DISEASES AND IMMUNITY Objectives: After discussing this report, the students must: 1. Be able to familiarize their selves on different types, kinds and classification, and causes of diseases. 2. Be aware of the deadliest disease known, its cause and its effects. 3. Be familiarized of the divisions of the immunity 4. Know the role and importance of immunity on the human body
DISEASE Disease – is a particular abnormal condition, a disorder of a structure or function which affects part or all of an organism. The study of disease is called pathology which includes the causal study of etiology. 4 MAJOR TYPES OF DISEASE
Pathogenic Diseases/ Infectious Agents Deficiency Diseases Hereditary Diseases Physiological Diseases
Pathogenic Diseases Diseases that are caused by pathogens and infectious agents like bacteria, fungi, parasites, and viruses. Examples: 1. Cholera 2. Syphilis 3. Gonorrhea
4. Pneumonia 5. Cellulitis 6. Whooping Cough
Deficiency Diseases A disease caused by a lack of essential dietary elements and especially a vitamin or mineral. Examples: 1. 2. 3. 4. 5.
Beriberi Pellagra Biotin Deficiency Scurvy Rickets
6. Ariboflavinosis 7. Vitamin Deficiency 8. Hypocobalaminemia 9. Paraesthesia 10. Night Blindness
Hereditary Diseases A disease or disorder that is inherited genetically which is transmitted on generation by generation. Examples: 1. Down syndrome 2. Color blindness 3. Hemophilia
4. Muscular dystrophy 5. Polygenic Disorders 6. Tay – Sachs Disease
Physiological Diseases An organic disease is one caused by a physical or physiological change to some tissue or organ of the body. It is commonly used in contrast with mental disorders. Examples: 1. Asthma 2. Hypertension 3. Diabetes 4. Glaucoma 5. Cancers 6. Obesity 7. Cataracts 8. Scoliosis 9. Kidney Stones 10. Cirrhosis CLASSIFICATION OF DISEASES
Communicable - an infectious disease transmissible (as from person to person) by direct contact with an affected individual or the individual's discharges or by indirect means. Examples: 1. Ebola 5. Rabies 2. Hepatitis 6. Tuberculosis 3. HIV/AIDS 7. Zika virus 4. Measles 8. Sexually transmitted disease
Non-communicable - is a medical condition or disease that is by definition noninfectious and non-transmissible among people. Examples: 1. Cancers 6. Osteoporosis 2. Chronis Diseases 7. Heart disease 3. Diabetes 8. Lung cancer 4. Hypertension 9. Leukemia 5. Alzheimer’s Disease 10. Seizures or epilepsy
CAUSES OF DISEASES
Airborne - spread when droplets of pathogens are expelled into the air due to coughing, sneezing or talking. Examples: 1. Anthrax 2. Chickenpox 3. Influenza
4. 5. 6. 7.
Measles Smallpox Cryptococcosis Tuberculosis
Infectious - liable to be transmitted to people, organisms, etc. through the environment. Examples:
1. Leptospirosis 2. Cholera 3. Dengue 4. Malaria 5. Meningitis Contagious - spread from one person or organism to another by direct or indirect contact Examples: 1. AIDS (Acquired Immunodeficiency Syndrome) 2. HIV (Human Immunodeficiency Syndrome) 3. Hepatitis B 4. Tuberculosis
Food Borne - is any illness resulting from the food spoilage of contaminated food, pathogenic bacteria, viruses, or parasites that contaminate food, as well as chemical or natural toxins such as poisonous mushrooms and various species of beans that have not been boiled for at least 10 minutes. Examples: 1. Perfringens food poisoning 2. Intestinal cryptosporidiosis 3. E. Coli Infection 4. Hepatitis A 5. Listeriosis
Lifestyle - A disease associated with the way a person or group of people lives. Lifestyle diseases include atherosclerosis, heart disease, and stroke; obesity and type 2 diabetes; and diseases associated with smoking and alcohol and drug abuse. Examples: 1. Obesity 2. Diabetes 3. Heart disease 4. Liver cirrhosis 5. Chronic Backache 6. Anxiety Disorders
TYPES OF DISEASES Body System
Mental - Mental illness is a broad, generic label for a category of illnesses that may include affective or emotional instability, behavioral dysregulation, cognitive dysfunction or impairment. Specific illnesses known as mental illnesses includes: o major depression o generalized anxiety disorders o schizophrenia, and o attention deficit hyperactivity disorder o Bipolar disorders o Postpartum depression o Feeding and eating disorders o Sexual and paraliphic disorders o Sleep and wake disorders o Childhood Disorders
Mental illness can be of biological (e.g., anatomical, chemical, or genetic) or psychological (e.g., trauma or conflict) origin. It can impair the affected person's ability to work or study and can harm interpersonal relationships.
