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resolver diversos problemas sobre la parabola
Reparación mediante cicatriz
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Formación de la cicatriz
La relativa contribución de reparación y regeneración son influidas por: a) Capacidad proliferativa de las células; b) integridad de la MEC; y c) la resolución o cronicidad de la lesión
Es una respuesta fibropoliferativa
Involucra daño severo o crónico, tanto a las células parenquimatosas como al
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Formación de la cicatriz Incluye las siguientes
características básicas 1.
Angiogénesis
2. Migración y proliferación de fibroblastos con depósito de TC
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Angiogénesis
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Angiogénesis
Angiogénesis de vasos preexistentes
1) Vasodilatación; 2) Degradación proteolítica de la membrana basal; 3) Migración de las células endoteliales; 4) Proliferación; 5) Maduración y 6) Reclutamiento de células periendoteliales
Angiogénesis de células precursoras endoteliales
Reclutadas de la MO
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Factores de crecimiento en angiogénesis
Familia de las VEGF (-A, -B, -C, -D y –E, y el PlGF) unidos a sus receptores VEGFR: Estimulan migración y proliferación de células endoteliales
FGF-1 y -2. Promueven migración de macrófagos y fibroblastos
Angiopoyetinas Ang1 y Ang2. Promueven la maduración de los vasos
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Dominio EGF-like es modificado por O-Glicanos mediante transfer transferasas asas especificas.
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Curación de las heridas cutáneas
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Curación de las heridas cutáneas 1. Formación del coágulo de sangre (Primeras 24 hrs)
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Factores de crecimiento
TGF-β: Estimula producción de colágeno , fibronectina y proteoglicanos
PDGF: Ocasiona migración y proliferación de FB y CML
IL-1 y -13, TNF: Estimulan la síntesis de colágena
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Factores que influyen en la curación de la herida
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Aspectos patológicos de la reparación.
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