DILUTION OF ANTIBIOTICS Sr No. Co Constituent 1 Amox Amoxyc ycil illi lin+ n+Cl Clav avul ulin inic ic acid acid
Antibiotic Inj Augpen
Strength 150 mg IV 300 mg IV 600 mg IV infusion 1.2 g IV infusion
Diluent for Constitution 5 ml S.W 5 ml S.W 10 ml S.W 20 ml S.W
Vol of I.F
50 ml 100 ml
Infusion Fluids within 20 minutes of reconstitution within 20 minutes of reconstitution S.W , N.S (0.9% w/v) S.W , N.S (0.9% w/v)
2
Ampicillin
Inj Biocillin
100 mg 500 mg
3ml S.W For IM, 5ml S.W For IV 3ml S.W For IM, 5ml S.W For IV
3
Azithromycin
Inj Azee
500 mg
4.8 ml S.W
4
Aztreonam
Inj Azactum
2g
6-10 ml S.W , 0.9%NaCl
S.W , N.S (0.9% w/v)
5
Bleomycin
Inj Bleocip 5 ml =15 units
5 ml IM 5 ml IV 60 units IP
1-5 ml S.W , 0.9%NaCl 5 ml S.W 5 ml N.S
S.W , N.S (0.9% w/v) S.W , N.S (0.9% w/v) N.S (0.9% w/v)
6
Cefazolin
Inj Reflin
250 mg 500 mg 1g
2 ml S.W 2 ml S.W 5 ml S.W
7
Cefipime
Inj Novapime
500 mg IV 500 mg IM 1 g IV 1 g IM 2g
5 ml S.W 1.3 ml S.W 10 ml S.W 2.4 ml S.W 10 ml S.W
8
Cefipime
Inj Maxipime
2g
10 ml S.W , N.S, 5%D
9
Cefi Cefipi pime me+T +Taz azob obac actu tum m
Inj Actamase
1000/125 mg
3ml S.W For IM 10ml S.W For IV
10
Cefi pi pirome
Inj Cefrom
1g
10ml water for injection
11
Cefo Cefope pera razo zone ne+su +sulb lbac actu tum m
Inj Cefmate
1g 2g
Diluent in the pack (N.S 0.9%) Diluent in the pack (N.S 0.9%)
12
Cefo Cefope pera razo zone ne+Su +Sulb lbac actu tum m
Inj Lactagard
750 mg 1.5 g 3g
2 ml S.W , N.S, 5% D 4 ml S.W , N.S, 5% D 8 ml S.W , N.S, 5% D
13
Ceftr eftria iax xone one
Inj Monocef 250 mg IM IM = 250 mg/ml 500 mg IM 1 g IM 2g IM
0.9 ml S.W , 0.9%NaCl, 5%D 1.8 ml S.W , 0.9%NaCl, 5%D 3.6 ml S.W , 0.9%NaCl, 5%D 7.2 ml S.W , 0.9%NaCl, 5%D
for 1mg/ml 500 ml for 2mg/ml 250 ml
50-100 ml
N.S (0.9, 0.45%), 5%D
S.W , N.S (0.9% w/v), 5%, 10% D
50-100 ml
N.S (0.9% w/v), sterile water, 5% D
100 ml
N.S (0.9% w/v) Diluent in the pack (N.S 0.9%) Diluent in the pack (N.S 0.9%)
20 ml 20 ml 20 ml
N.S (0.9% w/v), 5%D, S.W N.S (0.9% w/v), 5%D, S.W N.S (0.9% w/v), 5%D, S.W
IV = 100 mg/ml
250 mg IV 500 mg IV 1 g IV 2g IV
2.4 ml S.W, 0.9%NaCl, 5%D 4.8 ml S.W, 0.9%NaCl, 5%D 9.6 ml S.W, 0.9%NaCl, 5%D 19.2 ml S.W, 0.9%NaCl, 5%D
as per need as per need as per need as per need
N.S (0.9% w/v), S.W, 5%,10% D N.S (0.9% w/v), S.W, 5%,10% D N.S (0.9% w/v), S.W, 5%,10% D N.S (0.9% w/v), S.W, 5%,10% D
14
Cefotaxime
Inj Taxim
125 mg 500 mg 1g
2 ml S.W 2 ml S.W 4 ml S.W
15
