Biology project file for students of class 12th. A thoroughly described data for the students to score good marks.Full description
The first of five immunity challenges (pop quizes) taken by the students of the Northwestern University Class "The Tribe Has Spoken: Surviving TV's New Reality."Full description
MCQ on Electricity and MagnetismFull description
Law, Political Law
thinkiiit prefoundation
some MULTIPLE CHOICE QUESTIONS
book
infectious diseases
microelectronics
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FINAL EXAM OF MEDICAL IMMUNOLOGY (A) NAME:_________________
Reg.NO:__________________Points_________________
Each of the following questions contains four suggested answers, choose the best one. 1Antibody can bind to A antigenic determinents C the whole antigen molecule B BCR D TCR 2Factors influence immunogenicity include A foreignness B molecular size C chemical composition D all above 3 Haptens are the molecules that A possess antigenicity C possess immunogenicity B are large protein D can induce the production of antibody 4 The first immunoglobulin class produced in a primary response to an antigen is A IgA B IgG C IgM D IgE 5 The most abundant immunoglobulin class in serum is A IgA B IgG C IgM D IgE 6 The Ig which serves an important effector function at mucous membrane surface is A IgA B IgG C IgM D IgE 7 The domains by which immunoglobulin bind to epitope are A constant region B variable region C framework region D hinge region 8 The monomer of IgM is composed of A two γheavy chains,and two κor two λlight chains. B two μheavy chains,and two κor two λlight chains. A two εheavy chains,and two κor two λlight chains. A two δheavy chains,and two κor two λlight chains. 9 Papain can digest the entire IgG into A two Fab fragment and one Fc fragment. f ragment. A one Fab fragment and one Fc fragment. fr agment. A two F(ab’)2 fragment and one Fc fragment. A one F(ab’) 2 fragment and pFc’. 10 C1q-binding site of IgM is located in A CH1 B CH2 C CH3 D CH4 11The most efficient Ig involved in the classical pathway of complement activation is A IgA B IgG C IgM D IgE 12 In the classical pathway of complement activation, C 3 convertase is A C4b2a B C3bBb C C4b2a3b D C3bBb3b 13 The fragment that does not belong to the anaphylatoxin is A C3a B C3b C C4a C5a 14 The fragment involves in the opsonization is A C3a B C3b C C4a C5a 15 The regions that encode Class I HLA molecules are A locus A B locus B C locus C D all above 16 In Class I MHC molecules,peptide-binding site consist of 1
A α1 and α2 domains B α1 and α3 domains C α1 and β1 domains D β2m 17 Biological role of the MHC proteins do not contribute to A A fundamental role in regulating immune responses. B Ag presentation C Self-MHC restriction. D Control of B cell development 18 The component which is capable of lysing microorganisms is A C1-9 B C5-9 C C3-5 D C8-9 19 In the classical pathway of complement activtion,the activation sequence is A C123456789 B C124536789 C C142356789 D C124356789 20Which property does not belong to cytokines A Pleiotropy B Redundancy C Synergy D Specificity 21 The formation of C3bBb can be inhibited by A DAF B factor I C factor H D all above 22 MBL activates the complement system via its ability to A directly cleave C4 Cdirectly cleave C2 B directly cleave C3 D bind to C1q 1. All of the following are true about neutrophils EXCEPT that…
A. A. B. C.
They have have receptors for complement complement componen components ts and chemoattractive chemoattractive factors factors Are the main main cells involve involve in acute acute inflammation inflammation Their granules granules involved involved in microbial microbial killing killing Are the the cells of the the adaptive adaptive immune immune system system
2. All of the following are true about macrophages EXCEPT…
A. B. C. D.
Settle Settle mainl mainly y in the tiss tissue. ue. Can phagoc phagocyte yte microbes microbes and dead dead body body cells. cells. Expr Expres esss CD1 CD14 4 Only involve involve in innate immunity immunity
3. Opsonins include A. the complement complement component component C3b and antibody antibody C. Antigen Antigen B. MHC molecu molecules les D. Cytoki Cytokines nes 4. Nature killer killer cells A. can kill virus virus infected cells cells by specific receptors receptors recognizati recognization. on. B. Can secrete gamma interferon ( IFNγ ). C. Can not be activ activated ated by IL-2 IL-2.. D. Do not not expre express ss KAR KAR and and KIR. KIR.
