Cerebral Ischemia (Initiation of ischemic cascade) Anaerobic metabolism by mitochondria Generates large amounts of lactic acid
Failure production of adenosine triphosphatase
Production of oxygen free radicals and other reactive oxygen species
Failure of energy dependent process (ion pumping)
Metabolic Acidosis
Respiratory compensation
Shortness of breath
Release of excitatory neurotransmitter glutamate
Influx of calcium
Failure of mitochondria
Activates enzymes that digest cell proteins, lipids and nuclear material
Further energy depletion
Transient Ischemic Attack of right hemisphere
Transient Ischemic Attack of right hemisphere Brain sustains an irreversible cerebral damage Release of metalloprotrease (zinc and calcium-dependent enzymes) Break down of collagen, hyaluronic acid and other elements of connective tissue
Structural integrity loss of brain tissue and blood vessels
Vascular Congestion Impaired perfusion and function
motor weaknesses (dragging of left leg when walking)
Slurred speech; facial asymmetry
Asymmetrical movement of sternocleidomastoids; left lags
