HAZOP ANALYSIS To manufacture of Ambroxol hcl
Sta"e
Stag Stagee-1 1
Hazop Study - Proce ! for Ambroxol Stage-1 Po$ble Hazard % Opera#on &emed$al Ac#on fa$lure Oper peraona onal contr ontrol ol - ch checkp eckpoi oin nt shal hall be Boom valve incl includ uded ed in the the ba batch shee heet to to indi ndicat cate opened, or eakage !hether the boom valve has been closed of Boom "alve prior to charging methanol # is not eaking$ %harging of ðanol, ðanol addion pipe is kept to the Boom 'ire ire ha( ha(ard due due to of the the react eactor or *ipe lines are all S S and e+uipment motors are stac electricit) eacon of -Amino-.,/0ame proof$ ibromo Ben(aldeh)de %harging of -amino .,/ 2nstrucon is aid in the SO* , 3o Avoid !ith !ith 3ransans-4 4-am -aminoino- ibr ibromob omoben en((aldeh ldeh) )de# de# Spil pillag lage out out sid side e the the spill pillag age e outs outsid ide e the the 5+ 5+uipm uipmen ent, t,a a) ) do!n do!n th the %)clohexanol,in me methanol 3rans-4-amino reactor, *ol) Bags to %ollect the spilled &aterial,# !ith Sodium boroh)dride c)clo6exanol 3ransfer to the reactor 'ire 'ire ha( ha(ar ard d due due to SS scoops scoops to avoid avoid sta stacc elec electri tricit cit) )$ 3he 3he stac tac elec electr tric icit it) ) reac reacto torr is is ear earth thed ed b) cond conduc ucn ng g !ir !ires es 2rri 2rrita tao on n to to ski skin n # 7sin 7sing g hand hand glov gloves es # gog goggl gles es$$ e)es 3he temperature is raised b) slo! heang ll e0uxing the reacon re0ux8 the methanol "apour oss is due to oss oss of of ð ðano anoll 5xces 5xcessiv sive e hea heat, t, 2ns 2nstru truco con n is is 9iv 9iven en in in SO* SO*,, 3o 3o mass Open the steam valve to Opmum so as to Proce
maintain the re0ux
'ire ha(ard ha(ard due to stac stac 3o sepa separrate ate the the elec electr tric icit it) ), oper operat ator or ha(ard ha(ard if an) loading loading > 2st Stage 'rom the unlo unload adin ing g acv acvit it) ) li+uid carried carried out in a running running
%entrifuging
3he centrifuge is earthed b) conducng !ires$ 3he :ltraon is carried out through a centrifuge$ %entrifuges are high speed machines and sources of ha(ard in a chemical plant$ Ample precauons are taken to carr) out the centrifuging as ha(ard free as possible$ ;e are using a 4< inch dia SS.1= centrifuge, boom driven and top discharge$ this is a four point suspension suspension machines machines !hich !hich are put on special special vibra moun mountt for for smoo smooth th vibr vibra aon on fre free e noi noise sele less ss oper opera aon$ on$ 3he speed speed is controlle controlled d b) a variable variable fre+ue fre+uenc) nc) drive drive and and the the feedi eeding ng of the the cent centri rifu fug ge is done done b) pneumac pneumacall) all) control controlled led valves valves at lo!er lo!er *& under
centrifuge
%harging *uri:caon of
Ambroxol
nitrogen purging$ 5ven the bearing housing of the centrifuge is provided !ith a nitrogen purging facilit)$ An interlocking s)stem is provided for ensuring that the lids cannot be opened !hile the centrifuge is running and thereb) prevenng an) operaonal ha(ard b) human error $ All the limits s!itches and the safet) interlocking s!itches are 0ame proof including the "' controls$ Operaonal control - checkpoint shall be included in of Boom valve opened, Operaonal the batch sheet to indicate !hether the boom valve or eakage of Boom
acetone,
Stage-
%rude B) %arbon 3reatment # %r) %r)sstalli(aon b) 6c 6cl
has been closed prior to charging methanol # is not
"alve
eaking$
'ire ha(ard ha(ard due to stac stac 3o sepa separrate ate the the elec electr tric icit it) ), oper operat ator or ha(ard ha(ard if an) loading loading > 2st Stage 'rom the unlo unload adin ing g acv acvit it) ) li+uid carried carried out in a running running
%entrifuging
3he centrifuge is earthed b) conducng !ires$ 3he :ltraon is carried out through a centrifuge$ %entrifuges are high speed machines and sources of ha(ard in a chemical plant$ Ample precauons are taken to carr) out the centrifuging as ha(ard free as possible$ ;e are using a 4< inch dia SS.1= centrifuge, boom driven and top discharge$ this is a four point suspension suspension machines machines !hich !hich are put on special special vibra moun mountt for for smoo smooth th vibr vibra aon on fre free e noi noise sele less ss oper opera aon$ on$ 3he speed speed is controlle controlled d b) a variable variable fre+ue fre+uenc) nc) drive drive and and the the feedi eeding ng of the the cent centri rifu fug ge is done done b) pneumac pneumacall) all) control controlled led valves valves at lo!er lo!er *& under
centrifuge
%harging *uri:caon of
Ambroxol
nitrogen purging$ 5ven the bearing housing of the centrifuge is provided !ith a nitrogen purging facilit)$ An interlocking s)stem is provided for ensuring that the lids cannot be opened !hile the centrifuge is running and thereb) prevenng an) operaonal ha(ard b) human error $ All the limits s!itches and the safet) interlocking s!itches are 0ame proof including the "' controls$ Operaonal control - checkpoint shall be included in of Boom valve opened, Operaonal the batch sheet to indicate !hether the boom valve or eakage of Boom
acetone,
Stage-
%rude B) %arbon 3reatment # %r) %r)sstalli(aon b) 6c 6cl, centrifuging %harging of Ambr mbroxol %ru %rude
'iltraon
has been closed prior to charging methanol # is not
"alve
eaking$ 2nstrucon is aid in the SO* , 3o Avoid spillage outside
Spillage out side the react eactor or,,
Spillage,'ilter
the 5+uipment,a) do!n the *ol) Bags to %ollect the spilled &aterial,# 3ransfer to the reactor
%loth
Block
'ire ha(ard due stac ele elect ctri rici cit) t)
6cl Ad Addion
6)drochoric
to
acid
Spillage # 2rritaon
'ire ha(ard due to stac electricit), operator operator ha(ard ha(ard if an) unloading loading > acvit) acvit) carried carried out in a runn runnin ing g cen centr trif ifug uge e
3he 'iltraon Operaon Operaon is %arried out in %losed SS ine, 'ilter cloth cleaned for 5ver) Batch # this %leaning of the 'ilter along !ith %loth is 2ncorporated 2n the B* Acetone %harging SS pipe is 'ixed to the Boom of the re reactor *ipe ipe lin lines es are are all all SS and and e+ e+uipm uipmen entt mot motor orss ar are 0am 0ame e proof$ 3he Addion of 6)drochloric acid is charged through the %lose losed d lin lines, es, !ith !ithou outt an) Spil pillag lage,pe e,perrsonn sonnel el *rotecve *rotecve 5+uipments are 7sed to avoid the 5xposure # tackle the irritaon 3he centrifuge is earthed b) conducng !ires$ 3he :ltraon is carried out through a centrifuge$ %entrifuges are high speed machines and sources of ha(ard in a chemical plant$ Ample precauons are taken to carr) out the centrifuging as ha(ard free as possible$ ;e are using a 4< inch dia SS.1= centrifuge, boom boom driv driven en and and top top discha discharg rge$ e$ this this is a four four point point suspension machines !hich are put on special vibra mount mount for for smooth smooth vibra vibraon on free noiseless noiseless operaon operaon$$ 3he speed is controlled b) a variable fre+uenc) drive and the feeding feeding of the centrifuge centrifuge is done b) pneu pneuma mac cal all) l) cont contro roll lled ed valv valves es at lo!e lo!err *& *& unde underr nitrogen purging$ 5ven 5ven the bearing housing of the
'ire ha(ard ha(ard due to stac stac 3o sepa separrate ate the the elec electr tric icit it) ), oper operat ator or ha(ard ha(ard if an) loading loading > 2st Stage 'rom the unlo unload adin ing g acv acvit it) ) li+uid carried carried out in a running running
%entrifuging
3he centrifuge is earthed b) conducng !ires$ 3he :ltraon is carried out through a centrifuge$ %entrifuges are high speed machines and sources of ha(ard in a chemical plant$ Ample precauons are taken to carr) out the centrifuging as ha(ard free as possible$ ;e are using a 4< inch dia SS.1= centrifuge, boom driven and top discharge$ this is a four point suspension suspension machines machines !hich !hich are put on special special vibra moun mountt for for smoo smooth th vibr vibra aon on fre free e noi noise sele less ss oper opera aon$ on$ 3he speed speed is controlle controlled d b) a variable variable fre+ue fre+uenc) nc) drive drive and and the the feedi eeding ng of the the cent centri rifu fug ge is done done b) pneumac pneumacall) all) control controlled led valves valves at lo!er lo!er *& under
centrifuge
%harging *uri:caon of
Ambroxol
nitrogen purging$ 5ven the bearing housing of the centrifuge is provided !ith a nitrogen purging facilit)$ An interlocking s)stem is provided for ensuring that the lids cannot be opened !hile the centrifuge is running and thereb) prevenng an) operaonal ha(ard b) human error $ All the limits s!itches and the safet) interlocking s!itches are 0ame proof including the "' controls$ Operaonal control - checkpoint shall be included in of Boom valve opened, Operaonal the batch sheet to indicate !hether the boom valve or eakage of Boom
acetone,
Stage-
%rude B) %arbon 3reatment # %r) %r)sstalli(aon b) 6c 6cl, centrifuging %harging of Ambr mbroxol %ru %rude
'iltraon
has been closed prior to charging methanol # is not
"alve
eaking$ 2nstrucon is aid in the SO* , 3o Avoid spillage outside
Spillage out side the react eactor or,,
Spillage,'ilter
the 5+uipment,a) do!n the *ol) Bags to %ollect the spilled &aterial,# 3ransfer to the reactor
%loth
Block
'ire ha(ard due stac ele elect ctri rici cit) t)
6cl Ad Addion
6)drochoric
to
acid
Spillage # 2rritaon
'ire ha(ard due to stac electricit), operator operator ha(ard ha(ard if an) unloading loading > acvit) acvit) carried carried out in a runn runnin ing g cen centr trif ifug uge e
3he 'iltraon Operaon Operaon is %arried out in %losed SS ine, 'ilter cloth cleaned for 5ver) Batch # this %leaning of the 'ilter along !ith %loth is 2ncorporated 2n the B* Acetone %harging SS pipe is 'ixed to the Boom of the re reactor *ipe ipe lin lines es are are all all SS and and e+ e+uipm uipmen entt mot motor orss ar are 0am 0ame e proof$ 3he Addion of 6)drochloric acid is charged through the %lose losed d lin lines, es, !ith !ithou outt an) Spil pillag lage,pe e,perrsonn sonnel el *rotecve *rotecve 5+uipments are 7sed to avoid the 5xposure # tackle the irritaon 3he centrifuge is earthed b) conducng !ires$ 3he :ltraon is carried out through a centrifuge$ %entrifuges are high speed machines and sources of ha(ard in a chemical plant$ Ample precauons are taken to carr) out the centrifuging as ha(ard free as possible$ ;e are using a 4< inch dia SS.1= centrifuge, boom boom driv driven en and and top top discha discharg rge$ e$ this this is a four four point point suspension machines !hich are put on special vibra mount mount for for smooth smooth vibra vibraon on free noiseless noiseless operaon operaon$$ 3he speed is controlled b) a variable fre+uenc) drive and the feeding feeding of the centrifuge centrifuge is done b) pneu pneuma mac cal all) l) cont contro roll lled ed valv valves es at lo!e lo!err *& *& unde underr nitrogen purging$ 5ven 5ven the bearing housing of the
'iltraon
Spillage,'ilter
%loth
Block
'ire ha(ard due stac ele elect ctri rici cit) t)
6cl Ad Addion
6)drochoric
to
acid
Spillage # 2rritaon
'ire ha(ard due to stac electricit), operator operator ha(ard ha(ard if an) unloading loading > acvit) acvit) carried carried out in a runn runnin ing g cen centr trif ifug uge e
3he 'iltraon Operaon Operaon is %arried out in %losed SS ine, 'ilter cloth cleaned for 5ver) Batch # this %leaning of the 'ilter along !ith %loth is 2ncorporated 2n the B* Acetone %harging SS pipe is 'ixed to the Boom of the re reactor *ipe ipe lin lines es are are all all SS and and e+ e+uipm uipmen entt mot motor orss ar are 0am 0ame e proof$ 3he Addion of 6)drochloric acid is charged through the %lose losed d lin lines, es, !ith !ithou outt an) Spil pillag lage,pe e,perrsonn sonnel el *rotecve *rotecve 5+uipments are 7sed to avoid the 5xposure # tackle the irritaon 3he centrifuge is earthed b) conducng !ires$ 3he :ltraon is carried out through a centrifuge$ %entrifuges are high speed machines and sources of ha(ard in a chemical plant$ Ample precauons are taken to carr) out the centrifuging as ha(ard free as possible$ ;e are using a 4< inch dia SS.1= centrifuge, boom boom driv driven en and and top top discha discharg rge$ e$ this this is a four four point point suspension machines !hich are put on special vibra mount mount for for smooth smooth vibra vibraon on free noiseless noiseless operaon operaon$$ 3he speed is controlled b) a variable fre+uenc) drive and the feeding feeding of the centrifuge centrifuge is done b) pneu pneuma mac cal all) l) cont contro roll lled ed valv valves es at lo!e lo!err *& *& unde underr nitrogen purging$ 5ven 5ven the bearing housing of the centrifuge is provided !ith a nitrogen purging facilit)$ An interlocking s)stem is provided for ensuring that the lids cannot be opened !hile the centrifuge is running and thereb) prevenng an) operaonal ha(ard b) human error$ error$ All the limits s!itches and the
safet) interlocking s!itches are 0ame proof including the "' controls Solvent recover)
Separaon of solvents from r)ing operaon the product
?o spec speci: i:cc ha( ha(ar ard d %harging of & 6a(ardous !aste a@er disllaon
All All cha charg rgin ing g is is don done e b) b) vac vacuu uum m suc sucki king ng to avoid void spillages and through the closed SS pipe lines$
r)ing of the product in ?o speci:c ha(ard otocone vacuum r)er
%" is :ed !ith 0ame proof motors$ 7nloading into the bins b) actuated valve, 6ence ?o- ess 5xposure 6and gloves # goggles should be used$
safet) interlocking s!itches are 0ame proof including the "' controls Solvent recover)
Separaon of solvents from r)ing operaon the product
?o spec speci: i:cc ha( ha(ar ard d %harging of & 6a(ardous !aste a@er disllaon
All All cha charg rgin ing g is is don done e b) b) vac vacuu uum m suc sucki king ng to avoid void spillages and through the closed SS pipe lines$
r)ing of the product in ?o speci:c ha(ard otocone vacuum r)er
%" is :ed !ith 0ame proof motors$ 7nloading into the bins b) actuated valve, 6ence ?o- ess 5xposure 6and gloves # goggles should be used$
To manufacture of Anatrozole
Sta"e
Proce
Hazop Study - Proce ! for Anastro(ole Po$ble Hazard % Opera#on fa$lure %harging of , , , ,tetrameth)l-/- meth)l-1,.- ben(ene diacetonitrile
eacon of , , , ,-
Stage-1
tetrameth)l-/- meth)l1,.- ben(ene diacetonitrile !ith Acetonitrile, n-bromo succinamide, 5th)l acetate and ;ater then separate the organic la)er and disllaon organic la)er and added c)clohexane
Acetonitrile
n bromo succinamide
&emed$al Ac#on
2nstrucon is aid in the SO* , 3o Avoid Spillage out side the spillage outside the 5+uipment,a) do!n the reactor, *ol) Bags to %ollect the spilled &aterial,# 3ransfer to the reactor 'ire ha(ard due to SS scoops to avoid stac electricit)$ 3he stac electricit) reactor is earthed b) conducng !ires 2rritaon to skin # 7sing hand gloves # goggles$ e)es Operaonal control - checkpoint shall be Boom valve included in the batch sheet to indicate opened, or eakage !hether the boom valve has been closed of Boom "alve prior to charging Acetonitrile # is not eaking$ Acetonitrile addion pipe is kept to the 'ire ha(ard due to Boom of the reactor stac electricit) *ipe lines are all SS and e+uipment motors are 0ame proof$ 2nstrucon is aid in the SO* , 3o Avoid Spillage out side the spillage outside the 5+uipment,a) do!n the reactor, *ol) Bags to %ollect the spilled &aterial,# 3ransfer to the reactor
To manufacture of Anatrozole
Sta"e
Proce
Hazop Study - Proce ! for Anastro(ole Po$ble Hazard % Opera#on fa$lure %harging of , , , ,tetrameth)l-/- meth)l-1,.- ben(ene diacetonitrile
eacon of , , , ,-
Stage-1
tetrameth)l-/- meth)l1,.- ben(ene diacetonitrile !ith Acetonitrile, n-bromo succinamide, 5th)l acetate and ;ater then separate the organic la)er and disllaon organic la)er and added c)clohexane
Acetonitrile
n-bromo succinamide
5th)l acetate
isllaon of the organic la)er
%)clohexane
&emed$al Ac#on
2nstrucon is aid in the SO* , 3o Avoid Spillage out side the spillage outside the 5+uipment,a) do!n the reactor, *ol) Bags to %ollect the spilled &aterial,# 3ransfer to the reactor 'ire ha(ard due to SS scoops to avoid stac electricit)$ 3he stac electricit) reactor is earthed b) conducng !ires 2rritaon to skin # 7sing hand gloves # goggles$ e)es Operaonal control - checkpoint shall be Boom valve included in the batch sheet to indicate opened, or eakage !hether the boom valve has been closed of Boom "alve prior to charging Acetonitrile # is not eaking$ Acetonitrile addion pipe is kept to the 'ire ha(ard due to Boom of the reactor stac electricit) *ipe lines are all SS and e+uipment motors are 0ame proof$ 2nstrucon is aid in the SO* , 3o Avoid Spillage out side the spillage outside the 5+uipment,a) do!n the reactor, *ol) Bags to %ollect the spilled &aterial,# 3ransfer to the reactor 'ire ha(ard due to SS scoops to avoid stac electricit)$ 3he stac electricit) reactor is earthed b) conducng !ires 2rritaon to skin # 7sing hand gloves # goggles$ e)es
Operaonal control - checkpoint shall be Boom valve included in the batch sheet to indicate opened, or eakage !hether the boom valve has been closed of Boom "alve prior to charging 5th)l acetate # is not eaking$ 5th)l acetate addion pipe is kept to the 'ire ha(ard due to Boom of the reactor stac electricit) *ipe lines are all SS and e+uipment motors are 0ame proof$ 3he temperature is raised b) slo! heang ll isllaon8 the Acetonitrile oss of Acetonitrile "apour oss is due to 5xcessive heat, 2nstrucon is 9iven in SO*, 3o Open the steam valve to Opmum so as to maintain the isllaon$ Operaonal control - checkpoint shall be Boom valve included in the batch sheet to indicate opened, or eakage !hether the boom valve has been closed of Boom "alve prior to charging %)clohexane # is not eaking$ %)clohexane addion pipe is kept to the 'ire ha(ard due to Boom of the reactor stac electricit) *ipe lines are all SS and e+uipment motors are 0ame proof$ 3he centrifuge is earthed b) conducng 'ire ha(ard due to
5th)l acetate
isllaon of the organic la)er
%)clohexane
%entrifuging
3o separate the li+uid
Operaonal control - checkpoint shall be Boom valve included in the batch sheet to indicate opened, or eakage !hether the boom valve has been closed of Boom "alve prior to charging 5th)l acetate # is not eaking$ 5th)l acetate addion pipe is kept to the 'ire ha(ard due to Boom of the reactor stac electricit) *ipe lines are all SS and e+uipment motors are 0ame proof$ 3he temperature is raised b) slo! heang ll isllaon8 the Acetonitrile oss of Acetonitrile "apour oss is due to 5xcessive heat, 2nstrucon is 9iven in SO*, 3o Open the steam valve to Opmum so as to maintain the isllaon$ Operaonal control - checkpoint shall be Boom valve included in the batch sheet to indicate opened, or eakage !hether the boom valve has been closed of Boom "alve prior to charging %)clohexane # is not eaking$ %)clohexane addion pipe is kept to the 'ire ha(ard due to Boom of the reactor stac electricit) *ipe lines are all SS and e+uipment motors are 0ame proof$ 3he centrifuge is earthed b) conducng 'ire ha(ard due to !ires$ stac electricit), 3he :ltraon is carried out through a operator ha(ard if centrifuge$ %entrifuges are high speed an) loading > machines and sources of ha(ard in a chemical unloading acvit) plant$ Ample precauons are taken to carr)
carried out in a running centrifuge
Solvent recover)
%harging of & 6a(ardous !aste a@er disllaon
?o speci:c ha(ard
r)ing
Separaon of solvents from
r)ing of the product in
?o speci:c ha(ard
operaon
the product
"3
out the centrifuging as ha(ard free as possible$ ;e are using a 4< inch dia SS.1= centrifuge, boom driven and top discharge$ this is a four point suspension machines !hich are put on special vibra mount for smooth vibraon free noiseless operaon$ 3he speed is controlled b) a variable fre+uenc) drive and the feeding of the centrifuge is done b) pneumacall) controlled valves at lo!er *& under nitrogen purging$ 5ven the bearing housing of the centrifuge is provided !ith a nitrogen purging facilit)$ An interlocking s)stem is provided for ensuring that the lids cannot be opened !hile the centrifuge is running and thereb) prevenng an) operaonal ha(ard b) human error $ All the limits s!itches and the safet) interlocking s!itches are 0ame proof including the "' controls$ All charging is done b) vacuum sucking to avoid spillages and through the closed SS pipe lines$ "3 is :ed !ith 0ame proof motors$ 7nloading into the bins b) actuated valve, 6ence ?o- ess 5xposure
carried out in a running centrifuge
Solvent recover)
%harging of & 6a(ardous !aste a@er disllaon
?o speci:c ha(ard
r)ing
Separaon of solvents from
r)ing of the product in
?o speci:c ha(ard
operaon
the product
"3
Stage-
out the centrifuging as ha(ard free as possible$ ;e are using a 4< inch dia SS.1= centrifuge, boom driven and top discharge$ this is a four point suspension machines !hich are put on special vibra mount for smooth vibraon free noiseless operaon$ 3he speed is controlled b) a variable fre+uenc) drive and the feeding of the centrifuge is done b) pneumacall) controlled valves at lo!er *& under nitrogen purging$ 5ven the bearing housing of the centrifuge is provided !ith a nitrogen purging facilit)$ An interlocking s)stem is provided for ensuring that the lids cannot be opened !hile the centrifuge is running and thereb) prevenng an) operaonal ha(ard b) human error $ All the limits s!itches and the safet) interlocking s!itches are 0ame proof including the "' controls$ All charging is done b) vacuum sucking to avoid spillages and through the closed SS pipe lines$ "3 is :ed !ith 0ame proof motors$ 7nloading into the bins b) actuated valve, 6ence ?o- ess 5xposure 6and gloves # goggles should be used$ Operaonal control - checkpoint shall be included in the batch sheet to indicate !hether the boom valve has been closed prior to charging Acetone # is not eaking$
eacon of Stage C 2 material, !ith Acetone, *otassium carbonate and %harging Acetone 1,,4-3ria(ole then :ltrated
Boom valve
and added 5th)l acetate and 6)drochloric acid
Acetone addion pipe is kept to the Boom 'ire ha(ard due to of o f the reactor sta stacc ele elect ctri rici cit) t) *ipe *ipe line liness are are all all SS and and e+u e+uip ipme ment nt moto motors rs are 0ame proof$ 2nstrucon is aid in the SO* , 3o Avoid Spillage Spillage out out side the spillage spillage outsid outside e the 5+uipm 5+uipment, ent,a) a) do!n do!n the reactor, *ol) Bags to %ollect the spilled &aterial,# 3ransfer to the reactor 'ire 'ire ha( ha(ar ard d due due to SS sco scoop opss to avo avoid id sta stac c ele elect ctri rici cit) t)$$ 3he 3he sta stacc elec electr tric icit it) ) reac reacto torr is is ear earth thed ed b) b) con condu duc cng ng !ir !ires 2rri 2rrita tao on n to skin skin # 7sin 7sing g hand hand glo glove vess # gogg goggle les$ s$ e)es 2nstrucon is aid in the SO* , 3o Avoid Spillage Spillage out out side the spillage spillage outsid outside e the 5+uipm 5+uipment, ent,a) a) do!n do!n the reactor, *ol) Bags to %ollect the spilled &aterial,# 3ransfer to the reactor 'ire 'ire ha( ha(ar ard d due due to SS sco scoop opss to avo avoid id sta stac c ele elect ctri rici cit) t)$$ 3he 3he sta stacc elec electr tric icit it) ) reac reacto torr is is ear earth thed ed b) b) con condu duc cng ng !ir !ires 2rri 2rrita tao on n to skin skin # 7sin 7sing g hand hand glo glove vess # gogg goggle les$ s$ e)es 3he 'iltraon Operaon Operaon is %arried out in Spillage, Spillage,'ilt 'ilter er %loth %loth %losed %losed SS ine, 'ilter 'ilter cloth cloth cleane cleaned d for for 5ver) 5ver) Block Batch # this %leaning of the 'ilter along !ith %loth is 2ncorporated 2n the B* Acetone %harging %harging SS SS pipe is 'ixed to the
*otassium carbonate
1,,4-3ria(ole
'iltraon
opened, or eakage of Boom "alve
and added 5th)l acetate and 6)drochloric acid
*otassium carbonate
1,,4-3ria(ole
'iltraon
5th)l acetate
6)drochloric acid
isllaon of the organic la)er
Acetone addion pipe is kept to the Boom 'ire ha(ard due to of o f the reactor sta stacc ele elect ctri rici cit) t) *ipe *ipe line liness are are all all SS and and e+u e+uip ipme ment nt moto motors rs are 0ame proof$ 2nstrucon is aid in the SO* , 3o Avoid Spillage Spillage out out side the spillage spillage outsid outside e the 5+uipm 5+uipment, ent,a) a) do!n do!n the reactor, *ol) Bags to %ollect the spilled &aterial,# 3ransfer to the reactor 'ire 'ire ha( ha(ar ard d due due to SS sco scoop opss to avo avoid id sta stac c ele elect ctri rici cit) t)$$ 3he 3he sta stacc elec electr tric icit it) ) reac reacto torr is is ear earth thed ed b) b) con condu duc cng ng !ir !ires 2rri 2rrita tao on n to skin skin # 7sin 7sing g hand hand glo glove vess # gogg goggle les$ s$ e)es 2nstrucon is aid in the SO* , 3o Avoid Spillage Spillage out out side the spillage spillage outsid outside e the 5+uipm 5+uipment, ent,a) a) do!n do!n the reactor, *ol) Bags to %ollect the spilled &aterial,# 3ransfer to the reactor 'ire 'ire ha( ha(ar ard d due due to SS sco scoop opss to avo avoid id sta stac c ele elect ctri rici cit) t)$$ 3he 3he sta stacc elec electr tric icit it) ) reac reacto torr is is ear earth thed ed b) b) con condu duc cng ng !ir !ires 2rri 2rrita tao on n to skin skin # 7sin 7sing g hand hand glo glove vess # gogg goggle les$ s$ e)es 3he 'iltraon Operaon Operaon is %arried out in Spillage, Spillage,'ilt 'ilter er %loth %loth %losed %losed SS ine, 'ilter 'ilter cloth cloth cleane cleaned d for for 5ver) 5ver) Block Batch # this %leaning of the 'ilter along !ith %loth is 2ncorporated 2n the B* Acetone %harging %harging SS SS pipe is 'ixed to the 'ir 'ire ha ha(ard due due to Boom oom of the the rea react ctor or sta stacc ele elect ctri rici cit) t) *ipe *ipe line liness are are all all SS and and e+u e+uip ipme ment nt moto motors rs are 0ame proof$
Operaonal Operaonal control - checkpoint shall be Boom va valve included in in th the ba batch sh sheet to to in indicate opened, opened, or eakage eakage !hether !hether the the boom boom valve valve has has been been closed closed of Bo Boom "alv alve prio priorr to to cha charg rgin ing g 5th) 5th)ll ace aceta tatte # is not not eaking$ 5th)l acetate addion pipe is kept to the 'ir 'ire ha( ha(ar ard d due due to Bo Boom of the the rea react ctor or sta stacc ele elect ctri rici cit) t) *ipe *ipe line liness are are all all SS and and e+u e+uip ipme ment nt moto motors rs are 0ame proof$ Operaonal Operaonal control - checkpoint shall be Boom va valve included in in th the ba batch sh sheet to to in indicate opened, opened, or eakage eakage !hether !hether the the boom boom valve valve has has been been closed closed of Bo Boom "a "alve prior to to ch charging 6)drochloric acid # is not eaking$ 6)drochloric acid addion pipe is kept to the 'ir 'ire ha( ha(ar ard d due due to Bo Boom of the the rea react ctor or sta stacc ele elect ctri rici cit) t) *ipe *ipe line liness are are all all SS and and e+u e+uip ipme ment nt moto motors rs are 0ame proof$ 3he temperature is raised b) slo! heang ll isllaon8 the Acetone and eth)l oss oss of Acet Aceton one e acet aceta ate "apou apourr os osss is is due due to 5xce 5xcess ssiv ive e and eth)l eth)l acet acetat ate e heat, heat, 2nst 2nstruc rucon on is 9iven 9iven in SO* SO*,, 3o 3o Open Open the steam valve to Opmum so as to maintain the isllaon$ 3he centrifuge is earthed b) conducng 'ire ha(ard due to
5th)l acetate
6)drochloric acid
isllaon of the organic la)er
%entrifuging
3o separate the li+uid
Operaonal Operaonal control - checkpoint shall be Boom va valve included in in th the ba batch sh sheet to to in indicate opened, opened, or eakage eakage !hether !hether the the boom boom valve valve has has been been closed closed of Bo Boom "alv alve prio priorr to to cha charg rgin ing g 5th) 5th)ll ace aceta tatte # is not not eaking$ 5th)l acetate addion pipe is kept to the 'ir 'ire ha( ha(ar ard d due due to Bo Boom of the the rea react ctor or sta stacc ele elect ctri rici cit) t) *ipe *ipe line liness are are all all SS and and e+u e+uip ipme ment nt moto motors rs are 0ame proof$ Operaonal Operaonal control - checkpoint shall be Boom va valve included in in th the ba batch sh sheet to to in indicate opened, opened, or eakage eakage !hether !hether the the boom boom valve valve has has been been closed closed of Bo Boom "a "alve prior to to ch charging 6)drochloric acid # is not eaking$ 6)drochloric acid addion pipe is kept to the 'ir 'ire ha( ha(ar ard d due due to Bo Boom of the the rea react ctor or sta stacc ele elect ctri rici cit) t) *ipe *ipe line liness are are all all SS and and e+u e+uip ipme ment nt moto motors rs are 0ame proof$ 3he temperature is raised b) slo! heang ll isllaon8 the Acetone and eth)l oss oss of Acet Aceton one e acet aceta ate "apou apourr os osss is is due due to 5xce 5xcess ssiv ive e and eth)l eth)l acet acetat ate e heat, heat, 2nst 2nstruc rucon on is 9iven 9iven in SO* SO*,, 3o 3o Open Open the steam valve to Opmum so as to maintain the isllaon$ 3he centrifuge is earthed b) conducng 'ire ha(ard due to !ires$ stac electricit), 3he :ltraon is carried out through a operator ha(ard if centrifuge$ %e %entrifuges ar are high sp speed an) loading > machines and sources of ha(ard in a chemical unloading acvit) plant$ Ample precauons are taken to carr)
carr carrie ied d out out in a runnin running g cent centrif rifug uge e
r)i r)ing ng
Sepa Separraon aon of of sol solve vent ntss fro from m
r)i r)ing ng of the the pro produ duct ct in in
operaon
the product
"3
eacon of stage C22 material, Sodium
?o spec speci: i:cc ha(a ha(ard rd
out out the the cent centri rifu fugi ging ng as as ha( ha(ard ard free free as as possib possible$ le$ ;e ;e are are using using a 4< 4< inch inch dia dia SS.1= SS.1= centrifuge, boom driven and top discharge$ this is a four point suspension machines !hich are put on special vibra mount for smooth vibraon free noiseless operaon$ 3he speed is controlled b) a variable fre+uenc) drive and and the feeding of the centrifuge is done b) pneumacall) controlled valves at lo!er *& under nitrogen purging$ 5ven the bearing housing of the centrifuge is provided !ith a nitrogen purging facilit)$ An interlocking s)stem is provided for ensuring that the lids cannot be opened !hile the centrifuge is running and thereb) prevenng an) operaonal ha(ard b) human error $ All the limits s!itches and the safet) interlocking s!itches are 0ame proof including the "' controls$ "3 is :ed !ith 0ame proof motors$ 7nlo 7nload adin ing g int into o the the bin binss b) b) act actua uatted val valv ve,
Spillage Spillage out out side the
6ence ?o- ess 5xposure 6and gloves # goggles should be used$ 2nstrucon is aid in the SO* , 3o Avoid spillage spillage outsid outside e the 5+uipm 5+uipment, ent,a) a) do!n do!n the
carr carrie ied d out out in a runnin running g cent centrif rifug uge e
r)i r)ing ng
Sepa Separraon aon of of sol solve vent ntss fro from m
r)i r)ing ng of the the pro produ duct ct in in
operaon
the product
"3
Stage-.
eacon of stage C22 material, Sodium carbonate and 5th)l acetate !i !ith !a !ater th then separated the la)er and added 5th)l acetate and c)clohexane c)clohexane tnen
out out the the cent centri rifu fugi ging ng as as ha( ha(ard ard free free as as possib possible$ le$ ;e ;e are are using using a 4< 4< inch inch dia dia SS.1= SS.1= centrifuge, boom driven and top discharge$ this is a four point suspension machines !hich are put on special vibra mount for smooth vibraon free noiseless operaon$ 3he speed is controlled b) a variable fre+uenc) drive and and the feeding of the centrifuge is done b) pneumacall) controlled valves at lo!er *& under nitrogen purging$ 5ven the bearing housing of the centrifuge is provided !ith a nitrogen purging facilit)$ An interlocking s)stem is provided for ensuring that the lids cannot be opened !hile the centrifuge is running and thereb) prevenng an) operaonal ha(ard b) human error $ All the limits s!itches and the safet) interlocking s!itches are 0ame proof including the "' controls$ "3 is :ed !ith 0ame proof motors$ 7nlo 7nload adin ing g int into o the the bin binss b) b) act actua uatted val valv ve,
?o spec speci: i:cc ha(a ha(ard rd
Spillage Spillage out out side the reactor, Sodium ca carbonate 'ire ha(ard due to stac electricit)
centrifuge the reacon mass
2rritaon to skin e)es
#
Boom va valve opened, opened, or eakage eakage of Boo Boom m "alve alve 5th)l acetate 'ire ha(ard due sta stacc ele elect ctri rici cit) t)
isllaon of the organic la)er
to
oss of 5th)l acetate
Boom va valve opened, opened, or eakage eakage of Bo Boom "alv alve %)clohexane 'ire ha(ard due sta stacc ele elect ctri rici cit) t)
6ence ?o- ess 5xposure 6and gloves # goggles should be used$ 2nstrucon is aid in the SO* , 3o Avoid spillage spillage outsid outside e the 5+uipm 5+uipment, ent,a) a) do!n do!n the *ol) Bags to %ollect the spilled &aterial,# 3ransfer to the reactor SS scoops to avoid stac electricit)$ 3he reactor is earthed b) conducng !ires 7sing hand gloves # goggles$
to
Operaonal Operaonal control - checkpoint shall be included in in th the ba batch sh sheet to to in indicate !hether !hether the the boom boom valve valve has has been been closed closed prio priorr to char chargi ging ng 6)dro 6)droch chlo lori ricc acid acid # is not not eaking$ 6)drochloric acid addion pipe is kept to the Boom of the reactor *ipe *ipe line liness are are all all SS and and e+u e+uip ipme ment nt moto motors rs are 0ame proof$ 3he temperature is raised b) slo! heang ll isllaon8 th the 5th)l acetate "a "apour oss is due to 5xcessive heat, 2nstrucon is 9iven in SO*, 3o Open the steam valve to Opmum so as to maintain the isllaon$ isllaon$ Operaonal Operaonal control - checkpoint shall be included in in th the ba batch sh sheet to to in indicate !hether !hether the the boom boom valve valve has has been been closed closed prio priorr to to cha charg rgin ing g %)c %)clo lohe hexxane ane # is is not not eaking$ %)clohexane %)clohexane addion pipe is kept to the Boom of the reactor *ipe *ipe line liness are are all all SS and and e+u e+uip ipme ment nt moto motors rs
centrifuge the reacon mass
2rritaon to skin e)es
#
Boom va valve opened, opened, or eakage eakage of Boo Boom m "alve alve 5th)l acetate 'ire ha(ard due sta stacc ele elect ctri rici cit) t)
isllaon of the organic la)er
to
oss of 5th)l acetate
Boom va valve opened, opened, or eakage eakage of Bo Boom "alv alve %)clohexane 'ire ha(ard due sta stacc ele elect ctri rici cit) t) 'ire ha(ard due to
%entrifuging
3o separate the li+uid
stac electricit), opera operator tor ha(ard ha(ard if an) loading >
unloading acvit) carried out in a running centrifuge
Solvent recover)
%harging of & 6a(ardous !aste a@er disllaon
?o speci:c ha(ard
to
Operaonal Operaonal control - checkpoint shall be included in in th the ba batch sh sheet to to in indicate !hether !hether the the boom boom valve valve has has been been closed closed prio priorr to char chargi ging ng 6)dro 6)droch chlo lori ricc acid acid # is not not eaking$ 6)drochloric acid addion pipe is kept to the Boom of the reactor *ipe *ipe line liness are are all all SS and and e+u e+uip ipme ment nt moto motors rs are 0ame proof$ 3he temperature is raised b) slo! heang ll isllaon8 th the 5th)l acetate "a "apour oss is due to 5xcessive heat, 2nstrucon is 9iven in SO*, 3o Open the steam valve to Opmum so as to maintain the isllaon$ isllaon$ Operaonal Operaonal control - checkpoint shall be included in in th the ba batch sh sheet to to in indicate !hether !hether the the boom boom valve valve has has been been closed closed prio priorr to to cha charg rgin ing g %)c %)clo lohe hexxane ane # is is not not eaking$ %)clohexane %)clohexane addion pipe is kept to the Boom of the reactor *ipe *ipe line liness are are all all SS and and e+u e+uip ipme ment nt moto motors rs are 0ame proof$ 3he centrifuge is earthed b) conducng !ires$ 3he :ltr :ltra aon on is carr carried ied out out throu through gh a centrifuge$ %en %entrifuges are are hig high spe speed
machines and sources of ha(ard in a chemical
plant$ Ample precauons are taken to carr) out the centrifuging as ha(ard free as possible$ ;e are using a 4< inch dia SS.1= centrifuge, boom driven and top discharge$ this is a four point suspension machines !hich are put on special vibra mount for smooth vibraon free noiseless operaon$ 3he speed is controlled b) a variable fre+uenc) drive and the feeding of the centrifuge is done b) pneumacall) controlled valves at lo!er *& under nitrogen purging$ 5ven the bearing housing of the centrifuge is provided !ith a nitrogen purging facilit)$ An interlocking s)stem is provided for ensuring that the lids cannot be opened !hile the centrifuge is running and thereb) prevenng an) operaonal ha(ard b) human error $ All the limits s!itches and the safet) interlocking s!itches are 0ame proof including the "' controls$ All charging is done b) vacuum sucking to avoid spillages and through the closed SS pipe lines$ "3 is :ed !ith 0ame proof motors$
unloading acvit) carried out in a running centrifuge
Solvent recover)
%harging of & 6a(ardous !aste a@er disllaon
?o speci:c ha(ard
r)ing
Separaon of solvents from
r)ing of the product in
?o speci:c ha(ard
operaon
the product
"3
machines and sources of ha(ard in a chemical
plant$ Ample precauons are taken to carr) out the centrifuging as ha(ard free as possible$ ;e are using a 4< inch dia SS.1= centrifuge, boom driven and top discharge$ this is a four point suspension machines !hich are put on special vibra mount for smooth vibraon free noiseless operaon$ 3he speed is controlled b) a variable fre+uenc) drive and the feeding of the centrifuge is done b) pneumacall) controlled valves at lo!er *& under nitrogen purging$ 5ven the bearing housing of the centrifuge is provided !ith a nitrogen purging facilit)$ An interlocking s)stem is provided for ensuring that the lids cannot be opened !hile the centrifuge is running and thereb) prevenng an) operaonal ha(ard b) human error $ All the limits s!itches and the safet) interlocking s!itches are 0ame proof including the "' controls$ All charging is done b) vacuum sucking to avoid spillages and through the closed SS pipe lines$ "3 is :ed !ith 0ame proof motors$ 7nloading into the bins b) actuated valve, 6ence ?o- ess 5xposure 6and gloves # goggles should be used$
To manufacture of 'endamu#n Sta"e
Proce
Stage 2
eacon of 5th)l-4-/bis-h)drox) eth)l amino-1-meth)l-16ben(oid imida(ol-)lbutanoate in presence of thion)l chloride$
%entrifuging
Hazop Study - Proce ! for Bendamusn Po$ble Hazard % Opera#on &emed$al Ac#on fa$lure Addion of 5th)l-4-/2nstrucon is aid in the SO* , 3o Avoid bis-h)drox) eth)l Spillage out side the spillage outside the 5+uipment,a) do!n amino-1-meth)l-16reactor, the *ol) Bags to %ollect the spilled ben(oid imida(ol-&aterial,# 3ransfer to the reactor )lbutanoate 'ire ha(ard due to SS scoops to avoid stac electricit)$ 3he stac electricit) reactor is earthed b) conducng !ires 2rritaon to skin # e)es 7sing hand gloves # goggles$ %harging of 3hion)l Operaonal control - checkpoint shall be chloride Boom valve opened, included in the batch sheet to indicate or eakage of Boom !hether the boom valve has been closed "alve prior to charging thion)l chloride # is not eaking$ 3hion)l chloride addion pipe is kept to 'ire ha(ard due to the Boom of the reactor stac electricit) *ipe lines are all SS and e+uipment motors are 0ame proof$ 3he centrifuge is earthed b) conducng !ires$ 'ire ha(ard due to 3he :ltraon is carried out through a electricit), centrifuge$ %entrifuges are high speed stac 3o separate the 2st operator ha(ard if an) machines and sources of ha(ard in a
To manufacture of 'endamu#n Sta"e
Proce
Stage 2
eacon of 5th)l-4-/bis-h)drox) eth)l amino-1-meth)l-16ben(oid imida(ol-)lbutanoate in presence of thion)l chloride$
%entrifuging
Hazop Study - Proce ! for Bendamusn Po$ble Hazard % Opera#on &emed$al Ac#on fa$lure Addion of 5th)l-4-/2nstrucon is aid in the SO* , 3o Avoid bis-h)drox) eth)l Spillage out side the spillage outside the 5+uipment,a) do!n amino-1-meth)l-16reactor, the *ol) Bags to %ollect the spilled ben(oid imida(ol-&aterial,# 3ransfer to the reactor )lbutanoate 'ire ha(ard due to SS scoops to avoid stac electricit)$ 3he stac electricit) reactor is earthed b) conducng !ires 2rritaon to skin # e)es 7sing hand gloves # goggles$ %harging of 3hion)l Operaonal control - checkpoint shall be chloride Boom valve opened, included in the batch sheet to indicate or eakage of Boom !hether the boom valve has been closed "alve prior to charging thion)l chloride # is not eaking$ 3hion)l chloride addion pipe is kept to 'ire ha(ard due to the Boom of the reactor stac electricit) *ipe lines are all SS and e+uipment motors are 0ame proof$ 3he centrifuge is earthed b) conducng !ires$ 'ire ha(ard due to 3he :ltraon is carried out through a electricit), centrifuge$ %entrifuges are high speed stac 3o separate the 2st operator ha(ard if an) machines and sources of ha(ard in a Stage 'rom the li+uid loading > unloading chemical plant$ Ample precauons are acvit) carried out in a taken to carr) out the centrifuging as running centrifuge ha(ard free as possible$ ;e are using a 4< inch dia SS.1= centrifuge, boom driven and top discharge$ this is a four point
suspension machines !hich are put on special vibra mount for smooth vibraon free noiseless operaon$ 3he speed is controlled b) a variable fre+uenc) drive and the feeding of the centrifuge is done b) pneumacall) controlled valves at lo!er *& under nitrogen purging$ 5ven the bearing housing of the centrifuge is provided !ith a nitrogen purging facilit)$ An interlocking s)stem is provided for ensuring that the lids cannot be opened !hile the centrifuge is running and thereb) prevenng an) operaonal ha(ard b) human error$ All the limits s!itches and the safet) interlocking s!itches are 0ame proof including the "' controls$ Solvent recover) isllaon
%harging of & 6a(ardous !aste a@er disllaon
?o speci:c ha(ard
All charging is done b) vacuum sucking to avoid spillages and through the closed SS pipe lines$
suspension machines !hich are put on special vibra mount for smooth vibraon free noiseless operaon$ 3he speed is controlled b) a variable fre+uenc) drive and the feeding of the centrifuge is done b) pneumacall) controlled valves at lo!er *& under nitrogen purging$ 5ven the bearing housing of the centrifuge is provided !ith a nitrogen purging facilit)$ An interlocking s)stem is provided for ensuring that the lids cannot be opened !hile the centrifuge is running and thereb) prevenng an) operaonal ha(ard b) human error$ All the limits s!itches and the safet) interlocking s!itches are 0ame proof including the "' controls$ %harging of & 6a(ardous !aste a@er disllaon
Solvent recover) isllaon
?o speci:c ha(ard
All charging is done b) vacuum sucking to avoid spillages and through the closed SS pipe lines$
To manufacture b$calutam$de
Hazop Study - Proce ! for Proce
Opera#on
eacon of 1D ?-E4c)ano-.-tri0uorometh)l phen)lF-.-E4-0uorophen)l thioF--h)drox)--meth)l propanamide and *otassium permanganate in Acetonitrile$
%harging of 1D ?-E4-c)ano-.tri0uorometh)l phen)lF-.-E40uorophen)l thioF-h)drox)-meth)l propanamide %harging of *otassium permanganate
%harging of Acetonitrile
Po$ble Hazard % fa$lure Spillage out side the reactor, 'ire ha(ard due to stac electricit) 2rritaon to skin # e)es
Boom valve opened, or eakage of Boom "alve 'ire ha(ard due to stac electricit) Boom valve opened, or eakage of Boom "alve
B2%A73A&25
&emed$al Ac#on 2nstrucon is aid in the SO* , 3o Avoid spillage outside the 5+uipment, a) do!n the *ol) Bags to %ollect the spilled &aterial,# 3ransfer to the reactor SS scoops to avoid stac electricit)$ 3he reactor is earthed b) conducng !ires 7sing hand gloves # goggles$
Operaonal control - checkpoint shall be included in the batch sheet to indicate !hether the boom valve has been closed prior to charging *otassium permanganate # is not eaking$ *otassium permanganate addion pipe is kept to the Boom of the reactor$ *ipe lines are all SS and e+uipment motors are 0ame proof$ Operaonal control - checkpoint shall be included in the batch sheet to indicate !hether the boom valve has been closed prior to charging Acetonitrile # is not eaking$
To manufacture b$calutam$de
Hazop Study - Proce ! for Proce
Opera#on
eacon of 1D ?-E4c)ano-.-tri0uorometh)l phen)lF-.-E4-0uorophen)l thioF--h)drox)--meth)l propanamide and *otassium permanganate in Acetonitrile$
%harging of 1D ?-E4-c)ano-.tri0uorometh)l phen)lF-.-E40uorophen)l thioF-h)drox)-meth)l propanamide %harging of *otassium permanganate
%harging of Acetonitrile
'iltraon
Sta"e
Proce
%entrifuging
Po$ble Hazard % fa$lure Spillage out side the reactor, 'ire ha(ard due to stac electricit) 2rritaon to skin # e)es
Boom valve opened, or eakage of Boom "alve 'ire ha(ard due to stac electricit) Boom valve opened, or eakage of Boom "alve 'ire ha(ard due to stac electricit)
Spillage, %loth Block
B2%A73A&25
&emed$al Ac#on 2nstrucon is aid in the SO* , 3o Avoid spillage outside the 5+uipment, a) do!n the *ol) Bags to %ollect the spilled &aterial,# 3ransfer to the reactor SS scoops to avoid stac electricit)$ 3he reactor is earthed b) conducng !ires 7sing hand gloves # goggles$
Operaonal control - checkpoint shall be included in the batch sheet to indicate !hether the boom valve has been closed prior to charging *otassium permanganate # is not eaking$ *otassium permanganate addion pipe is kept to the Boom of the reactor$ *ipe lines are all SS and e+uipment motors are 0ame proof$ Operaonal control - checkpoint shall be included in the batch sheet to indicate !hether the boom valve has been closed prior to charging Acetonitrile # is not eaking$ Acetonitrile addion pipe is kept to the Boom of the reactor$ *ipe lines are all SS and e+uipment motors are 0ame proof$
'ilter 3he 'iltraon Operaon is %arried out in %losed SS ine, 'ilter cloth cleaned for 5ver) Batch # this %leaning of the 'ilter along !ith %loth is 2ncorporated 2n the B*
Hazop Study - Proce ! for 'I(AL)TA*I+, Opera#on Po$ble Hazard % &emed$al Ac#on fa$lure 'ire ha(ard due to Acetone %harging SS pipe is 'ixed to the Boom of the reactor stac electricit) *ipe lines are all SS and e+uipment motors are 0ame proof$ 3o separate the bicalutamide from the li+uid
'ire ha(ard due to stac electricit), operator ha(ard if an) loading > unloading acvit) carried out in a running centrifuge
3he centrifuge is earthed b) conducng !ires$ 3he :ltraon is carried out through a centrifuge$ %entrifuges are high speed machines and sources of ha(ard in a chemical plant$ Ample precauons are taken to carr) out the centrifuging as ha(ard free as possible$ ;e are using a 4< inch dia SS.1= centrifuge, boom driven and top discharge$ 3his is a four point suspension machines !hich are put on special vibra mount for smooth vibraon free noiseless operaon$ 3he speed is controlled b) a variable fre+uenc) drive and the feeding of the centrifuge is done b) pneumacall) controlled valves at lo!er *& under nitrogen purging$ 5ven the bearing housing of the centrifuge is provided !ith a nitrogen purging facilit)$ An interlocking s)stem is provided for ensuring that the lids cannot be opened !hile the centrifuge is running and thereb) prevenng an) operaonal ha(ard b) human error$ All the limits s!itches and the safet)
'iltraon
Sta"e
Proce
Spillage, %loth Block
'ilter 3he 'iltraon Operaon is %arried out in %losed SS ine, 'ilter cloth cleaned for 5ver) Batch # this %leaning of the 'ilter along !ith %loth is 2ncorporated 2n the B*
Hazop Study - Proce ! for 'I(AL)TA*I+, Opera#on Po$ble Hazard % &emed$al Ac#on fa$lure 'ire ha(ard due to Acetone %harging SS pipe is 'ixed to the Boom of the reactor stac electricit) *ipe lines are all SS and e+uipment motors are 0ame proof$
%entrifuging
3o separate the bicalutamide from the li+uid
'ire ha(ard due to stac electricit), operator ha(ard if an) loading > unloading acvit) carried out in a running centrifuge
Solvent recover)
isllaon of Acetonitrile and hexane
?o speci:c ha(ard
into mass r)ing Separaon of solvents operaon from the product
3he centrifuge is earthed b) conducng !ires$ 3he :ltraon is carried out through a centrifuge$ %entrifuges are high speed machines and sources of ha(ard in a chemical plant$ Ample precauons are taken to carr) out the centrifuging as ha(ard free as possible$ ;e are using a 4< inch dia SS.1= centrifuge, boom driven and top discharge$ 3his is a four point suspension machines !hich are put on special vibra mount for smooth vibraon free noiseless operaon$ 3he speed is controlled b) a variable fre+uenc) drive and the feeding of the centrifuge is done b) pneumacall) controlled valves at lo!er *& under nitrogen purging$ 5ven the bearing housing of the centrifuge is provided !ith a nitrogen purging facilit)$ An interlocking s)stem is provided for ensuring that the lids cannot be opened !hile the centrifuge is running and thereb) prevenng an) operaonal ha(ard b) human error$ All the limits s!itches and the safet) interlocking s!itches are 0ame proof including the "' controls$ All charging is done b) vacuum sucking to avoid spillages and through the closed SS pipe lines$
reacon
r)ing of product "acuum r)er
the ?o speci:c ha(ard in tra)
"3 is :ed !ith 0ame proof motors$ 7nloading into the bins b) actuated valve, 6ence ?o- ess 5xposure 6and gloves # goggles should be used$
To manufacture 'or#zom$b
Sta"e Stage 2
Hazop Study - Proce ! for 'or#zom$b Po$ble Hazard % Proce Opera#on fa$lure eacon of .- phen)l - Addion of eacon of .-Ep)ra(ine-phen)l --Ep)ra(ine-Spillage out side the carbon)l-aminoF carbon)l-aminoF reactor, propionic acid !ith - propionic acid Borolex-G-pinanediol 'ire ha(ard due to stac tri0uoro acec acid electricit) 2rritaon to skin # e)es %harging of &% Boom valve opened, or eakage of Boom "alve
'ire ha(ard due to stac
&emed$al Ac#on 2nstrucon is aid in the SO* , 3o Avoid spillage outside the 5+uipment, a) do!n the *ol) Bags to %ollect the spilled &aterial,# 3ransfer to the reactor SS scoops to avoid stac electricit)$ 3he reactor is earthed b) conducng !ires 7sing hand gloves # goggles$ Operaonal control - checkpoint shall be included in the batch sheet to indicate !hether the boom valve has been closed prior to charging &% # is not eaking$ &% addion pipe is kept to the Boom of the reactor
into mass r)ing Separaon of solvents operaon from the product
reacon
r)ing of product "acuum r)er
the ?o speci:c ha(ard in tra)
"3 is :ed !ith 0ame proof motors$ 7nloading into the bins b) actuated valve, 6ence ?o- ess 5xposure 6and gloves # goggles should be used$
To manufacture 'or#zom$b
Sta"e Stage 2
Hazop Study - Proce ! for 'or#zom$b Po$ble Hazard % Proce Opera#on fa$lure eacon of .- phen)l - Addion of eacon of .-Ep)ra(ine-phen)l --Ep)ra(ine-Spillage out side the carbon)l-aminoF carbon)l-aminoF reactor, propionic acid !ith - propionic acid Borolex-G-pinanediol 'ire ha(ard due to stac tri0uoro acec acid electricit) 2rritaon to skin # e)es %harging of &% Boom valve opened, or eakage of Boom "alve
'ire ha(ard due to stac electricit) 6)drox) succinamide
Spillage out side the reactor,
'ire ha(ard due to stac electricit) 2rritaon to skin # e)es 'iltraon
Solvent recover)
Stage 22
%harging of & 6a(ardous !aste
Spillage 'ilter %loth Block
a@er ?o speci:c ha(ard
&emed$al Ac#on 2nstrucon is aid in the SO* , 3o Avoid spillage outside the 5+uipment, a) do!n the *ol) Bags to %ollect the spilled &aterial,# 3ransfer to the reactor SS scoops to avoid stac electricit)$ 3he reactor is earthed b) conducng !ires 7sing hand gloves # goggles$ Operaonal control - checkpoint shall be included in the batch sheet to indicate !hether the boom valve has been closed prior to charging &% # is not eaking$ &% addion pipe is kept to the Boom of the reactor *ipe lines are all SS and e+uipment motors are 0ame proof$ 2nstrucon is aid in the SO* , 3o Avoid spillage outside the 5+uipment, a) do!n the
*ol) Bags to %ollect the spilled &aterial,# 3ransfer to the reactor SS scoops to avoid stac electricit)$ 3he reactor is earthed b) conducng !ires 7sing hand gloves # goggles$ 3he 'iltraon Operaon is %arried out in %losed SS ine, 'ilter cloth cleaned for 5ver) Batch # this %leaning of the 'ilter along !ith %loth is 2ncorporated 2n the B* All charging is done b) vacuum sucking to
disllaon
avoid spillages and through the closed SS pipe
'iltraon
lines$ 3he 'iltraon Operaon is %arried out in %losed SS ine, 'ilter cloth cleaned for 5ver)
Addion of stage 2 product
Spillage, 'ilter %loth Block
Spillage out side the reactor, 'ire ha(ard due to stac electricit) 2rritaon to skin # e)es