2
5. All of the following are secondary lymphoid organs except …
A. Spleen Spleen.. B. Bone marrow. marrow.
C. Lymph ymph nodes. nodes. D. Mucosa Mucosa associated associated lymphoid lymphoid tissue tissue .
6. All of the following are true about thymus Except…
A. B. C. D.
is the organ organ where where T cell precursors precursors mature. mature. Provid Provid positive positive selection selection and negativ negativee selection selection for T cells. cells. Absence Absence in new born mouse mouse will cause T cell cell mediate immunity immunity disorder disorder.. Absence Absence in new born born mouse mouse will not affect affect B cell mediate mediate immunity immunity .
7. T cells do not… not… A. B. C. D.
expr expres esss CD3 CD3 produce produce cytokines cytokines to help other cell types. types. Mediate Mediate their functi functions ons by by cell to cell contact. contact. Recognize Recognize protein antigens antigens without without APC cells’ cells’ associated associated..
8. Th2 cells do not… not… A. B. C. D.
expr expres esss CD4. CD4. Produc Producee IL-4,I IL-4,IL-1 L-10 0 et al. al. Involv Involvee in infl inflamm ammato atory ry . Help Help B cell activati activation. on.
9. Tc cells do not… A. express express CD8. CD8. B. Mediate killing killing of virus virus infected cells cells . C. release lytic granules D. recognize antigens with MHC class II molecles. 10. All of the following are true about cell mediated immunity Except…
A. Mediate by activated T cells and macrophages. B. Can be transferred by T cells. C. some times can cause delayed-type hypersensitivity. D.have no relationship with other cells. 11. T cell receptor (TCR) does not… A. provide T cell specificty. specificty. B. exist in a secreted form.. C. only recognize the MHC-antigen peptides complex. 3
D.usually express α /β dimers. 12. All of the following are professional APC Except … A. Mast cells. B. Macrophages.
C. B cells. D. Dendritic cells.
13. The endogenous pathway of antigen presentation involves… A. presentation of antigen associated with MHC class II molecules. B. presentation of antigen to cytolytic T cells. C. presentation of antigen to Th2 cells. D. presentation of antigen to B cells. 14. All of the following following are true about hypersensitivity Except… A. is an unsual unsual immune response. C. is a primary immune response. B. is caused by antigen. D. can be classfied into four types. 15. The method that detects the antibody blocking the actions of a microorganism is: A. B. C. D.
Aggl Agglut utin inati ation on Enzyme-lin Enzyme-linked ked immunosor immunosorbent bent assay Neut Neutral raliza izatio tion n Single Single radial immunodif immunodiffusio fusion n
16. In enzyme-linked immunosorbent assay: A. Antibody or antigen is bound bound to an enzyme, which catalyzes the reaction. B. Substrates in the reaction is converted to a colored end-product. C. Antigen or antibody can be detected quantitatively with extremely sensitivity. sensitivity. D. All the above. above. 17. All of the following are involved in Immediate hypersensitivity except… A. mast mast cells cells B. IgE IgE
C. histam histamine ine D. plate platele lets ts
18. Hemolytic disease of the newborn due to RhD incompatibility depends upon the… A. transplacent transplacental al passage passage of anti-RhD anti-RhD IgG antibodi antibodies. es. B. transplacent transplacental al passage passage of anti-RhD anti-RhD IgM IgM antibodie antibodiess C. productio production n of cytoxic cytoxic antibodie antibodiess by the baby baby.. 4
D.
The first pregnancy of the RhD +mother with RhD - fetus.
