Outoft hef ol l owi ngMU MUSCULARPATHOLOGI ESwhi chhav eandwhi chdonothaveel evat edCK? -Mu s cu l a rDy s t r o ph y -Hy po t h y r oi dMy My o pat h y -Hy per c or t i s ol i s m My o pa t h y -St at i nMy op at h y -I n fla mma mm t o r yMy o pa t h y( Po l y my my o s i t i s / De r ma t omy o si t i s ) -Po l y My My a l g i aRh eu ma ma t i c a Thi si sav er yi mpor t antc onc eptandv er yhi ghl i k el i hoodofbei ngas k ed.
DAI L YDOSEof USML MLE Co r r e cta ns we ri s:
HI GHCKi nf o l l o i wi n g: Dy s t r o ph i e s( Du c h en n ea n dBe c k e r ) I n fla mma mm t o r yMy o si t i s( Po l y my my o si t i s&De r ma t o my my o si t i s ) Hy po t h yr oi d St at i ns No r ma lCKi nf o l l o wi n g: Po l y my a l g i aRh eu ma ma t i c a Fi br omy al gi a Cor t i c os t er oi ds
NBME Answer with explanation in depth DAI L YDOSEOF OFUSML MLE· 9 .
Answer & Explanation: Explanation:
2 01 6.
Question analysis: 3 STEP REASONING includes seeing the clinical features, diagnosing the disease and the final question is based on Rx, actually specifically the drug MA is the question as!ed" #MA $ Mechanis% of action ' (o we ha)e to go in this sequence: *iagnose ''+ *rug ''+ MA #lassic -(M.E /or%at Multi'step reasoning Step 1: 0he )ignette presents an old %an #elderly $ possibly i%%unosuppressed showing unilateral right sided flan! pain followed by )esicles in the sa%e area" #that1s i%portant pain BE/RE )esicles in a der%ato%e -N2.A0ERA..3" 0his sequence is unique to (hingles" )erall it is easy to diagnose this particular case as shingles as it is classic" But re%e%ber"" Before not After"" this %aybe as!ed in another question in a co%plicated way though this one is easy" Answering (tep 4: (hingles
Step 2: 5hats the drug for (hingles 6 Answering (tep 7: 'o)ir group anti')irals #Acyclo)ir Step 3: 5hat1s the %echanis% of action of 'o)irs 6 Answering (tep 8: MA is inhibition of *NA poly%erase by chain ter%ination" Hence correct answer is: : !NA Replication
'''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''' ''''''''''''' /ollowing is a brief re'cap of the disease & Rx fro% all boo!s & ban!s of -(M.E co%bined at one place #9 ban!s,%any MAN3 boo!s: "#" $HH"% 3& Group'Su( Group: *NA )irus belonging to herpes )iridae fa%ily" )ORPHO*OG+: ds *NA, linear, icosahedral, with nuclear replication and are en)eloped by a %e%brane deri)ed fro% the Nuclear %e%brane #N0 ell Me%brane' re%e%ber this point" nly )irus to get it fro% Nuclear, rest all en)eloped )iruses get it fro% the cell %e%brane" Trans,ission% Respiratory secretions #Re%e%ber the disease is N0 spread pri%arily by touch"" touching shingles"" e)en rubbing yourself to is N0 the %ain trans%ission %echanis%" 0his is i%portant as a !ey pre)enti)e %edicine concept arises, try to answer the question: 5hich is %ost effecti)e way out of following for pre)enting outbrea! of hic!enpox: A' ;lo)es B'
t that a nifty concept 6 Re%e%ber it well as pre)enti)e %edicine is a recent update to -(M.E content guidelines" -linical .eatures: Multifaceted organis%: ' 2t causes ?R2MAR3 acute attac! in in the for% of hic!en ?ox #@aricella" ' And (EN*AR3 recurrence of disease in the for% of (hingles #oster"
A-/TE' hic!en ?ox #@aricella : CD cases in !ids & 4CD adults" More se)ere in adults" Macules ''+ @esicles''+ ?ustules e)entually crusting" A.. (0A;E( present at the sa%e ti%e" @esicles with red base #*ew on Rose drop sign" -%bilicated )esicle which %ay hae%orrhage" (tarts on trun! and %o)es to hands and feet" Also %ucous %e%brane and conuncti)a in)ol)ed" EN0R2/-;A. pattern" ?atient infectious 4 wee! before and F days after rash appears till it crusts" o%plications' Gids: Reye>s, Encephalitis #cerebellitis ataxia, ?neu%onia, ;ullian'Barre syndro%e, Ra%say < for chain extension" -nique ?roperty: ;uanosine analogue AKE : rystallinuria #?re)ention L
A%photericin B, Nystatin ' they cause hole for%ation within ?RE'for%ed ell 5all but don>t affect NE5 (3N0en in te .or, o. one .rien tal>in to anoter: Qs are stu.. u as> us< As are wat we reply ?