Batch # this %leaning of the 'ilter along !ith %loth is 2ncorporated 2n the B* 2nstrucon is aid in the SO* , 3o Avoid spillage outside the 5+uipment, a) do!n the *ol) Bags to %ollect the spilled &aterial,# 3ransfer to the reactor SS scoops to avoid stac electricit)$ 3he reactor is earthed b) conducng !ires 7sing hand gloves # goggles$ 3he Addion of 6)drochloric acid is charged
'ire ha(ard due to stac electricit) 2rritaon to skin # e)es 'iltraon
Solvent recover)
Stage 22
%harging of & 6a(ardous !aste
Spillage 'ilter %loth Block
a@er ?o speci:c ha(ard
All charging is done b) vacuum sucking to
disllaon
avoid spillages and through the closed SS pipe
'iltraon
lines$ 3he 'iltraon Operaon is %arried out in %losed SS ine, 'ilter cloth cleaned for 5ver)
Addion of stage 2 product
Spillage, 'ilter %loth Block
Spillage out side the reactor, 'ire ha(ard due to stac electricit) 2rritaon to skin # e)es
6%l Addion
6)drochoric acid Spillage # 2rritaon
%harging of ?-6eptane Boom valve opened, or eakage of Boom "alve
'ire ha(ard due to stac electricit)
Saturated sodium bicarbonate
Solvent recover)
*ol) Bags to %ollect the spilled &aterial,# 3ransfer to the reactor SS scoops to avoid stac electricit)$ 3he reactor is earthed b) conducng !ires 7sing hand gloves # goggles$ 3he 'iltraon Operaon is %arried out in %losed SS ine, 'ilter cloth cleaned for 5ver) Batch # this %leaning of the 'ilter along !ith %loth is 2ncorporated 2n the B*
%harging of & 6a(ardous ! aste a @er
Batch # this %leaning of the 'ilter along !ith %loth is 2ncorporated 2n the B* 2nstrucon is aid in the SO* , 3o Avoid spillage outside the 5+uipment, a) do!n the *ol) Bags to %ollect the spilled &aterial,# 3ransfer to the reactor SS scoops to avoid stac electricit)$ 3he reactor is earthed b) conducng !ires 7sing hand gloves # goggles$ 3he Addion of 6)drochloric acid is charged through the %losed lines, !ithout an) Spillage, personnel *rotecve 5+uipments are 7sed to avoid the 5xposure # tackle the irritaon
Operaonal control - checkpoint shall be included in the batch sheet to indicate !hether the boom valve has been closed prior to charging n-heptane # is not eaking$ n-heptane addion pipe is kept to the Boom of the reactor *ipe lines are all SS and e+uipment motors are 0ame proof$
'ire ha(ard due to stac electricit) 2rritaon to skin # e)es
2nstrucon is aid in the SO* , 3o Avoid spillage outside the 5+uipment, a) do!n the *ol) Bags to %ollect the spilled &aterial,# 3ransfer to the reactor SS scoops to avoid stac electricit)$ 3he reactor is earthed b) conducng !ires 7sing hand gloves # goggles$
?o speci:c ha(ard
All charging is done b) vacuum sucking to
Spillage out side the reactor,
disllaon
avoid spillages and through the closed SS pipe
%harging 5th)l acetate Boom valve opened, or eakage of Boom "alve
lines$ Operaonal control - checkpoint shall be included in the batch sheet to indicate !hether the boom valve has been closed prior to charging eth)l acetate # is not eaking$
%harging of ?-6eptane Boom valve opened, or eakage of Boom "alve
'ire ha(ard due to stac electricit)
Saturated sodium bicarbonate
Solvent recover)
%harging of & 6a(ardous ! aste a @er
'ire ha(ard due to stac electricit) 2rritaon to skin # e)es
2nstrucon is aid in the SO* , 3o Avoid spillage outside the 5+uipment, a) do!n the *ol) Bags to %ollect the spilled &aterial,# 3ransfer to the reactor SS scoops to avoid stac electricit)$ 3he reactor is earthed b) conducng !ires 7sing hand gloves # goggles$
?o speci:c ha(ard
All charging is done b) vacuum sucking to
Spillage out side the reactor,
disllaon
avoid spillages and through the closed SS pipe
%harging 5th)l acetate Boom valve opened, or eakage of Boom "alve
'ire ha(ard due to stac electricit)
%harging methanol Boom valve opened, or eakage of Boom "alve
'ire ha(ard due to stac electricit)
'iltraon
Solvent recover)
Operaonal control - checkpoint shall be included in the batch sheet to indicate !hether the boom valve has been closed prior to charging n-heptane # is not eaking$ n-heptane addion pipe is kept to the Boom of the reactor *ipe lines are all SS and e+uipment motors are 0ame proof$
Spillage, 'ilter %loth Block
lines$ Operaonal control - checkpoint shall be included in the batch sheet to indicate !hether the boom valve has been closed prior to charging eth)l acetate # is not eaking$ 5th)l acetate addion pipe is kept to the Boom of the reactor *ipe lines are all SS and e+uipment motors are 0ame proof$
Operaonal control - checkpoint shall be included in the batch sheet to indicate !hether the boom valve has been closed prior to charging methanol # is not eaking$ ðanol addion pipe is kept to the Boom of the reactor *ipe lines are all SS and e+uipment motors are 0ame proof$
3he 'iltraon Operaon is %arried out in %losed SS ine, 'ilter cloth cleaned for 5ver) Batch # this %leaning of the 'ilter along !ith %loth is 2ncorporated 2n the B*
%harging of & 6a(ardous !aste a@er ?o speci:c ha(ard
All charging is done b) vacuum sucking to
disllaon
avoid spillages and through the closed SS pipe
Stage 222 Boom valve opened, or eakage of Boom "alve %harging of methanol
lines$ Operaonal control - checkpoint shall be included in the batch sheet to indicate !hether the boom valve has been closed prior to charging methanol # is not eaking$ methanol addion pipe is kept to the Boom
%harging methanol Boom valve opened, or eakage of Boom "alve
'ire ha(ard due to stac electricit)
'iltraon
Solvent recover)
Spillage, 'ilter %loth Block
All charging is done b) vacuum sucking to
disllaon
avoid spillages and through the closed SS pipe
Boom valve opened, or eakage of Boom "alve %harging of methanol 'ire ha(ard due to stac electricit) Addion product
of stage 22 Spillage out side the reactor,
'ire ha(ard due to stac electricit) 2rritaon to skin # e)es
operaon
lines$ Operaonal control - checkpoint shall be included in the batch sheet to indicate !hether the boom valve has been closed prior to charging methanol # is not eaking$ methanol addion pipe is kept to the Boom of the reactor *ipe lines are all SS and e+uipment motors are 0ame proof$ 2nstrucon is aid in the SO* , 3o Avoid spillage outside the 5+uipment, a) do!n the
*ol) Bags to %ollect the spilled &aterial,# 3ransfer to the reactor SS scoops to avoid stac electricit)$ 3he reactor is earthed b) conducng !ires 7sing hand gloves # goggles$ 3he 'iltraon Operaon is %arried out in %losed SS ine, 'ilter cloth cleaned for 5ver) Batch # this %leaning of the 'ilter along !ith %loth is 2ncorporated 2n the B*
'iltraon
Spillage, 'ilter %loth Block
%harging of & 6a(ardous ! aste a @er
?o speci:c ha(ard
All charging is done b) vacuum sucking to
?o speci:c ha(ard
avoid spillages and through the closed SS pipe lines$ %" is :ed !ith 0ame proof motors$ 7nloading into the bins b) actuated valve,
disllaon
r)ing
3he 'iltraon Operaon is %arried out in %losed SS ine, 'ilter cloth cleaned for 5ver) Batch # this %leaning of the 'ilter along !ith %loth is 2ncorporated 2n the B*
%harging of & 6a(ardous !aste a@er ?o speci:c ha(ard
Stage 222
Solvent recover)
Operaonal control - checkpoint shall be included in the batch sheet to indicate !hether the boom valve has been closed prior to charging methanol # is not eaking$ ðanol addion pipe is kept to the Boom of the reactor *ipe lines are all SS and e+uipment motors are 0ame proof$
Separaon of solvents
r)ing of the product in
from the product
otocone vacuum r)er
6ence ?o- ess 5xposure 6and gloves # goggles should be used$
'ire ha(ard due to stac electricit) 2rritaon to skin # e)es
Solvent recover)
'iltraon
Spillage, 'ilter %loth Block
%harging of & 6a(ardous ! aste a @er
?o speci:c ha(ard
All charging is done b) vacuum sucking to
?o speci:c ha(ard
avoid spillages and through the closed SS pipe lines$ %" is :ed !ith 0ame proof motors$ 7nloading into the bins b) actuated valve,
disllaon
r)ing
operaon
*ol) Bags to %ollect the spilled &aterial,# 3ransfer to the reactor SS scoops to avoid stac electricit)$ 3he reactor is earthed b) conducng !ires 7sing hand gloves # goggles$ 3he 'iltraon Operaon is %arried out in %losed SS ine, 'ilter cloth cleaned for 5ver) Batch # this %leaning of the 'ilter along !ith %loth is 2ncorporated 2n the B*
Separaon of solvents
r)ing of the product in
from the product
otocone vacuum r)er
6ence ?o- ess 5xposure 6and gloves # goggles should be used$
To manufacture of (apec$tab$ne
Sta"e
Proce
Stage -1
eacon of /-meth)l tetrah)drofuran-,.,4tri)ltriacetate, /-'luoroc)tosine, Stannic chloride, 3&S%, 6&S and Sodium bicarbonate into &% and toluene$
Hazop Study - Proce ! for (AP,(ITA'IN, Opera#on Po$ble Hazard % fa$lure &emed$al Ac#on 2nstrucon is aid in the SO* , 3o Avoid spillage outside %harging /Spillage out side the the 5+uipment, a) do!n the *ol) Bags to %ollect the reactor, meth)l spilled &aterial,# 3ransfer to the reactor tetrah)drofuran- 'ire ha(ard due to stac SS scoops to avoid stac electricit)$ 3he reactor is ,.,4electricit) earthed b) conducng !ires tri)ltriacetate 2rritaon to skin # e)es 7sing hand gloves # goggles$ 2nstrucon is aid in the SO* , 3o Avoid spillage outside Spillage out side the the 5+uipment, a) do!n the *ol) Bags to %ollect the reactor, %harging of /spilled &aterial,# 3ransfer to the reactor 'luoroc)tosine 'ire ha(ard due to stac SS scoops to avoid stac electricit)$ 3he reactor is electricit) earthed b) conducng !ires 2rritaon to skin # e)es$ 7sing hand gloves # goggles$ 2nstrucon is aid in the SO* , 3o Avoid spillage outside Spillage out side the the 5+uipment, a) do!n the *ol) Bags to %ollect the reactor, %harging of spilled &aterial,# 3ransfer to the reactor 3&S% 'ire ha(ard due to stac SS scoops to avoid stac electricit)$ 3he reactor is electricit) earthed b) conducng !ires 2rritaon to skin # e)es$ 7sing hand gloves # goggles$ 2nstrucon is aid in the SO* , 3o Avoid spillage outside Spillage out side the the 5+uipment, a) do!n the *ol) Bags to %ollect the reactor, %harging of spilled &aterial,# 3ransfer to the reactor 6&S 'i ha d du t t SS t oid ta el ctricit) 3he ct is
To manufacture of (apec$tab$ne
Sta"e
Proce
Stage -1
eacon of /-meth)l tetrah)drofuran-,.,4tri)ltriacetate, /-'luoroc)tosine, Stannic chloride, 3&S%, 6&S and Sodium bicarbonate into &% and toluene$
Hazop Study - Proce ! for (AP,(ITA'IN, Opera#on Po$ble Hazard % fa$lure &emed$al Ac#on 2nstrucon is aid in the SO* , 3o Avoid spillage outside %harging /Spillage out side the the 5+uipment, a) do!n the *ol) Bags to %ollect the reactor, meth)l spilled &aterial,# 3ransfer to the reactor tetrah)drofuran- 'ire ha(ard due to stac SS scoops to avoid stac electricit)$ 3he reactor is ,.,4electricit) earthed b) conducng !ires tri)ltriacetate 2rritaon to skin # e)es 7sing hand gloves # goggles$ 2nstrucon is aid in the SO* , 3o Avoid spillage outside Spillage out side the the 5+uipment, a) do!n the *ol) Bags to %ollect the reactor, %harging of /spilled &aterial,# 3ransfer to the reactor 'luoroc)tosine 'ire ha(ard due to stac SS scoops to avoid stac electricit)$ 3he reactor is electricit) earthed b) conducng !ires 2rritaon to skin # e)es$ 7sing hand gloves # goggles$ 2nstrucon is aid in the SO* , 3o Avoid spillage outside Spillage out side the the 5+uipment, a) do!n the *ol) Bags to %ollect the reactor, %harging of spilled &aterial,# 3ransfer to the reactor 3&S% 'ire ha(ard due to stac SS scoops to avoid stac electricit)$ 3he reactor is electricit) earthed b) conducng !ires 2rritaon to skin # e)es$ 7sing hand gloves # goggles$ 2nstrucon is aid in the SO* , 3o Avoid spillage outside Spillage out side the the 5+uipment, a) do!n the *ol) Bags to %ollect the reactor, %harging of spilled &aterial,# 3ransfer to the reactor 6&S 'ire ha(ard due to stac SS scoops to avoid stac electricit)$ 3he reactor is electricit) earthed b) conducng !ires 2rritaon to skin # e)es$ 7sing hand gloves # goggles$
