Drugs containing aldehydes Introduction Aldehydes are a class of highly reactive organic chemical compounds that contain carbonyl group (in which a carbon atom is double-bound to an oxygen atom) and at least one hydrogen atom bound to the alpha carbon (the central carbon atom in the carbonyl group). Aldehydes are very easy to detect by smell. Some are very fragrant, and others have a smell resembling that of rotten rotten fruit. Formaldehyde is the simplest aldehyde, and has found applications in the manufacture of many organic chemicals such as dyes and medical drugs. Formaldehyde is also a good insecticide,It is probably most familiar to the general public in its application as a preservative.
1- Formalaz Generic Name: formaldehyde Dosage Form: liquid ACTIVE INGREDIENTS:
Formaldehyde 10% INACTIVE INGREDIENTS:
Water, Polysorbate 20, Hydroxyethyl Cellulose.
INDICATIONS: Drying agent for pre and post surgical removal of warts, or for non-surgical laser removal of warts where dryness is required.
Structure of formaldehy formaldehyde:de:O
CH2
2- Cinnamaldehyde is the organic compound that gives cinnamon its flavor and odor. This pale yellow viscous liquid occurs naturally in the bark of cinnamon trees and other species of the genusCinnamomum .
Properties
Mloecular formula
C9H8O
Solubility in water
Slightly Soluble
Synthesis is most economically obtained from the steam distillation of the oil of cinnamon bark
Applications 1-As a flavorant The most obvious application for cinnamaldehyde is as flavoring in items like chewing gum, ice cream, candy,
As an antimicrobial As an anti-cancer agent Perfumes
Amylcinnamaldehyde and hexylcinnamaldehyde The aldehyde vanillin is a constituent in many vanilla- scented perfumes.
IUPAC name (2E )-3-phenylprop-2-enal
Structure:_ O
3- Mepergan Brand Name: Mepergan Generic Name: Meperidine and Promethazine
Drug Description This product is available in concentration providing 25 mg each of meperidine hydrochloride and promethazine hydrochloride per mL with 0.1 mg edetate disodium, 0.04 mg calcium chloride, and not more than 0.75 mg sodiumformaldehyde sulfoxylate, 0.25 mg sodium metabisulfite, and 5 mg phenol with sodium acetate buffer.
INDICATIONS As a preanesthetic medication when analgesia and sedation are indicated. As an adjunct to local and general anesthesia.
4- Influenza A H1N1 Monovalent Vaccine Brand Name: Influenza A H1N1 Monovalent Vaccine Generic Name: Influenza A H1N1 Monovalent Vaccine
DRUG DESCRIPTION Influenza A (H1N1) 2009 Monovalent Vaccine is formulated to contain 15 mcg hemagglutinin (HA) of influenza A/California/07/2009 (H1N1) v-like virus per 0.5 mL dose. Gelatin 0.05% is added as a stabilizer. Each 0.5 mL dose may contain residual amounts of formaldehyde (not more than 100 mcg), polyethylene glycol p-isooctylphenyl ether (not more than 0.02%), and sucrose (not more than 2.0%).
INDICATIONS Influenza A (H1N1) 2009 Monovalent Vaccine is an inactivated influenza virus vaccine indicated for active immunization of persons 6 months of age and older against influenza disease caused by pandemic (H1N1) 2009 virus
5- Comvax Brand Name: Comvax Generic Name: Haemophilus b Conjugate and Hepatitis B Vaccine DRUG DESCRIPTION:_
Each 0.5 mL dose of COMVAX is form ulated to contain 7.5 mcg PRP conjugated to approximately 125 mcg OMPC, 5 mcg HBsAg, approximately 225 mcg aluminum as amorphous aluminum hydroxyphosphate sulfate, and 35 mcg sodium borate (decahydrate) as a pH stabilizer, in 0.9% sodium chloride. The vaccine contains not more than 0.0004% (w/v) residual formaldehyde.
6- Nystatin Oral Suspension Brand Name: Nystatin Oral Suspension Generic Name: Nystatin (oral) Structural formula:
DRUG DESCRIPTION Nystatin Oral Suspension, for oral administration, is cherry/mint flavored, containing 100,000 USP Nystatin Units per mL. Inactive ingredients: alcohol ( ≤ 1% v/v), 49.8% (w/v) sucrose, purified water, glycerin, sodium citrate, magnesium aluminum silicate, flavors, saccharin sodium, xanthan gum, benzaldehyde, edetate calcium disodium, meth-ylparaben and propylparaben.
Structure of benzaldehyde:O
INDICATIONS Nystatin Oral Suspension is indicated for the treatment of candidiasis in the oral cavity.
7- Rhinocort Aqua Brand Name: Rhinocort Aqua Generic Name: Budesonide DRUG DESCRIPTION
It is designated chemically as (RS)-11-beta, 16-alpha, 17, 21-tetrahydroxypregna-l,4-diene3,20-dione cyclic 16, 17-acetal with butyraldehyde. Its structural formula is: H3C
O
INDICATIONS Treatment of Seasonal or Perennial Allergic Rhinitis
8- Spot Indol reagent DRUG DESCRIPTION
The detection of indole indicates tryptophan degradation and can be accomplished by the addition of certain aldehydes to form coloured end products. Spot Indole contains the active ingredient p-dimethylaminocinnamaldehyde (PACA) which reacts with indole to produce a blue c ompound. Structure of aldehyde :O
N 2Me
Drugs containing ketones Introduction In organic chemistry, a ketone is a compound with the structure RC(=O)R', where R and R' can be a variety of atoms and groups of atoms. It features a carbonyl group (C=O) bonded to two other carbon atoms. Acetone is the simplest example of a ketone, and in fact the word ketone derives its name from Aketon , an old German word for acetone. Ketones differ from aldehydes in that the carbonyl is placed between two carbons rather than at the end of a carbon skeleton.
(1) Sonata (zaleplon)capsules DRUG DESCRIPTION
The chemical name:_ of zaleplon is N-[3-(3-cyanopyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-Nethylacetamide. Its empirical formula is:_ C17H15N5O its molecular weight :_is 305.34. The structural formula is shown below:_ N
N N
N
N
CH3
O
CH3
Generic Name: zaleplon (Pronunciation: ZAH le plon) Brand Names: Sonata
(2)FAMVIR (famciclovir) Tablets DRUG DESCRIPTION Chemical name :- Chemically, famciclovir is known as 2-[2-(2-amino-9H -purin-9-yl)ethyl]-l,3propanediol diacetate
molecular formula is C14H19N5O4 structure
Famciclovir is a white to pale yellow solid. It is freely soluble in acetone and methanol, and sparingly soluble in ethanol and isopropanol.
3-RAPAFLO brand name for silodosin The chemical name of silodosin is 1-(3-Hydroxypropyl)-5-[(2 R)-2-({2-[2-(2,2,2trifluoroethoxy)phenoxy]ethyl}amino)propyl]-2,3-dihydro-1 H -indole-7carboxamide molecular formula is C25H32F3N3O4
. It is very soluble in acetic acid, freely soluble in alcohol, and very slightly soluble in water. The structural formula of silodosin is:
(4) AGENERASE® (amprenavir) Oral Solution
DRUG DESCRIPTION
The chemical name of amprenavir is (3 S)-tetrahydro-3-furyl N -[(1S,2 R)-3-(4-amino N -isobutylbenzenesulfonamido)-1-benzyl-2-hydroxypropyl]carbamate. molecular formula of C25H35N3O6S
It has the following structural formula:
Amprenavir is a white to cream-colored solid with a solubility of approximately 0.04 mg/mL in water at 25°C.
References:http://science.jrank.org/pages/198/Aldehydes.html http://chemistry.about.com/od/chemicaldatabases/a/Chemical-Names-Of-CommonSubstances.htm http://www.sciencedirect.com/science?_ob=PdfExcerptURL&_imagekey=B8CWJ-4KWCS4712-1&_uoikey=B8CWJ-4KWCS4712&_piikey=S0378608000800306&_cdi=40060&_user=4861547&_acct=C000063557&_versi on=1&_userid=4861547&md5=7d5dd1bb2463f1ac99dff3d64d48ceb2&ie=/excerpt.pdf http://www.environment.gov.au/atmosphere/airquality/publications/sok/formaldehyde.html http://university.arabsbook.com/threads/71524-%D9%83%D8%AA%D8%A7%D8%A8Oxidation-of-Alcohols-to-Aldehydes-and-Ketones-A-Guide-to-Current-Common-Prac
http://findpdf.net/ebooks/books-about-synthetic-aldehydes-free-download.html
http://173-203-109-119.static.cloud-ips.com/aldehyde-examples-of-aldehydes /
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