4" 2s this the for%at in which you are going to %a!e all the content 6 A4" 0his is the first draft" 5hile it is %y belief that %ost people will find this to be an already good enough explanation, we wish to %a!e it ;REA0 not good" 5e will not re)eal exactly as of now but final stuff released will be %ade 4CCx better than what you see here" 0his is the first publicly released )ersion""a snea! pea! of sorts" 5e ha)e better plans in the pipeline but choose not to di)ulge yet" 5hat we can say is that it will ha)e %ore i%ages""%ore interacti)e"" %uch better" 5e are creating, and we say with all hu%ility al%ost a full Ban! end to end, 4H NBME, each has 7CC s each, 7CC answers and explanations" 2t is high quality stuff repeated innu%erable ti%es and tested hea)ily" 2t will be %ade al%ost of -5orld le)el quality and all totally 4CCD free" ?eople since decade""%aybe %ore are searching"" ha)e been wasting ti%e on foru%s"" people do this when exa% is near"" 2t is not appropriate that the NBME should ta!e OFC'O9C and not e)en gi)e correct answer""let alone explaination" 0hat all ends N5" 0his will sol)e all the proble%s" 7" 5ho are you 6 A7" 5e choose to re%ain anony%ous" All we want is to help others" 3ou can say: 5e are Anony%ous" 5e are .egion" 5e do notP"" NahPnah"" nothing sinister Q ust anony%ous because we wish to help others and change the syste% that>s all" 8" 2 a% scared shStless"" what if all this is %onitored by the NBME 6 5hat if they report us 6 5hat if they co%e to %y house 6 5hat if 2 go to ail 6 5hat if elephants could fly 6 5hat if 0ru%p>s hair is actually a giant bea)er controlling his %ind & %a!ing hi% a xenophobic %isogynist 6""""" A8" /irstly, we want to %a!e this clear as a glass of %oonshine #btw""another high yield %oonshine is ho%e%ade alcohol which %ay cause )arious !inds of poisoning""an i%portant one being Methanol for your test the reason why we choose to re%ain anony%ous #ah, well u do !now so%e of our na%es""but still is because we don>t want un'necessary spotlight" 5e thin! 7 steps forward" 5e are
pretty surePcancel that"" %a!e that we are 4C4D sure the wor! we do will create wa)es" 4CCCs of people will !now of it and e)en 4CCCs %ore will wonder who these people are who created such great content and ga)e it away for free6 ?eople will say: %aybe fools""they %ade the best stuff and didn>t %a!e a penny"" people %ay say %aybe it>s not good enoughP%aybe thisP%aybe that" 5e don>t want unnecessarily to be in that place where we are udged by so %any people" 5e wanna help" 5e will help" No need to !now na%es" End of story" .egality issue explained in depth: ne of us has a relati)e who happens to be a )ery good lawyer" 0he person has speciali=ed in 2? law" 2? $ 2ntellectual ?roperty" 0he following is a detailed point by point 4CCD proof why what we are doing is and shall stay always legal e)erywhere" A.5A3(" 2f questioned, we are and will go to court to defend our rights" ur original content will stay there fore)er" H: s legal then why didn>t anybody do it before 6 AH: Because nobody wanted to wor! as hard as we did #all ppl in)ol)ed + 79C, so%e +7TC And also btw, 2ncorrect"" An initiati)e had been started by @i!as Bhushan & 0ao .ee in 4F & 49" 2n all fairness, the boo! was @ER3 @ER3 poorly written" @i!as & 0ao ha)e done a good ob in step 4 /A" Rest, %ost of their content has not wor!ed co%%ercially" At ti%es, they were able to sell not e)en 4C'4F copies in so%e of their titles" uic!ly following the rise of /A 7F years ago"" these 7 thought -(M.E is %oney %achine and started %a!ing spin'off first aid boo!s"" 0otal there are o)er 4CC boo!s %ade by the%"" No not /A (tep 4"" that>s ust 4 boo!" 4CC different titled boo!s of /A series"" *on>t belie)e us 6 ;o and see"" they do dental""phar%acy""nursing all boo!s"" in ust %edical boo!s they ha)e +HC titles" ther fields together + 4CC al%ost 4FC boo!s" t buy it #actually it is not e)en a)ailable""its printing is halted because of lac! of sales as it is of the old -(M.E pattern and no one wants that stuff" AMAN .2NG: http:KKwww"a%a=on"co%K-nderground's""" ;;.E boo!s:
https:KKboo!s"google"co"inKboo!sKaboutK-nderground(tep4Answers"ht%l6 id$.cRgAAAA&rediresc$y 5e saw the boo! a long ti%e ago fro% which this idea spurned"" the boo! is dog shit"" it is so bad u will wonder if its sa%e @i!as and 0ao that %ade /A 6 0he answers are poorly written"" the explanations are non'existant" 0hey explain stuff in 4 line so%eti%es" s stuff and %a!e %oney off it 6 AF: 3ou need to either %eet a lawyer or read the following carefully to understand this concept" 0he thing that they did and which we will do is si%ple: Read the explanation to that boo! on a%a=on and what we propose to do is si%ply put in the preface of that boo!, as seen in a%a=on lin!: 0he stuff pro8ies answers to pre)ious test questions, # (ut not te @uestions" 0he crux is not to reproduce the questions" *MA opyright act protects original content owners against theft of their content by way of ?32N;" Meaning if so%eone will not use a ?2E* )ersion of the questions, then it is not a copyright e)asion #2t>s in the na%e isn>t it"" if you don>t ?3 then how dos copyright apply 6" -nder /ederal .aw, 4T -"("" UU F47, A %aor li%itation on copyright is that it protects only the original expression of ideas, and not the underlying ideas the%sel)es" 0o put it si%ply, nobody owns V(eptic (hoc!W"" no one has a copyright o)er V?leural EffusionW and it is not brea!ing the law to explain Vs Ro%eo and uliet" 2 sure as hell can tal! about it and explain it too" 9: M;, 2 can>t belie)e this Q 2s it true 6 A9: 3es" 4CCD"
T: 3ou sure you gonna post it free and not %a!e us pay 6 3ou !now good content fetches good %oney right 6 AT: All of those who are doing this initiati)e ha)e scored 79Cs and 7TCs" 5e say it with all hu%ility, but sorry to be blunt, we are pretty %uch set for life" (ure, we can %a!e boo!"" %aybe so%e people will buy" But %ost will %a!e copies" At %ost a few 4CCC dollars will be %ade by us" Now don>t get us wrong" My father is not the Ging of England and 2 would lo)e %oney as %uch as you would" But this is not the right )enue to %a!e it" 2n the -(, doctors who are s%art can %a!e tons of %oney in practice" 5hy not help our fellow colleagues and earn good wishes"" we will earn dollars and cents later for our entire life" 5hy not earn people>s lo)e today 6 :' : 3ou are really !ind hearted QQ 3ou don>t want anything bac! 6 : *o 7 things for us, and don>t forget if you use our content and li!e it" ?lease do these 7: /irst, tell all your friends about it and %a!e sure %ost nu%ber of people benefit off this" 5e will be happy to see %ore people getting better result" (econd, we belie)e in change"" change is the only constant & we thin! differently" 3ou can lo)e us or hate us but what no one will be able to do is to ignore the i%pact we %adeP"" (o %a!e use of this resource" 5e are writing and %a!ing )ideos e)en after exa%""%any people you will see acti)e before exa% but after their wor! is done no one loo!s bac! to help others" (o people ha)e been as!ing""%y inbox was full so i deacti)ated %y account" ?eople were literally i star)ing for this thing" As we all !now that NBME questions are li!e gold as they are %ade by -(M.E which %a!es NBME" Al%ost all past exa%inees will tell you it>s )alue" 2 won>t elaborate u see experiences yourself"" 4C'4F direct repeats and HC or so questions based on concepts of NBME is a)erage" : 5hen can 2 get %ore 6 2 can>t wait QQQ ;i)e it QQQ ;i)e it QQQQQQQQ
A:
