Medicinal plants of India with anti-diabetic potential ,
J.K. Grover , S. Yadav, V. Vats Department of Pharmacology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi-110049, India Abstract Since ancient times, plants have been an exemplary source of medicine. Ayurveda and other Indian literature mention the use of plants in treatment of various human ailments. India has about 45 000 plant species and among them, several thousands have been claimed to possess medicinal properties. Research conducted in last few decades on plants mentioned in ancient literature or used traditionally for diabetes have shown anti-diabetic property. The present paper reviews 45 such plants and their products (active, natural principles and crude extracts) that have been mentioned/used in the Indian traditional system of medicine and have shown experimental or clinical anti-diabetic activity. Indian plants which are most effective and the most commonly studied in relation to diabetes and their complications are: Allium cepa , Allium sativum , Aloe vera , Cajanus cajan , Coccinia indica , Caesalpinia bonducella , Ficus bengalenesis , Gymnema sylvestre , Momordica charantia , Ocimum sanctum , Pterocarpus marsupium , Swertia chirayita , Syzigium cumini , Tinospora cordifolia and Trigonella foenum graecum. Among these we have evaluated M. charantia , Eugenia jambolana , Mucuna pruriens , T. cordifolia , T. foenum graecum , O. sanctum , P. marsupium , Murraya koeingii and and Brassica juncea . All plants have shown varying degree of hypoglycemic and anti -hyperglycemic activity. activity. http://www.sciencedirect.com/science/article/pii/S0378874102000594
Ethnobotanical studies of medicinal plants used in the management of diabetes mellitus in South Western Nigeria a
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K.A. Abo , A.A. Fred-Jaiyesimi , A.E.A. Jaiyesimi Department of Pharmacognosy, University of Ibadan, Nigeria Olabisi Onabanjo University, Sagamu, Ogun State, Nigeria Abstract This survey was carried out in targeted areas of South West Nigeria in order to inventory plants used by traditional healers in the area for the management of diabetes mellitus. One hundred traditional healers who know and use medicinal plants for treating diabetes mellitus were interviewed. The inventory contains scientific, vernacular, common names of the plants used and method of preparation. Thirty-one plants commonly used by traditional healers in the region were identified. The survey shows plants from the Rutaceae, Leguminosae and Cucurbitaceae families are commonly used by traditional healers in South West Nigeria for the treatment of diabe tes mellitus. http://www.sciencedirect.com/science/article/pii/S0378874107004849
An Overview on Antidiabetic Medicinal Plants Having Insulin Mimetic Property Patel DK, Prasad SK, Kumar R, Hemalatha S *Pharmacognosy Research Laboratory, Department of Pharmaceutics, Institute of Technology, Ban aras Hindu University, Varanasi-221005, India ARTICLE INFO Article history: Received 17 October 2011 Received in revised form 5 November 2011 Accepted 25 November 2011 Available online 28 April 2012 Diabetes mellitus is one of the common metabolic disorders acquiring around 2.8% of the world’spopulation and is anticipated to cross 5.4% by the year 2025. Since long back herbal medicines have been the highly esteemed source of medicine therefore, they have become a growing part of modern, high-tech medicine. In view of the above aspects the present review provides profiles of plants (65 species) with hypoglycaemic properties, available through literature source from various database with proper categorization according to the parts used, mode of reduction in blood glucose (insulinomimetic or insulin secretagogues activity) and active phytoconstituents having insulin mimetics activity. From the review it was suggested that, plant showing hypoglycaemic potential mainly belongs to the family Leguminoseae, Lamiaceae, Liliaceae, Cucurbitaceae, Asteraceae, Moraceae, Rosaceae and Araliaceae. The most active plants are Allium sativum, Gymnema sylvestre, Citrullus colocynthis, Trigonella foenum greacum, Momordica charantia Ficus bengalensis. The review describes some new bioactive drugs and isolated compoundsfrom plants such as roseoside, epigallocatechin gallate, beta-pyrazol-1-ylalanine, cinchonain Ib, leucocyandin 3-O-beta-d-galactosyl cellobioside, leucopelargonidin-3- O-alpha-L rhamnoside, glycyrrhetinic acid, dehydrotrametenolic acid, strictinin, isostrictinin, pedunculagin, epicatechin and christinin-A showing significant insulinomimetic and antidiabetic activity with more efficacy
than conventional hypoglycaemic agents. Thus, from the review majorly, the antidiabetic activity of medicinal plants is attributed to the presence of polyphenols, flavonoids, terpenoids, coumarins and other constituents which show reduction in blood glucose levels. The review also discusses the management aspect of diabetes mellitus using these plants and their active principles. http://www.apjtb.com/zz/20124/15.pdf