19. All of the following are true about immune-complex mediated type III hypersensitivity except A. B. C. D.
immune-com immune-complex plex can be be formed by by serum serum products. products. Tissue Tissue damage damage can be caused caused by compleme complement nt activation. activation. Includ Includes es the Arthus Arthus reacti reaction. on. Requir Requires es cytoto cytotoxic xic T cells cells..
20. All of the following are true about delayed-type hypersensitivity except … A. is mediated mediated by T lymph lymphocytes ocytes.. B. includes includes contact contact sensitivity sensitivity.. C. includ includes es the tubercu tuberculin lin reactio reaction. n. D. includ includes es Farmer’ Farmer’ss lung. lung. 21. Live vaccines are dangerous to the following people except… A. a preg pregna nant nt woma woman. n. B. Teena eenage gers rs.. C. An immunologi immunologically cally incompetent incompetent host. host. D. Patients Patients receiving receiving immunosup immunosuppress pressive ive drugs. drugs. 22. Which of the following cell types is not involve in antibody production… A. Cytotoxic Cytotoxic T cells. C. Th2 cells. B. B cells. cells. D. Macroph Macrophage ages. s. 23. On the B cell surface, receptors for antigen are associated with… A. B5 molecules molecules C. MHC class I molecules. molecules. B. Igα and Igβ . D. MHC class II molecules. 24. All of the following are true about memory humoral immune response except … A. Usually Usually produce produce more more antibodies antibodies of of IgG class class B. The lag period period is much much shorter shorter than the primary primary immune immune response. response. C. The affinity affinity of antibodies antibodies is is maturated maturated.. D. Produce Produce IgM antibodies antibodies without without class class switching switching.. 25. Stimulation of antigen-specific T cells by appropriately presented antigen alone results in… A. aner anergy gy.. B. cell cell proli prolife ferat ratio ion. n. C. productio production n of of various various cytokines. cytokines. D. release release of perforin perforin and and granzyme granzymes. s. 26. B cells can express on their cell surface… 5
A. B. C. D.
membrane membrane IgM and and IgD stimulta stimultaneous neously ly.. CD2 CD2 molec molecul ules es.. CD3 CD3 molec molecul ules es.. IgG that can can bind several several different different unrelated unrelated antigens antigens..
27. T lymphocytes can be activated by… A. specific specific antigen. antigen. C. Cytokines. Cytokines. B. Mitoge Mitogen. n. D. All of the above. above. 28. Surface antigens on live cells can be identified by… A. ELIS ELISA. A. C. RIA RIA B. FACS D. All of the above. above. 29. Both immune complex disease and delayed type hypersensitivity involve… A. IgG or IgM IgM antib antibodi odies. es. B. Comp Comple leme ment nt.. C. Phag Phagoc ocyt ytic ic cells cells.. D. B cell cells. s. 30. B cell activation can be modulated by the following molecules except… A. CD19 CD19.. C. CD32 CD32.. B. CD21 CD21.. D. CD28 CD28..
Answer sheet for multiple choice question
1. A B C D 6. A B C D 11. A B C D 16. A B C D 21. A B C D 26. A B C D 31. A B C D 36. A B C D 41. A B C D 46. A B C D
2. A B C D 3. A B C D 4. A B C D 5. A B C D 7. A B C D 8. A B C D 9.A B C D 10.A B C D 12. A B C D 13. A B C D 14. A B C D 15. A B C D 17.A B C D 18 A B C D 19. A B C D 20. A B C D 22. A B C D 23.A B C D 24. A B C D 25. A B C D 27. A B C D 28. A B C D 29 A B C D 30. A B C D 32. A B C D 33. A B C D 34. A B C D 35. A B C D 37.A B C D 38 A B C D 39. A B C D 40. A B C D 42. A B C D 43.A B C D 44. A B C D 45. A B C D 47. A B C D 48. A B C D 49 A B C D 50. A B C D
