifica ically lly recogni recognized zed by the the T4 prot protein ein Immu Immuno nogl glob obin inss a. are an antibodies  b. are classified into five major classes, i.e., IgM , IgG, IgA, IgD, IgE c. have have a molecula molecularr specifi specificit city y to recogni recognize ze unique unique epito epitope pe d. posses possesss both vari variabl ablee and const constant ant regio region n domain domainss

26. The basic basic monomeri monomericc Immunoglob Immunoglobulin ulin unit unit is a. compos composed ed of four; four; polype polypeptid ptidee chai chains ns  b. only only an integr integral al membr membrane ane prot protein ein and and never never secre secreted ted c. one one of of fiv fivee maj major or cla class sses es d. synthe synthesiz sized ed by a T-ce T-cell ll withou withoutt carbohy carbohydra drate te 27. 27. Anti Antibo bodi dies es a. are carb carboh ohyd ydra rate tess  b. are made made from from alpha alpha and beta beta chai chains ns c. cont contai ain n no car carbo bohy hydr drat atee d. cont contai ain n heav heavy y and and ligh lightt chai chains ns 28. The basic basic monomeri monomericc immunoglobu immunoglobulin lin unit unit is a. compos composed ed of four four poly polypep peptid tides es chains chains  b. representa representative tive of a single single protein protein type type for all antibody antibody classes classes c. able to associa associate te with with JJ- chain chain to to form form multimers multimers in some some cases cases d. the same same stru structu cture re as the the T-ce T-cell ll antig antigen en recept receptor  or  29. The basic basic monomeric monomeric form form of an immunoglobu immunoglobulin lin a. is a tetra tetramer mer cons consisti isting ng of two two light light and and two two heavy heavy chain chainss  b. is associ associated ated with with J-ch J-chain ain in the the IgD IgD c. can occur occur as as multi multimer merss with with IgA and IgM d. exists exists only only on the cell cell surfa surface ce of of B-cell B-cellss 31. Immunoglobul Immunoglobulins ins are produced produced by by 1. Plasma ce cells 2. T-cells 3. B-cells 4. Macrophages 32. Antibodies Antibodies are distingui distinguished shed from antigens, antigens, becaus becausee they 1. can can onl only y be be prot protei eins ns 2. always always have have carbohydrate carbohydrate attached attached to their their heavy chains chains 3. can only only be made made by B-cel B-cells ls and and plasm plasmaa cells cells 4. cont contai ain n nuc nucle leic ic acid acidss 33. Antibodies Antibodies are distinct distinct from from antigens antigens 1. beca becaus usee they they can can onl only y be pro prote tein inss 2. becaus becausee they they are are only only produc produced ed by B-cell B-cellss 3. becaus becausee they they are not not normall normally y recogni recognized zed as as "foreign "foreign"" 4. becaus becausee they they are are only only produ produced ced by by T-ce T-cells lls 34. Antigen-ant Antigen-antibody ibody reaction reactionss can result in the following: following: 1. Agglutinat nation 2. comp comple leme ment nt fixa fixati tion on 3. viru viruss neu neutr tral aliz izat atio ion n 4. alle allerg rgic ic reac reacti tion onss 35. Effector Effector functions functions of of immunoglobul immunoglobulins ins are 1. The prope property rty of the the const constant ant regio region n domains domains of of L-chain L-chainss 2. The prope property rty of the the const constant ant regio region n domains domains of of J-chain J-chainss 3. The prope property rty of the the variab variable le region region doma domains ins of H-cha H-chains ins 4. The prope property rty of the the const constant ant regio region n domains domains of of H-chain H-chainss