Boom valve opened, or eakage of Boom "alve 'ire ha(ard due to stac electricit) Boom valve opened, or eakage of Boom "alve 'ire ha(ard due to stac electricit) Boom valve opened, or eakage of Boom "alve 'ire ha(ard due to stac electricit) 'ilter Spillage,
%harging of Stannic chloride
%harging of &%
%harging of toluene
%loth Block 'iltraon
'ire ha(ard due to stac electricit)
ll
of
of
Operaonal control - checkpoint shall be included in the batch sheet to indicate !hether the boom valve has been closed prior to charging Stannic chloride # is not eaking$ Stannic chloride add ion pipe is kept to the Boom of the reactor$
*ipe lines are all SS and e+uipment motors are 0ame proof$ Operaonal control - checkpoint shall be included in the batch sheet to indicate !hether the boom valve has been closed prior to charging &% # is not eaking$ &% addion pipe is kept to the Boom of the reactor$ *ipe lines are all SS and e+uipment motors are 0ame proof$ Operaonal control - checkpoint shall be included in the batch sheet to indicate !hether the boom valve has been closed prior to charging toluene # is not eaking$ toluene addion pipe is kept to the Boom of the reactor$ *ipe lines are all SS and e+uipment motors are 0ame proof$ 3he 'iltraon Operaon is %arried out in %losed SS ine, 'ilter cloth cleaned for 5ver) Batch # this %leaning of the 'ilter along !ith %loth is 2ncorporated 2n the B* 3ri meth)lamine and Sodium bicarbonate %harging SS pipe is 'ixed to the Boom of the reactor$ *ipe lines are all SS and e+uipment motors are 0ame proof$
h)l he
ed b) lo he
ll
0
he
ha
l
Boom valve opened, or eakage of Boom "alve 'ire ha(ard due to stac electricit) Boom valve opened, or eakage of Boom "alve 'ire ha(ard due to stac electricit) Boom valve opened, or eakage of Boom "alve 'ire ha(ard due to stac electricit) 'ilter Spillage,
%harging of Stannic chloride
%harging of &%
%harging of toluene
%loth Block 'iltraon
'ire ha(ard due to stac electricit)
Solvent recover)
%harge 2*A into reacon mass$
r)ing operaon
isllaon &% 3oluene
of oss of and acetate acetonitrile
%harging of 2*A
%entrifuging
3o separate the ocetaxel 3rih)drate stage-22 from the li+uid
Solvent
%harging of &Hs 6a(ard ous !aste
recover)
a@er centrifuging
Separaon
Stannic chloride add ion pipe is kept to the Boom of the reactor$
*ipe lines are all SS and e+uipment motors are 0ame proof$ Operaonal control - checkpoint shall be included in the batch sheet to indicate !hether the boom valve has been closed prior to charging &% # is not eaking$ &% addion pipe is kept to the Boom of the reactor$ *ipe lines are all SS and e+uipment motors are 0ame proof$ Operaonal control - checkpoint shall be included in the batch sheet to indicate !hether the boom valve has been closed prior to charging toluene # is not eaking$ toluene addion pipe is kept to the Boom of the reactor$ *ipe lines are all SS and e+uipment motors are 0ame proof$ 3he 'iltraon Operaon is %arried out in %losed SS ine, 'ilter cloth cleaned for 5ver) Batch # this %leaning of the 'ilter along !ith %loth is 2ncorporated 2n the B* 3ri meth)lamine and Sodium bicarbonate %harging SS pipe is 'ixed to the Boom of the reactor$ *ipe lines are all SS and e+uipment motors are 0ame proof$
eth)l 3he temperature is raised b) slo! heang ll re0ux8 the methanol and "apour oss is due to 5xcessive heat, 2nstrucon is 9iven in SO*, 3o Open the steam valve to Opmum so as to maintain the re0ux
Boom valve opened, or eakage of Boom "alve 'ire ha(ard due to
Operaonal control - checkpoint shall be included in the batch sheet to indicate !hether the boom valve has been closed prior to charging 2*A # is not eaking$
stac electricit)
are all SS and e+uipment motors are 0ame proof$
2*A addion pipe is kept to the Boom of the reactor$ *ipe lines
3he centrifuge is earthed b) conducng !ires$ 3he :ltraon is carried out through a centrifuge$ %entrifuges are high speed machines and sources of ha(ard in a chemical plant$ Ample precauons are taken to carr) out the centrifuging as ha(ard free as possible$ ;e are using a 4< 'ire ha(ard due to inch dia SS.1= centrifuge, boom driven and top discharge$ 3his is a four point stac electricit), suspension machines !hich are put on special vibra mount for smooth vibraon operator ha(ard if an) free noiseless operaon$ 3he speed is controlled b) a variable fre+uenc) drive unloading and the feeding of the centrifuge is done b) pneumacall) controlled valves at loading > acvit) carried out in a lo!er *& under nitrogen purging$ 5ven the bearing housing of the centrifuge running centrifuge is provided !ith a nitrogen purging facilit)$ An interlocking s)stem is provided for ensuring that the lids cannot be opened !hile the centrifuge is running and thereb) prevenng an) operaonal ha(ard b) human error$ All the limits s!itches and the safet) interlocking s!itches are 0ame proof including the "' controls$ All charging is done b) vacuum sucking to avoid spillages and through the closed ?o speci:c ha(ard
of r)ing of the product in vacuum
solvents from tra) dr)er the product
Operaonal control - checkpoint shall be included in the batch sheet to indicate !hether the boom valve has been closed prior to charging Stannic chloride # is not eaking$
?o speci:c ha(ard
SS pipe lines$ "3 is :ed !ith 0ame proof motors$ 7nloading into the bins b) actuated valve, 6ence ?o- ess 5xposure 6and gloves # goggles should be used$
%harge 2*A into reacon mass$
r)ing operaon
Stage-22
%harging of 2*A
%entrifuging
3o separate the ocetaxel 3rih)drate stage-22 from the li+uid
Solvent
%harging of &Hs 6a(ard ous !aste
recover)
a@er centrifuging
Separaon
Boom valve opened, or eakage of Boom "alve 'ire ha(ard due to
Operaonal control - checkpoint shall be included in the batch sheet to indicate !hether the boom valve has been closed prior to charging 2*A # is not eaking$
stac electricit)
are all SS and e+uipment motors are 0ame proof$
3he centrifuge is earthed b) conducng !ires$ 3he :ltraon is carried out through a centrifuge$ %entrifuges are high speed machines and sources of ha(ard in a chemical plant$ Ample precauons are taken to carr) out the centrifuging as ha(ard free as possible$ ;e are using a 4< 'ire ha(ard due to inch dia SS.1= centrifuge, boom driven and top discharge$ 3his is a four point stac electricit), suspension machines !hich are put on special vibra mount for smooth vibraon operator ha(ard if an) free noiseless operaon$ 3he speed is controlled b) a variable fre+uenc) drive unloading and the feeding of the centrifuge is done b) pneumacall) controlled valves at loading > acvit) carried out in a lo!er *& under nitrogen purging$ 5ven the bearing housing of the centrifuge running centrifuge is provided !ith a nitrogen purging facilit)$ An interlocking s)stem is provided for ensuring that the lids cannot be opened !hile the centrifuge is running and thereb) prevenng an) operaonal ha(ard b) human error$ All the limits s!itches and the safet) interlocking s!itches are 0ame proof including the "' controls$ All charging is done b) vacuum sucking to avoid spillages and through the closed ?o speci:c ha(ard
of r)ing of the product in vacuum
solvents from tra) dr)er the product
?o speci:c ha(ard
%harge
Boom valve opened,
capecitabine stage-2, *)riddine and npent)l
or eakage of Boom
chloroformate into &%$
"alve
%harging of *)riddine
'ire ha(ard due stac electricit)
Boom valve opened, %harging of n-pent)l
or eakage of Boom "alve
chloroformate
'ire ha(ard due stac electricit)
Boom valve opened, %harging of &%
2*A addion pipe is kept to the Boom of the reactor$ *ipe lines
or eakage of Boom "alve 'ire ha(ard due stac electricit)
SS pipe lines$ "3 is :ed !ith 0ame proof motors$ 7nloading into the bins b) actuated valve, 6ence ?o- ess 5xposure 6and gloves # goggles should be used$ Operaonal control - checkpoint shall be included in the batch sheet to indicate !hether the boom valve has been closed prior to charging *)riddine # is not eaking$
to *)riddine addion pipe is kept to the Boom of the reactor$ *ipe lines are all SS and e+uipment motors are 0ame proof$
Operaonal control - checkpoint shall be included in the batch sheet to indicate !hether the boom valve has been closed prior to charging n-pent)l chloroformate # is not eaking$
to ?-pent)l chloroformate addion pipe is kept to the Boom of the reactor$ *ipe lines are all SS and e+uipment motors are 0ame proof$
Operaonal control - checkpoint shall be included in the batch sheet to indicate !hether the boom valve has been closed prior to charging &% # is not eaking$ to &% addion pipe is kept to the Boom of the reactor$ *ipe lines are all SS and e+uipment motors are 0ame proof$
'ilter %loth 3he 'iltraon Operaon is %arried out in %losed SS ine, 'ilter cloth cleaned for 5ver) Batch # this %leaning of the 'ilter along !ith %loth is 2ncorporated 2n the Block B* 'ire ha(ard due to *)ridine %harging SS pipe is 'ixed to the Boom of the reactor$ *ipe lines are stac electricit) all SS and e+uipment motors are 0ame proof$ Operaonal control - checkpoint shall be included in the batch sheet to indicate Boom valve opened, !hether the boom valve has been closed prior to charging 6eptane # or eakage of Boom is not eaking$ "alve Spillage,
'iltraon
%harge 6eptane la)er
Solvent recover)
into organic
%harging of 6eptane
'ire ha(ard due stac electricit)$
isllaon of &%
3o separate
the
to 6eptane addion pipe is kept to the Boom of the reactor$ *ipe lines are all SS and e+uipment motors are 0ame proof$
3he temperature is raised b) slo! heang ll re0ux8 the methanol "apour oss is due to 5xcessive heat, 2nstrucon is 9iven in SO*, 3o Open the steam valve to Opmum so as to maintain the re0ux 3he centrifuge is earthed b) conducng !ires$ 'ire ha(ard due to 3he :ltraon is carried out through a centrifuge$ %entrifuges are high speed machines and sources of ha(ard in a chemical plant$ Ample precauons are stac electricit)
oss of &%
chloroformate into &%$
Boom valve opened, %harging of n-pent)l
or eakage of Boom "alve
chloroformate
'ire ha(ard due stac electricit)
to ?-pent)l chloroformate addion pipe is kept to the Boom of the reactor$ *ipe lines are all SS and e+uipment motors are 0ame proof$
Boom valve opened, %harging of &%
Operaonal control - checkpoint shall be included in the batch sheet to indicate !hether the boom valve has been closed prior to charging n-pent)l chloroformate # is not eaking$
or eakage of Boom "alve
Operaonal control - checkpoint shall be included in the batch sheet to indicate !hether the boom valve has been closed prior to charging &% # is not eaking$ to &% addion pipe is kept to the Boom of the reactor$ *ipe lines are all SS and e+uipment motors are 0ame proof$
'ire ha(ard due stac electricit)
'ilter %loth 3he 'iltraon Operaon is %arried out in %losed SS ine, 'ilter cloth cleaned for 5ver) Batch # this %leaning of the 'ilter along !ith %loth is 2ncorporated 2n the Block B* 'ire ha(ard due to *)ridine %harging SS pipe is 'ixed to the Boom of the reactor$ *ipe lines are stac electricit) all SS and e+uipment motors are 0ame proof$ Operaonal control - checkpoint shall be included in the batch sheet to indicate Boom valve opened, !hether the boom valve has been closed prior to charging 6eptane # or eakage of Boom is not eaking$ "alve Spillage,
'iltraon
%harge 6eptane la)er
into organic
%harging of 6eptane
to 6eptane addion pipe is kept to the Boom of the reactor$ *ipe lines are all SS and e+uipment motors are 0ame proof$
'ire ha(ard due stac electricit)$
Solvent recover)
isllaon of &%
%entrifuging
3o separate %apecitabine stage-22 from li+uid
the the
3he temperature is raised b) slo! heang ll re0ux8 the methanol "apour oss is due to 5xcessive heat, 2nstrucon is 9iven in SO*, 3o Open the steam valve to Opmum so as to maintain the re0ux 3he centrifuge is earthed b) conducng !ires$ 'ire ha(ard due to 3he :ltraon is carried out through a centrifuge$ %entrifuges are high speed machines and sources of ha(ard in a chemical plant$ Ample precauons are stac electricit), taken to carr) out the centrifuging as ha(ard free as possible$ ;e are using a 4< operator ha(ard if an) inch dia SS.1= centrifuge, boom driven and top discharge$ 3his is a four point loading > unloading suspension machines !hich are put on special vibra mount for smooth vibraon acvit) carried out in a free noiseless operaon$ 3he speed is controlled b) a variable fre+uenc) drive running centrifuge and the feeding of the centrifuge is done b) pneumacall) controlled valves at lo!er *& under nitrogen purging$ 5ven the bearing housing of t he centrifuge oss of &%
is provided !ith a nitrogen purging facilit)$ An interlocking s)stem is provided for ensuring that the lids cannot be opened !hile the centrifuge is running and thereb) prevenng an) operaonal ha(ard b) human error$ All the limits s!itches and the safet) interlocking s!itches are 0ame proof including the "' controls$
%harging of Solvent recover) r)ing operaon
&Hs
All charging is done b) vacuum sucking to avoid spillages and through the closed
6a(ardous !aste ?o speci:c ha(ard a@er centrifuging
Separaon of solvents from the
r)ing of the
product
product in "acuum tra) dr)er
SS pipe lines$
?o speci:c ha(ard Boom valve opened,
%harging of &%
%harge
or eakage of Boom "alve 'ire ha(ard due to stac electricit) Boom valve opened,
capecitabine stage-22,
&%, sodium h)droxide and %harging of h)drochloric acid into methanol methanol$ Stage-222
6%l Addion %harging of sodium h)droxide isllaon of &%
or eakage of Boom "alve
"3 is :ed !ith 0ame proof motors$ 7nloading into the bins b) actuated valve, 6ence ?o- ess 5xposure 6and gloves # goggles should be used$ Operaonal control - checkpoint shall be included in the batch sheet to indicate !hether the boom valve has been closed prior to charging &% # is not eaking$ &% addion pipe is kept to the Boom of the reactor$ *ipe lines are all SS and e+uipment motors are 0ame proof$ Operaonal control - checkpoint shall be included in the batch sheet to indicate !hether the boom valve has been closed prior to charging methanol # is not eaking$
'ire ha(ard due to ðanol addion pipe is kept to the Boom of the reactor$ *ipe lines are all stac electricit) SS and e+uipment motors are 0ame proof$ 6)drochoric acid 3he Addion of 6)drochloric acid is charged through the %losed lines, !ithout an) Spillage, personnel *rotecve 5+uipments are 7sed to avoid the 5xposure Spillage # 2rritaon # tackle the irritaon %orrosive nature 7se properl) personnel protecve e+uipment$ oss of
&%
and 3he temperature is raised b) slo! heang ll re0ux8 the methanol "apour oss
is provided !ith a nitrogen purging facilit)$ An interlocking s)stem is provided for ensuring that the lids cannot be opened !hile the centrifuge is running and thereb) prevenng an) operaonal ha(ard b) human error$ All the limits s!itches and the safet) interlocking s!itches are 0ame proof including the "' controls$
%harging of Solvent recover) r)ing operaon
&Hs
All charging is done b) vacuum sucking to avoid spillages and through the closed
6a(ardous !aste ?o speci:c ha(ard a@er centrifuging
Separaon of solvents from the
r)ing of the
product
product in "acuum tra) dr)er
SS pipe lines$
?o speci:c ha(ard Boom valve opened,
%harging of &%
%harge
or eakage of Boom "alve 'ire ha(ard due to stac electricit) Boom valve opened,
capecitabine stage-22,
&%, sodium h)droxide and %harging of h)drochloric acid into methanol methanol$ Stage-222
6%l Addion
or eakage of Boom "alve
"3 is :ed !ith 0ame proof motors$ 7nloading into the bins b) actuated valve, 6ence ?o- ess 5xposure 6and gloves # goggles should be used$ Operaonal control - checkpoint shall be included in the batch sheet to indicate !hether the boom valve has been closed prior to charging &% # is not eaking$ &% addion pipe is kept to the Boom of the reactor$ *ipe lines are all SS and e+uipment motors are 0ame proof$ Operaonal control - checkpoint shall be included in the batch sheet to indicate !hether the boom valve has been closed prior to charging methanol # is not eaking$
'ire ha(ard due to ðanol addion pipe is kept to the Boom of the reactor$ *ipe lines are all stac electricit) SS and e+uipment motors are 0ame proof$ 6)drochoric acid 3he Addion of 6)drochloric acid is charged through the %losed lines, !ithout an) Spillage, personnel *rotecve 5+uipments are 7sed to avoid the 5xposure Spillage # 2rritaon # tackle the irritaon %orrosive nature 7se properl) personnel protecve e+uipment$
%harging of sodium h)droxide isllaon of &%
oss of
and methanol$
methanol$
%harge toluene into reacon
%harging of
Boom valve opened,
mass
toluene
or eakage of Boom "alve
Operaonal control - checkpoint shall be included in the batch sheet to indicate !hether the boom valve has been closed prior to charging toluene # is not eaking$
'ire ha(ard due to stac electricit)
3oluene addion pipe is kept to the Boom of the reactor$ *ipe lines are all SS and e+uipment motors are 0ame proof$
Solvent recover)
3o separate the
&%
and 3he temperature is raised b) slo! heang ll re0ux8 the methanol "apour oss is due to 5xcessive heat, 2nstrucon is 9iven in SO*, 3o Open the steam valve to Opmum so as to maintain the re0ux
3he centrifuge is earthed b) conducng !ires$ 3he :ltraon is carried out through a centrifuge$ %entrifuges are high speed machines and sources of ha(ard in a chemical plant$ Ample precauons are taken to carr) out the centrifuging as 'ire ha(ard due to ha(ard free as possible$ ;e are using a 4< inch dia SS.1= centrifuge, boom driven and top discharge$ 3his is a four point stac electricit), suspension machines !hich are put on special vibra mount for operator ha(ard if
%entrifuging
Solvent recover)
%apecitabine an) loading > stage-222 from unloading acvit) the li+uid a carried out in running centrifuge
%harging of &Hs 6a(ardous ?o speci:c ha(ard !aste a@er centrifuging r)ing of the
smooth vibraon free noiseless operaon$ 3he speed is controlled b) a variable fre+uenc) drive and the feeding of the centrifuge is done b) pneumacall) controlled valves at lo!er *& under nitrogen purging$ 5ven the bearing housing of the centrifuge is provided !ith a nitrogen purging facilit)$ An interlocking s)stem is provided for ensuring that the lids cannot be opened !hile the centrifuge is running and thereb) prevenng an) operaonal ha(ard b) human error$ All the limits s!itches and the safet) interlocking s!itches are 0ame proof including the "' controls$ All charging is done b) vacuum sucking to avoid spillages and through the closed SS pipe lines$
"3 is :ed !ith 0ame proof motors 7nloading into the bins b)
'ire ha(ard due to stac electricit)
3o separate the
3oluene addion pipe is kept to the Boom of the reactor$ *ipe lines are all SS and e+uipment motors are 0ame proof$
3he centrifuge is earthed b) conducng !ires$ 3he :ltraon is carried out through a centrifuge$ %entrifuges are high speed machines and sources of ha(ard in a chemical plant$ Ample precauons are taken to carr) out the centrifuging as 'ire ha(ard due to ha(ard free as possible$ ;e are using a 4< inch dia SS.1= centrifuge, boom driven and top discharge$ 3his is a four point stac electricit), suspension machines !hich are put on special vibra mount for operator ha(ard if
%entrifuging
Solvent recover)
r)ing operaon
Separaon of solvents from the product
%apecitabine an) loading > stage-222 from unloading acvit) the li+uid a carried out in running centrifuge
%harging of &Hs 6a(ardous ?o speci:c ha(ard !aste a@er centrifuging r)ing of the product in ?o speci:c ha(ard "acuum tra) dr)er
smooth vibraon free noiseless operaon$ 3he speed is controlled b) a variable fre+uenc) drive and the feeding of the centrifuge is done b) pneumacall) controlled valves at lo!er *& under nitrogen purging$ 5ven the bearing housing of the centrifuge is provided !ith a nitrogen purging facilit)$ An interlocking s)stem is provided for ensuring that the lids cannot be opened !hile the centrifuge is running and thereb) prevenng an) operaonal ha(ard b) human error$ All the limits s!itches and the safet) interlocking s!itches are 0ame proof including the "' controls$ All charging is done b) vacuum sucking to avoid spillages and through the closed SS pipe lines$
"3 is :ed !ith 0ame proof motors$ 7nloading into the bins b) actuated valve, 6ence ?o- ess 5xposure 6and gloves # goggles should be used$
S$?o
+$cr$p#on
Yearly +ata ./. .// ./ -./0 I .1 . J
./1 .1
-./2
-./3
<
=
1
?o$of minor incident>accidents from
D
D
D
D
D
D
1
?o$of maKor incident>accidents from ?o$of occupaonal health
D
D
D
D
D
D
D
?o$of hot !ork permits ?o$of height !ork permits
14/
J
1J< .
4/
.< 1=/
?o$of vessel>con:ned space
/<
<
1D.
1IJ
. 4 /
=
diseases reported
entr) !ork permits
J
?o$of training programs conducted on O6#S
<
?o$of persons under gone training
I
?o$of compeons conducted for creang a!areness on safet) among emplo)ees
1D
5mergenc) response team
11
'irst aid trainings conducted
1
Planta#on done 5mergenc) control s)stem
1.
11D
1D
I/
1=D
14/
1/<
1J/
/
4/
=/
.J/
.
4.D
/
/
/
/
/
/
/
1
1
1
1/
1/
D
1J
D
D
D
1
D
1
D
4.
4=<
4<.D
4I/D
1
1
1
1
1