Organic - An organic disease is one caused by a physical or physiological change to some tissue or organ of the body. Examples: 1. Asthma 2. Hypertension 3. Diabetes 4. Glaucoma 5. Cancers 6. Obesity 7. Cataracts 8. Scoliosis 9. Kidney Stones 10. Cirrhosis
Stages
Incubation period is the time between infection and the appearance of symptoms. Latency period is the time between infection and the ability of the disease to spread to another person, which may precede, follow, or be simultaneous with the appearance of symptoms. Viral latency, in which the virus hides in the body in an inactive state. For example, varicella zoster virus causes chickenpox in the acute phase; after recovery from chickenpox, the virus may remain dormant in nerve cells for many years, and later cause herpes zoster.
Acute disease An acute disease is a short-lived disease, like the common cold. Examples: 1. 2. 3. 4. 5. 6. 7.
Breaking a bone Burn Strep throat Flu Asthma attack Heartburn Common Cold
Chronic disease A chronic disease is one that lasts for a long time, usually at least six months. During that time, it may be constantly present, or it may go into remission and periodically relapse. A chronic disease may be stable (does not get any worse) or it may be progressive (gets worse over time). Some chronic diseases can be permanently cured. Most chronic diseases can be beneficially treated, even if they cannot be permanently cured. Examples: 1. 2. 3. 4. 5. 6. 7. 8.
Osteoporosis Frequent Migraines Kidney Disease Coronary artery disease Epilepsy HIV Rheumatoid arthritis Parkinson’s Disease
Flare-up A flare-up can refer to either the recurrence of symptoms or an onset of more severe symptoms. Refractory disease A refractory disease is a disease that resists treatment, especially an individual case that resists treatment more than is normal for the specific disease in question. Example: 1. Leukemia
Progressive disease Progressive disease is a disease whose typical natural course is the worsening of the disease until death, serious debility, or organ failure occurs. Slowly progressive diseases are also chronic diseases; many are also degenerative diseases. The opposite of progressive disease is stable disease or static disease: a medical condition that exists, but does not get better or worse. Examples: 1. Alzheimer’s disease 2. Atherosclerosis 3. Cancer 4. Chronic Obstructive Pulmonary Clinical disease One that has clinical consequences, i.e., the stage of the disease that produces the characteristic signs and symptoms of that disease. AIDS is the clinical disease stage of HIV infection. Subclinical disease Also called silent disease, silent stage, or asymptomatic disease. This is a stage in some diseases before the symptoms are first noted. Examples: 1. Diabetes 2. Hypothyroidism 3. Rheumatoid athritis Terminal phase If a person will die soon from a disease, regardless of whether that disease typically causes death, then the stage between the earlier disease process and active dying is the terminal phase.
IMMUNITY Immunity is the body's ability to fight off harmful micro-organisms that invade it. It is the state of being immune from or insusceptible to a particular disease or the like. The immune system is typically divided into two categories – innate and adaptive:
Two Types of Immunity 1. Innate or Natural Immunity Innate immunity refers to nonspecific defense mechanisms that come into play immediately or within hours of antigen’s appearance in the body. These mechanisms include physical barriers such as skin, chemicals in the blood, and immune system cells that attack foreign cells in the body. The healthy individual is protected from potentially harmful micro-organisms in the environment by a number of effective mechanisms, present from birth, that do not depend upon prior exposure to any particular microorganism. 2. Adaptive or Acquired Immunity Adaptive Immunity refers to antigen-specific immune response. The adaptive immune response is more complex than the innate. The antigen first must be processed and recognized. Once an antigen has been recognized, the adaptive immune system creates an army of immune cells specifically designed to attack the antigen. Adaptive immunity also includes a “memory” that makes future responses against a specific antigen more efficient.
DIVISION OF IMMUNITY Passive Natural Active Adaptive Immunity
Passive Artificial
Immunity Innate Immunity
Active
Definitions: Antigen – Any substance that stimulates an immune response in the body (especially the production of Antibodies). Pathogen – Any disease-producing agent (especially a virus, bacterium or other microorganism). Antibodies – Large variety of proteins or substance normally present in the body or produced in response to antigen which it neutralizes, thus producing an immune response. Passive Immunity Passive Immunity is the transfer of active immunity, in the form of readymade antibodies, from one individual to another. It is conferred by an antibody produced in another host and may be acquired naturally or artificially (through an antibody-containing preparation). Passive Immunization is a preparation of antibodies that neutralizes a pathogen and is administered before or around the time of known or potential exposure. Active Immunity Resistance developed in response to stimulus by an antigen (infecting agent or vaccine) and is characterized by the production of antibodies by the host. Active Immunization stimulates the host’s immune system to produce specific antibodies or cellular immune responses or both which would protect against or eliminate a disease.