Ceftazidime
Inj Fortum
250 mg IM 500 mg IM 1 g IM 2 g IM 250 mg IV 500 mg IV 1 g IV 2 g IV 1 g IV infusion 2 g IV infusion
1 ml S.W 1.5 ml S.W 3 ml S.W 10 ml S.W 2.5 ml S.W 5 ml S.W 10 ml S.W 10 ml S.W 10 ml S.W 10 ml S.W
50 ml 50 ml
Sterile water Sterile water
250 mg IM 500 mg IM 1 g IM 2 g IM 250 mg IV infusion 500 mg IV infusion 1 g IV infusion 2 g IV infusion
for 250 mg/ml 0.9 ml S.W, N.S, 5 %, 10%D 1.8 ml S.W, N.S, 5 %, 10%D 3.6 ml S.W, N.S, 5 %, 10%D 7.2 ml S.W, N.S, 5 %, 10%D 2.4 ml S.W, N.S, 5 %, 10%D 4.8 ml S.W, N.S, 5 %, 10%D 9.6 ml S.W, N.S, 5 %, 10%D 19.2 ml S.W, N.S, 5 %, 10%D
50-100 ml 50-100 ml 50-100 ml 50-100 ml
N.S (0.9% w/v), S.W, 5% D, 10% D N.S (0.9% w/v), S.W, 5% D, 10% D N.S (0.9% w/v), S.W, 5% D, 10% D N.S (0.9% w/v), S.W, 5% D, 10% D
16
Ceftriaxone
Inj Oframax
17
Ceftriaxone+Sulbactum
Inj Formic
375 mg IV 750 mg IV 1.5 g IV 375 mg IM 750 mg IM 1.5 g IM
3 ml S.W for injection 5 ml S.W for injection 10 ml S.W for injection 1 ml S.W for injection 2 ml S.W for injection 5 ml S.W for injection
18
Ceftriaxone+Tazobactum
Inj Cefoprox XP 250 mg IV 500 mg IV 1 g IV
2.4 ml S.W, N.S, 5%D 4.8 ml S.W, N.S, 5%D 9.6 ml S.W, N.S, 5%D
19
Cefuroxime
Inj Supacef
250 mg IM 500 mg IM 1 g IM
0.5-0.9 ml S.W, N.S, 5%D 1.0-1.8 ml S.W, N.S, 5%D 2.1- 3.6 ml S.W, N.S, 5%D
250 mg IV 750 mg IV 1.5 g IV 250 mg IM
2 ml S.W 6 ml S.W 15 ml S.W 1 ml S.W
750 mg IM 1.5 g infusion
3 ml S.W 15 ml S.W
50 or 100 ml
N.S (0.9% w/v), 5%,10% D
250 ml
5%D, 5%D in 0.9, 0.45, 0.3% N.S
20
Clarithromycin
Inj Klacid
500 mg
10 ml S.W
21
Daptomic in
Inj Cubicin
350 mg 500 mg
N.S (0.9% w/v) only
22
Doripenem Not for direct injection
Inj Sudopen after dilution
250 mg 500 mg
10 ml S.W, 0.9%NaCl 10 ml S.W, 0.9%NaCl
100 ml 100 ml
N.S (0.9% w/v), 5% D N.S (0.9% w/v), 5% D
23
Ertapenem
Inj Invanz
1 g IV 1 g IM
10 ml S.W, 0.9%NaCl only 3.2 ml 1%, 2% lidocaine HCl inj
50 ml
N.S (0.9% w/v) only
24
Imipenam+Cilastatin
Inj I-nem
250 mg 500 mg
10 ml 0.9%NaCl 10 ml 0.9%NaCl
100 ml 100 ml
N.S (0.9% w/v), 5%,10% D N.S (0.9% w/v), 5%,10% D
25
Imipenam+Cilastatin
Inj Zienam
250 mg 500 mg
10 ml 0.9%NaCl, 5, 10% D 10 ml 0.9%NaCl, 5, 10% D
50 ml 100 ml
N.S (0.9% w/v), 5%,10% D N.S (0.9% w/v), 5%,10% D
26
Imipenem+Cilastatin
Inj Cilanem
250 mg 500 mg
10 ml S.W, N.S 0.9% 10 ml S.W, N.S 0.9%
100 ml 100 ml
N.S (0.9% w/v), 5%,10% D N.S (0.9% w/v), 5%,10% D
27
Levofloxacin
Inj Levoflox
28
Linezolid