TYPES OF ADAPTIVE IMMUNITY
Naturally Acquired Active Immunity
Antigens enter the body naturally; body induces antibodies and specialized lymphocytes. Can lasts up to few years or life-long.
Naturally Acquired Passive Immunity
Antibodies pass from mother to fetus via placenta or to infant via the mother’s milk. Can lasts up to weeks or months.
Artificially Acquired Active Immunity
Antigens are introduced in vaccines; body produces antibodies and specialized lymphocytes. Can lasts up to few years or life-long.
Artificially Acquired Passive Immunity
Preformed antibodies in immune serum and introduced by injection. Can lasts up to 3 weeks or month.
Vaccines A vaccine is an antigenic material that stimulates adaptive immunity to a disease. Vaccines can prevent the effects of infection by many pathogens. Vaccines are generally considered to be the most effective method of preventing infectious diseases. History of Vaccines Smallpox was the first disease people tried to prevent by purposely inoculating themselves with other types of infections. Smallpox inoculation was started in India before 200 BC. In 1796 British physician Edward Jenner tested the possibility of using the cowpox vaccine as an immunization for smallpox in humans for the first time. The word vaccination was first used by Edward Jenner. Louis Pasteur furthered the concept through his pioneering work in microbiology. Vaccination Vaccination (Latin: vacca—cow) is named because the first vaccine was derived from a virus affecting cows, the relatively benign cowpox virus, which provides a degree of immunity to smallpox, a contagious and deadly disease. The word "vaccination" was originally used specifically to describe the injection of the smallpox vaccine.
Vaccination is a method of giving antigen to stimulate the immune response through active immunization.
A vaccine is an immuno-biological substance designed to produce specific protection against a given disease.
A vaccine is “antigenic” but not “pathogenic”.
4 Major Types of Vaccines •
Live vaccines
•
Live Attenuated vaccines
•
Inactivated (killed vaccines)
•
Toxoids
Live Vaccines Live vaccines are made from live infectious agents without any amendment.
The only live vaccine is “Variola” small pox vaccine, made of live vaccinia cow-pox virus (not variola virus) which is not pathogenic but antigenic, giving cross immunity for variola.
Live Attenuated (avirulent) Vaccines Virulent pathogenic organisms are treated to become attenuated and avirulent but antigenic. They have lost their capacity to induce full-blown disease but retain their immunogenicity. Live Attenuated Vaccines can be used for:
Typhoid Polio Yellow fever Measles Mumps Influenza
Inactivated (killed) vaccines Organisms are killed or inactivated by heat or chemicals but remain antigenic. They are usually safe but less effective than live attenuated vaccines. The only absolute contraindication to their administration is a severe local or general reaction to a previous dose. Live Attenuated Vaccines can be used for:
Cholera Pertussis Rabies Intra-muscular influenza Japanese encephalitis
Toxoids They are prepared by detoxifying the exotoxins of some bacteria rendering them antigenic but not pathogenic. Adjuvant (e.g. alum precipitation) is used to increase the potency of vaccine. In general toxoids are highly efficacious and safe immunizing agents. Live Attenuated Vaccines can be used for:
Diphtheria Tetanus
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TECHNICAL TERMS
Antigen – Any substance that stimulates an immune response in the body (especially the production of Antibodies). Pathogen – Any disease-producing agent (especially a virus, bacterium or other microorganism). Antibodies – Large variety of proteins or substance normally present in the body or produced in response to antigen which it neutralizes, thus producing an immune response.
REVIEW QUESTIONS 1. What is the relationship between Disease and Immunity? 2. What is the difference between the Communicable and Non-communicable diseases? 3. What are the four major types of Diseases? 4. What are the two types of Immunity? 5. What are the difference between the passive and active immunity? 6. Differentiate the four types of vaccines and its uses.
SUMMARY In this report, it is discussed what is the definition of disease and immunity. Disease is a particular abnormal condition, a disorder of a structure or function which affects part or all of an organism and Immunity is the body's ability to fight off harmful micro-organisms that invade it. The four main types of diseases are Pathogenic, Deficiency, Hereditary and Physiological Diseases. Diseases are classified into two, it is the communicable and non-communicable disease. Diseases can be acquired by airborne, infections, lifestyle and it can be also foodborne. Acute, chronic, flare-up, refractory, progressive, clinical, subclinical and terminal phase are some types of diseases. the reporters gives also their thorough knowledge about the immunity, its two types are innate or natural immunity adaptive or acquired immunity. Vaccine was defined in this report, a vaccine is an antigenic material that stimulates adaptive immunity to a disease. Major types of vaccines are live vaccines, live attenuated vaccines, inactivated (killed vaccines), and toxoids.
CONCLUSION Therefore, it is concluded that being aware of different kinds of diseases, how it is being acquire, and how it can be prevented is very important.