Inj Linox
600 mg/300 ml
dilution form
300 ml
dilution form
29
Meropenem
Inj Merotec
500 mg 1g 500 mg IV bolus 1g IV bolus
5 ml N.S (0.9% w/v) 10 ml N.S (0.9% w/v) 10 ml S.W 20 ml S.W
50-200 ml 50-200 ml
N.S (0.9% w/v) N.S (0.9% w/v)
30
Meropenem
Inj Meroza
500 mg 1g
10 ml S.W, N.S (0.9% w/v) 20 ml S.W, N.S (0.9% w/v)
50 ml 50 ml
N.S (0.9% w/v) N.S (0.9% w/v)
31
Ofloxacin
Inj Oflox
200 mg
Available in Diluted form
100 ml
Available in Diluted form
32
Piperacillin+Tazobactum
Inj Tazact
1.125 g 2.25 g 4.5 g
5 ml S.W, N.S, 5%D 10 ml S.W, N.S, 5%D 20 ml S.W, N.S, 5%D
50-150 ml 50-150 ml 50-150 ml
N.S (0.9% w/v), sterile water, 5% D N.S (0.9% w/v), sterile water, 5% D N.S (0.9% w/v), sterile water, 5% D
33
Piperacillin+Tazobactum
Inj Piptamate
4.5 g
Diluent in the pack (N.S 0.9%)
34
Polymixin B
Inj Polymixin B 5 lac unit
2-3 ml 5% D
300 - 500 ml
5% D in water only
35
Tei copl anin
Inj Targocid
3 ml S.W for injection 3 ml S.W for injection
10-20 ml 10-20 ml
5% D, N.S (0.9% w/v) 5% D, N.S (0.9% w/v)
N.S (0.9% w/v) only
Available in Diluted form
200 mg 400 mg
Available in Diluted form
Diluent in the pack (N.S 0.9%)
36
Tei copl anin
Inj Ticocin
200 mg 400 mg
3 ml S.W for injection 3 ml S.W for injection
10-20 ml 10-20 ml
N.S (0.9% w/v) N.S (0.9% w/v)
37
Teigecycline
Inj Tevran
50 mg
5.3 ml N.S, 5%D
100 ml
N.S (0.9% w/v), 5% dextrose
38
Ticarcillin+Clavulinic Acid
Inj Timentin
3g
13 ml S.W, 0.9%NaCl
as per need
5% D, N.S (0.9% w/v) for 10 mg/ml - 300 ml diluent for 100 mg/ml - 30 ml diluent
39
Vanc omycin
Inj Vanlid
500 mg
10 ml S.W only
100 ml
5% D, N.S (0.9% w/v)
N.S = NORMAL SALINE D = DEXTROSE S.W = STERILE WATER
Duration of infusion 3-4 minutes 3-4 minutes 30-40 minutes 30-40 minutes
Over 60 minutes
20-60 minutes over 10 minutes
over 30 minutes
30-60 minutes
20-30 minutes over 30 minutes over 30 minutes 15-60 minutes
over 30 minutes over 30 minutes over 30 minutes over 30 minutes
15-30 minutes 15-30 minutes
30-60 minutes 30-60 minutes 30-60 minutes 30-60 minutes
over 30 minutes Over 60 minutes over 30 minutes
over 60 minutes
over 30 minutes
over 30 minutes over 30 minutes 40-60 minutes 40-60 minutes 40-60 minutes 40-60 minutes 60-90 minutes 30-120 minutes 15-30 minutes
15-30 minutes 15-30 minutes Over 60 minutes 30-60 minutes 30-60 minutes 30-60 minutes 30-60 minutes
upto 4 hours over 30 minutes
over 30 minutes
30-60 minutes over 30 minutes
Over 60 minutes
